ITMI951367A0 - Derivati della colchicina loro uso e formulazioni che li contengono - Google Patents
Derivati della colchicina loro uso e formulazioni che li contengonoInfo
- Publication number
- ITMI951367A0 ITMI951367A0 ITMI951367A ITMI951367A ITMI951367A0 IT MI951367 A0 ITMI951367 A0 IT MI951367A0 IT MI951367 A ITMI951367 A IT MI951367A IT MI951367 A ITMI951367 A IT MI951367A IT MI951367 A0 ITMI951367 A0 IT MI951367A0
- Authority
- IT
- Italy
- Prior art keywords
- formulations
- contain
- colchicine derivatives
- colchicine
- derivatives
- Prior art date
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title 1
- 229940045695 antineooplastic colchicine derivative Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/32—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI001367A IT1276996B1 (it) | 1995-06-27 | 1995-06-27 | Derivati della colchicina, loro uso e formulazioni che li contengono |
CN96194868A CN1091446C (zh) | 1995-06-27 | 1996-06-21 | 秋水仙碱衍生物,其应用及含它们的制剂 |
PL96324621A PL186770B1 (pl) | 1995-06-27 | 1996-06-21 | Pochodne kolchicyny, ich zastosowanie i zawierająca je kompozycja farmaceutyczna |
HU9901685A HU223103B1 (hu) | 1995-06-27 | 1996-06-21 | Kolchicinszármazékok és azokat tartalmazó gyógyászati készítmények |
EP96923889A EP0840738B1 (en) | 1995-06-27 | 1996-06-21 | Colchicine derivatives, the use thereof and formulations containing them |
AU64146/96A AU717082B2 (en) | 1995-06-27 | 1996-06-21 | Colchicine derivatives, the use thereof and formulations containing them |
SI9630366T SI0840738T1 (en) | 1995-06-27 | 1996-06-21 | Colchicine derivatives, the use thereof and formulations containing them |
PCT/EP1996/002718 WO1997001570A1 (en) | 1995-06-27 | 1996-06-21 | Colchicine derivatives, the use thereof and formulations containing them |
KR1019970709528A KR100379991B1 (ko) | 1995-06-27 | 1996-06-21 | 콜히친유도체,그의용도및그를함유한제제 |
DK96923889T DK0840738T3 (da) | 1995-06-27 | 1996-06-21 | Colchicinderivater, deres anvendelse og formuleringer indeholdende dem |
DE69618600T DE69618600T2 (de) | 1995-06-27 | 1996-06-21 | Colchicine derivate, deren verwendung und sie enthaltende formulierungen |
JP09504160A JP3130050B2 (ja) | 1995-06-27 | 1996-06-21 | コルヒチン誘導体、それらの使用およびそれらを含有する製剤 |
ES96923889T ES2171691T3 (es) | 1995-06-27 | 1996-06-21 | Derivados de la colchicina, uso de los mismos y formulaciones que los contienen. |
PT96923889T PT840738E (pt) | 1995-06-27 | 1996-06-21 | Derivados da colquicina sua utilizacao e formulacoes que os contem |
AT96923889T ATE212033T1 (de) | 1995-06-27 | 1996-06-21 | Colchicine derivate, deren verwendung und sie enthaltende formulierungen |
RU98101248/04A RU2163241C2 (ru) | 1995-06-27 | 1996-06-21 | Производные колхицина и фармацевтическая композиция на их основе |
CA002225284A CA2225284C (en) | 1995-06-27 | 1996-06-21 | Colchicine derivatives, the use thereof and formulations containing them |
US08/670,878 US5880160A (en) | 1995-06-27 | 1996-06-27 | Colchicine derivatives, the use thereof and formulations containing them |
NO19976001A NO310875B1 (no) | 1995-06-27 | 1997-12-19 | Kolkisinderivater, anvendelse derav og sammensetninger inneholdende slike |
