IN2013MN01519A - - Google Patents

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Publication number
IN2013MN01519A
IN2013MN01519A IN1519MUN2013A IN2013MN01519A IN 2013MN01519 A IN2013MN01519 A IN 2013MN01519A IN 1519MUN2013 A IN1519MUN2013 A IN 1519MUN2013A IN 2013MN01519 A IN2013MN01519 A IN 2013MN01519A
Authority
IN
India
Prior art keywords
pharmaceutically acceptable
acceptable salt
diaminopyrimidine derivative
delayed
gastroparesis
Prior art date
Application number
Other languages
English (en)
Inventor
Hyun Joo Lee
Dong Hoon Kim
Tae Kyun Kim
Young Ae Yoon
Jae Young Sim
Myung Hun Cha
Eun Jung Jung
Kyoung Kyu Ahn
Tai Au Lee
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of IN2013MN01519A publication Critical patent/IN2013MN01519A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IN1519MUN2013 2011-02-25 2012-02-24 IN2013MN01519A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20110016981 2011-02-25
PCT/KR2012/001423 WO2012115478A2 (en) 2011-02-25 2012-02-24 Diaminopyrimidine derivatives and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
IN2013MN01519A true IN2013MN01519A (pt) 2015-06-12

Family

ID=46721361

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1519MUN2013 IN2013MN01519A (pt) 2011-02-25 2012-02-24

Country Status (18)

Country Link
US (4) US9850227B2 (pt)
EP (2) EP2678331B1 (pt)
JP (2) JP5980236B2 (pt)
KR (2) KR101671348B1 (pt)
CN (2) CN103402997B (pt)
AU (2) AU2012221927B2 (pt)
BR (2) BR112013020641B1 (pt)
CA (2) CA2827030C (pt)
DK (1) DK2678332T3 (pt)
ES (2) ES2587304T3 (pt)
HK (2) HK1188214A1 (pt)
HU (1) HUE029988T2 (pt)
IN (1) IN2013MN01519A (pt)
MX (2) MX336155B (pt)
PL (2) PL2678332T3 (pt)
PT (1) PT2678332T (pt)
RU (1) RU2587493C2 (pt)
WO (2) WO2012115480A2 (pt)

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JP5980236B2 (ja) * 2011-02-25 2016-08-31 ユーハン・コーポレイションYUHAN Corporation ジアミノピリミジン誘導体及びその製造方法
JP6412503B2 (ja) 2012-11-21 2018-10-24 ピーティーシー セラピューティクス, インコーポレイテッド 置換逆ピリミジンBmi−1阻害剤
KR101657616B1 (ko) * 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
WO2015030847A1 (en) * 2013-08-30 2015-03-05 Ptc Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
EP3071553A4 (en) 2013-11-21 2017-08-02 PTC Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
CN104003944B (zh) * 2014-05-29 2016-08-24 西北师范大学 一种嘧菌胺的制备方法
KR102487451B1 (ko) * 2014-10-13 2023-01-11 주식회사유한양행 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN105646321A (zh) * 2016-01-07 2016-06-08 中国药科大学 (s)-3-羟基吡咯烷盐酸盐的制备方法
GB201604647D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
KR102441327B1 (ko) 2018-05-18 2022-09-07 주식회사유한양행 다이아미노피리미딘 유도체 또는 이의 산부가염의 신규의 제조방법
CN110317176A (zh) * 2019-07-04 2019-10-11 沈阳药科大学 2-氨基嘧啶类化合物及其用途
KR20220006776A (ko) * 2020-07-09 2022-01-18 주식회사유한양행 다이아미노피리미딘 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 약학 조성물 및 이의 제조방법

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Also Published As

Publication number Publication date
US10227330B2 (en) 2019-03-12
EP2678332B1 (en) 2016-05-18
CA2827072A1 (en) 2012-08-30
KR20120098484A (ko) 2012-09-05
JP2014506592A (ja) 2014-03-17
EP2678332A2 (en) 2014-01-01
US20180111918A1 (en) 2018-04-26
CN103391935B (zh) 2015-12-23
CN103402997A (zh) 2013-11-20
US10640490B2 (en) 2020-05-05
RU2587493C2 (ru) 2016-06-20
KR20120098483A (ko) 2012-09-05
BR112013020641B1 (pt) 2021-11-03
AU2012221925B2 (en) 2016-05-05
KR101671341B1 (ko) 2016-11-01
BR112013019942B1 (pt) 2022-01-11
WO2012115480A3 (en) 2012-10-18
RU2013142188A (ru) 2015-03-27
ES2579830T3 (es) 2016-08-17
KR101671348B1 (ko) 2016-11-01
MX2013009627A (es) 2014-02-17
AU2012221927B2 (en) 2016-04-28
EP2678332A4 (en) 2014-07-23
CA2827030C (en) 2019-01-08
MX336155B (es) 2016-01-07
WO2012115478A3 (en) 2012-10-18
PL2678332T3 (pl) 2016-12-30
EP2678331A2 (en) 2014-01-01
PL2678331T3 (pl) 2016-12-30
RU2013142187A (ru) 2015-03-27
US20130338179A1 (en) 2013-12-19
BR112013019942A2 (pt) 2018-08-14
US20180072705A1 (en) 2018-03-15
CN103402997B (zh) 2015-08-26
MX337477B (es) 2016-03-07
WO2012115480A2 (en) 2012-08-30
HK1188214A1 (zh) 2014-04-25
EP2678331B1 (en) 2016-04-27
PT2678332T (pt) 2016-08-22
CA2827030A1 (en) 2012-08-30
MX2013009549A (es) 2013-09-06
DK2678332T3 (en) 2016-08-15
CN103391935A (zh) 2013-11-13
EP2678331A4 (en) 2014-07-30
US20130331377A1 (en) 2013-12-12
CA2827072C (en) 2019-01-08
HK1188215A1 (en) 2014-04-25
JP5890436B2 (ja) 2016-03-22
BR112013020641A2 (pt) 2016-10-18
JP5980236B2 (ja) 2016-08-31
HUE029988T2 (en) 2017-04-28
US9850227B2 (en) 2017-12-26
WO2012115478A2 (en) 2012-08-30
US9890138B2 (en) 2018-02-13
ES2587304T3 (es) 2016-10-21
JP2014506591A (ja) 2014-03-17
US20150274700A2 (en) 2015-10-01

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