JO3263B1 - مشتق إندان سلفاميد جديد - Google Patents

مشتق إندان سلفاميد جديد

Info

Publication number
JO3263B1
JO3263B1 JOP/2013/0184A JOP20130184A JO3263B1 JO 3263 B1 JO3263 B1 JO 3263B1 JO P20130184 A JOP20130184 A JO P20130184A JO 3263 B1 JO3263 B1 JO 3263B1
Authority
JO
Jordan
Prior art keywords
sulfamide
indine
tetrafluoro
novel
derivative
Prior art date
Application number
JOP/2013/0184A
Other languages
English (en)
Inventor
Kosasa Takashi
Hanada Takahisa
Watanabe Toru
Tanaka Toshiaki
Teramoto Tetsuyuki
Sorimachi Keiichi
Saito Minako
Higashiyama Hiroyuki
Kazuta Yuji
Ishikawa Yukio
Kita Yoichi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of JO3263B1 publication Critical patent/JO3263B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/08—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of rings other than six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

مشتقات إندان سلفاميد جديدة أو ملح منها مقبول صيدليا مثل N - [(1S) -2, 2, 5, 7 - رابع فلورو -2, 3 - ثاني هيدرو -1H- إندين -1- يل] سلفاميد N - [(1S) -2, 2, 4, 7 - رابع فلورو -2, 3 - ثاني هيدرو -1H- إندين -1- يل] سلفاميد (+) - N- (2, 2, 4, 6, 7 - خامس فلورو -2, 3 - ثاني هيدرو -1H- إندين -1- يل] سلفاميد، لها تأثير محسن لمعامل حدة التشنج (Score) في نموذج فئران مصابة، وبالتالي فإن المركبات أو أملاحها وفقا للاختراع الحالي تكون متوقعة كعقار لمعالجة الصرع.
JOP/2013/0184A 2012-06-21 2013-06-18 مشتق إندان سلفاميد جديد JO3263B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662626P 2012-06-21 2012-06-21
US201261709737P 2012-10-04 2012-10-04
US201361751331P 2013-01-11 2013-01-11

Publications (1)

Publication Number Publication Date
JO3263B1 true JO3263B1 (ar) 2018-09-16

Family

ID=49768740

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0184A JO3263B1 (ar) 2012-06-21 2013-06-18 مشتق إندان سلفاميد جديد

Country Status (34)

Country Link
US (1) US9018260B2 (ar)
EP (1) EP2865663B1 (ar)
JP (1) JP5883135B2 (ar)
KR (1) KR101951519B1 (ar)
CN (1) CN104395285B (ar)
AR (1) AR091506A1 (ar)
AU (1) AU2013278450B2 (ar)
BR (1) BR112014031565B1 (ar)
CA (1) CA2877097C (ar)
CL (1) CL2014003429A1 (ar)
CY (1) CY1119171T1 (ar)
DK (1) DK2865663T3 (ar)
ES (1) ES2628374T3 (ar)
HR (1) HRP20170863T1 (ar)
HU (1) HUE033583T2 (ar)
IL (1) IL236295A (ar)
JO (1) JO3263B1 (ar)
LT (1) LT2865663T (ar)
ME (1) ME02753B (ar)
MX (1) MX355261B (ar)
MY (1) MY169073A (ar)
NZ (1) NZ702974A (ar)
PE (1) PE20150284A1 (ar)
PH (1) PH12014502805A1 (ar)
PL (1) PL2865663T3 (ar)
PT (1) PT2865663T (ar)
RS (1) RS56073B1 (ar)
RU (1) RU2619937C2 (ar)
SG (1) SG11201408359PA (ar)
SI (1) SI2865663T1 (ar)
SM (1) SMT201700287T1 (ar)
TW (1) TWI597263B (ar)
WO (1) WO2013191144A1 (ar)
ZA (1) ZA201409248B (ar)

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PE20160434A1 (es) 2013-09-09 2016-05-25 Peloton Therapeutics Inc Eteres de arilo y sus usos
ES2737148T3 (es) 2013-12-16 2020-01-10 Peloton Therapeutics Inc Análogos de sulfona y sulfoximina cíclicos y usos de los mismos
KR102250214B1 (ko) * 2013-12-19 2021-05-07 에자이 알앤드디 매니지먼트 가부시키가이샤 1-인단설파미드 유도체를 포함하는 통증에 대한 치료제 및/또는 예방제
WO2016144825A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
WO2016145032A1 (en) * 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
EP3268362B1 (en) 2015-03-11 2021-10-20 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
US10512626B2 (en) 2015-03-11 2019-12-24 Peloton Therapeautics, Inc. Compositions for use in treating glioblastoma
WO2016168510A1 (en) 2015-04-17 2016-10-20 Peloton Therapeutics, Inc. Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof
US11660275B2 (en) * 2018-03-20 2023-05-30 Eisai R&D Management Co., Ltd. Epilepsy treatment agent
JP2024026905A (ja) * 2020-11-25 2024-02-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 てんかん治療剤
KR20250005086A (ko) 2022-04-27 2025-01-09 에자이 알앤드디 매니지먼트 가부시키가이샤 파킨슨병의 치료를 위한 약학적 조성물

