IN2012DN00801A - - Google Patents

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Publication number
IN2012DN00801A
IN2012DN00801A IN801DEN2012A IN2012DN00801A IN 2012DN00801 A IN2012DN00801 A IN 2012DN00801A IN 801DEN2012 A IN801DEN2012 A IN 801DEN2012A IN 2012DN00801 A IN2012DN00801 A IN 2012DN00801A
Authority
IN
India
Prior art keywords
adamts
expression
methods
useful
proteins
Prior art date
Application number
Other languages
English (en)
Inventor
Grillberger Leopold
Spenger Alexandra
Hasslacher Meinhard
Grillberger Rana
Reiter Manfred
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of IN2012DN00801A publication Critical patent/IN2012DN00801A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/22—Zinc; Zn chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95—Protein-free medium and culture conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
IN801DEN2012 2009-07-31 2010-07-30 IN2012DN00801A (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23047709P 2009-07-31 2009-07-31
PCT/US2010/044020 WO2011014838A1 (en) 2009-07-31 2010-07-30 Cell culture medium for adamts protein expression

Publications (1)

Publication Number Publication Date
IN2012DN00801A true IN2012DN00801A (xx) 2015-06-26

Family

ID=42668009

Family Applications (1)

Application Number Title Priority Date Filing Date
IN801DEN2012 IN2012DN00801A (xx) 2009-07-31 2010-07-30

Country Status (22)

Country Link
US (7) US8313926B2 (xx)
EP (1) EP2459702B1 (xx)
JP (5) JP5451884B2 (xx)
KR (5) KR101573972B1 (xx)
CN (2) CN104962539B (xx)
AU (1) AU2010278751B2 (xx)
BR (2) BR112012002151B1 (xx)
CA (1) CA2769361A1 (xx)
CO (1) CO6501191A2 (xx)
EA (1) EA023193B1 (xx)
ES (1) ES2583258T3 (xx)
HK (1) HK1171790A1 (xx)
HR (1) HRP20160783T1 (xx)
HU (1) HUE029110T2 (xx)
IN (1) IN2012DN00801A (xx)
MX (2) MX2012001261A (xx)
NZ (1) NZ597727A (xx)
PL (1) PL2459702T3 (xx)
PT (1) PT2459702T (xx)
SG (1) SG178194A1 (xx)
SI (1) SI2459702T1 (xx)
WO (1) WO2011014838A1 (xx)

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* Cited by examiner, † Cited by third party
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CA2769361A1 (en) * 2009-07-31 2011-02-03 Baxter International Inc. Cell culture medium for adamts protein expression
BR112013000515B1 (pt) 2010-07-08 2021-11-03 Takeda Pharmaceutical Company Limited Método para produzir uma composição de fator von willebrand recombinante (rvwf)
PL2726600T3 (pl) 2011-07-01 2017-08-31 Amgen Inc. Hodowla ssaczych komórek
WO2014062535A1 (en) 2012-10-15 2014-04-24 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
WO2014159831A1 (en) 2013-03-13 2014-10-02 Merck Sharp & Dohme Corp. Adapted lepidopteran insect cells for the production of recombinant proteins
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
AR095196A1 (es) * 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
US10138467B2 (en) * 2013-10-14 2018-11-27 Ares Trading S.A. Medium for high performance mammalian fed-batch cultures
SG10202113019XA (en) 2014-06-04 2021-12-30 Amgen Inc Methods for harvesting mammalian cell cultures
KR101867134B1 (ko) * 2015-03-23 2018-06-12 한양대학교 산학협력단 포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법
PL3298138T3 (pl) * 2015-05-22 2022-12-05 Dupont Nutrition Biosciences Aps Dekarboksylaza acetomleczanowa
TW202330904A (zh) 2015-08-04 2023-08-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
EA201990373A1 (ru) 2016-08-04 2019-07-31 Баксалта Инкорпорэйтед Применение adamts13 для лечения, уменьшения интенсивности и/или предупреждения вазоокклюзивного криза при серповидноклеточной анемии, остром повреждении легкого и/или остром респираторном дистресс-синдроме
AU2017391164B2 (en) * 2016-11-04 2024-01-04 Takeda Pharmaceutical Company Limited Adeno-associated virus purification methods
MX2020009605A (es) * 2018-03-16 2021-01-08 Genzyme Corp Metodos para mejorar la viabilidad celular en un biorreactor de produccion.
WO2019245938A1 (en) * 2018-06-18 2019-12-26 Synthetic Biologics, Inc. Methods of making alkaline phosphatase agents
SG11202110968VA (en) 2019-12-06 2021-10-28 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
CA3173709A1 (en) 2020-04-02 2021-10-07 Friedmund BACHMANN Adamts13 variant, compositions, and uses thereof
US20230201319A1 (en) 2020-05-22 2023-06-29 Takeda Pharmaceutical Company Limited Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease
CN111808822B (zh) * 2020-07-02 2024-01-12 北京百普赛斯生物科技股份有限公司 细胞培养用补料液及提高重组hek293细胞蛋白表达量的方法

