JPS5634700A - Novel tetrahydrocorticosteroid derivative and antiserum - Google Patents

Novel tetrahydrocorticosteroid derivative and antiserum

Info

Publication number
JPS5634700A
JPS5634700A JP10901479A JP10901479A JPS5634700A JP S5634700 A JPS5634700 A JP S5634700A JP 10901479 A JP10901479 A JP 10901479A JP 10901479 A JP10901479 A JP 10901479A JP S5634700 A JPS5634700 A JP S5634700A
Authority
JP
Japan
Prior art keywords
formula
compound
tetrahydrocorticosteroid
group
antiserum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10901479A
Other languages
Japanese (ja)
Inventor
Akira Kobegawa
Seijiro Honma
Toshio Nanbara
Hiroshi Hosoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to JP10901479A priority Critical patent/JPS5634700A/en
Publication of JPS5634700A publication Critical patent/JPS5634700A/en
Pending legal-status Critical Current

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Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:A tetrahydrocorticosteroid compound of formula I [one of R1 and R2 is H and the other is H or OH, or R1 and R2 together form oxo group; Z is H or group of formula II (A1WA3 are lower alkyl); n is 2 or 3].
EXAMPLE: Tetrahydrocortisol-3-hemisuccinate.
USE: Intermediate of tetrahydrocorticosteroid antigen and antibody. Useful for the diagnosis of the adrenal function or steroid dysbolism of animals by the determination of tetrahydrocortisol or tetrahydrocortisone in urine.
PROCESS: The compound of formula I is prepared e.g. by (1) trisilylating the 21- position OH group of the steroid compound of formula III selectively to obtain a compound of formula IV (Z' is group of formula II), (2) reacting the compound with an acid anhydride of formula V, and if necessary, (3) hydrolyzing the reaction product.
COPYRIGHT: (C)1981,JPO&Japio
JP10901479A 1979-08-29 1979-08-29 Novel tetrahydrocorticosteroid derivative and antiserum Pending JPS5634700A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10901479A JPS5634700A (en) 1979-08-29 1979-08-29 Novel tetrahydrocorticosteroid derivative and antiserum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10901479A JPS5634700A (en) 1979-08-29 1979-08-29 Novel tetrahydrocorticosteroid derivative and antiserum

Publications (1)

Publication Number Publication Date
JPS5634700A true JPS5634700A (en) 1981-04-06

Family

ID=14499378

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10901479A Pending JPS5634700A (en) 1979-08-29 1979-08-29 Novel tetrahydrocorticosteroid derivative and antiserum

Country Status (1)

Country Link
JP (1) JPS5634700A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61257531A (en) * 1985-05-09 1986-11-15 Nippon Kokan Kk <Nkk> Continuous underground wall
JP2000143691A (en) * 1998-10-02 2000-05-26 Ortho Clinical Diagnostics Inc Reduced-type cortisol conjugate
CN105092831A (en) * 2015-08-14 2015-11-25 苏州博源医疗科技有限公司 17-hydroxycorticosteroid immunodetection reagent and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61257531A (en) * 1985-05-09 1986-11-15 Nippon Kokan Kk <Nkk> Continuous underground wall
JP2000143691A (en) * 1998-10-02 2000-05-26 Ortho Clinical Diagnostics Inc Reduced-type cortisol conjugate
EP0992512A3 (en) * 1998-10-02 2002-04-17 Ortho-Clinical Diagnostics, Inc. Reduced cortisol conjugate
JP2011148821A (en) * 1998-10-02 2011-08-04 Ortho Clinical Diagnostics Inc Reduced cortisol conjugate
CN105092831A (en) * 2015-08-14 2015-11-25 苏州博源医疗科技有限公司 17-hydroxycorticosteroid immunodetection reagent and preparation method thereof

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