JO3209B1 - طريقة لتصنيع نالتريكسون - Google Patents
طريقة لتصنيع نالتريكسونInfo
- Publication number
- JO3209B1 JO3209B1 JOP/2011/0328A JOP20110328A JO3209B1 JO 3209 B1 JO3209 B1 JO 3209B1 JO P20110328 A JOP20110328 A JO P20110328A JO 3209 B1 JO3209 B1 JO 3209B1
- Authority
- JO
- Jordan
- Prior art keywords
- naltrexone
- manufacturing
- morphinan
- dihydroxy
- epoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201001007 | 2010-11-05 | ||
| DKPA201100396 | 2011-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3209B1 true JO3209B1 (ar) | 2018-03-08 |
Family
ID=46552826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2011/0328A JO3209B1 (ar) | 2010-11-05 | 2011-10-31 | طريقة لتصنيع نالتريكسون |
Country Status (12)
| Country | Link |
|---|---|
| KR (1) | KR101837795B1 (zh) |
| CN (1) | CN103237804B (zh) |
| AR (1) | AR087142A1 (zh) |
| BR (1) | BR112013009407B8 (zh) |
| CL (1) | CL2013001251A1 (zh) |
| CO (1) | CO6700868A2 (zh) |
| IL (1) | IL225790A (zh) |
| JO (1) | JO3209B1 (zh) |
| PE (2) | PE20171309A1 (zh) |
| SG (1) | SG189369A1 (zh) |
| TW (1) | TWI516491B (zh) |
| ZA (1) | ZA201303224B (zh) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE178329T1 (de) * | 1989-10-16 | 1999-04-15 | Us Health | Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n- nor-zwischenverbindungen |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| FR2906252B1 (fr) * | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
| WO2008138383A1 (de) * | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
| ES2566559T3 (es) * | 2008-09-30 | 2016-04-13 | Mallinckrodt Llc | Procesos para la alquilación de grupos amino secundarios de derivados de morfinano |
-
2011
- 2011-10-31 JO JOP/2011/0328A patent/JO3209B1/ar active
- 2011-11-01 TW TW100139692A patent/TWI516491B/zh not_active IP Right Cessation
- 2011-11-03 AR ARP110104090A patent/AR087142A1/es unknown
- 2011-11-04 PE PE2017001285A patent/PE20171309A1/es not_active Application Discontinuation
- 2011-11-04 KR KR1020137011320A patent/KR101837795B1/ko active IP Right Grant
- 2011-11-04 BR BR112013009407A patent/BR112013009407B8/pt not_active IP Right Cessation
- 2011-11-04 PE PE2013000948A patent/PE20140357A1/es not_active Application Discontinuation
- 2011-11-04 SG SG2013027412A patent/SG189369A1/en unknown
- 2011-11-04 CN CN201180053349.6A patent/CN103237804B/zh active Active
-
2013
- 2013-04-17 IL IL225790A patent/IL225790A/en active IP Right Grant
- 2013-05-03 ZA ZA2013/03224A patent/ZA201303224B/en unknown
- 2013-05-03 CO CO13111250A patent/CO6700868A2/es active IP Right Grant
- 2013-05-06 CL CL2013001251A patent/CL2013001251A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG189369A1 (en) | 2013-05-31 |
| KR101837795B1 (ko) | 2018-03-12 |
| CL2013001251A1 (es) | 2013-08-30 |
| BR112013009407B8 (pt) | 2022-11-22 |
| TW201219396A (en) | 2012-05-16 |
| CN103237804A (zh) | 2013-08-07 |
| PE20140357A1 (es) | 2014-03-29 |
| BR112013009407B1 (pt) | 2021-07-20 |
| TWI516491B (zh) | 2016-01-11 |
| IL225790A0 (en) | 2013-06-27 |
| KR20130129928A (ko) | 2013-11-29 |
| CO6700868A2 (es) | 2013-06-28 |
| BR112013009407A2 (pt) | 2016-07-19 |
| AR087142A1 (es) | 2014-02-26 |
| CN103237804B (zh) | 2016-06-08 |
| IL225790A (en) | 2016-07-31 |
| PE20171309A1 (es) | 2017-09-05 |
| ZA201303224B (en) | 2014-07-30 |
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