ITMI20031618A1 - Derivati polisaccaridici dotati di alta attivita' - Google Patents

Derivati polisaccaridici dotati di alta attivita'

Info

Publication number
ITMI20031618A1
ITMI20031618A1 IT001618A ITMI20031618A ITMI20031618A1 IT MI20031618 A1 ITMI20031618 A1 IT MI20031618A1 IT 001618 A IT001618 A IT 001618A IT MI20031618 A ITMI20031618 A IT MI20031618A IT MI20031618 A1 ITMI20031618 A1 IT MI20031618A1
Authority
IT
Italy
Prior art keywords
sulphation
partial
acetylheparosan
high activity
relates
Prior art date
Application number
IT001618A
Other languages
English (en)
Italian (it)
Inventor
Jacopo Chini
Giovanni Cipolletti
Marco Manoni
Liana Salsini
Original Assignee
Inalco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inalco Spa filed Critical Inalco Spa
Priority to IT001618A priority Critical patent/ITMI20031618A1/it
Priority to JP2006522341A priority patent/JP2007501305A/ja
Priority to EP04766148A priority patent/EP1654288B9/en
Priority to DK04766148.3T priority patent/DK1654288T3/da
Priority to CA002534709A priority patent/CA2534709A1/en
Priority to PCT/EP2004/051391 priority patent/WO2005014656A1/en
Priority to KR1020067002532A priority patent/KR20060063933A/ko
Priority to CNA2004800223076A priority patent/CN1832966A/zh
Priority to BRPI0413346-3A priority patent/BRPI0413346A/pt
Priority to AU2004262584A priority patent/AU2004262584A1/en
Priority to US10/557,584 priority patent/US7687249B2/en
Priority to ES04766148T priority patent/ES2341249T3/es
Priority to AT04766148T priority patent/ATE458009T1/de
Priority to MXPA06001511A priority patent/MXPA06001511A/es
Priority to DE602004025583T priority patent/DE602004025583D1/de
Priority to RU2006106790/04A priority patent/RU2361881C2/ru
Publication of ITMI20031618A1 publication Critical patent/ITMI20031618A1/it
Priority to IL173482A priority patent/IL173482A0/en
Priority to ZA200601643A priority patent/ZA200601643B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
IT001618A 2003-08-06 2003-08-06 Derivati polisaccaridici dotati di alta attivita' ITMI20031618A1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT001618A ITMI20031618A1 (it) 2003-08-06 2003-08-06 Derivati polisaccaridici dotati di alta attivita'
AU2004262584A AU2004262584A1 (en) 2003-08-06 2004-07-07 Polysaccharides derivatives with high antithrombotic activity in plasma
US10/557,584 US7687249B2 (en) 2003-08-06 2004-07-07 Polysaccharide derivatives with high antithrombotic activity in plasma
DK04766148.3T DK1654288T3 (da) 2003-08-06 2004-07-07 Polysaccharid-derivater med en høj antitrombotisk aktivitet i plasma
CA002534709A CA2534709A1 (en) 2003-08-06 2004-07-07 Polysaccharides derivatives with high antithrombotic activity in plasma
PCT/EP2004/051391 WO2005014656A1 (en) 2003-08-06 2004-07-07 Polysaccharides derivatives with high antithrombotic activity in plasma
KR1020067002532A KR20060063933A (ko) 2003-08-06 2004-07-07 혈장에서 항혈전 활성이 높은 폴리사카라이드 유도체
CNA2004800223076A CN1832966A (zh) 2003-08-06 2004-07-07 具有在血浆中高抗血栓活性的多糖衍生物
BRPI0413346-3A BRPI0413346A (pt) 2003-08-06 2004-07-07 derivados de polissacarìdeos com alta atividade antitrombótica no plasma
JP2006522341A JP2007501305A (ja) 2003-08-06 2004-07-07 血漿中で高度の抗血栓活性を有する多糖類誘導体
EP04766148A EP1654288B9 (en) 2003-08-06 2004-07-07 Polysaccharides derivatives with high antithrombotic activity in plasma
ES04766148T ES2341249T3 (es) 2003-08-06 2004-07-07 Derivados polisacaridos con alta actividad antitrombotica en plasma.
AT04766148T ATE458009T1 (de) 2003-08-06 2004-07-07 Polysaccharidderivate mit antithrombotischer wirkung im plasma
MXPA06001511A MXPA06001511A (es) 2003-08-06 2004-07-07 Derivados de polisacaridos con alta actividad antitrombotica en plasma.
DE602004025583T DE602004025583D1 (de) 2003-08-06 2004-07-07 Polysaccharidderivate mit antithrombotischer wirkung im plasma
RU2006106790/04A RU2361881C2 (ru) 2003-08-06 2004-07-07 Производные полисахаридов с высокой антитромботической активностью в плазме
IL173482A IL173482A0 (en) 2003-08-06 2006-01-31 Polysaccharides derivatives with high antithrombotic activity in plasma
ZA200601643A ZA200601643B (en) 2003-08-06 2006-02-24 Polysaccharides derivatives with high antithromboitic activity in plasma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001618A ITMI20031618A1 (it) 2003-08-06 2003-08-06 Derivati polisaccaridici dotati di alta attivita'

