IL95975A - N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them - Google Patents

N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them

Info

Publication number
IL95975A
IL95975A IL95975A IL9597590A IL95975A IL 95975 A IL95975 A IL 95975A IL 95975 A IL95975 A IL 95975A IL 9597590 A IL9597590 A IL 9597590A IL 95975 A IL95975 A IL 95975A
Authority
IL
Israel
Prior art keywords
group
derivatives
alkylbenzimidazole
benzyl
production
Prior art date
Application number
IL95975A
Other languages
English (en)
Other versions
IL95975A0 (en
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to IL115437A priority Critical patent/IL115437A/en
Publication of IL95975A0 publication Critical patent/IL95975A0/xx
Publication of IL95975A publication Critical patent/IL95975A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Steroid Compounds (AREA)
IL95975A 1989-10-24 1990-10-12 N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them IL95975A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL115437A IL115437A (en) 1989-10-24 1990-10-12 N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP27738589 1989-10-24
JP32897489 1989-12-18
JP514790 1990-01-11
JP9167590 1990-04-05
JP9732490 1990-04-11
JP11314590 1990-04-27

Publications (2)

Publication Number Publication Date
IL95975A0 IL95975A0 (en) 1991-07-18
IL95975A true IL95975A (en) 1997-06-10

Family

ID=27547894

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95975A IL95975A (en) 1989-10-24 1990-10-12 N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US5128356A (de)
EP (1) EP0425921B1 (de)
JP (1) JP3099241B2 (de)
AT (1) ATE126219T1 (de)
AU (1) AU649418B2 (de)
CA (1) CA2028302C (de)
DE (1) DE69021502T2 (de)
FI (1) FI102068B (de)
HU (1) HUT55384A (de)
IE (1) IE67956B1 (de)
IL (1) IL95975A (de)
NO (1) NO177304C (de)
NZ (1) NZ235762A (de)
PT (2) PT95655B (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
ATE134624T1 (de) * 1990-02-19 1996-03-15 Ciba Geigy Ag Acylverbindungen
FR2670489B1 (fr) * 1990-12-18 1994-10-14 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2674523A1 (fr) * 1991-03-28 1992-10-02 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
DK0461039T3 (da) * 1990-06-08 1999-06-14 Hoechst Marion Roussel Inc Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
AU657498B2 (en) * 1990-12-14 1995-03-16 Novartis Ag Biphenylyl compounds
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
HUT67014A (en) * 1991-05-16 1995-01-30 Glaxo Group Ltd Benzofuran derivatives, pharmaceutical compositions containing them and process for the preparation of thereof
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
TW300219B (de) * 1991-09-14 1997-03-11 Hoechst Ag
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
JP2682353B2 (ja) * 1991-11-20 1997-11-26 武田薬品工業株式会社 経口用医薬組成物およびその製造法
TW284688B (de) * 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
ATE190058T1 (de) * 1991-12-27 2000-03-15 Kyowa Hakko Kogyo Kk Tricyclische verbindungen als angiotensin-ii- antagonisten
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
WO1993017682A1 (en) * 1992-03-04 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP2787539B2 (ja) * 1993-02-26 1998-08-20 松森　　昭 ウイルス性疾患の予防または治療剤
JP2003306432A (ja) * 1993-04-22 2003-10-28 Takeda Chem Ind Ltd 腎疾患の予防または治療剤
JP3810020B2 (ja) * 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
CA2125251C (en) 1993-06-07 2005-04-26 Yoshiyuki Inada A pharmaceutical composition for angiotensin ii-mediated diseases
US5721263A (en) 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
ZA945190B (en) * 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
AU679616B2 (en) * 1994-04-19 1997-07-03 Tanabe Seiyaku Co., Ltd. Imidazopyridine derivatives and process for preparing the same
US5753672A (en) * 1994-04-19 1998-05-19 Tanabe Seiyaku Co., Ltd. Imidazopyridine derivatives and process for preparing the same
CA2150610C (en) * 1994-06-01 1999-08-17 Mikiro Yanaka Benzene derivatives and pharmaceutical composition
AU677702B2 (en) * 1994-10-13 1997-05-01 Takeda Pharmaceutical Company Limited A prophylactic or therapeutic drug for renal diseases
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JP3166065B2 (ja) * 1996-02-08 2001-05-14 東京エレクトロン株式会社 処理装置及び処理方法
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MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
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WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
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US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
LT2624696T (lt) 2010-10-06 2017-03-10 Glaxosmithkline Llc Benzimidazolo deriniai kaip pi3 kinazės inhibitoriai
JP6359008B2 (ja) 2012-06-11 2018-07-18 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ−アルファ調節ベンゾイミダゾール
EP2970384A1 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonisten der guanylatcyclase und deren verwendungen
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP3514147B1 (de) 2013-04-04 2022-08-03 University of Maryland, Baltimore Steroidale verbindungen mit potenter androgenrezeptor-herabregulation und wirkung gegen prostatakrebs
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2016032538A1 (en) 2014-08-30 2016-03-03 Innovative Building Technologies, Llc Diaphragm to lateral support coupling in a structure
WO2016032537A1 (en) 2014-08-30 2016-03-03 Innovative Building Technologies, Llc A prefabricated wall panel for utility installation
CZ2015687A3 (cs) 2015-10-02 2017-04-12 Zentiva, K.S. Farmaceutická kompozice obsahující kombinaci kandesartanu, amlodipinu a hydrochlorthiazidu
WO2017156014A1 (en) 2016-03-07 2017-09-14 Innovative Building Technologies, Llc Waterproofing assemblies and prefabricated wall panels including the same
JP6806784B2 (ja) 2016-03-07 2021-01-06 イノベイティブ ビルディング テクノロジーズ，エルエルシー 建物のスラブを含まない床システム用の床及び天井パネル
JP6820939B2 (ja) 2016-03-07 2021-01-27 イノベイティブ ビルディング テクノロジーズ，エルエルシー 公共設備設置用の事前に組み立てられた壁パネル
JP6786617B2 (ja) 2016-03-07 2020-11-18 イノベイティブ ビルディング テクノロジーズ，エルエルシー 外部導管係合特徴部を備えたプレハブ式間仕切り壁
JP7090069B2 (ja) * 2017-03-15 2022-06-23 住友ファーマ株式会社 重水素化ベンズイミダゾール化合物およびその医薬用途
US10487493B2 (en) 2017-05-12 2019-11-26 Innovative Building Technologies, Llc Building design and construction using prefabricated components
US10323428B2 (en) 2017-05-12 2019-06-18 Innovative Building Technologies, Llc Sequence for constructing a building from prefabricated components
US10724228B2 (en) 2017-05-12 2020-07-28 Innovative Building Technologies, Llc Building assemblies and methods for constructing a building using pre-assembled floor-ceiling panels and walls
US11098475B2 (en) 2017-05-12 2021-08-24 Innovative Building Technologies, Llc Building system with a diaphragm provided by pre-fabricated floor panels
JP7038004B2 (ja) 2018-05-24 2022-03-17 本田技研工業株式会社 光学部品の洗浄方法及び洗浄装置