HK98109903A HK1009138A1 (en) | 1995-06-27 | 1998-08-13 | Colchicine derivatives, the use thereof and formulations containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI001367A IT1276996B1 (it) | 1995-06-27 | 1995-06-27 | Derivati della colchicina, loro uso e formulazioni che li contengono |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI951367A0 true ITMI951367A0 (it) | 1995-06-27 |
ITMI951367A1 ITMI951367A1 (it) | 1996-12-27 |
IT1276996B1 IT1276996B1 (it) | 1997-11-04 |
Family
ID=11371873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT95MI001367A IT1276996B1 (it) | 1995-06-27 | 1995-06-27 | Derivati della colchicina, loro uso e formulazioni che li contengono |
Country Status (19)
Country | Link |
---|---|
US (1) | US5880160A (it) |
EP (1) | EP0840738B1 (it) |
JP (1) | JP3130050B2 (it) |
KR (1) | KR100379991B1 (it) |
CN (1) | CN1091446C (it) |
AT (1) | ATE212033T1 (it) |
AU (1) | AU717082B2 (it) |
CA (1) | CA2225284C (it) |
DE (1) | DE69618600T2 (it) |
DK (1) | DK0840738T3 (it) |
ES (1) | ES2171691T3 (it) |
HK (1) | HK1009138A1 (it) |
HU (1) | HU223103B1 (it) |
IT (1) | IT1276996B1 (it) |
NO (1) | NO310875B1 (it) |
PL (1) | PL186770B1 (it) |
PT (1) | PT840738E (it) |
RU (1) | RU2163241C2 (it) |
WO (1) | WO1997001570A1 (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2759587B1 (fr) * | 1997-02-20 | 1999-03-19 | Synthelabo | Composition pharmaceutique pour l'administration buccale de thiocolchicoside |
IT1291550B1 (it) * | 1997-04-11 | 1999-01-11 | Indena Spa | Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
FR2774290B1 (fr) * | 1998-02-05 | 2000-06-16 | Synthelabo | Composition pharmaceutique pour l'administration par voie nasale de thiocolchicoside |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
US6399093B1 (en) | 1999-05-19 | 2002-06-04 | Advanced Medical Instruments | Method and composition to treat musculoskeletal disorders |
IT1318401B1 (it) | 2000-03-17 | 2003-08-25 | Indena Spa | Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono. |
KR20030014425A (ko) * | 2000-07-07 | 2003-02-17 | 앤지오젠 파마슈티칼스 리미티드 | 혈관 손상제인 콜치놀 유도체 |
US6624317B1 (en) | 2000-09-25 | 2003-09-23 | The University Of North Carolina At Chapel Hill | Taxoid conjugates as antimitotic and antitumor agents |
JP2004529204A (ja) * | 2001-05-28 | 2004-09-24 | ケムテック、リサーチ、インコーポレーション | 新規なアルカロイド誘導体及びこれを含有する医薬組成物 |
US6825236B2 (en) * | 2003-04-14 | 2004-11-30 | California Pacific Medical Center | Colchicine derivatives |
ITMI20031144A1 (it) * | 2003-06-06 | 2004-12-07 | Indena Spa | Analoghi del colchicoside. |
DE602004031621D1 (de) * | 2003-06-25 | 2011-04-14 | Je Il Pharmaceutical Co Ltd | Tricyclische derivate oder pharmazeutisch unnbedenkliche salze davon, deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten |
CN100341422C (zh) * | 2003-11-03 | 2007-10-10 | 李精华 | 降低鲜黄花菜中秋水仙碱含量的方法 |
TR200708925A1 (tr) * | 2007-12-26 | 2009-07-21 | Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | Kontrollü salım sağlayan flurbiprofen ve kas gevşetici kombinasyonları |
US8497290B2 (en) * | 2009-05-27 | 2013-07-30 | Takeda Pharmaceuticals U.S.A., Inc. | Thiocolchicine derivatives, method of making and methods of use thereof |
EP2470499B1 (en) | 2009-08-26 | 2019-06-12 | Alberta Health Services | Novel colchicine derivatives, methods and uses thereof |
