JPS5522698A - Preparation of maleimidobenzoic acid derivative - Google Patents

Preparation of maleimidobenzoic acid derivative

Info

Publication number
JPS5522698A
JPS5522698A JP10155679A JP10155679A JPS5522698A JP S5522698 A JPS5522698 A JP S5522698A JP 10155679 A JP10155679 A JP 10155679A JP 10155679 A JP10155679 A JP 10155679A JP S5522698 A JPS5522698 A JP S5522698A
Authority
JP
Japan
Prior art keywords
preparation
enzyme
carboxylic acid
acid derivative
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10155679A
Other languages
Japanese (ja)
Other versions
JPS588395B2 (en
Inventor
Tsunehiro Kitagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP10155679A priority Critical patent/JPS588395B2/en
Publication of JPS5522698A publication Critical patent/JPS5522698A/en
Publication of JPS588395B2 publication Critical patent/JPS588395B2/en
Expired legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

PURPOSE: To prepare the title derivative capable of selectively bonding an enzyme with an antigen, and useful as a bonding agent for the preparation of an enzyme- labelled antigen, by reacting a specific carboxylic acid, etc. with N-hydroxysuccinimide.
CONSTITUTION: A maleimidobenzoic acid derivative of formula III is prepared easily by reacting a carboxylic acid I or its reactive derivative at the carboxylic groups (e.g. a mixed anhydride or acid halide of isopropyl chlorocarbonate and the carboxylic acid I) with N-hydroxysuccinimide, pref. at 0W40°C for 20W240 minutes.
USE: Bonding agent for the preparation of an enzyme-labelled antigen useful for the trace analysis of hormones, etc. by enzyme immunoassay.
COPYRIGHT: (C)1980,JPO&Japio
JP10155679A 1979-08-08 1979-08-08 Method for producing maleimidobenzoic acid derivatives Expired JPS588395B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10155679A JPS588395B2 (en) 1979-08-08 1979-08-08 Method for producing maleimidobenzoic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10155679A JPS588395B2 (en) 1979-08-08 1979-08-08 Method for producing maleimidobenzoic acid derivatives

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP50148787A Division JPS5272284A (en) 1975-12-12 1975-12-12 Enzymeeimmunoassay reagent

Publications (2)

Publication Number Publication Date
JPS5522698A true JPS5522698A (en) 1980-02-18
JPS588395B2 JPS588395B2 (en) 1983-02-15

Family

ID=14303687

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10155679A Expired JPS588395B2 (en) 1979-08-08 1979-08-08 Method for producing maleimidobenzoic acid derivatives

Country Status (1)

Country Link
JP (1) JPS588395B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58208238A (en) * 1982-03-17 1983-12-03 サノフイ・ソシエテ・アノニム Novel conjugate for bonding enzyme and antibody by conjugate bond and medicine
JP2018155880A (en) * 2017-03-16 2018-10-04 保土谷化学工業株式会社 Charge control agents and toners using imidobenzoic acid derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58208238A (en) * 1982-03-17 1983-12-03 サノフイ・ソシエテ・アノニム Novel conjugate for bonding enzyme and antibody by conjugate bond and medicine
JP2018155880A (en) * 2017-03-16 2018-10-04 保土谷化学工業株式会社 Charge control agents and toners using imidobenzoic acid derivatives

Also Published As

Publication number Publication date
JPS588395B2 (en) 1983-02-15

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