SG11201408359PA - Novel indanesulfamide derivative - Google Patents
Novel indanesulfamide derivativeInfo
- Publication number
- SG11201408359PA SG11201408359PA SG11201408359PA SG11201408359PA SG11201408359PA SG 11201408359P A SG11201408359P A SG 11201408359PA SG 11201408359P A SG11201408359P A SG 11201408359PA SG 11201408359P A SG11201408359P A SG 11201408359PA SG 11201408359P A SG11201408359P A SG 11201408359PA
- Authority
- SG
- Singapore
- Prior art keywords
- ibaraki
- kgp
- sulfamide
- inden
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/08—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
(i2) mwu ft iz s-5 iv x m £ titz s issaj n d9) mm IHMMi _ (43) 2013 ^ 12 ^ 27 0(27.12.2013) WIPO I PCT (10) WO 2013/191144 A1 (51) C07C 307/08 (2006.01) A61K31/18 (2006.01) (21) (22) (25) g&fflgia)] =E. DP . A61K 31/277 (2006.01) A61P 25/08 (2006.01) PCT/JP2013/066623 2013 ^ 6 ^ 17 0(17.06.2013) 0*lg (26) @U8&M©Wi§: (30) fiBfcftf '— 1 61/662626 2012^6^ 21 0(21.06.2012) US 61/709737 2012 ^ 10 ^ 4 0(04.10.2012) US 61/751331 2013 ^1^110(11.01.2013) US (71) ttiHA: X—!f>r • T-)l • • T> K 7 -r- s • > h tt_(EISAI R&DJVIANAGE- MENT CO., LTD.) [JP/JP]; T 1128088 ICijliRXjS. E Al^JII E3T g 6 H 1 0-^- Tokyo (JP). (72) fj(H £f \"(KAZUTA Yu ji); T3002635 ^ limm^^5Tg 1 #±fe3 Ibaraki (JP). ;Jl ill *r (WATANABE Toru); T 3002635 18|0 < lirfT^ ^5TI1S»3 X-- PJT fa Ibaraki (JP). 5BJ ^ — (SORIMACHI Keii- chi); T 3002635 l#fO< I £rfT|£ ?•£-£• 5 T g 1 # Ibaraki (JP). StU oV-fc^SAITO Minako); T 3002635 »o< iimm^^5Tg 1 Site 3 X—yvtt Ibaraki (JP). H\"(KITA Yoichi); T 3002635 lifO < l£~ rfTKft-n 5 Tg 1#Jft3 X— +f J ttSC^a®[S®W5ERlT A Ibaraki (JP). EEI 4^ ?IJ & (TANAKA Toshiaki); T 1128088 ^5liRS;5l|E/h5JI| 4Tg 6# 1 0 X — +P >f 3; £ a fa Tofyo (JP). M UJ Si (HIGASHIYAMA Hiroyuki); T 3002635 IS§0< 5Tg 1 #±fe3 x—yvtta^a Ibaraki (JP). ft H $££.(HANADA Takahisa); T 3002635 5 T g 1 #±t3 x— Ibaraki (JP). £(TERAMOTO Tetsuyuki); T 3002635 ISIO < 5 T g 1 #±fe 3 X— Ibaraki (JP). /J\£f ftS&(KOSASA Takashi); T 3002635 lilO < li fI^5Tg1ftt3 X—!f>rtt3C^a®[ ;J$EJF R)T fa Ibaraki (JP). 5 J11 (ISHIKAWA Yukio); T 3002635 li|0< lirtT MJin 5 T g imm^i (54) Title: NOVEL INDANESULFAMIDE DERIVATIVE (54) : §T£H >£* >X)\sZ> y £ Rl§2»ft AA Vehicle (%) lOmg/kgp.o. 20mg/kgp.o. 50mg/kgp.o. (%) •t •t 0\ i-H cn i-H o CJ o & p<0.01 AA Compound of example 1 p<0.001 p<0.0001 (57) Abstract: A novel indanesulfamide com pound, such as N-[(lS)-2,2,5,7-tetrafluoro-2,3- dihydro-lH-inden-l-yl]- sulfamide, N-[(1S)- 2,2,4,7-tetrafluoro-2,3-dihydro- 1H- inden-1- yl]sulfamide and (+)-N-(2,2,4,6,7- pentafluoro- 2,3-dihydro-lH-inden-l-yl)sulfamide, or a pharmaceutically acceptable salt thereof has an effect of improving the severity (score) of an at tack in a mouse kindling model and therefore can be expected to serve as a therapeutic agent for epilepsy. (57)®$: N- [ ( 1 S) -2, 2, 5, 7 -7- h^7;U^-P-2, 3—V t RP - 1 H -4 >x>- 1 )\A XJl/77? h\ N - [ ( 1 S) - 2, 2, 4, 7-f h77JI/tO-2, 3 — y t K • — 1 H - - >T W > 1 -'f ;u ] X )l Z> 7 £ h\ ( +) - - N (2, 2, 4, 6, • — 2 , 3-5/th'O-IH-Of 5 K£<!fa>$fr X + > K U X/^Ef^Ucfcl^TfgfFS SJS (x=ir) §f= ft, o WO 2013/191144 AlllllllH Ibaraki (JP). (74) ft II A. 5?fit, ^(HASIX.AWA Yoshiki etal.); T 1000005 E ACDfa ~ T @ 1 MY PLAZA Tokyo (JP). (8i) ti^@(^a>&i^PBy, AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) (^am^su > ±T(Dmm(Dfcm% 11^ nlfb): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), J- — 7 V T (AM, AZ, BY, KG, KZ, RU, TJ, TM), 3 — • V / ^ (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). - (&&£ 21 &(3))
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662626P | 2012-06-21 | 2012-06-21 | |
| US201261709737P | 2012-10-04 | 2012-10-04 | |
| US201361751331P | 2013-01-11 | 2013-01-11 | |
