HUP0001827A2 - Kolchicin-származékok, eljárás előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények, és a vegyületek alkalmazása gyógyszerkészítmények előállítására - Google Patents

Kolchicin-származékok, eljárás előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények, és a vegyületek alkalmazása gyógyszerkészítmények előállítására

Info

Publication number
HUP0001827A2
HUP0001827A2 HU0001827A HUP0001827A HUP0001827A2 HU P0001827 A2 HUP0001827 A2 HU P0001827A2 HU 0001827 A HU0001827 A HU 0001827A HU P0001827 A HUP0001827 A HU P0001827A HU P0001827 A2 HUP0001827 A2 HU P0001827A2
Authority
HU
Hungary
Prior art keywords
producing
pharmaceutical compositions
colchicine derivatives
group
compositions containing
Prior art date
Application number
HU0001827A
Other languages
English (en)
Inventor
Ezio Bombardelli
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Publication of HUP0001827A2 publication Critical patent/HUP0001827A2/hu
Publication of HUP0001827A3 publication Critical patent/HUP0001827A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány (I) és (II) általános képletű kolchicin- és tiokolchicin-származékokra vonatkozik. A képletekben R jelentése metoxi- vagymetil-tio-csoport, és R1 jelentése alkil- vagy alkenilcsoport,aliciklusos vagy heterociklusos csoport, acilcsoport vagy béta-D-glükoz- vagy 6-dezoxi-galaktóz-maradék. A vegyületek tumorelleneshatást gyakorolnak mind normális rákos sejtekre, mind kemo-rezisztensfenotípusokra. A találmány szerinti vegyületek beadhatók injekcióbanvagy orális úton. Ó
HU0001827A 1996-06-07 1997-05-21 Colchicine derivatives, process for producing them, pharmaceutical compositions containing them, and use thereof for producing pharmaceutical compositions HUP0001827A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001168A IT1283110B1 (it) 1996-06-07 1996-06-07 Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono
PCT/EP1997/002577 WO1997047577A1 (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them

Publications (2)

Publication Number Publication Date
HUP0001827A2 true HUP0001827A2 (hu) 2001-05-28
HUP0001827A3 HUP0001827A3 (en) 2001-07-30

Family

ID=11374396

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001827A HUP0001827A3 (en) 1996-06-07 1997-05-21 Colchicine derivatives, process for producing them, pharmaceutical compositions containing them, and use thereof for producing pharmaceutical compositions

Country Status (20)

Country Link
US (1) US6080739A (hu)
EP (1) EP0906262B1 (hu)
JP (1) JP3285361B2 (hu)
KR (1) KR100306430B1 (hu)
CN (1) CN1122657C (hu)
AT (1) ATE222228T1 (hu)
AU (1) AU723752B2 (hu)
CZ (1) CZ294365B6 (hu)
DE (1) DE69714735T2 (hu)
DK (1) DK0906262T3 (hu)
ES (1) ES2182084T3 (hu)
HK (1) HK1019587A1 (hu)
HU (1) HUP0001827A3 (hu)
IT (1) IT1283110B1 (hu)
NO (1) NO311252B1 (hu)
PL (1) PL187528B1 (hu)
PT (1) PT906262E (hu)
RU (1) RU2181354C2 (hu)
SK (2) SK283736B6 (hu)
WO (1) WO1997047577A1 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) * 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2774290B1 (fr) * 1998-02-05 2000-06-16 Synthelabo Composition pharmaceutique pour l'administration par voie nasale de thiocolchicoside
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
IT1318401B1 (it) * 2000-03-17 2003-08-25 Indena Spa Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono.
US6720323B2 (en) * 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6825236B2 (en) 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
ITMI20040164A1 (it) * 2004-02-03 2004-05-03 Indena Spa Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
ES2355109T3 (es) * 2004-12-22 2011-03-22 Mestex Ag Mezcla de un agonista de receptor de vainilloide con una sustancia inhibidora de la regeneración nerviosa, su utilización para la fabricación de un analgésico y procedimiento de aplicación de este fármaco.
ITRM20070088A1 (it) 2007-02-19 2008-08-20 Francesco Fringuelli Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico.
US20110178180A1 (en) * 2010-01-18 2011-07-21 Kurt Nielsen Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
KR101343443B1 (ko) 2010-02-18 2013-12-19 재단법인 아산사회복지재단 콜키친 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
KR101130754B1 (ko) 2010-06-25 2012-03-28 제일약품주식회사 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL279678A (hu) * 1961-06-14
US3442953A (en) * 1963-06-19 1969-05-06 Roussel Uclaf Novel 7-oxo-7-desacetylaminocolchicine compounds
FR3032M (fr) * 1963-06-19 1964-12-28 Roussel Uclaf Nouveaux médicaments doués notamment d'activité antimitotique.
US4349548A (en) * 1981-11-20 1982-09-14 Merck & Co., Inc. Octahydrobenzo[6,7]cyclohept[1,2-b]-1,4-oxazines, compositions and use

Also Published As

Publication number Publication date
PL187528B1 (pl) 2004-07-30
HK1019587A1 (en) 2000-02-18
DE69714735D1 (de) 2002-09-19
WO1997047577A1 (en) 1997-12-18
EP0906262A1 (en) 1999-04-07
NO985676L (no) 1998-12-04
PL330284A1 (en) 1999-05-10
NO985676D0 (no) 1998-12-04
IT1283110B1 (it) 1998-04-07
CZ401098A3 (cs) 1999-05-12
ES2182084T3 (es) 2003-03-01
SK283737B6 (sk) 2003-12-02
DE69714735T2 (de) 2003-04-24
ITMI961168A0 (it) 1996-06-07
AU723752B2 (en) 2000-09-07
PT906262E (pt) 2002-11-29
JP2000503669A (ja) 2000-03-28
EP0906262B1 (en) 2002-08-14
SK167998A3 (en) 1999-07-12
US6080739A (en) 2000-06-27
DK0906262T3 (da) 2002-12-16
AU3027897A (en) 1998-01-07
SK283736B6 (sk) 2003-12-02
ITMI961168A1 (it) 1997-12-07
ATE222228T1 (de) 2002-08-15
NO311252B1 (no) 2001-11-05
HUP0001827A3 (en) 2001-07-30
RU2181354C2 (ru) 2002-04-20
CZ294365B6 (cs) 2004-12-15
CN1219924A (zh) 1999-06-16
KR100306430B1 (ko) 2001-11-30
CN1122657C (zh) 2003-10-01
JP3285361B2 (ja) 2002-05-27
KR20000016387A (ko) 2000-03-25

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees