IN2014DN05987A - - Google Patents

Info

Publication number
IN2014DN05987A
IN2014DN05987A IN5987DEN2014A IN2014DN05987A IN 2014DN05987 A IN2014DN05987 A IN 2014DN05987A IN 5987DEN2014 A IN5987DEN2014 A IN 5987DEN2014A IN 2014DN05987 A IN2014DN05987 A IN 2014DN05987A
Authority
IN
India
Application number
Other languages
English (en)
Inventor
William K Mcvicar
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of IN2014DN05987A publication Critical patent/IN2014DN05987A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
IN5987DEN2014 2012-01-26 2014-07-16 IN2014DN05987A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261591037P 2012-01-26 2012-01-26
PCT/US2013/023166 WO2013112850A1 (fr) 2012-01-26 2013-01-25 Polymorphes anhydres de nitrate de méthyle [(2r,3s,4r,5r)-5-(6- (cyclopentylamino)-9h-purin-9-yle)-3,4-dihydroxytetrahydrofuran-2-yle)] et processus de préparation de ceux-ci

Publications (1)

Publication Number Publication Date
IN2014DN05987A true IN2014DN05987A (fr) 2015-06-26

Family

ID=48870739

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5987DEN2014 IN2014DN05987A (fr) 2012-01-26 2014-07-16

Country Status (25)

Country Link
US (2) US9278991B2 (fr)
EP (2) EP3235825A1 (fr)
JP (2) JP2015508751A (fr)
KR (1) KR20140128974A (fr)
CN (1) CN104093731B (fr)
AU (2) AU2013211957B2 (fr)
BR (1) BR112014018413A8 (fr)
CA (1) CA2861009A1 (fr)
CY (1) CY1119271T1 (fr)
DK (1) DK2807178T3 (fr)
EA (1) EA027109B1 (fr)
ES (1) ES2637332T3 (fr)
HR (1) HRP20171204T1 (fr)
HU (1) HUE035750T2 (fr)
IL (1) IL233812A0 (fr)
IN (1) IN2014DN05987A (fr)
LT (1) LT2807178T (fr)
MX (1) MX2014009086A (fr)
NZ (1) NZ627778A (fr)
PL (1) PL2807178T3 (fr)
PT (1) PT2807178T (fr)
RS (1) RS56150B1 (fr)
SG (2) SG10201701343QA (fr)
SI (1) SI2807178T1 (fr)
WO (1) WO2013112850A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011230580A1 (en) 2010-03-26 2012-10-11 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using N6 -cyclopentyladenosine (CPA), CPA derivatives or prodrugs thereof
PL2807178T3 (pl) 2012-01-26 2017-12-29 Inotek Pharmaceuticals Corporation Bezwodne polimorfy azotanu (2R,3S,4R,5R)-5-(6-(cyklopentyloamino)-9H-puryn-9-ylo)-3,4-dihydroksytetrahydrofuran-2-ylo)metylu i sposoby ich wytwarzania
MX2015013234A (es) * 2013-03-15 2016-04-15 Inotek Pharmaceuticals Corp Formulaciones oftalmicas.

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4935635B1 (fr) 1970-12-28 1974-09-25
CH563405A5 (fr) 1971-09-10 1975-06-30 Duschinsky Robert Dr Schweiz I
DE2226295A1 (de) 1972-05-30 1973-12-20 Henning Berlin Gmbh Salpetersaeureester von purinnucleosiden und verfahren zur herstellung derselben
DE2342479A1 (de) 1973-08-23 1975-03-13 Merck Patent Gmbh Ribonucleosid-5'-nitrate und verfahren zu ihrer herstellung
GB2001976B (en) 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
US4849311A (en) 1986-09-24 1989-07-18 Toa Nenryo Kogyo Kabushiki Kaisha Immobilized electrolyte membrane
US4968697A (en) 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5219840A (en) 1987-04-06 1993-06-15 Sandoz Ltd. Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives
US5591887A (en) 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5221763A (en) 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
ES2213504T1 (es) 1988-09-06 2004-09-01 Pfizer Health Ab Derivados de prostaglandina para el tratamiento del glaucoma o hipertension ocular.
US5140015A (en) 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US5280015A (en) 1990-09-05 1994-01-18 The United States Of America As Represented By The Department Of Health And Human Services 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides
JP3020580B2 (ja) 1990-09-28 2000-03-15 株式会社日立製作所 マイクロ波プラズマ処理装置
US5206222A (en) 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
HU212570B (en) 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5407793A (en) 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
US5278150A (en) 1992-04-24 1994-01-11 Whitby Research, Inc. 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions
DK62692D0 (fr) 1992-05-14 1992-05-14 Novo Nordisk As
AU4772493A (en) 1992-07-15 1994-02-14 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Sulfo-derivatives of adenosine
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5338430A (en) 1992-12-23 1994-08-16 Minnesota Mining And Manufacturing Company Nanostructured electrode membranes
US5443836A (en) 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
WO1995002604A1 (fr) 1993-07-13 1995-01-26 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Agonistes du recepteur de l'adenosine a¿3?
US5589467A (en) 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
WO1995011681A1 (fr) 1993-10-29 1995-05-04 Merck & Co., Inc. Antagonistes du recepteur de l'adenosine humaine
US5620676A (en) 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
EP0704215A3 (fr) 1994-06-02 1998-04-01 Takeda Chemical Industries, Ltd. Inhibiteur de l'aumentation de la perméabilité vasculaire
GB9414193D0 (en) 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
US5801159A (en) 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
CN1164122A (zh) 1996-03-01 1997-11-05 株式会社日立制作所 等离子处理机及其处理方法
AU2022497A (en) 1996-03-13 1997-10-01 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033879A1 (fr) 1996-03-15 1997-09-18 Merck & Co., Inc. Composes et methodes d'inhibition selective de l'activation du recepteur a3 de l'adenosine chez l'homme
US5789416B1 (en) 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
CA2289731A1 (fr) 1997-05-09 1998-11-12 The United States Of America, Represented By The Secretary, Department O F Health And Human Services Methodes visant a reduire une lesion ischemique cardiaque par administration d'agonistes et d'antagonistes du recepteur d'adenosine et compositions afferentes
AU9596698A (en) 1997-10-15 1999-05-03 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US6329349B1 (en) 1997-10-23 2001-12-11 Trustees Of The University Of Pennsylvania Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid A and adenosine receptor agents
GB9723590D0 (en) 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
GB9723566D0 (en) 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
FR2775901B1 (fr) 1998-03-13 2000-07-21 Logeais Labor Jacques Sels de cetoacides et de derives amines, et leur utilisation pour la preparation de medicaments
GB9813535D0 (en) 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
EP1096975B1 (fr) 1998-07-16 2005-03-16 The Trustees Of The University Of Pennsylvania Utilisation d'antagonistes du recepteur a3 a l'adenosine pour la preparation d'un medicament pour la reduction de la pression intra-oculaire
CA2347512C (fr) 1998-10-16 2005-12-06 Pfizer Inc. Derives d'adenine
IL127947A0 (en) 1999-01-07 1999-11-30 Can Fite Technologies Ltd Pharmaceutical use of adenosine agonists
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
JP2003502434A (ja) 1999-06-22 2003-01-21 スィーヴィー セラピューティクス インコーポレイテッド チオフェンａ２ａ受容体アゴニスト
US6214807B1 (en) 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6180615B1 (en) 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
GB9924361D0 (en) 1999-10-14 1999-12-15 Pfizer Ltd Purine derivatives
US6368573B1 (en) 1999-11-15 2002-04-09 King Pharmaceuticals Research And Development, Inc. Diagnostic uses of 2-substituted adenosine carboxamides
US6258793B1 (en) 1999-12-03 2001-07-10 Cv Therapeutics, Inc. N6 heterocyclic 5′ modified adenosine derivatives
GB9930071D0 (en) 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
US20020048610A1 (en) * 2000-01-07 2002-04-25 Cima Michael J. High-throughput formation, identification, and analysis of diverse solid-forms
GB0003960D0 (en) 2000-02-18 2000-04-12 Pfizer Ltd Purine derivatives
US20010051612A1 (en) 2000-02-23 2001-12-13 Gloria Cristalli 2-Thioether A2A receptor agonists
US20030010454A1 (en) 2000-03-27 2003-01-16 Bailey Andrew D. Method and apparatus for varying a magnetic field to control a volume of a plasma
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US6753322B2 (en) 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US6921753B2 (en) 2000-06-27 2005-07-26 Pfizer Inc Purine derivatives
WO2002009702A2 (fr) 2000-07-28 2002-02-07 Inspire Pharmaceuticals, Inc. Methode de reduction de la pression intraoculaire avec des derives d'indole
JP4012070B2 (ja) 2001-01-16 2007-11-21 カン−フィテ・バイオファーマ・リミテッド ウイルスの複製を阻害するためのアデノシンａ３受容体アゴニストの使用
GB2372742A (en) 2001-03-03 2002-09-04 Univ Leiden C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses
EP1241176A1 (fr) 2001-03-16 2002-09-18 Pfizer Products Inc. Dérivés de purine pour le traitement de l'ischémie
US20040204481A1 (en) 2001-04-12 2004-10-14 Pnina Fishman Activation of natural killer cells by adenosine A3 receptor agonists
US20030013675A1 (en) 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US7713946B2 (en) 2002-07-11 2010-05-11 Cv Therapeutics, Inc. Partial and full agonists A1 adenosine receptors
CA2456806C (fr) 2001-08-08 2011-10-18 Brown University Research Foundation Procedes de micronisation de medicaments hydrophobes
NZ556354A (en) 2001-10-01 2008-10-31 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
JP2005530736A (ja) 2002-04-18 2005-10-13 シーブイ・セラピューティクス・インコーポレイテッド ベーターブロッカー、カルシウムチャネルブロッカー、または心臓のグリコシドと共にａ１アデノシンアゴニストを投与することを含む不整脈の処置方法
JP2005523928A (ja) 2002-04-30 2005-08-11 アルコン，インコーポレイテッド 眼内圧の低下および緑内障性網膜症／眼神経障害の処置の両方のための独特の手段としての、結合組織増殖因子（ｃｔｇｆ）の活性および／または発現を調節するか、阻害するか、または調整する薬剤
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
WO2004056181A1 (fr) 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Preconditionnement, arret, protection, conservation et retablissement d'un organe
GB2436255B (en) 2002-12-23 2007-11-28 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery
CA2468664C (fr) 2003-06-03 2012-03-06 Allergan, Inc. Compositions a base de kerotolac tromethamine pour traiter ou prevenir la douleur oculaire
CA2554716A1 (fr) 2004-01-22 2005-08-04 Nitromed, Inc. Composes nitroses et/ou nitrosyles, compositions et procede pour les utiliser
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
CN101010085B (zh) 2004-05-26 2012-12-26 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
PT1758596E (pt) * 2004-05-26 2010-06-23 Inotek Pharmaceuticals Corp Derivados de purina como agonistas do receptor de adenosina a1 e processos para a sua utilização
WO2006017052A1 (fr) 2004-07-12 2006-02-16 Cv Therapeutics, Inc. Procédé pour la préparation d'agonistes du récepteur a1 de l'adénosine
WO2007002139A2 (fr) 2005-06-22 2007-01-04 The Trustees Of The University Of Pennsylvania Neuroprotection de cellules ganglionnaires de la retine
CN101321460A (zh) 2005-11-30 2008-12-10 伊诺泰克制药公司 嘌呤衍生物及其用法
AU2007293169A1 (en) 2006-02-02 2008-03-13 Allergan, Inc. Compositions and methods for the treatment of ophthalmic disease
US8784886B2 (en) 2006-03-09 2014-07-22 GlaxoSmithKline, LLC Coating capsules with active pharmaceutical ingredients
EP1996020A4 (fr) * 2006-03-23 2011-04-27 Inotek Pharmaceuticals Corp Composes puriques et leurs procedes d'utilisation
US8163737B2 (en) 2006-06-13 2012-04-24 Vertex Pharmaceuticals Incorporated CGRP receptor antagonists
US20080050335A1 (en) 2006-07-25 2008-02-28 Osmotica Corp. Ophthalmic Solutions
EP2076267A4 (fr) 2006-10-06 2013-07-31 Univ Pennsylvania Antagonistes de récepteur d'adénosine a3 d'espèces croisées pour réduire une pression intraoculaire
CA2667117C (fr) 2006-11-10 2016-04-26 Basf Se Modification cristalline de fipronil
JP5576659B2 (ja) 2006-12-05 2014-08-20 ザ ロイヤル インスティテューション フォー ジ アドバンスメント オブ ラーニング／ マギル ユニバーシティ Ｔｒｋレセプター調節因子の使用方法
JP2008266143A (ja) 2007-04-16 2008-11-06 Santen Pharmaceut Co Ltd アデノシン誘導体を有効成分として含有する緑内障治療剤
CN101980603A (zh) 2007-10-11 2011-02-23 比奥根艾迪克Ma公司 LINGO-1和TrkB拮抗剂的用途
WO2009076580A2 (fr) 2007-12-12 2009-06-18 Thomas Jefferson University Compositions et procédés pour le traitement et la prévention de maladies cardiovasculaires
JP2011511802A (ja) 2008-02-07 2011-04-14 ギリアード・パロ・アルト・インコーポレイテッド Ａｂｃａ−１を上昇させる化合物およびかかる化合物の使用方法
ES2422872T3 (es) * 2008-08-19 2013-09-16 Universiteit Leiden Moduladores alostéricos del receptor de adenosina A3
CA2742871C (fr) 2008-11-13 2018-10-23 Herb Lin Procedes et compositions pour la regulation de l'homeostasie du fer par modulation de la proteine bmp-6
BRPI1009971A2 (pt) 2009-05-01 2016-03-15 Inoteck Pharmaceuticals Corp método de redução da pressão intraocular em humanos
WO2010150812A1 (fr) 2009-06-25 2010-12-29 ライオン株式会社 Composition ophtalmique et méthode de prévention de la nébulosité/précipitation
KR20120091049A (ko) * 2009-10-26 2012-08-17 이노텍 파마슈티컬스 코포레이션 안과용 제제 및 이의 제조 방법
WO2011077435A1 (fr) 2009-12-22 2011-06-30 Bar-Ilan University Compositions et procédés pour la réduction de la pression intraoculaire
EP2523669B1 (fr) * 2010-01-11 2016-12-07 Inotek Pharmaceuticals Corporation Combinaison, nécessaire et méthode utilisés pour réduire la pression intraoculaire
US20110217262A1 (en) 2010-03-05 2011-09-08 Kornfield Julia A Treatment of Ocular Surface Disorders by Increasing Conjunctival Vascular Permeability
PT2555776T (pt) * 2010-03-19 2017-02-01 Inotek Pharmaceuticals Corp Composições de combinação de agonistas de adenosina a1 e bloqueadores não selectivos dos receptores adrenérgicos beta para redução da pressão intra-ocular
PT2555775T (pt) * 2010-03-19 2017-02-01 Inotek Pharmaceuticals Corp Composições de combinação de agonistas de adenosina a1 e inibidores de anidrase carbónica para redução da pressão intra-ocular
AU2011230580A1 (en) * 2010-03-26 2012-10-11 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using N6 -cyclopentyladenosine (CPA), CPA derivatives or prodrugs thereof
AU2011230618A1 (en) 2010-03-26 2012-10-11 Inotek Pharmaceuticals Corporation Adenosine compounds and their use thereof
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
US20140241990A1 (en) 2011-09-30 2014-08-28 Tufts University Methods of using adenosine a1 receptor activation for treating depression
PL2807178T3 (pl) 2012-01-26 2017-12-29 Inotek Pharmaceuticals Corporation Bezwodne polimorfy azotanu (2R,3S,4R,5R)-5-(6-(cyklopentyloamino)-9H-puryn-9-ylo)-3,4-dihydroksytetrahydrofuran-2-ylo)metylu i sposoby ich wytwarzania
MX2015013234A (es) 2013-03-15 2016-04-15 Inotek Pharmaceuticals Corp Formulaciones oftalmicas.
US20140275128A1 (en) 2013-03-15 2014-09-18 Inotek Pharmaceuticals Corporation Method of providing ocular neuroprotection

Also Published As

Publication number Publication date
CN104093731A (zh) 2014-10-08
EP2807178A4 (fr) 2015-09-16
US20160137686A1 (en) 2016-05-19
SI2807178T1 (sl) 2017-09-29
US9278991B2 (en) 2016-03-08
BR112014018413A8 (pt) 2017-07-11
EP2807178B9 (fr) 2017-11-29
EP2807178A1 (fr) 2014-12-03
JP2018024636A (ja) 2018-02-15
CN104093731B (zh) 2017-05-24
MX2014009086A (es) 2015-06-05
WO2013112850A1 (fr) 2013-08-01
US9718853B2 (en) 2017-08-01
SG11201403979TA (en) 2014-08-28
AU2017204674A1 (en) 2017-07-27
IL233812A0 (en) 2014-09-30
CY1119271T1 (el) 2018-02-14
EP2807178B1 (fr) 2017-05-17
EP3235825A1 (fr) 2017-10-25
CA2861009A1 (fr) 2013-08-01
NZ627778A (en) 2017-01-27
EA027109B1 (ru) 2017-06-30
PT2807178T (pt) 2017-08-08
AU2013211957B2 (en) 2017-08-10
US20130196940A1 (en) 2013-08-01
RS56150B1 (sr) 2017-11-30
KR20140128974A (ko) 2014-11-06
PL2807178T3 (pl) 2017-12-29
ES2637332T3 (es) 2017-10-11
HUE035750T2 (en) 2018-05-28
JP2015508751A (ja) 2015-03-23
BR112014018413A2 (fr) 2017-06-20
EA201491393A1 (ru) 2015-01-30
SG10201701343QA (en) 2017-04-27
LT2807178T (lt) 2017-08-25
HRP20171204T1 (hr) 2017-10-06
AU2013211957A1 (en) 2014-08-14
DK2807178T3 (en) 2017-09-04

Similar Documents

Publication Publication Date Title
BR112014017635A2 (fr)
BR112014017614A2 (fr)
BR112014018163A2 (fr)
BR112014018688A2 (fr)
BR112014017592A2 (fr)
BR112014017625A2 (fr)
BR112014017659A2 (fr)
BR112014017646A2 (fr)
AR092201A1 (fr)
BR112014017638A2 (fr)
BR112014017974A2 (fr)
BR112014020244A2 (fr)
BR112013027865A2 (fr)
BR112014017634A2 (fr)
BR112014017609A2 (fr)
BR112014017644A2 (fr)
BR112014017647A2 (fr)
BR112014017588A2 (fr)
BR112014017618A2 (fr)
BR112014013184A8 (fr)
BR112014017652A2 (fr)
BR112014017621A2 (fr)
BR112014017630A2 (fr)
BR112014017622A2 (fr)
BR112014017941A2 (fr)