JP2000143691A5 - - Google Patents
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- Publication number
- JP2000143691A5 JP2000143691A5 JP1999282460A JP28246099A JP2000143691A5 JP 2000143691 A5 JP2000143691 A5 JP 2000143691A5 JP 1999282460 A JP1999282460 A JP 1999282460A JP 28246099 A JP28246099 A JP 28246099A JP 2000143691 A5 JP2000143691 A5 JP 2000143691A5
- Authority
- JP
- Japan
- Prior art keywords
- labeled
- cortisol
- hydrogen
- immobilized
- together form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 84
- 229960000890 hydrocortisone Drugs 0.000 description 42
- 229910052739 hydrogen Inorganic materials 0.000 description 24
- 239000001257 hydrogen Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 20
- 229920001059 synthetic polymer Polymers 0.000 description 14
- 150000002431 hydrogen Chemical class 0.000 description 13
- 229920005615 natural polymer Polymers 0.000 description 13
- 125000005647 linker group Chemical group 0.000 description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 11
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 description 6
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- -1 methylenecarbonyloxy Chemical group 0.000 description 5
- 239000007822 coupling agent Substances 0.000 description 4
- 102000013415 peroxidase activity proteins Human genes 0.000 description 4
- 108040007629 peroxidase activity proteins Proteins 0.000 description 4
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 3
- 210000000628 antibody-producing cell Anatomy 0.000 description 3
- 239000003638 chemical reducing agent Substances 0.000 description 3
- 229940125890 compound Ia Drugs 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 2
- LQILVUYCDHSGEU-UHFFFAOYSA-N 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylic acid Chemical group C1CC(C(=O)O)CCC1CN1C(=O)C=CC1=O LQILVUYCDHSGEU-UHFFFAOYSA-N 0.000 description 1
- 0 C**N=C(CC1)C=C(CCC2C(CC3)C(C)(C4)C3(C(*)=O)O)C1(C)C2C4O Chemical compound C**N=C(CC1)C=C(CCC2C(CC3)C(C)(C4)C3(C(*)=O)O)C1(C)C2C4O 0.000 description 1
- 230000001837 anti-cortisol effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- NKLCHDQGUHMCGL-UHFFFAOYSA-N cyclohexylidenemethanone Chemical group O=C=C1CCCCC1 NKLCHDQGUHMCGL-UHFFFAOYSA-N 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10283698P | 1998-10-02 | 1998-10-02 | |
| US60/102836 | 1998-10-02 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011090267A Division JP2011148821A (ja) | 1998-10-02 | 2011-04-14 | 還元型コルチゾール接合体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000143691A JP2000143691A (ja) | 2000-05-26 |
| JP2000143691A5 true JP2000143691A5 (enExample) | 2006-11-24 |
Family
ID=22291927
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11282460A Withdrawn JP2000143691A (ja) | 1998-10-02 | 1999-10-04 | 還元型コルチゾ―ル接合体 |
| JP2011090267A Pending JP2011148821A (ja) | 1998-10-02 | 2011-04-14 | 還元型コルチゾール接合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011090267A Pending JP2011148821A (ja) | 1998-10-02 | 2011-04-14 | 還元型コルチゾール接合体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6383766B1 (enExample) |
| EP (1) | EP0992512B1 (enExample) |
| JP (2) | JP2000143691A (enExample) |
| AT (1) | ATE312842T1 (enExample) |
| CA (1) | CA2283597C (enExample) |
| DE (1) | DE69928888T2 (enExample) |
| DK (1) | DK0992512T3 (enExample) |
| ES (1) | ES2253866T3 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| CA2376057A1 (en) * | 1999-06-08 | 2000-12-14 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
