IT1147087B - Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione - Google Patents

Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione

Info

Publication number
IT1147087B
IT1147087B IT48848/80A IT4884880A IT1147087B IT 1147087 B IT1147087 B IT 1147087B IT 48848/80 A IT48848/80 A IT 48848/80A IT 4884880 A IT4884880 A IT 4884880A IT 1147087 B IT1147087 B IT 1147087B
Authority
IT
Italy
Prior art keywords
disorders
procedure
preparation
treatment
nervous system
Prior art date
Application number
IT48848/80A
Other languages
English (en)
Italian (it)
Other versions
IT8048848A0 (it
Inventor
Martin George Baxter
Albert Reginald Elphick
Alistair Ainslie Miller
Alan Sawyerdavid
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1147087(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IT8048848A0 publication Critical patent/IT8048848A0/it
Application granted granted Critical
Publication of IT1147087B publication Critical patent/IT1147087B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT48848/80A 1979-06-01 1980-05-30 Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione IT1147087B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (2)

Publication Number Publication Date
IT8048848A0 IT8048848A0 (it) 1980-05-30
IT1147087B true IT1147087B (it) 1986-11-19

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48848/80A IT1147087B (it) 1979-06-01 1980-05-30 Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione

Country Status (30)

Country Link
US (2) US4486354A (https=)
EP (2) EP0021121B1 (https=)
JP (2) JPS5625169A (https=)
AR (1) AR227521A1 (https=)
AT (1) AT370097B (https=)
AU (2) AU530999B2 (https=)
BG (1) BG60427B2 (https=)
CA (1) CA1112643A (https=)
CS (1) CS234018B2 (https=)
CZ (1) CZ384891A3 (https=)
DD (1) DD151309A5 (https=)
DK (1) DK153787C (https=)
ES (1) ES491998A0 (https=)
FI (1) FI67844C (https=)
GE (1) GEP19960470B (https=)
GR (1) GR68380B (https=)
HU (1) HU182086B (https=)
IE (1) IE49823B1 (https=)
IL (1) IL60201A (https=)
IT (1) IT1147087B (https=)
MX (1) MX9202962A (https=)
MY (1) MY8500062A (https=)
NL (1) NL950007I2 (https=)
NZ (1) NZ193890A (https=)
PL (1) PL124029B1 (https=)
SU (1) SU1055331A3 (https=)
UA (1) UA5576A1 (https=)
YU (1) YU145680A (https=)
ZA (1) ZA803250B (https=)
ZW (1) ZW12980A1 (https=)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
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US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
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US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
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GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
ES2097516T3 (es) * 1992-06-12 1997-04-01 Wellcome Found Uso de isetionato de 3,5-diamino-6-(2,3-diclorofenil)-1,2,4-triazina para el tratamiento y prevencion de la dependencia, tolerancia y sensibilidad a los farmacos y drogas.
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
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GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
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GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
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US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
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BRPI0616402A2 (pt) * 2005-09-23 2011-06-21 Janssen Pharmaceutica Nv moduladores de canabinóide de hexaidro-cicloeptapirazol
US7825151B2 (en) * 2005-09-23 2010-11-02 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
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US8012957B2 (en) * 2006-03-27 2011-09-06 Janssen Pharmaceutica Nv Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators
WO2007122638A2 (en) * 2006-04-26 2007-11-01 Ratnamani Bio-Chemicals & Pharmaceuticals Pvt. Ltd. An improved process for preparation of lamotrigine intermediates
EP2024345B1 (en) * 2006-05-31 2009-12-16 Calaire Chimie SAS Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride
GB0613836D0 (en) 2006-07-13 2006-08-23 Univ Greenwich New medical use of triazine derivatives
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US7943653B2 (en) * 2007-08-13 2011-05-17 Janssen Pharmaceutica N.V. Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators
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US8486927B2 (en) * 2007-11-09 2013-07-16 Thar Pharmaceuticals Crystalline forms of lamotrigine
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JP5656980B2 (ja) 2009-05-13 2015-01-21 ウェルズ ファーゴ バンク ナショナル アソシエイション オリゴマー含有の置換芳香族トリアジン化合物
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GB2471729A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
GB2471713A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
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GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
WO2013183985A1 (en) 2012-06-05 2013-12-12 Erasmus University Medical Center Rotterdam Method of treating cognitive impairment and compounds for use therein
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Family Cites Families (8)

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GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (https=) * 1964-05-05
GB1204631A (en) * 1967-10-12 1970-09-09 Shell Int Research Pharmacologically active benzylideneamino guanidines and their use
GB1223492A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
DE3069556D1 (en) * 1979-08-16 1984-12-06 Wellcome Found Solid pharmaceutical formulation containing substitued phenyl-triazines

Also Published As

Publication number Publication date
AR227521A1 (es) 1982-11-15
EP0059987A1 (en) 1982-09-15
JPS5625169A (en) 1981-03-10
US4602017A (en) 1986-07-22
PL124029B1 (en) 1982-12-31
AT370097B (de) 1983-02-25
ATA289680A (de) 1982-07-15
JPH0144179B2 (https=) 1989-09-26
FI67844B (fi) 1985-02-28
IE801126L (en) 1980-12-01
ZA803250B (en) 1982-01-27
FI801758A7 (fi) 1980-12-02
AU530999B2 (en) 1983-08-04
AU566870B2 (en) 1987-11-05
MX9202962A (es) 1992-07-01
DD151309A5 (de) 1981-10-14
UA5576A1 (uk) 1994-12-28
JPS6133163A (ja) 1986-02-17
DK233880A (da) 1980-12-02
EP0021121A1 (en) 1981-01-07
IL60201A (en) 1984-05-31
ES8104993A1 (es) 1981-05-16
GR68380B (https=) 1981-12-28
IT8048848A0 (it) 1980-05-30
YU145680A (en) 1983-02-28
CA1112643A (en) 1981-11-17
US4486354A (en) 1984-12-04
BG60427B2 (bg) 1995-03-31
NZ193890A (en) 1984-07-06
NL950007I2 (nl) 1997-02-03
GEP19960470B (en) 1996-08-29
FI67844C (fi) 1985-06-10
IE49823B1 (en) 1985-12-25
CS234018B2 (en) 1985-03-14
MY8500062A (en) 1985-12-31
HU182086B (en) 1983-12-28
EP0059987B1 (en) 1985-08-14
DK153787C (da) 1989-01-16
IL60201A0 (en) 1980-07-31
AU5890680A (en) 1980-12-04
ES491998A0 (es) 1981-05-16
JPH0144706B2 (https=) 1989-09-29
ZW12980A1 (en) 1982-01-06
PL224633A1 (https=) 1981-02-13
EP0021121B1 (en) 1983-05-11
NL950007I1 (nl) 1995-06-16
CZ384891A3 (en) 1993-10-13
DK153787B (da) 1988-09-05
SU1055331A3 (ru) 1983-11-15

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