IT1291550B1 - Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante - Google Patents

Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante

Info

Publication number
IT1291550B1
IT1291550B1 IT97MI000845A ITMI970845A IT1291550B1 IT 1291550 B1 IT1291550 B1 IT 1291550B1 IT 97MI000845 A IT97MI000845 A IT 97MI000845A IT MI970845 A ITMI970845 A IT MI970845A IT 1291550 B1 IT1291550 B1 IT 1291550B1
Authority
IT
Italy
Prior art keywords
thiocolchicine
derivatives
activities
myorelaxing
colchicine
Prior art date
Application number
IT97MI000845A
Other languages
English (en)
Inventor
Ezio Bombardelli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI000845A priority Critical patent/IT1291550B1/it
Application filed by Indena Spa filed Critical Indena Spa
Priority to DK98106236T priority patent/DK0870761T3/da
Priority to PT98106236T priority patent/PT870761E/pt
Priority to AT98106236T priority patent/ATE260252T1/de
Priority to ES98106236T priority patent/ES2216197T3/es
Priority to EP98106236A priority patent/EP0870761B1/en
Priority to SI9830614T priority patent/SI0870761T1/xx
Priority to DE1998621815 priority patent/DE69821815T2/de
Priority to KR1019980012058A priority patent/KR100559526B1/ko
Priority to US09/056,365 priority patent/US5973204A/en
Priority to RU98106625/04A priority patent/RU2190598C2/ru
Priority to AU60733/98A priority patent/AU738857B2/en
Priority to JP10112841A priority patent/JP2916470B2/ja
Priority to CA002234480A priority patent/CA2234480C/en
Priority to CN98109694A priority patent/CN1089336C/zh
Publication of ITMI970845A1 publication Critical patent/ITMI970845A1/it
Application granted granted Critical
Publication of IT1291550B1 publication Critical patent/IT1291550B1/it
Priority to HK99102778A priority patent/HK1017880A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
IT97MI000845A 1997-04-11 1997-04-11 Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante IT1291550B1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT97MI000845A IT1291550B1 (it) 1997-04-11 1997-04-11 Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
PT98106236T PT870761E (pt) 1997-04-11 1998-04-06 Derivados de tiocolchicina com actividades anti-inflamatoria e relaxante muscular
AT98106236T ATE260252T1 (de) 1997-04-11 1998-04-06 Thiocolchicin-derivate mit entzündungshemmender und muskelrelaxierender wirkung
ES98106236T ES2216197T3 (es) 1997-04-11 1998-04-06 Derivados de tiocolquicina con actividades antiinflamatoria y relajante muscular.
EP98106236A EP0870761B1 (en) 1997-04-11 1998-04-06 Thiocolchicine derivatives with antiinflammatory and muscle relaxant activities
SI9830614T SI0870761T1 (en) 1997-04-11 1998-04-06 Thiocolchicine derivatives with antiinflammatory and muscle relaxant activities
DE1998621815 DE69821815T2 (de) 1997-04-11 1998-04-06 Thiocolchicin-Derivate mit entzündungshemmender und muskelrelaxierender Wirkung
KR1019980012058A KR100559526B1 (ko) 1997-04-11 1998-04-06 항염증작용과 근육이완작용을 갖는 콜히친 및 치오콜히친유도체들
DK98106236T DK0870761T3 (da) 1997-04-11 1998-04-06 Thiocolchicinderivater med antiinflammatoriske og muskelafslppende aktiviteter
US09/056,365 US5973204A (en) 1997-04-11 1998-04-07 Colchicine and thiocolchicine derivatives with antiinflammatory and muscle relaxant activities
RU98106625/04A RU2190598C2 (ru) 1997-04-11 1998-04-08 Производные тиоколхицина, способы их получения, соединение, фармацевтическая композиция
AU60733/98A AU738857B2 (en) 1997-04-11 1998-04-09 Colchicine and thiocolchicine derivatives with antiflammatory and muscle relaxant activities
JP10112841A JP2916470B2 (ja) 1997-04-11 1998-04-09 抗炎症および筋弛緩活性を示すコルヒチンおよびチオコルヒチン誘導体
CA002234480A CA2234480C (en) 1997-04-11 1998-04-09 Colchicine and thiocolchicine derivatives with antiinflammatory and muscle relaxant activities
CN98109694A CN1089336C (zh) 1997-04-11 1998-04-09 有抗炎和肌肉松驰活性的秋水仙碱和硫代秋水仙碱衍生物
HK99102778A HK1017880A1 (en) 1997-04-11 1999-06-30 Colchicine and thiocolchicine derivatives with antiinflammatory and muscle relaxant activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000845A IT1291550B1 (it) 1997-04-11 1997-04-11 Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante

Publications (2)

Publication Number Publication Date
ITMI970845A1 ITMI970845A1 (it) 1998-10-11
IT1291550B1 true IT1291550B1 (it) 1999-01-11

Family

ID=11376857

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI000845A IT1291550B1 (it) 1997-04-11 1997-04-11 Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante

Country Status (16)