| NZ511705A (en) * | 2001-05-14 | 2004-03-26 | Horticulture & Food Res Inst | Methods and rapid immunoassay device for detecting progesterone and other steroids |
| JP2004063363A (ja) * | 2002-07-31 | 2004-02-26 | Semiconductor Energy Lab Co Ltd | 電界発光素子用材料、およびそれを用いた電界発光素子 |
| DE102004034008A1 (de) * | 2004-07-14 | 2006-02-09 | Rösner Research GmbH & Co.KG | Verfahren zur Herstellung von Albumin-Corticoid-Konjugaten |
| GB2418665B8 (en) * | 2004-10-04 | 2008-03-25 | Biotrin Intellectual Pty Ltd | Stabilising diluent for a protein-horseradish peroxidase conjugate |
| CN104251903A (zh) * | 2007-11-22 | 2014-12-31 | 特拉斯医药有限公司 | 血液试样的品质评估方法 |
| JP2017150815A (ja) * | 2014-05-29 | 2017-08-31 | 株式会社日立製作所 | 臨床検査キット及び化学物質検出方法 |
| JP7579190B2 (ja) * | 2020-03-30 | 2024-11-07 | ミナリスメディカル株式会社 | 競合法による検体中のステロイドホルモンの測定用キットの安定化方法 |
| CN119306830B (zh) * | 2023-07-11 | 2025-06-20 | 东莞市朋志生物科技有限公司 | 抗皮质醇抗体、检测皮质醇的试剂和试剂盒 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3992158A (en) | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
| US3867258A (en) | 1973-11-08 | 1975-02-18 | American Cyanamid Co | Lactate dehydrogenase test material |
| CA1054034A (en) | 1975-06-20 | 1979-05-08 | Barbara J. Bruschi | Multilayer analytical element |
| US4042435A (en) | 1976-01-05 | 1977-08-16 | The Goodyear Tire & Rubber Company | Closed torus wound carcass for a closed torus tire |
| US4050898A (en) | 1976-04-26 | 1977-09-27 | Eastman Kodak Company | Integral analytical element |
| US4081525A (en) * | 1976-08-16 | 1978-03-28 | Beckman Instruments, Inc. | Radioimmunoassay of plasma steroids |
| US4128629A (en) * | 1977-07-05 | 1978-12-05 | Corning Glass Works | Extraction-free cortisol assay |
| US4153668A (en) | 1978-01-03 | 1979-05-08 | Eastman Kodak Company | Multi-zone analytical element and method using same |
| IL56467A (en) * | 1978-02-10 | 1982-04-30 | Sin Hang Lee | Cytochemical agents and methods for the detection of steroid hormone receptors in human tissues |
| US4258001A (en) | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
| JPS55164356A (en) | 1979-06-08 | 1980-12-22 | Fuji Photo Film Co Ltd | Multi-layer analysis sheet for liquid sample analysis |
| JPS5634700A (en) * | 1979-08-29 | 1981-04-06 | Teikoku Hormone Mfg Co Ltd | Novel tetrahydrocorticosteroid derivative and antiserum |
| US4372745A (en) | 1979-12-19 | 1983-02-08 | Electro-Nucleonics, Inc. | Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| JPS57101761A (en) | 1980-12-17 | 1982-06-24 | Konishiroku Photo Ind Co Ltd | Analyzing element |
| US4483921A (en) | 1981-01-12 | 1984-11-20 | Collaborative Research, Inc. | Immunoassay with antigen or antibody labeled liposomes sequestering enzyme |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| DE3380125D1 (en) | 1982-03-22 | 1989-08-03 | Amersham Int Plc | Assay for the free portion of substances in biological fluids |
| US5599720A (en) * | 1982-08-27 | 1997-02-04 | Multilyte Limited | Measurement of analyte concentration |
| US4510251A (en) * | 1982-11-08 | 1985-04-09 | Abbott Laboratories | Fluorescent polarization assay for ligands using aminomethylfluorescein derivatives as tracers |
| JPS6020149A (ja) * | 1983-07-15 | 1985-02-01 | Teikoku Hormone Mfg Co Ltd | 免疫化学的測定方法及びその試薬 |
| US4847080A (en) | 1984-03-07 | 1989-07-11 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers |
| DE3662730D1 (en) | 1985-01-24 | 1989-05-11 | Inst Int Pathologie Cellulaire | Immunoassay method for antibodies of different classes in a liquid sample |
