IL98319A - Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them - Google Patents
Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing themInfo
- Publication number
- IL98319A IL98319A IL98319A IL9831991A IL98319A IL 98319 A IL98319 A IL 98319A IL 98319 A IL98319 A IL 98319A IL 9831991 A IL9831991 A IL 9831991A IL 98319 A IL98319 A IL 98319A
- Authority
- IL
- Israel
- Prior art keywords
- radicals
- carbon atoms
- alkyl
- optionally substituted
- radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epoxy Resins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9008538A FR2664271B1 (fr) | 1990-07-05 | 1990-07-05 | Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
FR9104882A FR2675503B1 (fr) | 1991-04-19 | 1991-04-19 | Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
Publications (2)
Publication Number | Publication Date |
---|---|
IL98319A0 IL98319A0 (en) | 1992-06-21 |
IL98319A true IL98319A (en) | 1997-04-15 |
Family
ID=26228128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL98319A IL98319A (en) | 1990-07-05 | 1991-05-31 | Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
US (3) | US5412101A (es) |
EP (1) | EP0465368B1 (es) |
JP (2) | JP3192171B2 (es) |
KR (1) | KR100216006B1 (es) |
CN (1) | CN1045769C (es) |
AT (1) | ATE166344T1 (es) |
AU (1) | AU653160B2 (es) |
CA (1) | CA2046265C (es) |
DE (1) | DE69129428T2 (es) |
DK (1) | DK0465368T3 (es) |
ES (1) | ES2117001T3 (es) |
FI (1) | FI111542B (es) |
HU (1) | HU217444B (es) |
IE (1) | IE912335A1 (es) |
IL (1) | IL98319A (es) |
MA (1) | MA22203A1 (es) |
MX (1) | MX9100092A (es) |
OA (1) | OA09506A (es) |
RU (1) | RU2086542C1 (es) |
UA (1) | UA26130A (es) |
WO (1) | WO2004074258A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
DK0573218T3 (da) * | 1992-06-02 | 2001-06-18 | Sankyo Co | 4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse |
GB9213934D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Chemical compounds |
GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
IT1255461B (it) * | 1992-07-28 | 1995-11-02 | Luso Farmaco Inst | Eteri di imidazoli ad attivita' a ii antagonista |
US5376666A (en) * | 1992-11-30 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl |
JP3501484B2 (ja) * | 1992-12-17 | 2004-03-02 | 三共株式会社 | ビフェニル誘導体 |
FR2711367B1 (fr) * | 1993-10-19 | 1995-12-01 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
US5395844A (en) * | 1993-06-10 | 1995-03-07 | The Du Pont Merck Pharmaceutical Company | Imidazole 5-position substituted angiotensin II antagonists |
US5409926A (en) * | 1993-07-19 | 1995-04-25 | Merck & Co., Inc. | AT-2 antagonist inhibition of vascular restenosis |
FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
DE69532245T2 (de) * | 1994-09-26 | 2004-09-16 | Shionogi & Co., Ltd. | Imidazolderivat |
EP0855392A3 (de) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19739113A1 (de) * | 1997-09-06 | 1999-03-11 | Gefinex Polymerschaeume Gmbh | Vorexpandierte polyolefinische Schaumpartikel |
DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
KR20010048940A (ko) * | 1999-11-30 | 2001-06-15 | 서평원 | 프로세서의 디바이스 제어 시스템 |
KR20040022238A (ko) * | 2001-08-09 | 2004-03-11 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체 화합물 및 그 화합물을 유효성분으로서 함유하는 약제 |
EP1752450A1 (en) | 2005-08-01 | 2007-02-14 | Merck Sante | Imidazole derivatives as fructose-1,6-bisphosphatase inhibitors and pharmaceutical compositions containing them |
US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7828840B2 (en) | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
EP2321281A4 (en) * | 2008-09-02 | 2011-09-28 | Elder Pharmaceuticals Ltd | INFLAMMATORY CONNECTIONS |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EA201592263A1 (ru) | 2013-06-05 | 2016-05-31 | Синерджи Фармасьютикалз, Инк. | Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования |
JP6807684B2 (ja) * | 2016-09-08 | 2021-01-06 | ナブテスコ株式会社 | シールアダプタ |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179512A (en) * | 1977-03-01 | 1979-12-18 | Merck & Co., Inc. | 4-Substituted-2-arylimidazoles |
PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US4882348A (en) * | 1987-12-29 | 1989-11-21 | Smithkline Beckman Corporation | 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
-
1991
- 1991-05-31 IL IL98319A patent/IL98319A/xx not_active IP Right Cessation
- 1991-07-03 MA MA22476A patent/MA22203A1/fr unknown
- 1991-07-04 EP EP91401857A patent/EP0465368B1/fr not_active Expired - Lifetime
- 1991-07-04 AT AT91401857T patent/ATE166344T1/de not_active IP Right Cessation
- 1991-07-04 ES ES91401857T patent/ES2117001T3/es not_active Expired - Lifetime
- 1991-07-04 FI FI913250A patent/FI111542B/fi not_active IP Right Cessation
- 1991-07-04 KR KR1019910011310A patent/KR100216006B1/ko not_active IP Right Cessation
- 1991-07-04 DE DE69129428T patent/DE69129428T2/de not_active Expired - Fee Related
- 1991-07-04 IE IE233591A patent/IE912335A1/en not_active IP Right Cessation
- 1991-07-04 US US07/838,289 patent/US5412101A/en not_active Expired - Lifetime
- 1991-07-04 RU SU915001537A patent/RU2086542C1/ru not_active IP Right Cessation
- 1991-07-04 HU HU265/91A patent/HU217444B/hu not_active IP Right Cessation
- 1991-07-04 AU AU80163/91A patent/AU653160B2/en not_active Ceased
- 1991-07-04 WO PCT/FR1991/000543 patent/WO2004074258A1/fr unknown
- 1991-07-04 DK DK91401857T patent/DK0465368T3/da active
- 1991-07-04 UA UA5001537A patent/UA26130A/uk unknown
- 1991-07-04 CA CA002046265A patent/CA2046265C/fr not_active Expired - Fee Related
- 1991-07-05 MX MX9100092A patent/MX9100092A/es active IP Right Grant
- 1991-07-05 OA OA60035A patent/OA09506A/fr unknown
- 1991-07-05 CN CN91105292A patent/CN1045769C/zh not_active Expired - Fee Related
- 1991-07-05 JP JP19114491A patent/JP3192171B2/ja not_active Expired - Fee Related
-
1995
- 1995-01-09 US US08/369,909 patent/US5599830A/en not_active Expired - Fee Related
-
1996
- 1996-10-09 US US08/723,471 patent/US5684028A/en not_active Expired - Fee Related
-
2000
- 2000-10-18 JP JP2000317651A patent/JP3261403B2/ja not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
HCE | Change of name and address of proprietor(s) | ||
KB | Patent renewed | ||
HCA | Change of name of proprietor(s) after amalgamation | ||
MM9K | Patent not in force due to non-payment of renewal fees |