ITRM20120398A1 - Procedimento di sintesi pemetrexed e suo sale di lisina. - Google Patents

Procedimento di sintesi pemetrexed e suo sale di lisina. Download PDF

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Publication number
ITRM20120398A1
ITRM20120398A1 IT000398A ITRM20120398A ITRM20120398A1 IT RM20120398 A1 ITRM20120398 A1 IT RM20120398A1 IT 000398 A IT000398 A IT 000398A IT RM20120398 A ITRM20120398 A IT RM20120398A IT RM20120398 A1 ITRM20120398 A1 IT RM20120398A1
Authority
IT
Italy
Prior art keywords
pemetrexed
salt
lysine
acid
water
Prior art date
Application number
IT000398A
Other languages
English (en)
Italian (it)
Inventor
Fabrizio Bonaccorsi
Federico Calvani
Franco Pasqui
Original Assignee
Berlin Chemie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlin Chemie Ag filed Critical Berlin Chemie Ag
Priority to IT000398A priority Critical patent/ITRM20120398A1/it
Priority to TW102128058A priority patent/TWI609017B/zh
Priority to PT137771440T priority patent/PT2882753T/pt
Priority to SI201330427A priority patent/SI2882753T1/sl
Priority to EP13777144.0A priority patent/EP2882753B1/en
Priority to AU2013301156A priority patent/AU2013301156B2/en
Priority to CN201380041935.8A priority patent/CN104736540B/zh
Priority to RU2015108042A priority patent/RU2609006C2/ru
Priority to SM20160474T priority patent/SMT201600474T1/it
Priority to KR1020157005932A priority patent/KR102288417B1/ko
Priority to HK15110234.8A priority patent/HK1209426B/en
Priority to LTEP13777144.0T priority patent/LT2882753T/lt
Priority to BR112015002429A priority patent/BR112015002429A8/pt
Priority to PCT/IB2013/056497 priority patent/WO2014024164A1/en
Priority to PL13777144T priority patent/PL2882753T3/pl
Priority to HUE13777144A priority patent/HUE032304T2/en
Priority to HRP20170011TT priority patent/HRP20170011T1/hr
Priority to DK13777144.0T priority patent/DK2882753T3/en
Priority to IN833DEN2015 priority patent/IN2015DN00833A/en
Priority to RS20161202A priority patent/RS55515B1/sr
Priority to MX2015001712A priority patent/MX362858B/es
Priority to ES13777144.0T priority patent/ES2607890T3/es
Publication of ITRM20120398A1 publication Critical patent/ITRM20120398A1/it
Priority to ZA2015/01549A priority patent/ZA201501549B/en
Priority to CY20161101351T priority patent/CY1118514T1/el
Priority to SM201600474T priority patent/SMT201600474B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT000398A 2012-08-08 2012-08-08 Procedimento di sintesi pemetrexed e suo sale di lisina. ITRM20120398A1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
IT000398A ITRM20120398A1 (it) 2012-08-08 2012-08-08 Procedimento di sintesi pemetrexed e suo sale di lisina.
TW102128058A TWI609017B (zh) 2012-08-08 2013-08-06 培美曲塞及其離胺酸鹽之製備方法
LTEP13777144.0T LT2882753T (lt) 2012-08-08 2013-08-08 Pemetreksedo ir jo lizino druskos gavimo būdas
PCT/IB2013/056497 WO2014024164A1 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof
EP13777144.0A EP2882753B1 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof
AU2013301156A AU2013301156B2 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof
CN201380041935.8A CN104736540B (zh) 2012-08-08 2013-08-08 培美曲塞及其赖氨酸盐的制备方法
RU2015108042A RU2609006C2 (ru) 2012-08-08 2013-08-08 Способ получения пеметрекседа и его лизиновой соли
SM20160474T SMT201600474T1 (it) 2012-08-08 2013-08-08 Procedimento per la preparazione di pemetrexed e suo sale di lisina
KR1020157005932A KR102288417B1 (ko) 2012-08-08 2013-08-08 페메트렉시드 및 이의 라이신 염의 제조공정
HK15110234.8A HK1209426B (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof
PT137771440T PT2882753T (pt) 2012-08-08 2013-08-08 Processo para a preparação de pemetrexed e sal de lisina do mesmo
BR112015002429A BR112015002429A8 (pt) 2012-08-08 2013-08-08 processo para preparar pemetrexede e sal de lisina deste
SI201330427A SI2882753T1 (sl) 2012-08-08 2013-08-08 Postopek za pripravo pemetrekseda in njegove lizinske soli
PL13777144T PL2882753T3 (pl) 2012-08-08 2013-08-08 Sposób wytwarzania pemetreksedu i jego soli z lizyną
HUE13777144A HUE032304T2 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof
HRP20170011TT HRP20170011T1 (hr) 2012-08-08 2013-08-08 Postupak za izradu pemetrekseda i njegove lizinske soli
DK13777144.0T DK2882753T3 (en) 2012-08-08 2013-08-08 PROCEDURE FOR PREPARING PEMETREXED AND LYSSEAL SALES THEREOF
IN833DEN2015 IN2015DN00833A (h) 2012-08-08 2013-08-08
RS20161202A RS55515B1 (sr) 2012-08-08 2013-08-08 Postupak pripremanja pemetrekseda i njegovih lizinskih soli
MX2015001712A MX362858B (es) 2012-08-08 2013-08-08 Proceso para la preparacion de pemetrexed y sal de lisina del mismo.
ES13777144.0T ES2607890T3 (es) 2012-08-08 2013-08-08 Proceso para la preparación de pemetrexed y de sal de lisina del mismo
ZA2015/01549A ZA201501549B (en) 2012-08-08 2015-03-06 Process for the preparation of pemetrexed and lysin salt thereof
CY20161101351T CY1118514T1 (el) 2012-08-08 2016-12-28 Μεθοδος για την παρασκευη πεμετρεξιδης και αλατος λυσινης αυτης
SM201600474T SMT201600474B (it) 2012-08-08 2016-12-28 Procedimento per la preparazione di pemetrexed e suo sale di lisina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000398A ITRM20120398A1 (it) 2012-08-08 2012-08-08 Procedimento di sintesi pemetrexed e suo sale di lisina.