Country Link
US (1) US5973204A (it)
EP (1) EP0870761B1 (it)
JP (1) JP2916470B2 (it)
KR (1) KR100559526B1 (it)
CN (1) CN1089336C (it)
AT (1) ATE260252T1 (it)
AU (1) AU738857B2 (it)
CA (1) CA2234480C (it)
DE (1) DE69821815T2 (it)
DK (1) DK0870761T3 (it)
ES (1) ES2216197T3 (it)
HK (1) HK1017880A1 (it)
IT (1) IT1291550B1 (it)
PT (1) PT870761E (it)
RU (1) RU2190598C2 (it)
SI (1) SI0870761T1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) * 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6720323B2 (en) * 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
JP4430071B2 (ja) 2003-06-25 2010-03-10 ジェ イル ファーマシューティカル カンパニー リミテッド トリサイクリック誘導体またはその薬学的に許容される塩、その製造方法およびそれを含有する薬学的組成物
ITMI20051418A1 (it) * 2005-07-22 2007-01-23 Indena Spa Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
JP5435995B2 (ja) * 2009-01-30 2014-03-05 出光興産株式会社 環状化合物の製造方法
EP2435403A4 (en) * 2009-05-27 2015-04-01 Takeda Pharmaceuticals Usa Inc THIOCOLCHICINE DERIVATIVES AND MANUFACTURING AND USE METHOD THEREFOR
WO2011091114A2 (en) * 2010-01-22 2011-07-28 Mutual Pharmaceutical Company, Inc. Thiocolchicine and colchicine analogs, methods of making and methods of use thereof
EP2924022A1 (en) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphous form of a thiocolchicine derivative
AU2019295499A1 (en) * 2018-06-29 2021-01-07 Alberta Health Services Methods and uses of colchicine derivatives
RU2740530C1 (ru) * 2020-06-11 2021-01-15 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Способ профилактики развития постперикардиотомного синдрома и пароксизмов фибрилляции предсердий у кардиохирургических больных

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2820029A (en) * 1954-02-10 1958-01-14 U C L A F New thio-derivatives of colchiceine compounds and a process of making same
FR1344474A (fr) * 1962-10-18 1963-11-29 Roussel Uclaf Dérivés de la colchicine et de la thiocolchicine et procédé de préparation
ATE113273T1 (de) * 1988-08-24 1994-11-15 Advance Biofactures Corp 3-demethylthiocolchicincarbonate und n- acylanaloge.
IT1276996B1 (it) * 1995-06-27 1997-11-04 Indena Spa Derivati della colchicina, loro uso e formulazioni che li contengono

Also Published As

Publication number Publication date
KR100559526B1 (ko) 2006-06-28
CN1208033A (zh) 1999-02-17
KR19980081125A (ko) 1998-11-25
CA2234480C (en) 2006-12-12
HK1017880A1 (en) 1999-12-03
AU6073398A (en) 1998-10-15
ATE260252T1 (de) 2004-03-15
EP0870761A1 (en) 1998-10-14
PT870761E (pt) 2004-05-31
SI0870761T1 (en) 2004-06-30
JPH1121277A (ja) 1999-01-26
CN1089336C (zh) 2002-08-21
ES2216197T3 (es) 2004-10-16
AU738857B2 (en) 2001-09-27
EP0870761B1 (en) 2004-02-25
RU2190598C2 (ru) 2002-10-10
DK0870761T3 (da) 2004-06-28
JP2916470B2 (ja) 1999-07-05
DE69821815D1 (de) 2004-04-01
US5973204A (en) 1999-10-26
ITMI970845A1 (it) 1998-10-11
DE69821815T2 (de) 2005-01-13
CA2234480A1 (en) 1998-10-11

Similar Documents

Publication Publication Date Title
DE69604714D1 (de) Stilbenderivate und diese enthaltende pharmazeutische Zusammensetzungen
IT1291550B1 (it) Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante
ATE185562T1 (de) Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
ATE212033T1 (de) Colchicine derivate, deren verwendung und sie enthaltende formulierungen
ATE53376T1 (de) Entzuendungshemmende agentien.
ES2111871T3 (es) Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2055235T3 (es) Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
HUP0001827A2 (hu) Kolchicin-származékok, eljárás előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények, és a vegyületek alkalmazása gyógyszerkészítmények előállítására
ES2160308T3 (es) Nuevos derivados amino-metil-heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
BR9814495A (pt) Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo
IT1301679B1 (it) Derivati dell'iperforina, loro uso e formulazioni che licontengono.
MX9400274A (es) Nuevos derivados 2-ciano-3-hidroxipropenamidas, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
DE69907720D1 (de) Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten
SV1998000013A (es) Derivados de 5-aroilnaftaleno ref.-ran 4070\115
IT1244881B (it) Derivati dell'1-arilsolfonil 2-pirrolidone, loro procedimento di preparazione e i nuovi intermedi cosi' ottenuti ,il loro impiego come farmaci e le composizioni farmaceutiche che li contengono
ES2062313T3 (es) 13-bromo- y 13,14-dibromo-ergolinas, a su preparacion y a su utilizacion en medicamentos.
DE69819002D1 (de) Polyhydroxyalkylpyrazine derivate,deren herstellung und diese enthaltende arzneimitteln
ITMI910581A0 (it) Derivati dell'acido 5-fenil-1h-pirazol-4-propionico, loro preparazione e loro impiego come medicamenti
BR9915898A (pt) Compostos, composição farmacêutica, e, utilização de um composto
IT1191915B (it) Derivati di 3-ammino 3-ossoazetidina comprendente in posizione 1 un radicale tetrazolilico sostituito da un radicale organico scindibile,loro procedimento di preparazione,loro applicazione come medicamenti e composizioni che li contengono
IT1297002B1 (it) Derivati dell'azulene, metodo per la loro produzione e composizione farmaceutica contenente questi composti
ITMI911841A1 (it) Derivati dell'eseridina utili per il trattamento delle malattie associaate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ITMI930054A0 (it) Derivati della taurina ad attivita' anti-aggregante piastrinica procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
GT199400041A (es) Derivados de n4 (oxicarbonil substituidos)-5'desoxi-5-fluorocitidina
ECSP982682A (es) Nueva 3, 4 diariltiazolina 2- uno o 2- tiono derivados, sus metodos de preparacion y su uso terapeutico

Legal Events

Date Code Title Description
0001 Granted