IT1252708B - Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. - Google Patents
Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.Info
- Publication number
- IT1252708B IT1252708B ITMI913448A ITMI913448A IT1252708B IT 1252708 B IT1252708 B IT 1252708B IT MI913448 A ITMI913448 A IT MI913448A IT MI913448 A ITMI913448 A IT MI913448A IT 1252708 B IT1252708 B IT 1252708B
- Authority
- IT
- Italy
- Prior art keywords
- cyclohexan
- ace
- carbonyl
- preparation
- ossoethl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI913448A IT1252708B (it) | 1991-12-23 | 1991-12-23 | Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
AU30871/92A AU657591B2 (en) | 1991-12-23 | 1992-12-12 | Stable salts of (+)-(1S,2R)-2-((N-(2-hydroxylamino-2-oxoethyl)-N-methyl- amino)carbonyl)cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them |
BR9205652A BR9205652A (pt) | 1991-12-23 | 1992-12-12 | Sais estáveis de (+) - (15,2R)-N- (2-hidroxilamina-2-oxoetil)N-metilamino carbonil ciclohexano-ácido carboxilico, processo de sua preparaçao, e composiçao farmaceutica |
PCT/EP1992/002903 WO1993013056A1 (en) | 1991-12-23 | 1992-12-12 | Stable salts of (+)-(1s,2r)-2-[[n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl]cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them |
EP92924726A EP0575572A1 (en) | 1991-12-23 | 1992-12-12 | Stable salts of (+)-(1s,2r)-2- n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl]cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them |
CA002104372A CA2104372A1 (en) | 1991-12-23 | 1992-12-12 | Stable salts of (+)-(1s,2r)-2-¬¬n-(2-hydroxylamino-2-oxoethyl) -n-methyl-amino|carbonyl|cyclohexane-1-carboxylic acid, pro ess for their preparation and pharmaceutical compositions containing them |
HU9302389A HUT69287A (en) | 1991-12-23 | 1992-12-12 | Process to prepare stable salts of(+)-(1s,2r)-2-{[n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl} cyclohexane-1-carboxylic acid and pharmaceutical compns. contg. them |
RU9293052414A RU2079489C1 (ru) | 1991-12-23 | 1992-12-12 | Стабильные соли (+)-(1s,2r)-2[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]-карбонил]циклогексан-1-карбоновой кислоты, способ их получения и фармацевтическая композиция |
JP5511398A JPH06506002A (ja) | 1991-12-23 | 1992-12-12 | (+)−(1s,2r)−2−[[n−(2−ヒドロキシルアミノ−2−オキソエチル)−n−メチル−アミノ]カルボニル]シクロヘキサン−1−カルボン酸の安定な塩 |
CS923796A CZ379692A3 (en) | 1991-12-23 | 1992-12-21 | Stable salts of (+)-(1s,2r)-2-//n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino/carbonyl /cyclohexane-1-carboxylic acid, process of their preparation and pharmaceutical compositions in which said stable salts are contained |
NZ245547A NZ245547A (en) | 1991-12-23 | 1992-12-21 | Salts of (+)-(1s,2r)-2-[[n-(2-hydroxylamino-2- oxoethyl)-n-methylamino]carbonyl]cyclohexane-1- carboxylic acid with metals and organic bases; pharmaceutical compositions |
SK3796-92A SK379692A3 (en) | 1991-12-23 | 1992-12-21 | Stable salts of (+)-(1s,2r)-2-//n-(2-hydroxylamino-2- -oxoethyl)-n-methyl-amino/carbonyl/cyclohexan-1-carboxylic acid, method of their preparation and pharmaceutical agents containing these salts |
SI9200409A SI9200409A (en) | 1991-12-23 | 1992-12-22 | (+)-(1s,1r)-2-((n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino) carbonyl)cyclohexan-1-carboxylic acids stable salts, process for the preparation thereof and pharmaceutical preparations comprising the same |
MA23040A MA22749A1 (fr) | 1991-12-23 | 1992-12-22 | Sels stables d'acide de (+)-(15,2r)-2-(n-2 hydroxylamino -2-oxoethyl) -n-methyl-amino) carbonyl) cyclo hexane -1-carboxylique; procede pour leur preparation et compositions pharmaceutiques les contenant |
HR921454A HRP921454A2 (en) | 1991-12-23 | 1992-12-22 | Stable salts of (1r,2s)-2-n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino onyl cyclohexane-1-carboxylic acid, process for their aration and pharmaceutical compositions containing them |
PT101156A PT101156A (pt) | 1991-12-23 | 1992-12-23 | Sais estaveis do acido (+)-(i,s,2r)-2-{{n-(2-hidroxilamino-2-oxoetil)n-metilamino}carboni}ciclo-hexano-1-carboxilico, seu processo de preparacao, composicoes farmaceuticas e uso como anti-hipertensivo |
MX9207543A MX9207543A (es) | 1991-12-23 | 1992-12-23 | Sales estables de acido (+)-(1s,2r)-[[b.(2-hidroxilamino-2-oxoetil)-n-metilamino]carbonil]cicl ohexan-1-carboxilico, procedimiento para su preparacion, y composiciones farmaceuticas que las contienen |
TNTNSN92117A TNSN92117A1 (fr) | 1991-12-23 | 1992-12-23 | Sels stables d'acide (+) (-1s,2r) -2 [n-2-hydroxylamino-2- oxoethyl] -n-methyl-amino] carbonyl] cyclohexane -1- carboxylique, procede pour leur preparation et compositions pharmaceutiques les contenant |
LVP-92-358A LV10426B (en) | 1991-12-23 | 1992-12-23 | STABLE SALTS OF (+)-(1S,2R)-2-{£N-(2-hydroxylamino-2-oxoethyl)-N-methylamino|carbonyl}-cyclohexane-1-carbocyclic acid, process for their preparation and pharmaceutical compositions containing them |
PL92297118A PL169086B1 (pl) | 1991-12-23 | 1992-12-23 | Sposób wytwarzania nowych soli kwasu (+)-(1 S,2R)-2-{[N-(2-hydroksyamino-2-ketoetylo)- N-metyloamino] karbonylo} cykloheksanokarboksylowego-1 PL |
ZA9210004A ZA9210004B (en) | 1991-12-23 | 1992-12-23 | Stable salts of (+)-(1S,2R)-2-((N-(-2-hydroxylamino-2-oxoethyl)-N-methyl-amino)carbonyl)cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them |
CN92113839A CN1079474A (zh) | 1991-12-23 | 1992-12-23 | 新的抗高血压化合物及它们的制备方法和含它们的药物组合物 |
YU110892A YU110892A (sh) | 1991-12-23 | 1992-12-23 | Stabilne soli(+)-(1s,2r)-2-{[n-(2-hidroksiamino-2-oksoetil)-n-metilamino]karbonil}-cikloheksan-1-karbonske kiseline, postupak za njihovo dobijanje i preparati koji ih sadrže |
BG98050A BG98050A (bg) | 1991-12-23 | 1993-08-18 | Устойчиви соли на (+)-(1s,2r)-2-//n-(2-хидроксиламино-2- оксоетил)-n-метил-амино/карбонил/циклохексан-1-карбонова киселина, метод за получаването им и фармацевтични състави, в които те се съдържат |
FI933685A FI933685A (fi) | 1991-12-23 | 1993-08-20 | Stabila salter av (+)-(1s,2r)-2-((n-(2-hydroxylamino-2-oxoetyl)-n-metylamino)karbonyl)cyklohexan-1-karboxylsyra, deras framstaellningsmetoderoch farmaceutiska sammansaettningar innehaollande dessa |
NO93932982A NO932982L (no) | 1991-12-23 | 1993-08-20 | Stabile salter av (+)-(1s,2r)-2-((n-(2-hydroksylamino-2-oksoetyl)-n-metylamino)karbonyl)cykloheksan-1-karboksylsyreog fremgangsmaate for fremstilling derav og farmasoeytiske sammensetninger som inneholder disse |
EE9400006A EE9400006A (et) | 1991-12-23 | 1994-05-23 | (+)-(1R,2S)-2-[[N-(2-hüdroksüamino-2-oksoetüül)-N-metüülamino]karbonüül]tsükloh eksaan-1-karboksüülhappe stabiilsed soolad, nende valmistamise meetod ja neid sisaldavad farmakoloogilised ühendid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI913448A IT1252708B (it) | 1991-12-23 | 1991-12-23 | Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI913448A0 ITMI913448A0 (it) | 1991-12-23 |
ITMI913448A1 ITMI913448A1 (it) | 1993-06-23 |
IT1252708B true IT1252708B (it) | 1995-06-26 |
Family
ID=11361409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI913448A IT1252708B (it) | 1991-12-23 | 1991-12-23 | Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0575572A1 (lv) |
JP (1) | JPH06506002A (lv) |
CN (1) | CN1079474A (lv) |
AU (1) | AU657591B2 (lv) |
BG (1) | BG98050A (lv) |
BR (1) | BR9205652A (lv) |
CA (1) | CA2104372A1 (lv) |
CZ (1) | CZ379692A3 (lv) |
EE (1) | EE9400006A (lv) |
FI (1) | FI933685A (lv) |
HR (1) | HRP921454A2 (lv) |
HU (1) | HUT69287A (lv) |
IT (1) | IT1252708B (lv) |
LV (1) | LV10426B (lv) |
MA (1) | MA22749A1 (lv) |