Publications (1)

Publication Number Publication Date
ITRM20120398A1 true ITRM20120398A1 (it) 2014-02-09

Family

ID=47018368

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000398A ITRM20120398A1 (it) 2012-08-08 2012-08-08 Procedimento di sintesi pemetrexed e suo sale di lisina.

Country Status (23)

Country Link
EP (1) EP2882753B1 (h)
KR (1) KR102288417B1 (h)
CN (1) CN104736540B (h)
AU (1) AU2013301156B2 (h)
BR (1) BR112015002429A8 (h)
CY (1) CY1118514T1 (h)
DK (1) DK2882753T3 (h)
ES (1) ES2607890T3 (h)
HR (1) HRP20170011T1 (h)
HU (1) HUE032304T2 (h)
IN (1) IN2015DN00833A (h)
IT (1) ITRM20120398A1 (h)
LT (1) LT2882753T (h)
MX (1) MX362858B (h)
PL (1) PL2882753T3 (h)
PT (1) PT2882753T (h)
RS (1) RS55515B1 (h)
RU (1) RU2609006C2 (h)
SI (1) SI2882753T1 (h)
SM (2) SMT201600474T1 (h)
TW (1) TWI609017B (h)
WO (1) WO2014024164A1 (h)
ZA (1) ZA201501549B (h)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107641124A (zh) * 2016-07-22 2018-01-30 上海创诺制药有限公司 一种培美曲塞二酸新晶型及其制备方法
CN109836425B (zh) * 2017-11-24 2023-01-24 江苏创诺制药有限公司 一种合成培美酸的制备工艺
EP3749317A4 (en) 2018-02-07 2022-06-22 L.E.A.F Holdings Group LLC PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
CN110128426B (zh) * 2018-02-09 2021-12-14 鲁南制药集团股份有限公司 培美曲塞谷氨酸盐
CN110128428A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞丙氨酸盐
CN110128427A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞缬氨酸盐
CN111333658A (zh) * 2020-05-06 2020-06-26 贵州联科中贝制药科技有限公司 一种培美曲塞二钠水合物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0589720A2 (en) * 1992-09-25 1994-03-30 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
EP2301909A1 (en) * 2008-05-30 2011-03-30 Shanghai Cdymax Pharmaceuticals Co., Ltd Processes for preparing pemetrexed disodium and its intermediate,4-(4-carbomethoxyphenyl)butanal
EP2409978A2 (en) * 2010-07-22 2012-01-25 Chemi SPA A novel process for the synthesis of pemetrexed disodium salt
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed

Family Cites Families (10)

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EP0440795B1 (en) 1988-10-31 1994-10-19 MITSUI TOATSU CHEMICALS, Inc. Process for preparing organic group-substituted sodium aluminum hydride
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
DE19725647A1 (de) 1997-06-18 1998-12-24 Basf Ag Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme
ZA987550B (en) 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
IL150480A0 (en) 2000-02-25 2002-12-01 Lilly Co Eli A NOVEL-CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4, 7-DIHYDRO-4-OXO-3H-PYRROLO[2, 3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR
KR20090052355A (ko) * 2006-08-14 2009-05-25 시코르, 인크. 순도가 높은 페메트렉세드 이산 및 이의 제조 방법
WO2008021385A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Processes for preparing intermediates of pemetrexed
WO2012015810A2 (en) 2010-07-28 2012-02-02 Eagle Pharmaceuticals, Inc. Pharmaceutical compositions containing pemetrexed having extended storage stability

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0589720A2 (en) * 1992-09-25 1994-03-30 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
EP2301909A1 (en) * 2008-05-30 2011-03-30 Shanghai Cdymax Pharmaceuticals Co., Ltd Processes for preparing pemetrexed disodium and its intermediate,4-(4-carbomethoxyphenyl)butanal
EP2409978A2 (en) * 2010-07-22 2012-01-25 Chemi SPA A novel process for the synthesis of pemetrexed disodium salt
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed

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BARNETT C J ET AL: "A PRACTICAL SYNTHESIS OF MULTITARGETED ANTIFOLATE LY231514", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, CAMBRIDGE, GB, vol. 3, no. 3, 1 January 1999 (1999-01-01), pages 184 - 188, XP000982091, DOI: 10.1021/OP9802172 *
EDWARD C. TAYLOR ET AL: "A New and Efficient Synthesis of Pyrrolo 2,3- d |pyrimidine Anticancer Agents: Alimta (LY231514, MTA), Homo-Alimta, TNP-351, and Some Aryl 5-Substituted Pyrrolo 2,3- d |pyrimidines", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 26, 1 December 2003 (2003-12-01), pages 9938 - 9947, XP055002811, ISSN: 0022-3263, DOI: 10.1021/jo030248h *
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Also Published As

Publication number Publication date
WO2014024164A1 (en) 2014-02-13
CY1118514T1 (el) 2017-07-12
IN2015DN00833A (h) 2015-06-12
SI2882753T1 (sl) 2017-02-28
TWI609017B (zh) 2017-12-21
KR20150045458A (ko) 2015-04-28
MX362858B (es) 2019-02-20
AU2013301156B2 (en) 2017-08-31
LT2882753T (lt) 2016-12-12
DK2882753T3 (en) 2017-01-16
BR112015002429A8 (pt) 2019-07-30
AU2013301156A1 (en) 2015-02-05
SMT201600474T1 (it) 2017-03-08
PT2882753T (pt) 2016-12-27
RS55515B1 (sr) 2017-05-31
SMT201600474B (it) 2017-03-08
HK1209426A1 (en) 2016-04-01
CN104736540B (zh) 2017-08-25
KR102288417B1 (ko) 2021-08-11
CN104736540A (zh) 2015-06-24
ES2607890T3 (es) 2017-04-04
BR112015002429A2 (pt) 2017-07-04
HUE032304T2 (en) 2017-09-28
EP2882753B1 (en) 2016-10-05
RU2015108042A (ru) 2016-09-27
EP2882753A1 (en) 2015-06-17
MX2015001712A (es) 2015-08-14
PL2882753T3 (pl) 2017-04-28
HRP20170011T1 (hr) 2017-03-10
TW201412741A (zh) 2014-04-01
RU2609006C2 (ru) 2017-01-30
ZA201501549B (en) 2016-01-27

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