| JPS61272661A (ja) | 1985-05-29 | 1986-12-02 | Hitachi Ltd | イムノアツセイ法 |
| EP0204523B1 (en) | 1985-05-31 | 1992-02-26 | Syntex (U.S.A.) Inc. | Glucose-6-phosphate dehydrogenase conjugates, their preparation and use |
| US4859610A (en) | 1985-06-05 | 1989-08-22 | Synbiotics Corporation | Immunoassay incubation device |
| US4855226A (en) | 1985-06-07 | 1989-08-08 | Beckman Instruments, Inc. | Novel competitive assay for theophylline and reagent for use therein |
| US4670381A (en) | 1985-07-19 | 1987-06-02 | Eastman Kodak Company | Heterogeneous immunoassay utilizing horizontal separation in an analytical element |
| JP2591738B2 (ja) | 1985-08-21 | 1997-03-19 | ベーリンガー マンヘイム コーポレイション | 特異的結合アッセイにおける成分の分離，混合および検出のための方法および装置 |
| US4868106A (en) | 1985-10-17 | 1989-09-19 | Konishiroku Photo Industry Co., Ltd. | Analytical element and method for determining a component in a test sample |
| JPS62119457A (ja) * | 1985-11-19 | 1987-05-30 | Sapporo Imuno Diagnostic Lab:Kk | 先天性副腎皮質過形成のマススクリ−ニング用診断薬キツト |
| US4822747A (en) | 1986-12-09 | 1989-04-18 | Miles Inc. | Polyacrylamide gel particles having hapten moieties bound thereto as immunoassay reagent |
| US4863876A (en) | 1987-01-15 | 1989-09-05 | Hevey Richard C | Method of detecting and quantifying ligands in liquids via biotin-avidin-medicated fluorescence polarization |
| US4847194A (en) | 1987-03-13 | 1989-07-11 | Becton, Dickinson And Company | Colorimetric detection of delta-5-3-ketosteroid isomerase and immunoassay based thereon |
| US4857453A (en) | 1987-04-07 | 1989-08-15 | Syntex (U.S.A.) Inc. | Immunoassay device |
| US4857454A (en) | 1987-04-09 | 1989-08-15 | a Division of Yeshiva University Albert Einstein College of Medicine of Yeshiva University | Spectrophotometric method for kinetic absorbance measurements in two-phase enzyme immunoassay and apparatus therefor |
| US4950592A (en) | 1987-05-12 | 1990-08-21 | Eastman Kodak Company | Blend of monoclonal antibodies |
| US4853335A (en) | 1987-09-28 | 1989-08-01 | Olsen Duane A | Colloidal gold particle concentration immunoassay |
| AU3359493A (en) * | 1992-01-17 | 1993-08-03 | Selective Antibodies Limited | Determination of haptens |
| US5559256A (en) | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
| US5650324A (en) | 1994-05-31 | 1997-07-22 | Johnson & Johnson Clinical Diagnostics, Inc. | Inhibitor and anti-inhibitor monoclonal antibodies specific for horseradish peroxidase |
| US5663054A (en) | 1995-03-03 | 1997-09-02 | Abbott Laboratories | Determination of steroids by competitive immunoassay |
| US5912114A (en) * | 1997-09-12 | 1999-06-15 | Johnson & Johnson Medical, Inc. | Wound diagnosis by quantitating cortisol in wound fluids |
-
1999
- 1999-09-24 CA CA002283597A patent/CA2283597C/en not_active Expired - Lifetime
- 1999-09-30 US US09/408,931 patent/US6383766B1/en not_active Expired - Lifetime
- 1999-10-01 ES ES99307762T patent/ES2253866T3/es not_active Expired - Lifetime
- 1999-10-01 DK DK99307762T patent/DK0992512T3/da active
- 1999-10-01 AT AT99307762T patent/ATE312842T1/de active IP Right Revival
- 1999-10-01 EP EP99307762A patent/EP0992512B1/en not_active Expired - Lifetime
- 1999-10-01 DE DE69928888T patent/DE69928888T2/de not_active Expired - Lifetime
- 1999-10-04 JP JP11282460A patent/JP2000143691A/ja not_active Withdrawn
-
2011
- 2011-04-14 JP JP2011090267A patent/JP2011148821A/ja active Pending
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