HUT77223A - Kolchicinszármazékok, eljárás előállításukra és azokat tartalmazó gyógszerkészítmények, valamint alkalmazásuk gyógyszerkészítmények előállítására - Google Patents

Kolchicinszármazékok, eljárás előállításukra és azokat tartalmazó gyógszerkészítmények, valamint alkalmazásuk gyógyszerkészítmények előállítására

Info

Publication number
HUT77223A
HUT77223A HU9701700A HU9701700A HUT77223A HU T77223 A HUT77223 A HU T77223A HU 9701700 A HU9701700 A HU 9701700A HU 9701700 A HU9701700 A HU 9701700A HU T77223 A HUT77223 A HU T77223A
Authority
HU
Hungary
Prior art keywords
producing
pharmaceutical compositions
colchicine derivatives
compositions containing
derivatives
Prior art date
Application number
HU9701700A
Other languages
English (en)
Other versions
HU223779B1 (hu
Inventor
Ezio Bombardelli
Bruno Gabetta
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Publication of HUT77223A publication Critical patent/HUT77223A/hu
Publication of HU223779B1 publication Critical patent/HU223779B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
HU9701700A 1994-10-05 1995-09-27 Kolchicinszármazékok, eljárás előállításukra és azokat tartalmazó gyógszerkészítmények, valamint alkalmazásuk gyógyszerkészítmények előállítására HU223779B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico
PCT/EP1995/003823 WO1996011184A1 (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof

Publications (2)

Publication Number Publication Date
HUT77223A true HUT77223A (hu) 1998-03-02
HU223779B1 HU223779B1 (hu) 2005-01-28

Family

ID=11369650

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701700A HU223779B1 (hu) 1994-10-05 1995-09-27 Kolchicinszármazékok, eljárás előállításukra és azokat tartalmazó gyógszerkészítmények, valamint alkalmazásuk gyógyszerkészítmények előállítására

Country Status (23)

Country Link
US (1) US5843910A (hu)
EP (2) EP0784613B1 (hu)
JP (1) JP2921990B2 (hu)
KR (1) KR100255074B1 (hu)
CN (2) CN1075059C (hu)
AT (2) ATE181060T1 (hu)
AU (1) AU692624B2 (hu)
CA (1) CA2201723C (hu)
CZ (1) CZ290309B6 (hu)
DE (2) DE69533267T2 (hu)
DK (2) DK0909763T3 (hu)
ES (2) ES2131863T3 (hu)
FI (1) FI120452B (hu)
GR (1) GR3030449T3 (hu)
HK (2) HK1017361A1 (hu)
HU (1) HU223779B1 (hu)
IT (1) IT1270124B (hu)
NO (1) NO308030B1 (hu)
PL (1) PL182204B1 (hu)
PT (1) PT909763E (hu)
RU (1) RU2145598C1 (hu)
SK (1) SK281831B6 (hu)
WO (1) WO1996011184A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique
US6433187B1 (en) 1998-12-17 2002-08-13 Tularik Inc. Certain polycyclic compounds useful as tubulin-binding agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
US6720323B2 (en) * 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
IL153484A0 (en) * 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
ATE492556T1 (de) * 2008-05-28 2011-01-15 Indena Spa Verfahren zur glycosidierung von colchicin und thiocolchicin
ES2745255T3 (es) 2009-08-26 2020-02-28 Alberta Health Services Derivados de colchicina novedosos, métodos y usos de los mismos
EP3207026B1 (en) 2014-10-14 2018-12-12 Council of Scientific and Industrial Research 10-substituted colchicinoids as potent anticancer agents
CN116082182A (zh) * 2021-11-08 2023-05-09 天津市昕晨投资发展有限公司 秋水仙碱衍生物的制备方法及其用途
CN114907228B (zh) * 2022-06-27 2023-11-28 深圳市锦泰医药科技合伙企业(有限合伙) 一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH513119A (de) * 1968-02-23 1971-09-30 Merck Patent Gmbh Verfahren zur Herstellung neuer Halogencolchicinderivate
GB1345991A (en) * 1972-05-05 1974-02-06 Roussel Uclaf Thiocolchicine derivatives
ATE113273T1 (de) * 1988-08-24 1994-11-15 Advance Biofactures Corp 3-demethylthiocolchicincarbonate und n- acylanaloge.

Also Published As

Publication number Publication date
JPH10507169A (ja) 1998-07-14
NO308030B1 (no) 2000-07-10
DK0909763T3 (da) 2004-11-22
AU3743295A (en) 1996-05-02
DK0784613T3 (da) 1999-11-15
JP2921990B2 (ja) 1999-07-19
DE69510212T2 (de) 1999-11-11
CN1159801A (zh) 1997-09-17
FI120452B (fi) 2009-10-30
IT1270124B (it) 1997-04-28
EP0909763A2 (en) 1999-04-21
PT909763E (pt) 2004-10-29
DE69533267T2 (de) 2005-08-04
SK42497A3 (en) 1997-11-05
FI971364A (fi) 1997-05-30
EP0909763A3 (en) 2003-01-22
CA2201723A1 (en) 1996-04-18
CN1127480C (zh) 2003-11-12
EP0909763B1 (en) 2004-07-14
PL182204B1 (en) 2001-11-30
WO1996011184A1 (en) 1996-04-18
ES2131863T3 (es) 1999-08-01
AU692624B2 (en) 1998-06-11
HK1001394A1 (en) 1998-06-19
CN1308059A (zh) 2001-08-15
KR100255074B1 (ko) 2000-05-01
EP0784613A1 (en) 1997-07-23
DE69533267D1 (de) 2004-08-19
FI971364A0 (fi) 1997-04-03
ITMI942026A1 (it) 1996-04-05
EP0784613B1 (en) 1999-06-09
CA2201723C (en) 2003-03-25
ATE271061T1 (de) 2004-07-15
DE69510212D1 (de) 1999-07-15
ITMI942026A0 (it) 1994-10-05
CZ290309B6 (cs) 2002-07-17
SK281831B6 (sk) 2001-08-06
HU223779B1 (hu) 2005-01-28
RU2145598C1 (ru) 2000-02-20
ATE181060T1 (de) 1999-06-15
ES2224322T3 (es) 2005-03-01
US5843910A (en) 1998-12-01
NO971503D0 (no) 1997-04-03
PL319455A1 (en) 1997-08-04
CN1075059C (zh) 2001-11-21
GR3030449T3 (en) 1999-09-30
CZ101597A3 (en) 1997-10-15
NO971503L (no) 1997-05-14
HK1017361A1 (en) 1999-11-19

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20041207

MM4A Lapse of definitive patent protection due to non-payment of fees