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US3383414A (en) * 1964-08-26 1968-05-14 Sandoz Ag Benzocycloalkyl sulfamides
US3709677A (en) 1969-06-25 1973-01-09 Sandoz Ag N-substituted sulfamoyl compounds useful as herbicides
EP1401805A1 (en) * 2001-06-26 2004-03-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Valproyltaurinamide derivatives as anticonvulsant and cns active agents
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
ES2310366T3 (es) * 2004-08-24 2009-01-01 Janssen Pharmaceutica Nv Nuevos derivados de heteroaril sulfonamida benzo-condensada utiles como agentes anticonvulsivos.
US20070155823A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
CN100572365C (zh) * 2006-01-26 2009-12-23 全哲山 用作抗癫痫药的1,2,4-三唑并[4,3-a]喹啉-1-酮衍生物及其可药用盐
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
CL2007002994A1 (es) 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
AR070949A1 (es) * 2007-10-19 2010-05-19 Solvay Pharm Gmbh Compuestos derivados de sulfamato de uso medico, medicamentos y composiciones farmaceuticas que los comprenden, procedimientos para preparar estos compuestos y su uso
TW201012803A (en) * 2008-06-06 2010-04-01 Organon Nv Heterocyclic derivatives
EP2417101B1 (en) * 2009-04-09 2013-10-23 Merck Sharp & Dohme B.V. Indane derivatives
KR101771755B1 (ko) * 2009-11-13 2017-08-25 셀진 인터내셔널 Ii 에스에이알엘 선택적 헤테로시클릭 스핑고신 1 포스페이트 수용체 조절자
RS61829B1 (sr) * 2009-11-13 2021-06-30 Receptos Llc Selektivni modulatori receptora sfingozin 1 fosfata i metode hiralne sinteze
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Also Published As

Publication number Publication date
CN104395285B (zh) 2016-04-13
PH12014502805B1 (en) 2015-02-23
PH12014502805A1 (en) 2015-02-23
PE20150284A1 (es) 2015-02-21
EP2865663A4 (en) 2016-02-17
BR112014031565A2 (pt) 2017-06-27
LT2865663T (lt) 2017-07-10
EP2865663B1 (en) 2017-04-05
ZA201409248B (en) 2015-12-23
TW201402530A (zh) 2014-01-16
RU2014151013A (ru) 2016-08-10
KR20150032838A (ko) 2015-03-30
HRP20170863T1 (hr) 2017-09-08
IL236295A (en) 2016-09-29
US20140371319A1 (en) 2014-12-18
HUE033583T2 (hu) 2017-12-28
RS56073B1 (sr) 2017-10-31
SI2865663T1 (sl) 2017-07-31
NZ702974A (en) 2016-03-31
MX355261B (es) 2018-04-12
IL236295A0 (en) 2015-02-26
JPWO2013191144A1 (ja) 2016-05-26
WO2013191144A1 (ja) 2013-12-27
JP5883135B2 (ja) 2016-03-09
CL2014003429A1 (es) 2015-03-27
ES2628374T3 (es) 2017-08-02
AR091506A1 (es) 2015-02-11
US9018260B2 (en) 2015-04-28
PL2865663T3 (pl) 2017-09-29
CN104395285A (zh) 2015-03-04
MX2014015492A (es) 2015-05-08
ME02753B (me) 2018-01-20
CY1119171T1 (el) 2018-02-14
HK1207363A1 (en) 2016-01-29
SMT201700287T1 (it) 2017-07-18
MY169073A (en) 2019-02-13
PT2865663T (pt) 2017-06-02
DK2865663T3 (en) 2017-06-19
CA2877097C (en) 2018-08-07
BR112014031565B1 (pt) 2022-04-12
CA2877097A1 (en) 2013-12-27
EP2865663A1 (en) 2015-04-29
RU2619937C2 (ru) 2017-05-22
TWI597263B (zh) 2017-09-01
AU2013278450A1 (en) 2015-01-22
SG11201408359PA (en) 2015-01-29
KR101951519B1 (ko) 2019-02-22
AU2013278450B2 (en) 2017-04-20
BR112014031565A8 (pt) 2021-06-08

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