MX (1) | MX9207543A (lv) |
NZ (1) | NZ245547A (lv) |
PL (1) | PL169086B1 (lv) |
PT (1) | PT101156A (lv) |
RU (1) | RU2079489C1 (lv) |
SI (1) | SI9200409A (lv) |
SK (1) | SK379692A3 (lv) |
TN (1) | TNSN92117A1 (lv) |
WO (1) | WO1993013056A1 (lv) |
YU (1) | YU110892A (lv) |
ZA (1) | ZA9210004B (lv) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1264860B1 (it) * | 1993-06-21 | 1996-10-17 | Guidotti & C Spa Labor | Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici |
US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
FR2817241B1 (fr) | 2000-11-30 | 2003-03-07 | Cebal | Tube aluminium avec embout secable |
EP2079304A4 (en) * | 2006-09-28 | 2010-01-06 | Merck & Co Inc | AMINBASE SALTS FROM SAHA AND POLYMORPHE DAVON |
US20210332635A1 (en) * | 2020-04-27 | 2021-10-28 | Carter-Hoffmann LLC | Door movement system for cabinet |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1224627B (it) * | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
-
1991
- 1991-12-23 IT ITMI913448A patent/IT1252708B/it active IP Right Grant
-
1992
- 1992-12-12 WO PCT/EP1992/002903 patent/WO1993013056A1/en not_active Application Discontinuation
- 1992-12-12 AU AU30871/92A patent/AU657591B2/en not_active Ceased
- 1992-12-12 JP JP5511398A patent/JPH06506002A/ja active Pending
- 1992-12-12 HU HU9302389A patent/HUT69287A/hu unknown
- 1992-12-12 RU RU9293052414A patent/RU2079489C1/ru active
- 1992-12-12 BR BR9205652A patent/BR9205652A/pt not_active Application Discontinuation
- 1992-12-12 CA CA002104372A patent/CA2104372A1/en not_active Abandoned
- 1992-12-12 EP EP92924726A patent/EP0575572A1/en not_active Withdrawn
- 1992-12-21 CZ CS923796A patent/CZ379692A3/cs unknown
- 1992-12-21 SK SK3796-92A patent/SK379692A3/sk unknown
- 1992-12-21 NZ NZ245547A patent/NZ245547A/en unknown
- 1992-12-22 HR HR921454A patent/HRP921454A2/hr not_active Application Discontinuation
- 1992-12-22 MA MA23040A patent/MA22749A1/fr unknown
- 1992-12-22 SI SI9200409A patent/SI9200409A/sl unknown
- 1992-12-23 LV LVP-92-358A patent/LV10426B/lv unknown
- 1992-12-23 TN TNTNSN92117A patent/TNSN92117A1/fr unknown
- 1992-12-23 CN CN92113839A patent/CN1079474A/zh active Pending
- 1992-12-23 YU YU110892A patent/YU110892A/sh unknown
- 1992-12-23 PL PL92297118A patent/PL169086B1/pl unknown
- 1992-12-23 ZA ZA9210004A patent/ZA9210004B/xx unknown
- 1992-12-23 MX MX9207543A patent/MX9207543A/es unknown
- 1992-12-23 PT PT101156A patent/PT101156A/pt not_active Application Discontinuation
-
1993
- 1993-08-18 BG BG98050A patent/BG98050A/bg unknown
- 1993-08-20 FI FI933685A patent/FI933685A/fi not_active Application Discontinuation
-
1994
- 1994-05-23 EE EE9400006A patent/EE9400006A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
HU9302389D0 (en) | 1993-11-29 |
ITMI913448A0 (it) | 1991-12-23 |
LV10426A (lv) | 1995-02-20 |
PL297118A1 (en) | 1993-09-06 |
NZ245547A (en) | 1995-12-21 |
LV10426B (en) | 1995-08-20 |
JPH06506002A (ja) | 1994-07-07 |
TNSN92117A1 (fr) | 1993-06-08 |
EE9400006A (et) | 1995-12-15 |
WO1993013056A1 (en) | 1993-07-08 |
BG98050A (bg) | 1994-04-29 |
FI933685A0 (fi) | 1993-08-20 |
SK379692A3 (en) | 1995-04-12 |
FI933685A (fi) | 1993-08-20 |
HUT69287A (en) | 1995-09-28 |
BR9205652A (pt) | 1994-05-03 |
ZA9210004B (en) | 1993-12-13 |
CN1079474A (zh) | 1993-12-15 |
EP0575572A1 (en) | 1993-12-29 |
AU3087192A (en) | 1993-07-28 |
SI9200409A (en) | 1993-09-30 |
ITMI913448A1 (it) | 1993-06-23 |
HRP921454A2 (en) | 1995-02-28 |
MX9207543A (es) | 1993-08-01 |
RU2079489C1 (ru) | 1997-05-20 |
MA22749A1 (fr) | 1993-07-01 |
PT101156A (pt) | 1994-06-30 |
CA2104372A1 (en) | 1993-06-24 |
CZ379692A3 (en) | 1993-09-15 |
YU110892A (sh) | 1996-01-08 |
PL169086B1 (pl) | 1996-05-31 |
AU657591B2 (en) | 1995-03-16 |
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