IT1191235B - Procedimento per la preparazione di 3 idrossi ml 236b derivati particolarmente per il trattamento dell iperlipemia e la profilassi dell arteriosclerosi - Google Patents

Procedimento per la preparazione di 3 idrossi ml 236b derivati particolarmente per il trattamento dell iperlipemia e la profilassi dell arteriosclerosi

Info

Publication number
IT1191235B
IT1191235B IT68359/82A IT6835982A IT1191235B IT 1191235 B IT1191235 B IT 1191235B IT 68359/82 A IT68359/82 A IT 68359/82A IT 6835982 A IT6835982 A IT 6835982A IT 1191235 B IT1191235 B IT 1191235B
Authority
IT
Italy
Prior art keywords
hyperlipemia
arteriosclerosis
prophylaxis
hydroxy
procedure
Prior art date
Application number
IT68359/82A
Other languages
English (en)
Italian (it)
Other versions
IT8268359A0 (it
Inventor
Terahara Akira
Tanaka Minoru
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of IT8268359A0 publication Critical patent/IT8268359A0/it
Application granted granted Critical
Publication of IT1191235B publication Critical patent/IT1191235B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365Nocardia
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/872Nocardia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT68359/82A 1981-11-20 1982-11-22 Procedimento per la preparazione di 3 idrossi ml 236b derivati particolarmente per il trattamento dell iperlipemia e la profilassi dell arteriosclerosi IT1191235B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56186641A JPS5889191A (ja) 1981-11-20 1981-11-20 3−ヒドロキシ−ml−236b誘導体の製造法

Publications (2)

Publication Number Publication Date
IT8268359A0 IT8268359A0 (it) 1982-11-22
IT1191235B true IT1191235B (it) 1988-02-24

Family

ID=16192138

Family Applications (1)

Application Number Title Priority Date Filing Date
IT68359/82A IT1191235B (it) 1981-11-20 1982-11-22 Procedimento per la preparazione di 3 idrossi ml 236b derivati particolarmente per il trattamento dell iperlipemia e la profilassi dell arteriosclerosi

Country Status (18)

Country Link
US (1) US4537859A (esLanguage)
JP (1) JPS5889191A (esLanguage)
KR (1) KR880002483B1 (esLanguage)
AT (1) AT387585B (esLanguage)
AU (1) AU551720B2 (esLanguage)
BE (1) BE895080A (esLanguage)
CA (1) CA1186647A (esLanguage)
CH (1) CH651065A5 (esLanguage)
DE (1) DE3242849A1 (esLanguage)
DK (1) DK159328C (esLanguage)
ES (1) ES517542A0 (esLanguage)
FI (1) FI70925C (esLanguage)
FR (1) FR2516935A1 (esLanguage)
GB (1) GB2111052B (esLanguage)
IT (1) IT1191235B (esLanguage)
NL (1) NL194373C (esLanguage)
SE (1) SE453996B (esLanguage)
ZA (1) ZA828535B (esLanguage)

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IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
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SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
CN1240844C (zh) 1999-01-20 2006-02-08 协和发酵工业株式会社 HMG-CoA还原酶抑制剂的制备方法
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Also Published As

Publication number Publication date
DE3242849C2 (esLanguage) 1989-01-05
DK516182A (da) 1983-05-21
SE8206580L (sv) 1983-05-21
CH651065A5 (de) 1985-08-30
IT8268359A0 (it) 1982-11-22
ATA425182A (de) 1988-07-15
FI823978A0 (fi) 1982-11-19
FI70925C (fi) 1986-10-27
NL194373C (nl) 2002-02-04
AU9061082A (en) 1983-05-26
AT387585B (de) 1989-02-10
SE8206580D0 (sv) 1982-11-18
JPS5889191A (ja) 1983-05-27
FR2516935A1 (fr) 1983-05-27
ES8402350A1 (es) 1984-01-16
FI70925B (fi) 1986-07-18
ES517542A0 (es) 1984-01-16
AU551720B2 (en) 1986-05-08
NL8204505A (nl) 1983-06-16
KR880002483B1 (ko) 1988-11-19
FI823978L (fi) 1983-05-21
GB2111052B (en) 1985-05-09
SE453996B (sv) 1988-03-21
JPH0371116B2 (esLanguage) 1991-11-12
DK159328B (da) 1990-10-01
NL194373B (nl) 2001-10-01
CA1186647A (en) 1985-05-07
DE3242849A1 (de) 1983-06-01
FR2516935B1 (esLanguage) 1985-02-08
BE895080A (fr) 1983-03-16
GB2111052A (en) 1983-06-29
US4537859A (en) 1985-08-27
KR840002451A (ko) 1984-07-02
DK159328C (da) 1991-02-25
ZA828535B (en) 1983-10-26

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