IN2012DN03156A - - Google Patents

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Publication number
IN2012DN03156A
IN2012DN03156A IN3156DEN2012A IN2012DN03156A IN 2012DN03156 A IN2012DN03156 A IN 2012DN03156A IN 3156DEN2012 A IN3156DEN2012 A IN 3156DEN2012A IN 2012DN03156 A IN2012DN03156 A IN 2012DN03156A
Authority
IN
India
Prior art keywords
target
biological sample
targets
probes
bound probes
Prior art date
Application number
Other languages
English (en)
Inventor
Sood Anup
Richard Nelson John
Gerdes Michael
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Electric filed Critical Gen Electric
Publication of IN2012DN03156A publication Critical patent/IN2012DN03156A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IN3156DEN2012 2009-10-21 2010-10-21 IN2012DN03156A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/582,745 US9677125B2 (en) 2009-10-21 2009-10-21 Detection of plurality of targets in biological samples
PCT/EP2010/065876 WO2011048184A1 (en) 2009-10-21 2010-10-21 Detection of plurality of targets in biological samples

Publications (1)

Publication Number Publication Date
IN2012DN03156A true IN2012DN03156A (de) 2015-09-18

Family

ID=43103438

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3156DEN2012 IN2012DN03156A (de) 2009-10-21 2010-10-21

Country Status (11)

Country Link
US (1) US9677125B2 (de)
EP (1) EP2491132B1 (de)
JP (1) JP2013507941A (de)
KR (1) KR20120088716A (de)
CN (1) CN102803510A (de)
AU (1) AU2010309739A1 (de)
BR (1) BR112012009481A2 (de)
CA (1) CA2777421A1 (de)
IN (1) IN2012DN03156A (de)
RU (1) RU2012115681A (de)
WO (1) WO2011048184A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013096851A1 (en) 2011-12-22 2013-06-27 President And Fellows Of Harvard College Compositions and methods for analyte detection
US8568991B2 (en) 2011-12-23 2013-10-29 General Electric Company Photoactivated chemical bleaching of dyes
US9176032B2 (en) 2011-12-23 2015-11-03 General Electric Company Methods of analyzing an H and E stained biological sample
KR101460439B1 (ko) * 2012-05-14 2014-11-12 서울대학교산학협력단 나노프로브 및 이를 이용한 표적 물질 검출방법
CA3022975C (en) * 2012-06-14 2019-10-01 Erasmus University Medical Center Rotterdam Methods, reagents and kits for detecting minimal residual disease.
WO2014099222A1 (en) * 2012-12-17 2014-06-26 Clarient Diagnostic Services, Inc. Chemical bleaching of dyes using radical photoinitiators
EP2965087B1 (de) 2013-03-06 2018-10-17 General Electric Company Verfahren zur analyse einer h&e-gefärbten biologischen probe
CN112301024A (zh) 2013-03-15 2021-02-02 通用医疗公司 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性
US10760064B2 (en) 2013-03-15 2020-09-01 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
US10011850B2 (en) 2013-06-21 2018-07-03 The General Hospital Corporation Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
AU2014296253A1 (en) 2013-07-30 2016-02-04 President And Fellows Of Harvard College Quantitative DNA-based imaging and super-resolution imaging
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
AU2014346559B2 (en) 2013-11-07 2020-07-09 Editas Medicine,Inc. CRISPR-related methods and compositions with governing gRNAs
RU2662969C2 (ru) 2014-03-11 2018-07-31 Президент Энд Феллоуз Оф Гарвард Колледж Высокопроизводительная и высокомультиплексная визуализация при помощи программируемых зондов на основе нуклеиновых кислот
US9909167B2 (en) * 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
ES2968004T3 (es) 2014-07-30 2024-05-06 Harvard College Construcción de bibliotecas de sondas
US9926546B2 (en) 2015-08-28 2018-03-27 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
US9512446B1 (en) 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
US10370698B2 (en) 2016-07-27 2019-08-06 The Board Of Trustees Of The Leland Stanford Junior University Highly-multiplexed fluorescent imaging
CN106290812A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法
CN106290877A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 急性髓系白血病粒细胞抗原表达量检测试剂盒及检测方法
WO2018218150A1 (en) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
JP2021505132A (ja) * 2017-11-30 2021-02-18 アラーキス セラピューティクス, インコーポレイテッド 核酸結合光プローブおよびその使用
JP6999527B2 (ja) * 2018-09-25 2022-01-18 株式会社日立ハイテク 試験方法、分注装置
US11397179B2 (en) 2018-12-31 2022-07-26 Robert Bosch Gmbh PH-modulated imaging of targets close to a solid surface
JP7405400B2 (ja) * 2019-11-20 2023-12-26 Necソリューションイノベータ株式会社 核酸分子およびその用途
EP4322837A1 (de) * 2021-04-16 2024-02-21 Advanced Cell Diagnostics, Inc. Materialien und verfahren im zusammenhang mit der bildverarbeitung

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405720A (en) * 1981-03-04 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services Silver stains for protein in gels
GB8405437D0 (en) 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
JPH01196567A (ja) * 1988-02-01 1989-08-08 Hitachi Ltd 核酸検査方法及び核酸検査装置
US5401469A (en) * 1989-04-19 1995-03-28 Ibiden Co., Ltd. Plastic optical biomaterials assay device
JP3130513B2 (ja) 1989-04-19 2001-01-31 イビデン株式会社 生体活性物質測定用装置
JP3188303B2 (ja) * 1992-04-10 2001-07-16 株式会社日立製作所 ポリヌクレオチド検出法
US5843640A (en) 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
WO1994009022A1 (en) 1992-10-09 1994-04-28 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue
US5776755A (en) * 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
JPH09500280A (ja) 1993-07-20 1997-01-14 ユニバーシテイ・オブ・マサチユセツツ・メデイカル・センター 核酸のインビボハイブリッド形成方法
FR2711671A1 (fr) 1993-10-22 1995-05-05 Centre Nat Rech Scient Procédé de détection et de quantification d'une séquence nucléotidique dans une population cellulaire.
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
DE4421891C2 (de) 1994-06-23 1996-05-15 Helmut Prof Dr Med Feucht Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene
US5571643A (en) * 1994-07-22 1996-11-05 Martin; Mark T. Spectrophotometric quantitation of images in X-ray film and electrophoresis gel bands
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5763152A (en) * 1995-03-31 1998-06-09 Fuji Photo Film Co., Ltd. Silver halide photographic light-sensitive material
EP0801306A1 (de) 1996-04-10 1997-10-15 Becton, Dickinson and Company Methode zur immunohistochemischen Quantifizierung von co-lokalisierten Molekülen
DE19709348C2 (de) * 1996-05-29 1999-07-01 Schubert Walter Dr Md Automatisches Multi-Epitop-Ligand-Kartierungsverfahren
WO1998002577A1 (en) 1996-07-15 1998-01-22 The Children's Medical Center Corporation Method to co-detect introduced genes and their products
US6735531B2 (en) * 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
EP1095161A2 (de) * 1998-07-10 2001-05-02 Chromagen, Inc. Neue polycyclische aromatische fluorogene substrate für hydrolasen
DE19835284C2 (de) 1998-08-05 2001-03-01 Tuhh Tech Gmbh Vorrichtung und Verfahren zur automatischen Fokussierung und Belichtung von Bildaufnahmesystemen
WO2000014281A2 (en) * 1998-08-21 2000-03-16 Naxcor Assays using crosslinkable immobilized nucleic acids
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
CA2345276C (en) 1998-10-09 2011-03-29 Ludwig Institute For Cancer Research Flt4 (vegfr-3) as a target for tumor imaging and anti-tumor therapy
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000058507A1 (en) 1999-03-30 2000-10-05 Solexa Ltd. Polynucleotide sequencing
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
WO2001023610A2 (en) * 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
GB0002389D0 (en) * 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
DE10014685B4 (de) * 2000-03-24 2004-07-01 Schubert, Walter, Dr. Verfahren zur Identifizierung von zellspezifischen Zielstrukturen
US20020106648A1 (en) * 2000-05-05 2002-08-08 Lizardi Paul M. Highly multiplexed reporter carrier systems
IL136232A0 (en) 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
JP2002323416A (ja) 2001-02-20 2002-11-08 Hitachi Ltd 検査容器
US20020114742A1 (en) * 2001-02-20 2002-08-22 Hitachi, Ltd. Test chamber
US20050230255A1 (en) 2001-03-30 2005-10-20 Sumner Lloyd W Silver destaining method
US7219016B2 (en) * 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US20020173053A1 (en) * 2001-04-27 2002-11-21 Bassam Damaj Multiple simultaneous antigen detection by immunohistochemistry
JP3899845B2 (ja) 2001-05-23 2007-03-28 日本光電工業株式会社 染色標本の脱色方法および装置
US20040241688A1 (en) * 2001-07-19 2004-12-02 Cuneyt Bukusoglu Human tissue specific drug screening procedure
DE10143757A1 (de) 2001-09-06 2003-03-27 Werner M Methode zur Darstellung von Merkmalen in Geweben
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
WO2003061711A2 (en) * 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
US6731831B2 (en) 2002-02-27 2004-05-04 Xiang Zheng Tu Optical switch array assembly for DNA probe synthesis and detection
US7776195B2 (en) * 2002-05-28 2010-08-17 Autogenomics, Inc. Integrated sample processing platform
JP2004041121A (ja) 2002-07-12 2004-02-12 Hitachi Ltd アレルギー解析方法及びシステム
WO2004061446A1 (en) * 2002-12-18 2004-07-22 Aclara Biosciences, Inc. Single cell analysis of membrane molecules
US20040241776A1 (en) 2003-05-22 2004-12-02 Agdia, Inc. Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes
JP3936689B2 (ja) 2003-09-09 2007-06-27 日本碍子株式会社 シアニン系有機色素劣化環境の検知方法
US7463778B2 (en) * 2004-01-30 2008-12-09 Hewlett-Packard Development Company, L.P Motion estimation for compressing multiple view images
JP4538628B2 (ja) 2004-03-16 2010-09-08 学校法人慶應義塾 遺伝子発現検出方法
JP4189495B2 (ja) 2004-08-02 2008-12-03 国立大学法人群馬大学 ゲノムdnaのメチル化検出方法
MX2007008506A (es) * 2005-01-13 2010-05-17 Progenika Biopharma Sa Metodos y productos para genotipificacion in vitro.
US20070072211A1 (en) * 2005-06-30 2007-03-29 Roche Molecular Systems, Inc. Asymmetric PCR coupled with post-PCR characterization for the identification of nucleic acids
JP2007033159A (ja) 2005-07-25 2007-02-08 Assay Corp 蛍光分子で標識された測定対象物質
EP1950566A4 (de) 2005-11-10 2008-11-26 Univ Toyama Nat Univ Corp Verfahren zur bewertung von bindungseigenschaften von biosubstanzen und biosubstanz bindenden substanzen
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
JP2009232707A (ja) * 2008-03-26 2009-10-15 Canon Inc 一塩基多型の検出法及びプローブ固定担体

Also Published As

Publication number Publication date
RU2012115681A (ru) 2013-11-27
CA2777421A1 (en) 2011-04-28
US9677125B2 (en) 2017-06-13
AU2010309739A1 (en) 2012-05-03
KR20120088716A (ko) 2012-08-08
EP2491132B1 (de) 2018-03-21
BR112012009481A2 (pt) 2016-11-29
CN102803510A (zh) 2012-11-28
EP2491132A1 (de) 2012-08-29
WO2011048184A1 (en) 2011-04-28
JP2013507941A (ja) 2013-03-07
US20110092381A1 (en) 2011-04-21

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