ITMI942026A0 - Derivati della colchicina e loro impiego terapeutico - Google Patents
Derivati della colchicina e loro impiego terapeuticoInfo
- Publication number
- ITMI942026A0 ITMI942026A0 ITMI942026A ITMI942026A ITMI942026A0 IT MI942026 A0 ITMI942026 A0 IT MI942026A0 IT MI942026 A ITMI942026 A IT MI942026A IT MI942026 A ITMI942026 A IT MI942026A IT MI942026 A0 ITMI942026 A0 IT MI942026A0
- Authority
- IT
- Italy
- Prior art keywords
- therapeutic use
- colchicine derivatives
- colchicine
- derivatives
- therapeutic
- Prior art date
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title 1
- 229940045695 antineooplastic colchicine derivative Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI942026A IT1270124B (it) | 1994-10-05 | 1994-10-05 | Derivati della colchicina e loro impiego terapeutico |
| PL95319455A PL182204B1 (en) | 1994-10-05 | 1995-09-27 | Derivatives of colchicine and their tharapeutic application |
| JP8512296A JP2921990B2 (ja) | 1994-10-05 | 1995-09-27 | コルヒチン誘導体及びその治療的利用 |
| DE69510212T DE69510212T2 (de) | 1994-10-05 | 1995-09-27 | Colchicin-derivate sowie ihre therapeutische verwendung |
| ES95935393T ES2131863T3 (es) | 1994-10-05 | 1995-09-27 | Derivados de colchicina y su uso terapeutico. |
| DK98121484T DK0909763T3 (da) | 1994-10-05 | 1995-09-27 | Colchicin-derivater og terapeutisk anvendelse deraf |
| AU37432/95A AU692624B2 (en) | 1994-10-05 | 1995-09-27 | Colchicine derivatives and the therapeutical use thereof |
| DE69533267T DE69533267T2 (de) | 1994-10-05 | 1995-09-27 | Colchicin-derivate sowie ihre therapeutische Verwendung |
| HU9701700A HU223779B1 (hu) | 1994-10-05 | 1995-09-27 | Kolchicinszármazékok, eljárás előállításukra és azokat tartalmazó gyógszerkészítmények, valamint alkalmazásuk gyógyszerkészítmények előállítására |
| DK95935393T DK0784613T3 (da) | 1994-10-05 | 1995-09-27 | Colchicinderivater og den terapeutiske anvendelse deraf |
| AT95935393T ATE181060T1 (de) | 1994-10-05 | 1995-09-27 | Colchicin-derivate sowie ihre therapeutische verwendung |
| KR1019970702190A KR100255074B1 (ko) | 1994-10-05 | 1995-09-27 | 콜히친 유도체 및 그의 치료적 용도 |
| EP98121484A EP0909763B1 (en) | 1994-10-05 | 1995-09-27 | Colchicine derivatives and the therapeutical use thereof |
| RU97107153A RU2145598C1 (ru) | 1994-10-05 | 1995-09-27 | Производные колхицина, способ их получения, фармацевтическая композиция |
| EP95935393A EP0784613B1 (en) | 1994-10-05 | 1995-09-27 | Colchicine derivatives and the therapeutical use thereof |
| AT98121484T ATE271061T1 (de) | 1994-10-05 | 1995-09-27 | Colchicin-derivate sowie ihre therapeutische verwendung |
| US08/817,626 US5843910A (en) | 1994-10-05 | 1995-09-27 | Colchicine derivatives and the therapeutical use thereof |
| CZ19971015A CZ290309B6 (cs) | 1994-10-05 | 1995-09-27 | Deriváty kolchicinu, způsob výroby a farmaceutický prostředek s jejich obsahem |
| ES98121484T ES2224322T3 (es) | 1994-10-05 | 1995-09-27 | Derivados de colchicina y su uso terapeutico. |
| CN95195499A CN1075059C (zh) | 1994-10-05 | 1995-09-27 | 秋水仙素衍生物及其治疗用途 |
| PCT/EP1995/003823 WO1996011184A1 (en) | 1994-10-05 | 1995-09-27 | Colchicine derivatives and the therapeutical use thereof |
| PT98121484T PT909763E (pt) | 1994-10-05 | 1995-09-27 | Derivados de colchicina e a sua utilizacao terapeutica |