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EP0400835A1 (de) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituierte Benzimidazole als Angiotensin II-Hemmer
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same

Also Published As

Publication number Publication date
JP3099241B2 (ja) 2000-10-16
JPH049373A (ja) 1992-01-14
DE69021502T2 (de) 1996-01-11
HUT55384A (en) 1991-05-28
FI102068B1 (fi) 1998-10-15
EP0425921A1 (de) 1991-05-08
PT95655A (pt) 1991-09-13
NO904569L (no) 1991-04-25
AU649418B2 (en) 1994-05-26
IL95975A0 (en) 1991-07-18
EP0425921B1 (de) 1995-08-09
FI102068B (fi) 1998-10-15
NO177304C (no) 1995-08-23
IE67956B1 (en) 1996-05-15
FI905215A0 (fi) 1990-10-23
PT101875A (pt) 1997-12-31
DE69021502D1 (de) 1995-09-14
NO904569D0 (no) 1990-10-23
PT95655B (pt) 1996-09-30
CA2028302A1 (en) 1991-04-25
AU6461290A (en) 1991-05-02
HU906539D0 (en) 1991-04-29
PT101875B (pt) 1999-04-30
US5128356A (en) 1992-07-07
NZ235762A (en) 1992-04-28
CA2028302C (en) 2002-01-15
NO177304B (no) 1995-05-15
IE903803A1 (en) 1991-04-24
ATE126219T1 (de) 1995-08-15

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