IT1143922B - 4-aroilimidazol-2-oni dotati di proprieta'anti-ipertensive cardiotoniche e antitrombotiche e procedimento per la loro preparazione - Google Patents

4-aroilimidazol-2-oni dotati di proprieta'anti-ipertensive cardiotoniche e antitrombotiche e procedimento per la loro preparazione

Info

Publication number
IT1143922B
IT1143922B IT48997/80A IT4899780A IT1143922B IT 1143922 B IT1143922 B IT 1143922B IT 48997/80 A IT48997/80 A IT 48997/80A IT 4899780 A IT4899780 A IT 4899780A IT 1143922 B IT1143922 B IT 1143922B
Authority
IT
Italy
Prior art keywords
aroilimidazol
oni
cardiotonic
thrombotic
procedure
Prior art date
Application number
IT48997/80A
Other languages
English (en)
Italian (it)
Other versions
IT8048997A0 (it
Inventor
Richard A Schnettler
Richard C Dage
J Martin Grisar
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1143922(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of IT8048997A0 publication Critical patent/IT8048997A0/it
Application granted granted Critical
Publication of IT1143922B publication Critical patent/IT1143922B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT48997/80A 1979-06-18 1980-06-17 4-aroilimidazol-2-oni dotati di proprieta'anti-ipertensive cardiotoniche e antitrombotiche e procedimento per la loro preparazione IT1143922B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4980879A 1979-06-18 1979-06-18
US11920780A 1980-02-07 1980-02-07

Publications (2)

Publication Number Publication Date
IT8048997A0 IT8048997A0 (it) 1980-06-17
IT1143922B true IT1143922B (it) 1986-10-29

Family

ID=26727558

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48997/80A IT1143922B (it) 1979-06-18 1980-06-17 4-aroilimidazol-2-oni dotati di proprieta'anti-ipertensive cardiotoniche e antitrombotiche e procedimento per la loro preparazione

Country Status (20)

Country Link
AT (1) AT375349B (forum.php)
AU (1) AU532783B2 (forum.php)
CA (1) CA1132554A (forum.php)
CH (1) CH646155A5 (forum.php)
DE (1) DE3021792A1 (forum.php)
DK (1) DK160269C (forum.php)
ES (1) ES492255A0 (forum.php)
FR (1) FR2459233A1 (forum.php)
GB (1) GB2055364B (forum.php)
HK (1) HK61486A (forum.php)
HU (1) HU186736B (forum.php)
IE (1) IE50646B1 (forum.php)
IL (1) IL60243A (forum.php)
IT (1) IT1143922B (forum.php)
MY (1) MY8600709A (forum.php)
NL (2) NL193752C (forum.php)
NO (1) NO152841C (forum.php)
NZ (1) NZ193935A (forum.php)
PH (1) PH18683A (forum.php)
SE (2) SE447107B (forum.php)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
US4381393A (en) * 1981-05-04 1983-04-26 Merrell Dow Pharmaceuticals Inc. 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4329470A (en) 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4329471A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4371737A (en) * 1981-05-04 1983-02-01 Merrell Dow Pharmaceuticals Inc. 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
CA1167853A (en) * 1981-05-04 1984-05-22 J. Martin Grisar 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones
US4526981A (en) * 1981-05-04 1985-07-02 Merrell Dow Pharmaceuticals Inc. [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2007530563A (ja) * 2004-03-22 2007-11-01 ミオゲン インコーポレイティッド （ｓ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用
WO2005092333A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
TWI435729B (zh) 2005-11-09 2014-05-01 Combinatorx Inc 治療病症之方法，組合物及套組
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合
CN114539157B (zh) * 2022-03-03 2023-12-22 曲靖师范学院 一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them

Also Published As

Publication number Publication date
ES8105299A1 (es) 1981-06-01
IL60243A (en) 1987-01-30
PH18683A (en) 1985-08-29
SE8004253L (sv) 1980-12-19
NO801796L (no) 1980-12-19
DK160269B (da) 1991-02-18
NL8003498A (nl) 1980-12-22
SE8501452D0 (sv) 1985-03-25
SE8501452L (sv) 1985-03-25
GB2055364B (en) 1983-06-08
DK259080A (da) 1980-12-19
DE3021792C2 (forum.php) 1989-08-10
NL193752C (nl) 2000-09-04
NL300015I1 (nl) 2000-11-01
HU186736B (en) 1985-09-30
NZ193935A (en) 1985-05-31
IE50646B1 (en) 1986-06-11
SE464559B (sv) 1991-05-13
DE3021792A1 (de) 1981-01-22
DK160269C (da) 1991-07-22
AU5911880A (en) 1981-01-08
ATA314280A (de) 1983-12-15
AU532783B2 (en) 1983-10-13
ES492255A0 (es) 1981-06-01
NL300015I2 (nl) 2000-10-02
GB2055364A (en) 1981-03-04
NO152841B (no) 1985-08-19
FR2459233B1 (forum.php) 1983-09-23
NL193752B (nl) 2000-05-01
AT375349B (de) 1984-07-25
IL60243A0 (en) 1980-09-16
IT8048997A0 (it) 1980-06-17
IE801162L (en) 1980-12-18
HK61486A (en) 1986-08-29
MY8600709A (en) 1986-12-31
CH646155A5 (de) 1984-11-15
SE447107B (sv) 1986-10-27
CA1132554A (en) 1982-09-28
FR2459233A1 (fr) 1981-01-09
NO152841C (no) 1985-11-27

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Legal Events

Date Code Title Description
ITCP Complementary protection certificate

Free format text: CCP 156

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 156, 19920424; MERREL DOW PHARMACEUTICALS INC.

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950419