DE68919025T2 - 3-Demethylthiocolchicincarbonate und N-Acylanaloge. - Google Patents

3-Demethylthiocolchicincarbonate und N-Acylanaloge.

Info

Publication number
DE68919025T2
DE68919025T2 DE68919025T DE68919025T DE68919025T2 DE 68919025 T2 DE68919025 T2 DE 68919025T2 DE 68919025 T DE68919025 T DE 68919025T DE 68919025 T DE68919025 T DE 68919025T DE 68919025 T2 DE68919025 T2 DE 68919025T2
Authority
DE
Germany
Prior art keywords
demethylthiocolchicine
carbonates
acyl analogs
analogs
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68919025T
Other languages
English (en)
Other versions
DE68919025D1 (de
Inventor
Arnold Dr Brossi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advance Biofactures Corp
Original Assignee
Advance Biofactures Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advance Biofactures Corp filed Critical Advance Biofactures Corp
Publication of DE68919025D1 publication Critical patent/DE68919025D1/de
Application granted granted Critical
Publication of DE68919025T2 publication Critical patent/DE68919025T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Luminescent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE68919025T 1988-08-24 1989-08-17 3-Demethylthiocolchicincarbonate und N-Acylanaloge. Expired - Fee Related DE68919025T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23590788A 1988-08-24 1988-08-24

Publications (2)

Publication Number Publication Date
DE68919025D1 DE68919025D1 (de) 1994-12-01
DE68919025T2 true DE68919025T2 (de) 1995-03-02

Family

ID=22887351

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68919025T Expired - Fee Related DE68919025T2 (de) 1988-08-24 1989-08-17 3-Demethylthiocolchicincarbonate und N-Acylanaloge.

Country Status (10)

Country Link
EP (1) EP0356137B1 (de)
JP (1) JPH02142765A (de)
AT (1) ATE113273T1 (de)
AU (1) AU618395B2 (de)
CA (1) CA1338432C (de)
DE (1) DE68919025T2 (de)
DK (1) DK416289A (de)
ES (1) ES2062014T3 (de)
FI (1) FI95461C (de)
ZA (1) ZA896411B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270124B (it) * 1994-10-05 1997-04-28 Indena Spa Derivati della colchicina e loro impiego terapeutico
IT1291550B1 (it) * 1997-04-11 1999-01-11 Indena Spa Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
WO2010138670A2 (en) 2009-05-27 2010-12-02 Mutual Pharmaceutical Company, Inc. Thiocolchicine derivatives, method of making and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US235907A (en) * 1880-12-28 sqhlimp
FR1099138A (fr) * 1954-02-10 1955-08-30 Roussel Uclaf Thiodérivés tropoloniques de la colchicine et leur procédé d'obtention
US2820029A (en) * 1954-02-10 1958-01-14 U C L A F New thio-derivatives of colchiceine compounds and a process of making same

Also Published As

Publication number Publication date
FI893955A0 (fi) 1989-08-23
JPH02142765A (ja) 1990-05-31
AU618395B2 (en) 1991-12-19
FI95461B (fi) 1995-10-31
CA1338432C (en) 1996-07-02
EP0356137A3 (en) 1990-11-07
DK416289A (da) 1990-02-25
FI95461C (fi) 1996-02-12
FI893955A (fi) 1990-02-25
DK416289D0 (da) 1989-08-23
ATE113273T1 (de) 1994-11-15
DE68919025D1 (de) 1994-12-01
ZA896411B (en) 1990-05-30
EP0356137A2 (de) 1990-02-28
EP0356137B1 (de) 1994-10-26
ES2062014T3 (es) 1994-12-16
AU4019189A (en) 1990-03-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee