DE69907720D1 - Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten - Google Patents

Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten

Info

Publication number
DE69907720D1
DE69907720D1 DE69907720T DE69907720T DE69907720D1 DE 69907720 D1 DE69907720 D1 DE 69907720D1 DE 69907720 T DE69907720 T DE 69907720T DE 69907720 T DE69907720 T DE 69907720T DE 69907720 D1 DE69907720 D1 DE 69907720D1
Authority
DE
Germany
Prior art keywords
phospholipid derivatives
compounds
inflammatory medicaments
tester end
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69907720T
Other languages
English (en)
Other versions
DE69907720T2 (de
Inventor
Alexander Kozak
Israel Shapiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DPHARM Ltd
D Pharm Ltd
Original Assignee
DPHARM Ltd
D Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DPHARM Ltd, D Pharm Ltd filed Critical DPHARM Ltd
Application granted granted Critical
Publication of DE69907720D1 publication Critical patent/DE69907720D1/de
Publication of DE69907720T2 publication Critical patent/DE69907720T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69907720T 1998-11-19 1999-11-18 Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten Expired - Lifetime DE69907720T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL12714398 1998-11-19
IL12714398A IL127143A0 (en) 1998-11-19 1998-11-19 Phospholipid terivatives of non-steroidal anti inflammatory drugs
PCT/IL1999/000623 WO2000031083A1 (en) 1998-11-19 1999-11-18 Phospholipid derivatives of non-steroidal anti-inflammatory drugs

Publications (2)

Publication Number Publication Date
DE69907720D1 true DE69907720D1 (de) 2003-06-12
DE69907720T2 DE69907720T2 (de) 2004-02-26

Family

ID=11072158

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69907720T Expired - Lifetime DE69907720T2 (de) 1998-11-19 1999-11-18 Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten

Country Status (11)

Country Link
US (3) US6730696B1 (de)
EP (1) EP1131326B1 (de)
JP (1) JP2002530410A (de)
AT (1) ATE239739T1 (de)
AU (1) AU766045B2 (de)
CA (1) CA2346869C (de)
DE (1) DE69907720T2 (de)
IL (1) IL127143A0 (de)
NZ (1) NZ510938A (de)
WO (1) WO2000031083A1 (de)
ZA (1) ZA200102718B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127143A0 (en) 1998-11-19 1999-09-22 Dpharm Ltd Phospholipid terivatives of non-steroidal anti inflammatory drugs
US7410956B2 (en) * 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
US20070053984A1 (en) * 2005-03-03 2007-03-08 Monique Spann-Wade Topical gels compositions
DE102006019907A1 (de) * 2006-04-28 2007-10-31 Müller-Enoch, Dieter, Prof. Dr. Verwendung von substituierten Glycerinderivaten zur Herstellung einer pharmazeutischen Zubereitung
US20080317684A1 (en) * 2006-09-06 2008-12-25 Isw Group, Inc. Topical Compositions
CN101842119A (zh) * 2007-10-30 2010-09-22 阿瑟拉生物技术公司 心血管疾病的诊断和治疗方法及组合物
US20130244982A1 (en) * 2010-12-02 2013-09-19 Bengurion University Of The Negev Research And Development Authority Conjugates of a phospholipid and a drug for the treatment of inflammatory bowel disease
US20230285292A1 (en) * 2020-06-23 2023-09-14 The Trustees Of The University Of Pennsylvania Compositions and methods of using a pla2-responsive drug delivery system

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US5352673A (en) * 1989-08-29 1994-10-04 Dennis Edward A Prodrugs
AU7872491A (en) * 1990-05-07 1991-11-27 Vical, Inc. Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs
US5563257A (en) * 1990-08-20 1996-10-08 Boehringer Mannheim Gmbh Phospholipid derivatives of nucleosides
US5256641A (en) 1990-11-01 1993-10-26 State Of Oregon Covalent polar lipid-peptide conjugates for immunological targeting
US5543389A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization Covalent polar lipid-peptide conjugates for use in salves
US5149794A (en) 1990-11-01 1992-09-22 State Of Oregon Covalent lipid-drug conjugates for drug targeting
AU668873B2 (en) 1991-07-12 1996-05-23 Chimerix, Inc. Antiviral liponucleosides: treatment of hepatitis B
JPH07188280A (ja) * 1993-12-28 1995-07-25 L T T Kenkyusho:Kk ホスファチジルエタノールアミン類結合生理活性物質およびその中間体
US5534499A (en) * 1994-05-19 1996-07-09 The University Of British Columbia Lipophilic drug derivatives for use in liposomes
EP0805684B1 (de) 1995-01-27 2002-06-12 The Board Of Regents, The University Of Texas System Verfahren zur erhöhung der therapeutischen wirkung von nsaids und dazu verwendbare zwitterionische phospholipidhaltige zusammensetungen
JP3781877B2 (ja) * 1997-10-03 2006-05-31 株式会社ムック アスコルビン酸誘導体またはその塩、および医薬
IL127143A0 (en) * 1998-11-19 1999-09-22 Dpharm Ltd Phospholipid terivatives of non-steroidal anti inflammatory drugs