US20110178180A1 (en) * | 2010-01-18 | 2011-07-21 | Kurt Nielsen | Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof |
EP2562156B1 (en) * | 2010-02-18 | 2018-11-07 | The Asan Foundation | Colchicine derivatives or pharmaceutically acceptable salts thereof, method for preparing said derivatives, and pharmaceutical composition comprising said derivatives |
KR101130754B1 (ko) * | 2010-06-25 | 2012-03-28 | 제일약품주식회사 | 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3120583B2 (ja) * | 1992-08-25 | 2000-12-25 | 株式会社デンソー | 高周波増幅器の安定化回路 |
US5426224A (en) * | 1993-03-18 | 1995-06-20 | The University Of North Carolina At Chapel Hill | Mammalian DNA topoisomerase II inhibitor and method |
-
1995
- 1995-06-27 IT IT95MI001367A patent/IT1276996B1/it active IP Right Grant
-
1996
- 1996-06-21 PT PT96923889T patent/PT840738E/pt unknown
- 1996-06-21 AU AU64146/96A patent/AU717082B2/en not_active Ceased
- 1996-06-21 EP EP96923889A patent/EP0840738B1/en not_active Expired - Lifetime
- 1996-06-21 KR KR1019970709528A patent/KR100379991B1/ko not_active IP Right Cessation
- 1996-06-21 CN CN96194868A patent/CN1091446C/zh not_active Expired - Fee Related
- 1996-06-21 AT AT96923889T patent/ATE212033T1/de not_active IP Right Cessation
- 1996-06-21 DE DE69618600T patent/DE69618600T2/de not_active Expired - Fee Related
- 1996-06-21 RU RU98101248/04A patent/RU2163241C2/ru not_active IP Right Cessation
- 1996-06-21 PL PL96324621A patent/PL186770B1/pl not_active IP Right Cessation
- 1996-06-21 JP JP09504160A patent/JP3130050B2/ja not_active Expired - Fee Related
- 1996-06-21 CA CA002225284A patent/CA2225284C/en not_active Expired - Fee Related
- 1996-06-21 DK DK96923889T patent/DK0840738T3/da active
- 1996-06-21 ES ES96923889T patent/ES2171691T3/es not_active Expired - Lifetime
- 1996-06-21 WO PCT/EP1996/002718 patent/WO1997001570A1/en active IP Right Grant
- 1996-06-21 HU HU9901685A patent/HU223103B1/hu not_active IP Right Cessation
- 1996-06-27 US US08/670,878 patent/US5880160A/en not_active Expired - Fee Related
-
1997
- 1997-12-19 NO NO19976001A patent/NO310875B1/no not_active IP Right Cessation
-
1998
- 1998-08-13 HK HK98109903A patent/HK1009138A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO310875B1 (no) | 2001-09-10 |
KR100379991B1 (ko) | 2003-07-22 |
AU6414696A (en) | 1997-01-30 |
EP0840738A1 (en) | 1998-05-13 |
US5880160A (en) | 1999-03-09 |
EP0840738B1 (en) | 2002-01-16 |
CN1091446C (zh) | 2002-09-25 |
CN1188482A (zh) | 1998-07-22 |
CA2225284C (en) | 2006-12-12 |
NO976001L (no) | 1997-12-19 |
DK0840738T3 (da) | 2002-05-06 |
DE69618600T2 (de) | 2002-08-08 |
IT1276996B1 (it) | 1997-11-04 |
HUP9901685A3 (en) | 2001-07-30 |
RU2163241C2 (ru) | 2001-02-20 |
CA2225284A1 (en) | 1997-01-16 |
ATE212033T1 (de) | 2002-02-15 |
DE69618600D1 (de) | 2002-02-21 |
PL186770B1 (pl) | 2004-02-27 |
HUP9901685A2 (hu) | 1999-09-28 |
PT840738E (pt) | 2002-05-31 |
NO976001D0 (no) | 1997-12-19 |
HK1009138A1 (en) | 1999-05-28 |
AU717082B2 (en) | 2000-03-16 |
KR19990028217A (ko) | 1999-04-15 |
ITMI951367A1 (it) | 1996-12-27 |
WO1997001570A1 (en) | 1997-01-16 |
PL324621A1 (en) | 1998-06-08 |
JPH11501324A (ja) | 1999-02-02 |
ES2171691T3 (es) | 2002-09-16 |
JP3130050B2 (ja) | 2001-01-31 |
HU223103B1 (hu) | 2004-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |