RU94031162A - Производные 19-нор-стероидов, имеющих 11-бета-положении тиокарбоновую цепь, способы их получения, фармацевтическая композиция и промежуточные продукты синтеза - Google Patents

Производные 19-нор-стероидов, имеющих 11-бета-положении тиокарбоновую цепь, способы их получения, фармацевтическая композиция и промежуточные продукты синтеза

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Publication number
RU94031162A
RU94031162A RU94031162/04A RU94031162A RU94031162A RU 94031162 A RU94031162 A RU 94031162A RU 94031162/04 A RU94031162/04 A RU 94031162/04A RU 94031162 A RU94031162 A RU 94031162A RU 94031162 A RU94031162 A RU 94031162A
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RU
Russia
Prior art keywords
synthesis
alkyl
hydrogen
compounds
chain
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RU94031162/04A
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English (en)
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RU2111213C1 (ru
Inventor
Клоссне Андре
Fr]
Нике Франсуа
Тетш Жан-Жорж
Ван де Вельд Патрик
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Руссель-Юклаф (FR)
Руссель-Юклаф
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Publication of RU94031162A publication Critical patent/RU94031162A/ru
Application granted granted Critical
Publication of RU2111213C1 publication Critical patent/RU2111213C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Объектом изобретения являются соединения формулы I, где Rи R'вместе образуют кетонную, гидразоновую, оксимную или метиленовую группу или являются водородом, алкилом, алкенилом или алкинилом, необязательно замещенным; R- водород, алкил; R- водород, галоид, алкил; m = 0, 1 или 2; X - метилен, арилен или ариленокси, связанный со стероидом через атом углерода; Y - алифатическая цепь, линейная или разветвленная, насыщенная или ненасыщенная, необязательно прерванная атомом кислорода; Z - алкил, линейный или разветвленный, или арил, или арилалкил, и соли присоединения этих соединений, их получение, применение в качестве лекарства, композиции, содержащие их, и новые промежуточные продукты для их получения.

Claims (1)

  1. Объектом изобретения являются соединения формулы I, где R17 и R'17 вместе образуют кетонную, гидразоновую, оксимную или метиленовую группу или являются водородом, алкилом, алкенилом или алкинилом, необязательно замещенным; R3 - водород, алкил; R16 - водород, галоид, алкил; m = 0, 1 или 2; X - метилен, арилен или ариленокси, связанный со стероидом через атом углерода; Y - алифатическая цепь, линейная или разветвленная, насыщенная или ненасыщенная, необязательно прерванная атомом кислорода; Z - алкил, линейный или разветвленный, или арил, или арилалкил, и соли присоединения этих соединений, их получение, применение в качестве лекарства, композиции, содержащие их, и новые промежуточные продукты для их получения.
RU94031162/04A 1991-12-20 1992-12-17 Производные 19-норстероидов, способы их получения, фармацевтическая композиция и промежуточные соединения RU2111213C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9115856A FR2685332A1 (fr) 1991-12-20 1991-12-20 Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
FR91/15856 1991-12-20

Publications (2)

Publication Number Publication Date
RU94031162A true RU94031162A (ru) 1996-04-20
RU2111213C1 RU2111213C1 (ru) 1998-05-20

Family

ID=9420274

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94031162/04A RU2111213C1 (ru) 1991-12-20 1992-12-17 Производные 19-норстероидов, способы их получения, фармацевтическая композиция и промежуточные соединения

Country Status (20)

Country Link
US (2) US6281204B1 (ru)
EP (1) EP0623140B1 (ru)
JP (1) JP3445271B2 (ru)
KR (1) KR100278465B1 (ru)
CN (1) CN1036718C (ru)
AT (1) ATE165365T1 (ru)
AU (1) AU666916B2 (ru)
CA (1) CA2124339C (ru)
DE (1) DE69225243T2 (ru)
DK (1) DK0623140T3 (ru)
ES (1) ES2115754T3 (ru)
FI (1) FI114866B (ru)
FR (1) FR2685332A1 (ru)
HU (1) HU221482B (ru)
IL (1) IL104105A (ru)
MX (1) MX9207421A (ru)
NZ (1) NZ246624A (ru)
RU (1) RU2111213C1 (ru)
WO (1) WO1993013123A1 (ru)
ZA (1) ZA929859B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
FR2706454B1 (fr) * 1993-06-17 1995-09-15 Roussel Uclaf Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant.
DE19510862A1 (de) * 1995-03-16 1996-09-19 Schering Ag Verwendung von Antiestrogenen zur männlichen Fertilitätskontrolle
DE19526146A1 (de) * 1995-07-07 1997-01-09 Schering Ag Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE19724187A1 (de) 1997-06-02 1998-12-03 Schering Ag 11beta-Arylsubstituierte 14,17-Ethanoestratriene, Verfahren zur Herstellung dieser Verbindungen, sowie ihre Verwendung zur Herstellung von Arzneimitteln
HUP9802054A3 (en) * 1997-10-14 2001-02-28 Bayer Ag Process for producing 4,4,5,5,5-pentafluor-1-pentanol
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6503896B1 (en) 1997-12-24 2003-01-07 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
FR2780060B1 (fr) * 1998-06-23 2000-08-04 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant
ATE222922T1 (de) * 1998-11-20 2002-09-15 Akzo Nobel Nv Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11
DE19929715A1 (de) * 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
EP1238285A1 (en) * 1999-11-30 2002-09-11 Akzo Nobel N.V. Steroid compounds for steroid receptor binding assays
WO2005090379A1 (en) * 2004-03-17 2005-09-29 The Central Science Laboratory, 'csl' Compounds and sensor for detecion of polycyclic aromatic hydrocarbons
EP1623713A1 (en) * 2004-07-09 2006-02-08 Proskelia SAS Cominations of pure anti-estrogen with aromatase inhibitors
EP1630167A1 (en) * 2004-07-09 2006-03-01 Proskelia SAS Polymorphs of 19-Nor steroid derivatives
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
DE102008061722A1 (de) 2008-12-12 2010-06-17 Saltigo Gmbh Verfahren zur Herstellung von Perfluoralkyl- oder Perfluoralkoxyalkanolen
CA2935015C (en) 2014-01-29 2022-05-31 Umecrine Cognition Ab Steroid compound for use in the treatment of hepatic encephalopathy
AR103384A1 (es) 2015-01-12 2017-05-03 Umecrine Cognition Ab 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA
US10278977B2 (en) 2016-06-06 2019-05-07 Umecrine Cognition Ab Methods for treating hypersomnolence
CN110117217B (zh) * 2018-12-19 2021-09-28 浙江普洛家园药业有限公司 1-溴代甲基-2,3,5,6-四氟-4-(三氟甲基)苯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
ES2112268T3 (es) * 1990-08-14 1998-04-01 Hoechst Marion Roussel Inc Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.

Also Published As

Publication number Publication date
AU3357093A (en) 1993-07-28
RU2111213C1 (ru) 1998-05-20
CN1036718C (zh) 1997-12-17
FR2685332B1 (ru) 1995-06-02
HU221482B (en) 2002-10-28
DK0623140T3 (da) 1999-02-15
CA2124339A1 (fr) 1993-07-08
ES2115754T3 (es) 1998-07-01
IL104105A (en) 1997-07-13
CA2124339C (fr) 2005-02-15
AU666916B2 (en) 1996-02-29
US6596885B2 (en) 2003-07-22
NZ246624A (en) 1995-12-21
MX9207421A (es) 1993-07-01
WO1993013123A1 (fr) 1993-07-08
ATE165365T1 (de) 1998-05-15
DE69225243T2 (de) 1998-10-29
HUT68068A (en) 1995-05-29
FI114866B (fi) 2005-01-14
KR100278465B1 (ko) 2001-02-01
ZA929859B (en) 1993-12-20
IL104105A0 (en) 1993-05-13
FI942944A (fi) 1994-06-17
FI942944A0 (fi) 1994-06-17
CN1075722A (zh) 1993-09-01
EP0623140B1 (fr) 1998-04-22
US20020072624A1 (en) 2002-06-13
US6281204B1 (en) 2001-08-28
HU9402134D0 (en) 1994-09-28
EP0623140A1 (fr) 1994-11-09
JP3445271B2 (ja) 2003-09-08
FR2685332A1 (fr) 1993-06-25
DE69225243D1 (de) 1998-05-28
JPH07502281A (ja) 1995-03-09

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Effective date: 20061218