DE69510212T2 - Colchicin-derivate sowie ihre therapeutische verwendung - Google Patents

Colchicin-derivate sowie ihre therapeutische verwendung

Info

Publication number
DE69510212T2
DE69510212T2 DE69510212T DE69510212T DE69510212T2 DE 69510212 T2 DE69510212 T2 DE 69510212T2 DE 69510212 T DE69510212 T DE 69510212T DE 69510212 T DE69510212 T DE 69510212T DE 69510212 T2 DE69510212 T2 DE 69510212T2
Authority
DE
Germany
Prior art keywords
derivatives
colchicin
therapeutic use
antitumoral
antiproliferative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69510212T
Other languages
English (en)
Other versions
DE69510212D1 (de
Inventor
Ezio Bombardelli
Bruno Gabetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of DE69510212D1 publication Critical patent/DE69510212D1/de
Publication of DE69510212T2 publication Critical patent/DE69510212T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE69510212T 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische verwendung Expired - Lifetime DE69510212T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico
PCT/EP1995/003823 WO1996011184A1 (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof

Publications (2)

Publication Number Publication Date
DE69510212D1 DE69510212D1 (de) 1999-07-15
DE69510212T2 true DE69510212T2 (de) 1999-11-11

Family

ID=11369650

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69510212T Expired - Lifetime DE69510212T2 (de) 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische verwendung
DE69533267T Expired - Lifetime DE69533267T2 (de) 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische Verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69533267T Expired - Lifetime DE69533267T2 (de) 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische Verwendung

Country Status (23)

Country Link
US (1) US5843910A (de)
EP (2) EP0909763B1 (de)
JP (1) JP2921990B2 (de)
KR (1) KR100255074B1 (de)
CN (2) CN1075059C (de)
AT (2) ATE181060T1 (de)
AU (1) AU692624B2 (de)
CA (1) CA2201723C (de)
CZ (1) CZ290309B6 (de)
DE (2) DE69510212T2 (de)
DK (2) DK0909763T3 (de)
ES (2) ES2224322T3 (de)
FI (1) FI120452B (de)
GR (1) GR3030449T3 (de)
HK (2) HK1017361A1 (de)
HU (1) HU223779B1 (de)
IT (1) IT1270124B (de)
NO (1) NO308030B1 (de)
PL (1) PL182204B1 (de)
PT (1) PT909763E (de)
RU (1) RU2145598C1 (de)
SK (1) SK281831B6 (de)
WO (1) WO1996011184A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique
AU2190700A (en) 1998-12-17 2000-07-03 Tularik Inc. Tubulin-binding agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
US20050277627A1 (en) * 2000-07-07 2005-12-15 Arnould Jean C Colchinol derivatives as vascular damaging agents
US6720323B2 (en) 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
ES2356494T3 (es) * 2008-05-28 2011-04-08 Indena S.P.A. Procedimiento para la glucosidación de colchicina y tiocolchicina.
DK2470499T3 (da) * 2009-08-26 2019-09-23 Alberta Health Services Nye colchicin-derivativer, fremgangsmåder og anvendelse deraf
EP3207026B1 (de) 2014-10-14 2018-12-12 Council of Scientific and Industrial Research 10-substituierte colchicinoide als hochwirksame antikrebsmittel
CN116082182A (zh) * 2021-11-08 2023-05-09 天津市昕晨投资发展有限公司 秋水仙碱衍生物的制备方法及其用途
CN114907228B (zh) * 2022-06-27 2023-11-28 深圳市锦泰医药科技合伙企业(有限合伙) 一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH513119A (de) * 1968-02-23 1971-09-30 Merck Patent Gmbh Verfahren zur Herstellung neuer Halogencolchicinderivate
GB1345991A (en) * 1972-05-05 1974-02-06 Roussel Uclaf Thiocolchicine derivatives
DE68919025T2 (de) * 1988-08-24 1995-03-02 Advance Biofactures Corp 3-Demethylthiocolchicincarbonate und N-Acylanaloge.

Also Published As

Publication number Publication date
DK0784613T3 (da) 1999-11-15
PL319455A1 (en) 1997-08-04
RU2145598C1 (ru) 2000-02-20
KR100255074B1 (ko) 2000-05-01
JPH10507169A (ja) 1998-07-14
US5843910A (en) 1998-12-01
ATE181060T1 (de) 1999-06-15
PT909763E (pt) 2004-10-29
NO971503D0 (no) 1997-04-03
FI971364A0 (fi) 1997-04-03
AU3743295A (en) 1996-05-02
HK1017361A1 (en) 1999-11-19
EP0909763A2 (de) 1999-04-21
AU692624B2 (en) 1998-06-11
CA2201723A1 (en) 1996-04-18
SK42497A3 (en) 1997-11-05
ES2131863T3 (es) 1999-08-01
GR3030449T3 (en) 1999-09-30
CZ101597A3 (en) 1997-10-15
HUT77223A (hu) 1998-03-02
CN1075059C (zh) 2001-11-21
DE69533267D1 (de) 2004-08-19
DE69510212D1 (de) 1999-07-15
CN1127480C (zh) 2003-11-12
ITMI942026A0 (it) 1994-10-05
CZ290309B6 (cs) 2002-07-17
DE69533267T2 (de) 2005-08-04
SK281831B6 (sk) 2001-08-06
NO308030B1 (no) 2000-07-10
WO1996011184A1 (en) 1996-04-18
CA2201723C (en) 2003-03-25
EP0909763B1 (de) 2004-07-14
EP0784613A1 (de) 1997-07-23
HU223779B1 (hu) 2005-01-28
FI971364A (fi) 1997-05-30
HK1001394A1 (en) 1998-06-19
NO971503L (no) 1997-05-14
FI120452B (fi) 2009-10-30
DK0909763T3 (da) 2004-11-22
CN1159801A (zh) 1997-09-17
PL182204B1 (en) 2001-11-30
EP0909763A3 (de) 2003-01-22
ATE271061T1 (de) 2004-07-15
IT1270124B (it) 1997-04-28
ITMI942026A1 (it) 1996-04-05
EP0784613B1 (de) 1999-06-09
ES2224322T3 (es) 2005-03-01
CN1308059A (zh) 2001-08-15
JP2921990B2 (ja) 1999-07-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC