IN2014CN03968A - - Google Patents

Info

Publication number
IN2014CN03968A
IN2014CN03968A IN3968CHN2014A IN2014CN03968A IN 2014CN03968 A IN2014CN03968 A IN 2014CN03968A IN 3968CHN2014 A IN3968CHN2014 A IN 3968CHN2014A IN 2014CN03968 A IN2014CN03968 A IN 2014CN03968A
Authority
IN
India
Prior art keywords
chain variable
variable region
antigens
polypeptide containing
fluorochrome
Prior art date
Application number
Other languages
English (en)
Inventor
Hiroshi Ueda
Ryoji Abe
Hiroaki Takagi
Original Assignee
Ushio Electric Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ushio Electric Inc filed Critical Ushio Electric Inc
Publication of IN2014CN03968A publication Critical patent/IN2014CN03968A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/946—CNS-stimulants, e.g. cocaine, amphetamines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9486—Analgesics, e.g. opiates, aspirine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IN3968CHN2014 2011-11-02 2012-11-01 IN2014CN03968A (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011241402 2011-11-02
PCT/JP2012/007025 WO2013065314A1 (ja) 2011-11-02 2012-11-01 蛍光標識抗体可変領域含有ポリペプチド複合体を用いた蛍光免疫測定方法

Publications (1)

Publication Number Publication Date
IN2014CN03968A true IN2014CN03968A (enExample) 2015-10-23

Family

ID=48191686

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3968CHN2014 IN2014CN03968A (enExample) 2011-11-02 2012-11-01

Country Status (8)

Country Link
US (1) US20140329228A1 (enExample)
EP (1) EP2775305A4 (enExample)
JP (2) JP5817838B2 (enExample)
KR (1) KR101603456B1 (enExample)
CN (1) CN103917872B (enExample)
CA (1) CA2854432A1 (enExample)
IN (1) IN2014CN03968A (enExample)
WO (1) WO2013065314A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015062365A (ja) * 2013-09-25 2015-04-09 Ｎｅｃソリューションイノベータ株式会社 ラクトパミンに結合する核酸分子およびその用途
JP2015062364A (ja) * 2013-09-25 2015-04-09 Ｎｅｃソリューションイノベータ株式会社 クレンブテロールに結合する核酸分子およびその用途
WO2015122484A1 (ja) * 2014-02-13 2015-08-20 ウシオ電機株式会社 大麻成分の抽出方法、大麻成分の検査用デバイス及び大麻成分の検査方法
US10648984B2 (en) * 2014-04-15 2020-05-12 Cezanne S.A.S. Immunoassay and antibodies for the detection of chromogranin A
JP5949890B2 (ja) * 2014-12-24 2016-07-13 ウシオ電機株式会社 蛍光標識された抗体可変領域を含むポリペプチドを含む抗原結合タンパク質を用いた蛍光免疫測定方法
JP6473366B2 (ja) * 2015-03-31 2019-02-20 シスメックス株式会社 温度判定方法、標的ペプチドの検出方法および温度判定試薬
AU2016261299B2 (en) * 2015-05-11 2019-12-05 Janssen Vaccines & Prevention B.V. Influenza virus neutralizing peptidomimetic compounds
WO2016208466A1 (ja) * 2015-06-22 2016-12-29 ウシオ電機株式会社 検出対象物質の検出方法
JP2017020896A (ja) * 2015-07-10 2017-01-26 国立大学法人北陸先端科学技術大学院大学 Ｎ末端標識剤、これを用いた蛍光標識タンパク質及びその製造方法
CN107923070A (zh) * 2015-08-25 2018-04-17 生物辐射实验室股份有限公司 数字式免疫测定
JP2017049184A (ja) * 2015-09-03 2017-03-09 国立大学法人東京工業大学 抗体のヌクレオチド結合部位（ｎｂｓ）を利用して蛍光標識された抗体
JP6885595B2 (ja) * 2015-12-04 2021-06-16 国立大学法人 東京大学 リガンド蛍光センサータンパク質とその使用
CN105647918A (zh) * 2016-02-20 2016-06-08 深圳市圣必智科技开发有限公司 抗乙肝e抗原的红色荧光抗体的制备方法
KR101847264B1 (ko) 2016-03-29 2018-04-10 국립암센터 항원 반응형 항체-형광염료 결합체 및 이를 이용한 표적 세포의 형광영상 검출방법
CN107044888B (zh) * 2017-03-17 2019-03-01 同济大学 基于荧光染料ThT、RET基因的温度计的构建方法
WO2018211126A1 (en) 2017-05-19 2018-11-22 Philip Morris Products S.A. Diagnostic test for distinguishing the smoking status of a subject
JPWO2020026733A1 (ja) * 2018-07-30 2021-08-19 国立大学法人東京工業大学 蛍光標識抗体又は抗体断片
JP7461661B2 (ja) * 2019-06-05 2024-04-04 国立大学法人東京工業大学 複数の蛍光色素を結合させたペプチドを用いるホモジニアス免疫測定法
CN114057881B (zh) * 2021-12-28 2023-10-13 杭州贤至生物科技有限公司 抗氯胺酮特异性抗体、质粒载体及方法
CN117659201B (zh) * 2022-08-23 2024-09-24 东莞市朋志生物科技有限公司 抗可卡因抗体或其功能性片段、检测可卡因的试剂和试剂盒
CN120399035A (zh) * 2025-04-09 2025-08-01 华南农业大学 一种用于检测溴虫腈的半抗原、人工抗原及其应用

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JPH02195256A (ja) * 1989-01-24 1990-08-01 Matsushita Electric Ind Co Ltd 免疫的検出方法および装置
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
JP3784111B2 (ja) 1996-07-31 2006-06-07 ロシュ ダイアグノスティックス コーポレーション 抗原濃度測定方法
JPH10282098A (ja) 1997-04-11 1998-10-23 Matsushita Electric Ind Co Ltd 蛍光免疫測定法
JP4193249B2 (ja) 1998-11-11 2008-12-10 三菱化学株式会社 Ｃ末端がラベル化されたタンパク質の製造方法
JP3439195B2 (ja) * 2000-02-17 2003-08-25 浜松ホトニクス株式会社 抗原の定量的検出方法
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CN100473988C (zh) * 2004-07-08 2009-04-01 厦门大学 具有荧光共振能量转移特点的蛋白组合及其用途
WO2007033514A1 (fr) * 2005-09-19 2007-03-29 Xiamen University Combinaison de protéines caractérisée dans le transfert d'énergie entre molécules fluorescentes et utilisation de cette combinaison de protéines
WO2009021026A1 (en) * 2007-08-06 2009-02-12 University Of Kentucky Research Foundation Semi-synthetic antibodies as recognition elements
WO2009154026A1 (ja) * 2008-06-20 2009-12-23 国立大学法人岡山大学 石灰化小球に対する抗体及びその用途
JP2011095085A (ja) * 2009-10-29 2011-05-12 Hipep Laboratories プリオンの測定方法
KR101335560B1 (ko) * 2009-11-19 2013-12-31 우시오덴키 가부시키가이샤 형광 면역 측정 방법

Also Published As

Publication number Publication date
CA2854432A1 (en) 2013-05-10
CN103917872A (zh) 2014-07-09
JP6070769B2 (ja) 2017-02-01
JP5817838B2 (ja) 2015-11-18
US20140329228A1 (en) 2014-11-06
JP2015193631A (ja) 2015-11-05
EP2775305A1 (en) 2014-09-10
CN103917872B (zh) 2016-05-18
WO2013065314A1 (ja) 2013-05-10
EP2775305A4 (en) 2015-06-24
KR20140084266A (ko) 2014-07-04
JPWO2013065314A1 (ja) 2015-04-02
KR101603456B1 (ko) 2016-03-14

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