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CA2769361A1 (en) * 2009-07-31 2011-02-03 Baxter International Inc. Cell culture medium for adamts protein expression

Also Published As

Publication number Publication date
US20190071660A1 (en) 2019-03-07
ES2583258T3 (es) 2016-09-20
MX2012001261A (es) 2012-05-22
AU2010278751A1 (en) 2012-02-09
JP5936232B2 (ja) 2016-06-22
PL2459702T3 (pl) 2016-12-30
SG178194A1 (en) 2012-03-29
US9127265B2 (en) 2015-09-08
EP2459702B1 (en) 2016-05-04
JP2018093881A (ja) 2018-06-21
JP7083059B2 (ja) 2022-06-09
NZ597727A (en) 2013-08-30
JP5451884B2 (ja) 2014-03-26
CA2769361A1 (en) 2011-02-03
SI2459702T1 (sl) 2016-11-30
US10724024B2 (en) 2020-07-28
BR112012002151A2 (pt) 2020-03-03
PT2459702T (pt) 2016-08-02
EP2459702A1 (en) 2012-06-06
EA201270224A1 (ru) 2012-09-28
KR101756354B1 (ko) 2017-07-26
AU2010278751B2 (en) 2014-05-15
MX344970B (es) 2017-01-12
CO6501191A2 (es) 2012-08-15
KR20150138425A (ko) 2015-12-09
US20200308566A1 (en) 2020-10-01
US20110086413A1 (en) 2011-04-14
JP6567707B2 (ja) 2019-08-28
JP2016144471A (ja) 2016-08-12
CN102549145B (zh) 2015-05-20
KR20150044981A (ko) 2015-04-27
JP2019201661A (ja) 2019-11-28
JP2013500724A (ja) 2013-01-10
HRP20160783T1 (hr) 2016-08-12
WO2011014838A1 (en) 2011-02-03
HUE029110T2 (en) 2017-02-28
US20130071906A1 (en) 2013-03-21
KR101574056B1 (ko) 2015-12-02
EA023193B1 (ru) 2016-05-31
CN104962539A (zh) 2015-10-07
US9441216B2 (en) 2016-09-13
JP2014061005A (ja) 2014-04-10
CN104962539B (zh) 2019-09-17
KR101912552B1 (ko) 2018-10-26
US11254921B2 (en) 2022-02-22
US8313926B2 (en) 2012-11-20
KR20170140411A (ko) 2017-12-20
JP6511007B2 (ja) 2019-05-08
HK1171790A1 (zh) 2013-04-05
US20170051270A1 (en) 2017-02-23
US20150329848A1 (en) 2015-11-19
BR112012002151B1 (pt) 2021-07-06
US8759026B2 (en) 2014-06-24
CN102549145A (zh) 2012-07-04
KR101573972B1 (ko) 2015-12-02
KR20170081747A (ko) 2017-07-12
BR122021005965B1 (pt) 2022-01-25
KR20120046301A (ko) 2012-05-09
KR101808496B1 (ko) 2017-12-12
US20140329294A1 (en) 2014-11-06
JP6883071B2 (ja) 2021-06-09
JP2021112210A (ja) 2021-08-05
US10072254B2 (en) 2018-09-11

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