| PCT/JP2013/066623 WO2013191144A1 (en) | 2012-06-21 | 2013-06-17 | Novel indanesulfamide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201408359PA true SG11201408359PA (en) | 2015-01-29 |
Family
ID=49768740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201408359PA SG11201408359PA (en) | 2012-06-21 | 2013-06-17 | Novel indanesulfamide derivative |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9018260B2 (en) |
| EP (1) | EP2865663B1 (en) |
| JP (1) | JP5883135B2 (en) |
| KR (1) | KR101951519B1 (en) |
| CN (1) | CN104395285B (en) |
| AR (1) | AR091506A1 (en) |
| AU (1) | AU2013278450B2 (en) |
| BR (1) | BR112014031565B1 (en) |
| CA (1) | CA2877097C (en) |
| CL (1) | CL2014003429A1 (en) |
| CY (1) | CY1119171T1 (en) |
| DK (1) | DK2865663T3 (en) |
| ES (1) | ES2628374T3 (en) |
| HK (1) | HK1207363A1 (en) |
| HR (1) | HRP20170863T1 (en) |
| HU (1) | HUE033583T2 (en) |
| IL (1) | IL236295A (en) |
| JO (1) | JO3263B1 (en) |
| LT (1) | LT2865663T (en) |
| ME (1) | ME02753B (en) |
| MX (1) | MX355261B (en) |
| MY (1) | MY169073A (en) |
| NZ (1) | NZ702974A (en) |
| PE (1) | PE20150284A1 (en) |
| PH (1) | PH12014502805B1 (en) |
| PL (1) | PL2865663T3 (en) |
| PT (1) | PT2865663T (en) |
| RS (1) | RS56073B1 (en) |
| RU (1) | RU2619937C2 (en) |
| SG (1) | SG11201408359PA (en) |
| SI (1) | SI2865663T1 (en) |
| TW (1) | TWI597263B (en) |
| WO (1) | WO2013191144A1 (en) |
| ZA (1) | ZA201409248B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105530923B (en) | 2013-09-09 | 2019-07-23 | 佩洛通治疗公司 | Aryl ether and application thereof |
| EP3083639B1 (en) | 2013-12-16 | 2019-05-29 | Peloton Therapeutics, Inc. | Cyclic sulfone and sulfoximine analogs and uses thereof |
| JP6518595B2 (en) * | 2013-12-19 | 2019-05-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Therapeutic and / or preventive agent for pain comprising 1-indansulfamide derivative |
| WO2016145045A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating glioblastoma |
| EP3267792A4 (en) * | 2015-03-11 | 2018-09-26 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
| WO2016144825A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
| US10155726B2 (en) | 2015-03-11 | 2018-12-18 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
| WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| US9796697B2 (en) | 2015-06-12 | 2017-10-24 | Peloton Therapeutics, Inc. | Tricyclic inhibitors of HIF-2-alpha and uses thereof |
| EP3769759B1 (en) * | 2018-03-20 | 2023-11-15 | Eisai R&D Management Co., Ltd. | Combination of an indanesulfamide derivative with perampanel for use in the treatment of epilepsy |
| JP2024026905A (en) * | 2020-11-25 | 2024-02-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Therapeutic agent for epilepsy |
| WO2023210617A1 (en) * | 2022-04-27 | 2023-11-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Pharmaceutical composition for treatment of parkinson's disease |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3383414A (en) | 1964-08-26 | 1968-05-14 | Sandoz Ag | Benzocycloalkyl sulfamides |
| US3709677A (en) | 1969-06-25 | 1973-01-09 | Sandoz Ag | N-substituted sulfamoyl compounds useful as herbicides |
| EP1401805A1 (en) * | 2001-06-26 | 2004-03-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Valproyltaurinamide derivatives as anticonvulsant and cns active agents |
| TW200307539A (en) * | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| ES2310366T3 (en) * | 2004-08-24 | 2009-01-01 | Janssen Pharmaceutica Nv | NEW DERIVATIVES OF HETEROARIL SULFONAMIDE BENZO-CONDENSED USEFUL AS ANTI-CONVERSIVE AGENTS. |
| US20070155823A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
| CN100572365C (en) * | 2006-01-26 | 2009-12-23 | 全哲山 | As 1,2 of antiepileptic drug, 4-triazolo [4,3-a] quinoline-1-ketone derivatives and pharmacologically acceptable salt thereof |
