ES8207533A1 - Un procedimiento para la preparacion de derivados de pirazo-lopiridacina - Google Patents
Un procedimiento para la preparacion de derivados de pirazo-lopiridacinaInfo
- Publication number
- ES8207533A1 ES8207533A1 ES502994A ES502994A ES8207533A1 ES 8207533 A1 ES8207533 A1 ES 8207533A1 ES 502994 A ES502994 A ES 502994A ES 502994 A ES502994 A ES 502994A ES 8207533 A1 ES8207533 A1 ES 8207533A1
- Authority
- ES
- Spain
- Prior art keywords
- aryl
- lower alkyl
- formula
- intermediates
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIRAZOLOPIRIDACINA. CONSISTE EN DISOCIAR REACTIVAMENTE EL GRUPO DE ALCOXILO INFERIOR O ARIL-(ALQUILO INFERIOR) DE UN COMPUESTO DE FORMULA GENERAL (I). SI SE DESEA SE SEPARA LA MEZCLA DIASTEREOISOMERICA OBTENIDA EN LOS RACEMATOS DIASTEROISOMERICOS Y/O SE RESUELVE UN RACEMATO OBTENIDO EN LOS DOS AITPDAS Y/O SE CONVIERTE EL COMPUESTO OBTENIDO (II) EN LA SAL CORRESPONDIENTE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8019342 | 1980-06-13 | ||
GB8107621 | 1981-03-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES502994A0 ES502994A0 (es) | 1982-10-01 |
ES8207533A1 true ES8207533A1 (es) | 1982-10-01 |
Family
ID=26275850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES502994A Expired ES8207533A1 (es) | 1980-06-13 | 1981-06-12 | Un procedimiento para la preparacion de derivados de pirazo-lopiridacina |
Country Status (10)
Country | Link |
---|---|
US (2) | US4399136A (es) |
EP (1) | EP0042100A1 (es) |
AU (1) | AU7138281A (es) |
DK (1) | DK249581A (es) |
ES (1) | ES8207533A1 (es) |
FI (1) | FI811834L (es) |
GR (1) | GR74580B (es) |
MC (1) | MC1390A1 (es) |
NO (1) | NO812007L (es) |
PT (1) | PT73186B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ204130A (en) * | 1982-05-12 | 1986-03-14 | Hoffmann La Roche | Bicyclic heterocyclic compounds and pharmaceutical compositions |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
ZW11586A1 (en) * | 1985-07-01 | 1987-12-30 | Hoffmann La Roche | Bicyclic compounds |
US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
BR9205752A (pt) * | 1991-03-19 | 1994-11-08 | Ciba Geigy Ag | Novos compostos herbicidamente, acaricidamente e inseticidamente ativos |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
DE69220744T2 (de) * | 1991-09-27 | 1997-11-13 | Merrell Pharma Inc | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung |
DK0625987T3 (da) * | 1992-02-14 | 1999-01-11 | Merrell Pharma Inc | Aminoacetylmercaptoacetylamid-derivater, der kan anvendes som inhibitorer af enkephalinase og ACE |
ATE182892T1 (de) * | 1992-05-15 | 1999-08-15 | Merrell Pharma Inc | Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren |
US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
DE69329701T2 (de) * | 1992-10-30 | 2001-05-10 | Merrell Pharma Inc | Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer |
GB9223739D0 (en) * | 1992-11-12 | 1992-12-23 | Univ London | Process for the preparation of (3r) and (3s) piperazic acid derivatives |
KR100348949B1 (ko) * | 1994-02-14 | 2003-01-24 | 메렐 파마슈티칼스 인크. | 엔케팔리나제의억제제로서유용한신규의인단-2-머캅토아세틸아미드디술파이드유도체 |
ES2131806T3 (es) * | 1994-02-14 | 1999-08-01 | Merrell Pharma Inc | Nuevos derivados de disulfuro de mercaptoacetilamida utiles como inhibidores de encefalinasa y ace. |
HUT76479A (en) * | 1994-02-14 | 1997-09-29 | Merrell Pharma Inc | Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
DK0750631T3 (da) * | 1994-02-14 | 2000-10-23 | Merrell Pharma Inc | Mercaptoacetylamido-1,3,4,5-tetrahydrobenzo[c]azepin-3-ondisulfidderivater som enkephalinase- og ACE-inhibitorer |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
DE69531489T2 (de) * | 1994-03-24 | 2004-04-08 | Merrell Pharmaceuticals Inc., Cincinnati | Cholesterin senkende mercaptoacetylamiddisulfidderivate |
DE69514912T2 (de) * | 1994-03-24 | 2000-10-05 | Merrell Pharma Inc | Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten |
US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL60617A0 (en) * | 1979-07-23 | 1980-09-16 | Sparamedica Ag | Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them |
EP0025941B1 (de) * | 1979-09-19 | 1983-05-04 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate |
-
1981
- 1981-06-03 EP EP81104239A patent/EP0042100A1/de not_active Withdrawn
- 1981-06-04 DK DK249581A patent/DK249581A/da not_active Application Discontinuation
- 1981-06-05 AU AU71382/81A patent/AU7138281A/en not_active Abandoned
- 1981-06-10 US US06/272,351 patent/US4399136A/en not_active Expired - Fee Related
- 1981-06-12 ES ES502994A patent/ES8207533A1/es not_active Expired
- 1981-06-12 NO NO812007A patent/NO812007L/no unknown
- 1981-06-12 GR GR65228A patent/GR74580B/el unknown
- 1981-06-12 PT PT73186A patent/PT73186B/pt unknown
- 1981-06-12 MC MC811520A patent/MC1390A1/xx unknown
- 1981-06-12 FI FI811834A patent/FI811834L/fi not_active Application Discontinuation
-
1983
- 1983-04-25 US US06/488,508 patent/US4487929A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4399136A (en) | 1983-08-16 |
EP0042100A1 (de) | 1981-12-23 |
AU7138281A (en) | 1981-12-17 |
NO812007L (no) | 1981-12-14 |
GR74580B (es) | 1984-06-29 |
PT73186A (en) | 1981-07-01 |
DK249581A (da) | 1981-12-14 |
ES502994A0 (es) | 1982-10-01 |
MC1390A1 (fr) | 1982-04-27 |
FI811834L (fi) | 1981-12-14 |
US4487929A (en) | 1984-12-11 |
PT73186B (en) | 1983-04-26 |
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