Also Published As

Publication number Publication date
CA2346869A1 (en) 2000-06-02
US20040147485A1 (en) 2004-07-29
EP1131326A1 (de) 2001-09-12
US7173018B2 (en) 2007-02-06
US7417035B2 (en) 2008-08-26
DE69907720T2 (de) 2004-02-26
US6730696B1 (en) 2004-05-04
AU1292800A (en) 2000-06-13
ATE239739T1 (de) 2003-05-15
JP2002530410A (ja) 2002-09-17
WO2000031083A1 (en) 2000-06-02
EP1131326B1 (de) 2003-05-07
EP1131326A4 (de) 2002-03-27
ZA200102718B (en) 2001-10-05
CA2346869C (en) 2010-03-23
IL127143A0 (en) 1999-09-22
NZ510938A (en) 2002-11-26
AU766045B2 (en) 2003-10-09
US20070191310A1 (en) 2007-08-16

Similar Documents

Publication Publication Date Title
ATE208397T1 (de) Arylsubstituierte 5,5 verknüpfte aromatische nitroverbindungen als entzündungshemmende wirkstoffe
DK1104758T3 (da) Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler
DK1586322T3 (da) Sammensætninger indeholdende thalidomid og dextamethason til behandling af cancer
HUP0402422A2 (hu) Deuterizált szubsztituált pirazolil-benzolszulfonamid-származékok, az ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
EE200100558A (et) Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine
BRPI9701248B1 (pt) Compostos para a terapia de tumores e distúrbios inflamatórios, produto farmacêutico e formulação farmacêutica dos mesmos
MY128659A (en) Novel aminodicarboxylic acid derivatives having pharmaceutical properties
NO982294L (no) Farmas°ytiske blandinger omfattende flurbiprofen
ATE235895T1 (de) Arzneistoff-abgabesystem enthaltend eine festgepackte, feste arzneistoffbasis
RU94040864A (ru) Конденсированные индольные производные, их получение, фармацевтическая композиция
BR9909565A (pt) Derivados bicìclicos do ácido hidroxâmico
NO962841D0 (no) Anvendelse av 2-hydroksy-5-fenylazobenzosyrederivater som colon cancer kjemopreventativer og kjemoterapeutiske midler
HUP9602215A2 (hu) 4-Klór-5-(imidazolin-2-il-amino)-6-metoxi-2-metil-pirimidin alkalmazása megvonási tünetek kezelésére alkalmas gyógyszerkészítmény előállítására
ES2192234T3 (es) Composiciones farmaceuticas parenterales conteniendo sales de amonioalquilo de acidos 2-arilpropionicos.
YU35102A (sh) Derivati heterociklo-alkilsulfonil pirazola kao anti- inflamatorni/analgetički agensi
BR0013311A (pt) Derivados substituìdos de 1,5-dihidropirrol-2-ona eficazes como antagonistas de receptores nmda para o tratamento de estados de dor
BR0112807A (pt) Derivados de indol e sua aplicação como medicamento
DE69907720D1 (de) Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten
CO4410330A1 (es) Nuevos derivados de bencimidazol farmacologicamente activos y sus sales de adicion acida
ATE360428T1 (de) Analgetisches arzneimittel
DE69821815D1 (de) Thiocolchicin-Derivate mit entzündungshemmender und muskelrelaxierender Wirkung
DE69819539D1 (de) Antithrombotische mittel
ATE266029T1 (de) Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
ES2188908T3 (es) Derivados de cis-3,4-cromano utiles para la prevencion o tratamiento de sindromes relacionados con el estrogenos.
AR029320A1 (es) Acidos aril carboxilicos y derivados de tetrazol, un proceso para su fabricacion, una composicion farmaceutica y el uso de los mismos para la produccion de un medicamento

Legal Events

Date Code Title Description
8364 No opposition during term of opposition