IL98143A - Polymeric balloons filled with air or gas used as suspensions in liquid carriers for ambiguous acography - Google Patents
Polymeric balloons filled with air or gas used as suspensions in liquid carriers for ambiguous acographyInfo
- Publication number
- IL98143A IL98143A IL9814391A IL9814391A IL98143A IL 98143 A IL98143 A IL 98143A IL 9814391 A IL9814391 A IL 9814391A IL 9814391 A IL9814391 A IL 9814391A IL 98143 A IL98143 A IL 98143A
- Authority
- IL
- Israel
- Prior art keywords
- polymer
- membrane
- phase
- mlcroballoons
- hydrophobic
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Acoustics & Sound (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Materials For Medical Uses (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP90810367 | 1990-05-18 |
Publications (2)
Publication Number | Publication Date |
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IL98143A0 IL98143A0 (en) | 1992-06-21 |
IL98143A true IL98143A (en) | 1995-10-31 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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IL9814391A IL98143A (en) | 1990-05-18 | 1991-05-15 | Polymeric balloons filled with air or gas used as suspensions in liquid carriers for ambiguous acography |
Country Status (19)
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US (7) | US5711933A (ja) |
EP (1) | EP0458745B2 (ja) |
JP (1) | JP2897190B2 (ja) |
KR (1) | KR0142180B1 (ja) |
CN (1) | CN1055414C (ja) |
AT (1) | ATE112173T1 (ja) |
AU (1) | AU636481B2 (ja) |
CA (1) | CA2042722C (ja) |
DE (1) | DE69104264T3 (ja) |
DK (1) | DK0458745T4 (ja) |
ES (1) | ES2061217T5 (ja) |
HU (2) | HUT58508A (ja) |
IE (1) | IE66895B1 (ja) |
IL (1) | IL98143A (ja) |
IS (1) | IS1862B (ja) |
NZ (1) | NZ238160A (ja) |
PL (1) | PL166827B1 (ja) |
RU (1) | RU2110991C1 (ja) |
ZA (1) | ZA913729B (ja) |
Families Citing this family (275)
Publication number | Priority date | Publication date | Assignee | Title |
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US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
US20010024638A1 (en) * | 1992-11-02 | 2001-09-27 | Michel Schneider | Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof |
US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US7083778B2 (en) | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US20040208826A1 (en) * | 1990-04-02 | 2004-10-21 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
IN172208B (ja) | 1990-04-02 | 1993-05-01 | Sint Sa | |
USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US6989141B2 (en) | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
US20030194376A1 (en) * | 1990-05-18 | 2003-10-16 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US5562099A (en) * | 1990-10-05 | 1996-10-08 | Massachusetts Institute Of Technology | Polymeric microparticles containing agents for imaging |
US5487390A (en) * | 1990-10-05 | 1996-01-30 | Massachusetts Institute Of Technology | Gas-filled polymeric microbubbles for ultrasound imaging |
US5370901A (en) | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
GB9106686D0 (en) † | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
DE69219331T3 (de) * | 1991-06-03 | 2001-06-07 | Nycomed Imaging As, Oslo | Verbesserungen im bezug auf kontrastmittel |
GB9116610D0 (en) * | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
NZ244147A (en) † | 1991-09-03 | 1994-09-27 | Hoechst Ag | Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents |
US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
DK0605477T4 (da) * | 1991-09-17 | 2007-10-01 | Ge Healthcare As | Gasformige ultralydskontrastmidler |
MX9205298A (es) | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
GB9200391D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
RU2122432C1 (ru) * | 1992-03-06 | 1998-11-27 | Нюкомед Имагинг АС | Контрастные агенты и их применение |
US5674468A (en) * | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
GB9204918D0 (en) | 1992-03-06 | 1992-04-22 | Nycomed As | Chemical compounds |
DE4219723A1 (de) * | 1992-06-13 | 1993-12-16 | Schering Ag | Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik |
US6383470B1 (en) | 1992-09-26 | 2002-05-07 | Thomas Fritzsch | Microparticle preparations made of biodegradable copolymers |
DE4232755A1 (de) * | 1992-09-26 | 1994-03-31 | Schering Ag | Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren |
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
EP0680341B1 (en) * | 1993-01-25 | 2001-05-09 | Sonus Pharmaceuticals, Inc. | Phase shift colloids as ultrasound contrast agents |
US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
CZ350895A3 (en) * | 1993-07-02 | 1996-10-16 | Molecular Biosystems Inc | In protein encapsulated micro-spheres containing insoluble gas as well as their preparation and use as ultrasonic diagnostic |
US5855865A (en) * | 1993-07-02 | 1999-01-05 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
CA2164813C (en) * | 1993-07-30 | 2009-11-24 | Ernest G. Schutt | Stabilized microbubble compositions for ultrasound |
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1991
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- 1991-05-14 DE DE69104264T patent/DE69104264T3/de not_active Expired - Lifetime
- 1991-05-14 ES ES91810366T patent/ES2061217T5/es not_active Expired - Lifetime
- 1991-05-14 DK DK91810366T patent/DK0458745T4/da active
- 1991-05-14 AT AT91810366T patent/ATE112173T1/de not_active IP Right Cessation
- 1991-05-14 EP EP91810366A patent/EP0458745B2/en not_active Expired - Lifetime
- 1991-05-15 IL IL9814391A patent/IL98143A/en not_active IP Right Cessation
- 1991-05-15 KR KR1019910007865A patent/KR0142180B1/ko not_active IP Right Cessation
- 1991-05-15 IS IS3707A patent/IS1862B/is unknown
- 1991-05-16 CA CA002042722A patent/CA2042722C/en not_active Expired - Lifetime
- 1991-05-16 NZ NZ238160A patent/NZ238160A/en unknown
- 1991-05-16 HU HU911646A patent/HUT58508A/hu unknown
- 1991-05-16 PL PL91290271A patent/PL166827B1/pl not_active IP Right Cessation
- 1991-05-16 ZA ZA913729A patent/ZA913729B/xx unknown
- 1991-05-16 HU HU9101646A patent/HU226007B1/hu unknown
- 1991-05-17 IE IE168791A patent/IE66895B1/en not_active IP Right Cessation
- 1991-05-17 JP JP3113100A patent/JP2897190B2/ja not_active Expired - Fee Related
- 1991-05-17 RU SU4895423A patent/RU2110991C1/ru active
- 1991-05-17 CN CN91103411A patent/CN1055414C/zh not_active Expired - Lifetime
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1994
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1997
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- 1997-09-12 US US08/929,274 patent/US6123922A/en not_active Expired - Fee Related
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2003
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