Publications (1)

Publication Number Publication Date
ITMI20031618A1 true ITMI20031618A1 (it) 2005-02-07

Family

ID=34131211

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001618A ITMI20031618A1 (it) 2003-08-06 2003-08-06 Derivati polisaccaridici dotati di alta attivita'

Country Status (18)

Country Link
US (1) US7687249B2 (https=)
EP (1) EP1654288B9 (https=)
JP (1) JP2007501305A (https=)
KR (1) KR20060063933A (https=)
CN (1) CN1832966A (https=)
AT (1) ATE458009T1 (https=)
AU (1) AU2004262584A1 (https=)
BR (1) BRPI0413346A (https=)
CA (1) CA2534709A1 (https=)
DE (1) DE602004025583D1 (https=)
DK (1) DK1654288T3 (https=)
ES (1) ES2341249T3 (https=)
IL (1) IL173482A0 (https=)
IT (1) ITMI20031618A1 (https=)
MX (1) MXPA06001511A (https=)
RU (1) RU2361881C2 (https=)
WO (1) WO2005014656A1 (https=)
ZA (1) ZA200601643B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058592A1 (en) * 2005-11-21 2007-05-24 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
GB0818255D0 (en) 2008-10-06 2008-11-12 Agency Science Tech & Res Isolation and identification of glycosaminoglycans
US9498494B2 (en) 2008-09-11 2016-11-22 Agency For Science, Technology And Research Glycosaminoglycans
CN101698838B (zh) * 2008-12-26 2012-05-23 北京大学 尿苷二磷酸葡萄糖醛酸异构酶及其编码基因与应用
ITMI20091445A1 (it) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione
SG178349A1 (en) 2009-09-01 2012-03-29 Zhenyu Wang K5 heparosan fermentation and purification
EP2598652A4 (en) 2010-07-29 2014-04-30 Shire Human Genetic Therapies TESTS FOR THE DETECTION OF GLYCOSAMINOGLYCANES
EP2809796A4 (en) * 2012-02-01 2016-08-17 Shire Human Genetic Therapies TESTS FOR THE DETECTION OF GLYCOSAMINOGLYCANES
CN102796723A (zh) * 2012-09-11 2012-11-28 深圳市海普瑞药业股份有限公司 肝素酶i的固定化方法
CN102888390B (zh) * 2012-10-30 2014-09-03 深圳市海普瑞药业股份有限公司 肝素酶ⅲ的固定化方法
CN103059165B (zh) * 2012-12-26 2015-04-29 安徽丰原药业股份有限公司 一种多糖酰化物及其制备方法
JP6879216B2 (ja) * 2015-12-28 2021-06-02 味の素株式会社 抗凝固活性を有するヘパラン硫酸の製造法
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
WO2018043666A1 (ja) 2016-08-31 2018-03-08 王子ホールディングス株式会社 酸性キシロオリゴ糖の製造方法
JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
EP3632451A4 (en) 2017-05-31 2021-03-10 Oji Holdings Corporation MOISTURIZING TOPICAL PREPARATION
WO2019054344A1 (ja) 2017-09-12 2019-03-21 王子ホールディングス株式会社 ポリ硫酸ペントサン及びポリ硫酸ペントサンの製造方法
AU2018387999B2 (en) 2017-12-20 2021-06-17 Oji Holdings Corporation Pentosan polysulfate and medicine containing pentosan polysulfate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
FR2669932B1 (fr) 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1290814B1 (it) 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
SE9701454D0 (sv) 1997-04-18 1997-04-18 Ulf Lindahl new DNA sequences and a process for enzyme manufacture
US20020062019A1 (en) 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
PL375088A1 (en) * 2002-06-18 2005-11-14 Glycores 2000 S.R.L. Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation

Also Published As

Publication number Publication date
EP1654288B1 (en) 2010-02-17
ES2341249T3 (es) 2010-06-17
AU2004262584A1 (en) 2005-02-17
CN1832966A (zh) 2006-09-13
WO2005014656A1 (en) 2005-02-17
EP1654288B9 (en) 2010-06-23
RU2361881C2 (ru) 2009-07-20
DK1654288T3 (da) 2010-09-20
DE602004025583D1 (de) 2010-04-01
EP1654288A1 (en) 2006-05-10
KR20060063933A (ko) 2006-06-12
ZA200601643B (en) 2007-05-30
ATE458009T1 (de) 2010-03-15
US7687249B2 (en) 2010-03-30
JP2007501305A (ja) 2007-01-25
US20070042993A1 (en) 2007-02-22
RU2006106790A (ru) 2007-09-20
IL173482A0 (en) 2006-06-11
CA2534709A1 (en) 2005-02-17
MXPA06001511A (es) 2006-05-15
BRPI0413346A (pt) 2006-10-10

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