| SK424-97A SK281831B6 (sk) | 1994-10-05 | 1995-09-27 | Kolchicínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
| CA002201723A CA2201723C (en) | 1994-10-05 | 1995-09-27 | Colchicine derivatives and the therapeutical use thereof |
| FI971364A FI120452B (fi) | 1994-10-05 | 1997-04-03 | Kolkisiinijohdannaiset ja niiden terapeuttinen käyttö |
| NO971503A NO308030B1 (no) | 1994-10-05 | 1997-04-03 | Kolkisinderivater og deres terapeutiske anvendelse |
| HK99102643A HK1017361A1 (en) | 1994-10-05 | 1998-01-16 | Colchicine derivatives and the therapeutical use thereof |
| HK98100368A HK1001394A1 (en) | 1994-10-05 | 1998-01-16 | Colchicine derivatives and the therapeutical use thereof |
| AU61958/98A AU699789B2 (en) | 1994-10-05 | 1998-04-16 | Colchicine derivatives and the therapeutical use thereof |
| GR990401514T GR3030449T3 (en) | 1994-10-05 | 1999-06-10 | Colchicine derivatives and the therapeutical use thereof |
| CN00131989A CN1127480C (zh) | 1994-10-05 | 2000-11-02 | 秋水仙素衍生物及其治疗用途 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI942026A IT1270124B (it) | 1994-10-05 | 1994-10-05 | Derivati della colchicina e loro impiego terapeutico |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI942026A0 true ITMI942026A0 (it) | 1994-10-05 |
| ITMI942026A1 ITMI942026A1 (it) | 1996-04-05 |
| IT1270124B IT1270124B (it) | 1997-04-28 |
Family
ID=11369650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI942026A IT1270124B (it) | 1994-10-05 | 1994-10-05 | Derivati della colchicina e loro impiego terapeutico |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5843910A (it) |
| EP (2) | EP0909763B1 (it) |
| JP (1) | JP2921990B2 (it) |
| KR (1) | KR100255074B1 (it) |
| CN (2) | CN1075059C (it) |
| AT (2) | ATE181060T1 (it) |
| AU (1) | AU692624B2 (it) |
| CA (1) | CA2201723C (it) |
| CZ (1) | CZ290309B6 (it) |
| DE (2) | DE69510212T2 (it) |
| DK (2) | DK0909763T3 (it) |
| ES (2) | ES2224322T3 (it) |
| FI (1) | FI120452B (it) |
| GR (1) | GR3030449T3 (it) |
| HK (2) | HK1001394A1 (it) |
| HU (1) | HU223779B1 (it) |
| IT (1) | IT1270124B (it) |
| NO (1) | NO308030B1 (it) |
| PL (1) | PL182204B1 (it) |
| PT (1) | PT909763E (it) |
| RU (1) | RU2145598C1 (it) |
| SK (1) | SK281831B6 (it) |
| WO (1) | WO1996011184A1 (it) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| FR2779147B1 (fr) * | 1998-05-27 | 2000-06-30 | Synthelabo | Derive de thiocolchicoside sa preparation et son application en therapeutique |
| AU2190700A (en) | 1998-12-17 | 2000-07-03 | Tularik Inc. | Tubulin-binding agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| US6399093B1 (en) | 1999-05-19 | 2002-06-04 | Advanced Medical Instruments | Method and composition to treat musculoskeletal disorders |
| US6720323B2 (en) * | 2000-07-07 | 2004-04-13 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| EP1301497A1 (en) * | 2000-07-07 | 2003-04-16 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
| US6624317B1 (en) | 2000-09-25 | 2003-09-23 | The University Of North Carolina At Chapel Hill | Taxoid conjugates as antimitotic and antitumor agents |
| ITMI20031144A1 (it) * | 2003-06-06 | 2004-12-07 | Indena Spa | Analoghi del colchicoside. |
| SI2128170T1 (sl) * | 2008-05-28 | 2011-04-29 | Indena Spa | Postopek za glikozidacijo kolhicina in tiokolhicina |
| PL2470499T3 (pl) | 2009-08-26 | 2019-11-29 | Alberta Health Services | Nowe pochodne kolchicyny, sposoby i ich zastosowania |
| CA2964437C (en) | 2014-10-14 | 2023-09-19 | Council Of Scientific & Industrial Research | 10-substituted colchicinoids as potent anticancer agents |
| WO2023077977A1 (zh) * | 2021-11-08 | 2023-05-11 | 天津市昕晨投资发展有限公司 | 秋水仙碱衍生物的制备方法及其用途 |
| CN114907228B (zh) * | 2022-06-27 | 2023-11-28 | 深圳市锦泰医药科技合伙企业(有限合伙) | 一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH513119A (de) * | 1968-02-23 | 1971-09-30 | Merck Patent Gmbh | Verfahren zur Herstellung neuer Halogencolchicinderivate |
| GB1345991A (en) * | 1972-05-05 | 1974-02-06 | Roussel Uclaf | Thiocolchicine derivatives |
| ES2062014T3 (es) * | 1988-08-24 | 1994-12-16 | Advance Biofactures Corp | Carbonatos de 3-desmetiltiocolchicina y analogos n-acilados. |
-
1994
- 1994-10-05 IT ITMI942026A patent/IT1270124B/it active IP Right Grant
-
1995
- 1995-09-27 JP JP8512296A patent/JP2921990B2/ja not_active Expired - Lifetime
- 1995-09-27 AU AU37432/95A patent/AU692624B2/en not_active Ceased
- 1995-09-27 AT AT95935393T patent/ATE181060T1/de not_active IP Right Cessation
- 1995-09-27 KR KR1019970702190A patent/KR100255074B1/ko not_active IP Right Cessation
- 1995-09-27 EP EP98121484A patent/EP0909763B1/en not_active Expired - Lifetime
- 1995-09-27 WO PCT/EP1995/003823 patent/WO1996011184A1/en active IP Right Grant
- 1995-09-27 PL PL95319455A patent/PL182204B1/pl not_active IP Right Cessation
- 1995-09-27 DK DK98121484T patent/DK0909763T3/da active
- 1995-09-27 CZ CZ19971015A patent/CZ290309B6/cs not_active IP Right Cessation
- 1995-09-27 CA CA002201723A patent/CA2201723C/en not_active Expired - Fee Related
- 1995-09-27 DK DK95935393T patent/DK0784613T3/da active
- 1995-09-27 SK SK424-97A patent/SK281831B6/sk not_active IP Right Cessation
- 1995-09-27 ES ES98121484T patent/ES2224322T3/es not_active Expired - Lifetime
- 1995-09-27 ES ES95935393T patent/ES2131863T3/es not_active Expired - Lifetime
- 1995-09-27 AT AT98121484T patent/ATE271061T1/de not_active IP Right Cessation
- 1995-09-27 US US08/817,626 patent/US5843910A/en not_active Expired - Fee Related
- 1995-09-27 EP EP95935393A patent/EP0784613B1/en not_active Expired - Lifetime
- 1995-09-27 DE DE69510212T patent/DE69510212T2/de not_active Expired - Lifetime
- 1995-09-27 DE DE69533267T patent/DE69533267T2/de not_active Expired - Lifetime
- 1995-09-27 PT PT98121484T patent/PT909763E/pt unknown
- 1995-09-27 CN CN95195499A patent/CN1075059C/zh not_active Expired - Fee Related
- 1995-09-27 RU RU97107153A patent/RU2145598C1/ru not_active IP Right Cessation
- 1995-09-27 HU HU9701700A patent/HU223779B1/hu not_active IP Right Cessation
-
1997
- 1997-04-03 NO NO971503A patent/NO308030B1/no not_active IP Right Cessation
- 1997-04-03 FI FI971364A patent/FI120452B/fi active IP Right Grant
-
1998
- 1998-01-16 HK HK98100368A patent/HK1001394A1/xx not_active IP Right Cessation
- 1998-01-16 HK HK99102643A patent/HK1017361A1/xx not_active IP Right Cessation
-
1999
- 1999-06-10 GR GR990401514T patent/GR3030449T3/el unknown
-
2000
- 2000-11-02 CN CN00131989A patent/CN1127480C/zh not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971029 |