| JP2009184924A (en) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | Compound for biological reagent |
| CL2007002994A1 (en) | 2006-10-19 | 2008-02-08 | Wyeth Corp | HETEROCICLIC DERIVATIVE COMPOUNDS CONTAINING SULFAMOIL, INHIBITORS OF HSP90; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT OF CANCER, SUCH AS CANCER OF BREAST, COLON AND PROSTATE, BETWEEN OTHERS. |
| TWI433674B (en) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | Cyclopamine analogs |
| AR070949A1 (en) * | 2007-10-19 | 2010-05-19 | Solvay Pharm Gmbh | COMPOUNDS DERIVED FROM SULFAMATE FOR MEDICAL USE, MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, PROCEDURES TO PREPARE THESE COMPOUNDS AND THEIR USE |
| TW201012803A (en) * | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
| US8633237B2 (en) * | 2009-04-09 | 2014-01-21 | Merck Sharp & Dohme B.V. | Indane derivatives |
| ES2675799T3 (en) * | 2009-11-13 | 2018-07-12 | Celgene International Ii Sàrl | Selective sphingosine 1-heterocyclic phosphate receptor modulators |
| EA035768B1 (en) * | 2009-11-13 | 2020-08-07 | Селджин Интернэшнел Ii Сарл | Method of preparing a compound comprising an indane group with chiral carbon atom in a 5-membered ring of the indane group |
| WO2011097337A1 (en) * | 2010-02-04 | 2011-08-11 | Advanced Neural Dynamics, Inc. | Novel sulfamides exhibiting neuroprotective action and methods for use thereof |
| US20120077814A1 (en) * | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
-
2013
- 2013-06-17 PE PE2014002429A patent/PE20150284A1/en active IP Right Grant
- 2013-06-17 JP JP2014521462A patent/JP5883135B2/en active Active
- 2013-06-17 LT LTEP13807707.8T patent/LT2865663T/en unknown
- 2013-06-17 KR KR1020147035140A patent/KR101951519B1/en active IP Right Grant
- 2013-06-17 NZ NZ702974A patent/NZ702974A/en unknown
- 2013-06-17 US US14/370,633 patent/US9018260B2/en active Active
- 2013-06-17 EP EP13807707.8A patent/EP2865663B1/en active Active
- 2013-06-17 DK DK13807707.8T patent/DK2865663T3/en active
- 2013-06-17 AU AU2013278450A patent/AU2013278450B2/en active Active
- 2013-06-17 MY MYPI2014703797A patent/MY169073A/en unknown
- 2013-06-17 MX MX2014015492A patent/MX355261B/en active IP Right Grant
- 2013-06-17 RU RU2014151013A patent/RU2619937C2/en active
- 2013-06-17 PT PT138077078T patent/PT2865663T/en unknown
- 2013-06-17 ES ES13807707.8T patent/ES2628374T3/en active Active
- 2013-06-17 PL PL13807707T patent/PL2865663T3/en unknown
- 2013-06-17 WO PCT/JP2013/066623 patent/WO2013191144A1/en active Application Filing
- 2013-06-17 CA CA2877097A patent/CA2877097C/en active Active
- 2013-06-17 SI SI201330677A patent/SI2865663T1/en unknown
- 2013-06-17 HU HUE13807707A patent/HUE033583T2/en unknown
- 2013-06-17 CN CN201380031833.8A patent/CN104395285B/en active Active
- 2013-06-17 BR BR112014031565-5A patent/BR112014031565B1/en active IP Right Grant
- 2013-06-17 SG SG11201408359PA patent/SG11201408359PA/en unknown
- 2013-06-17 ME MEP-2017-128A patent/ME02753B/en unknown
- 2013-06-17 RS RS20170587A patent/RS56073B1/en unknown
- 2013-06-18 JO JOP/2013/0184A patent/JO3263B1/en active
- 2013-06-19 AR ARP130102174 patent/AR091506A1/en active IP Right Grant
- 2013-06-21 TW TW102122236A patent/TWI597263B/en active
-
2014
- 2014-12-15 IL IL236295A patent/IL236295A/en active IP Right Grant
- 2014-12-15 ZA ZA2014/09248A patent/ZA201409248B/en unknown
- 2014-12-17 PH PH12014502805A patent/PH12014502805B1/en unknown
- 2014-12-17 CL CL2014003429A patent/CL2014003429A1/en unknown
-
2015
- 2015-08-17 HK HK15107900.7A patent/HK1207363A1/en unknown
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2017
- 2017-06-06 HR HRP20170863TT patent/HRP20170863T1/en unknown
- 2017-06-15 CY CY20171100633T patent/CY1119171T1/en unknown
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