HUE053923T2 - Eljárás antikoaguláns aktivitással rendelkezõ heparán-szulfát elõállítására - Google Patents

Eljárás antikoaguláns aktivitással rendelkezõ heparán-szulfát elõállítására

Info

Publication number
HUE053923T2
HUE053923T2 HUE16881650A HUE16881650A HUE053923T2 HU E053923 T2 HUE053923 T2 HU E053923T2 HU E16881650 A HUE16881650 A HU E16881650A HU E16881650 A HUE16881650 A HU E16881650A HU E053923 T2 HUE053923 T2 HU E053923T2
Authority
HU
Hungary
Prior art keywords
heparan sulfate
anticoagulant activity
producing heparan
producing
anticoagulant
Prior art date
Application number
HUE16881650A
Other languages
English (en)
Inventor
Yuriko Tokura
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of HUE053923T2 publication Critical patent/HUE053923T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02008—Heparin-sulfate lyase (4.2.2.8)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE16881650A 2015-12-28 2016-12-16 Eljárás antikoaguláns aktivitással rendelkezõ heparán-szulfát elõállítására HUE053923T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015256988 2015-12-28

Publications (1)

Publication Number Publication Date
HUE053923T2 true HUE053923T2 (hu) 2021-08-30

Family

ID=59225768

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16881650A HUE053923T2 (hu) 2015-12-28 2016-12-16 Eljárás antikoaguláns aktivitással rendelkezõ heparán-szulfát elõállítására

Country Status (6)

Country Link
US (1) US10704068B2 (hu)
EP (1) EP3399044B1 (hu)
JP (1) JP6879216B2 (hu)
ES (1) ES2869525T3 (hu)
HU (1) HUE053923T2 (hu)
WO (1) WO2017115674A1 (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017115674A1 (ja) * 2015-12-28 2017-07-06 味の素株式会社 抗凝固活性を有するヘパラン硫酸の製造法
JP7088026B2 (ja) * 2017-01-19 2022-06-21 味の素株式会社 ヘキスロン酸残基が異性化されたヘパロサン化合物の製造方法
EP4050036A1 (en) 2017-09-05 2022-08-31 Ajinomoto Co., Inc. 3-o-sulfation enzyme mutant, and method for using same
CN109321508B (zh) * 2018-10-12 2022-12-27 北京化工大学 产heparosan的基因工程菌及其应用
WO2022015794A1 (en) * 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
EP3911737A1 (en) 2019-01-15 2021-11-24 Optimvia, LLC Engineered aryl sulfate-dependent enzymes
CN114616340A (zh) 2019-07-09 2022-06-10 奥普蒂姆维亚有限公司 合成抗凝血多糖的方法
CN114763518B (zh) * 2021-09-10 2023-04-28 江南大学 发酵生产肝素的酵母工程菌的构建及其应用
CA3236567A1 (en) * 2021-11-05 2023-05-11 Rensselaer Polytechnic Institute Methods for the chemoenzymatic synthesis of low molecular weight heparin from low molecular weight heparosan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080207895A1 (en) * 2002-11-27 2008-08-28 Rosenberg Robert D Methods for synthesizing polysaccharides
ITMI20031618A1 (it) 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
CA2540699A1 (en) 2003-10-01 2005-04-14 Momenta Pharmaceuticals, Inc. Polysaccharides for pulmonary delivery of active agents
GB0419346D0 (en) 2004-09-01 2004-09-29 Smyth Stephen M F Method and apparatus for improved headphone virtualisation
FR2874931B1 (fr) * 2004-09-08 2006-11-24 Aventis Pharma Sa Procede de production de polysaccharide k5
CN101531723A (zh) 2009-02-27 2009-09-16 江南大学 一种用生物酶对肝素进行选择性结构修饰制备肝素衍生物的方法
WO2012116048A1 (en) * 2011-02-22 2012-08-30 Rensselaer Polytechnic Institute Single step heparosan n-deacetylation and depolymerization for making bioengineered heparin
JP6569530B2 (ja) * 2013-10-02 2019-09-04 味の素株式会社 ヘパロサン生産細菌及びヘパロサンの製造法
WO2017115674A1 (ja) * 2015-12-28 2017-07-06 味の素株式会社 抗凝固活性を有するヘパラン硫酸の製造法

Also Published As

Publication number Publication date
JPWO2017115674A1 (ja) 2018-10-18
US20180298411A1 (en) 2018-10-18
EP3399044B1 (en) 2021-02-03
EP3399044A1 (en) 2018-11-07
US10704068B2 (en) 2020-07-07
EP3399044A4 (en) 2019-08-07
JP6879216B2 (ja) 2021-06-02
ES2869525T3 (es) 2021-10-25
WO2017115674A1 (ja) 2017-07-06

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