DE69714735D1 - Colchicin-skelett verbindungen, ihre verwendung als arzneimittel und diese verbindungen enthaltende zusammensetzungen - Google Patents

Colchicin-skelett verbindungen, ihre verwendung als arzneimittel und diese verbindungen enthaltende zusammensetzungen

Info

Publication number
DE69714735D1
DE69714735D1 DE69714735T DE69714735T DE69714735D1 DE 69714735 D1 DE69714735 D1 DE 69714735D1 DE 69714735 T DE69714735 T DE 69714735T DE 69714735 T DE69714735 T DE 69714735T DE 69714735 D1 DE69714735 D1 DE 69714735D1
Authority
DE
Germany
Prior art keywords
compounds
pct
colchicin
compositions containing
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69714735T
Other languages
English (en)
Other versions
DE69714735T2 (de
Inventor
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of DE69714735D1 publication Critical patent/DE69714735D1/de
Application granted granted Critical
Publication of DE69714735T2 publication Critical patent/DE69714735T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69714735T 1996-06-07 1997-05-21 Colchicin-skelett verbindungen, ihre verwendung als arzneimittel und diese verbindungen enthaltende zusammensetzungen Expired - Lifetime DE69714735T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001168A IT1283110B1 (it) 1996-06-07 1996-06-07 Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono
PCT/EP1997/002577 WO1997047577A1 (en) 1996-06-07 1997-05-21 Colchicine-skeleton compounds, their use as medicaments and compositions containing them

Publications (2)

Publication Number Publication Date
DE69714735D1 true DE69714735D1 (de) 2002-09-19
DE69714735T2 DE69714735T2 (de) 2003-04-24

Family

ID=11374396

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714735T Expired - Lifetime DE69714735T2 (de) 1996-06-07 1997-05-21 Colchicin-skelett verbindungen, ihre verwendung als arzneimittel und diese verbindungen enthaltende zusammensetzungen

Country Status (20)

Country Link
US (1) US6080739A (de)
EP (1) EP0906262B1 (de)
JP (1) JP3285361B2 (de)
KR (1) KR100306430B1 (de)
CN (1) CN1122657C (de)
AT (1) ATE222228T1 (de)
AU (1) AU723752B2 (de)
CZ (1) CZ294365B6 (de)
DE (1) DE69714735T2 (de)
DK (1) DK0906262T3 (de)
ES (1) ES2182084T3 (de)
HK (1) HK1019587A1 (de)
HU (1) HUP0001827A3 (de)
IT (1) IT1283110B1 (de)
NO (1) NO311252B1 (de)
PL (1) PL187528B1 (de)
PT (1) PT906262E (de)
RU (1) RU2181354C2 (de)
SK (2) SK283737B6 (de)
WO (1) WO1997047577A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) * 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2774290B1 (fr) * 1998-02-05 2000-06-16 Synthelabo Composition pharmaceutique pour l'administration par voie nasale de thiocolchicoside
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
IT1318401B1 (it) * 2000-03-17 2003-08-25 Indena Spa Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono.
US6720323B2 (en) 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
ITMI20040164A1 (it) * 2004-02-03 2004-05-03 Indena Spa Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
US20100047181A1 (en) * 2004-12-22 2010-02-25 Mestex Ag Mixture of a vanilloid receptor agonist and a substance inhibiting nerve regeneration, use thereof for producing a painkiller, and method for applying said painkiller
ITRM20070088A1 (it) 2007-02-19 2008-08-20 Francesco Fringuelli Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico.
US20110178180A1 (en) * 2010-01-18 2011-07-21 Kurt Nielsen Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
EP2562156B1 (de) 2010-02-18 2018-11-07 The Asan Foundation Colchicinderivate oder pharmazeutisch zuverlässige salze davon, verfahren zur herstellung solcher derivate und pharmazeutische zusammensetzung mit solchen derivaten
KR101130754B1 (ko) 2010-06-25 2012-03-28 제일약품주식회사 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL279678A (de) * 1961-06-14
US3442953A (en) * 1963-06-19 1969-05-06 Roussel Uclaf Novel 7-oxo-7-desacetylaminocolchicine compounds
FR3032M (fr) * 1963-06-19 1964-12-28 Roussel Uclaf Nouveaux médicaments doués notamment d'activité antimitotique.
US4349548A (en) * 1981-11-20 1982-09-14 Merck & Co., Inc. Octahydrobenzo[6,7]cyclohept[1,2-b]-1,4-oxazines, compositions and use

Also Published As

Publication number Publication date
IT1283110B1 (it) 1998-04-07
PL330284A1 (en) 1999-05-10
SK167998A3 (en) 1999-07-12
US6080739A (en) 2000-06-27
NO311252B1 (no) 2001-11-05
RU2181354C2 (ru) 2002-04-20
EP0906262B1 (de) 2002-08-14
HUP0001827A2 (hu) 2001-05-28
WO1997047577A1 (en) 1997-12-18
AU3027897A (en) 1998-01-07
NO985676L (no) 1998-12-04
SK283736B6 (sk) 2003-12-02
DK0906262T3 (da) 2002-12-16
HUP0001827A3 (en) 2001-07-30
JP2000503669A (ja) 2000-03-28
SK283737B6 (sk) 2003-12-02
ES2182084T3 (es) 2003-03-01
CZ294365B6 (cs) 2004-12-15
ITMI961168A1 (it) 1997-12-07
CZ401098A3 (cs) 1999-05-12
KR100306430B1 (ko) 2001-11-30
PT906262E (pt) 2002-11-29
NO985676D0 (no) 1998-12-04
HK1019587A1 (en) 2000-02-18
DE69714735T2 (de) 2003-04-24
ITMI961168A0 (it) 1996-06-07
JP3285361B2 (ja) 2002-05-27
AU723752B2 (en) 2000-09-07
KR20000016387A (ko) 2000-03-25
ATE222228T1 (de) 2002-08-15
CN1219924A (zh) 1999-06-16
PL187528B1 (pl) 2004-07-30
EP0906262A1 (de) 1999-04-07
CN1122657C (zh) 2003-10-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC