IL95610A - HISTORY OF N-ARIL AND N-TROARILAMIDE AND URAA AND PHARMACEUTICALS FOR INHIBITION OF NOZLE COENZIMA A: NOZOLOL CHOLSTROL - Google Patents

HISTORY OF N-ARIL AND N-TROARILAMIDE AND URAA AND PHARMACEUTICALS FOR INHIBITION OF NOZLE COENZIMA A: NOZOLOL CHOLSTROL

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Publication number
IL95610A
IL95610A IL9561090A IL9561090A IL95610A IL 95610 A IL95610 A IL 95610A IL 9561090 A IL9561090 A IL 9561090A IL 9561090 A IL9561090 A IL 9561090A IL 95610 A IL95610 A IL 95610A
Authority
IL
Israel
Prior art keywords
amide
alkyl
group
phenyl
substituted
Prior art date
Application number
IL9561090A
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English (en)
Hebrew (he)
Other versions
IL95610A0 (en
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL95610A0 publication Critical patent/IL95610A0/xx
Priority to IL11032194A priority Critical patent/IL110321A0/xx
Priority to IL11032494A priority patent/IL110324A0/xx
Publication of IL95610A publication Critical patent/IL95610A/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/72—Nitrogen atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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IL9561090A 1989-09-15 1990-09-07 HISTORY OF N-ARIL AND N-TROARILAMIDE AND URAA AND PHARMACEUTICALS FOR INHIBITION OF NOZLE COENZIMA A: NOZOLOL CHOLSTROL IL95610A (en)

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IL11032194A IL110321A0 (en) 1989-09-15 1994-07-14 Intermediates to n-aryl and n-heteroarylamide and urea derivatives
IL11032494A IL110324A0 (en) 1989-09-15 1994-07-14 Intermediates to n-aryl and n-heteroarylamide and urea derivatives

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PCT/US1989/004033 WO1991004027A1 (en) 1989-09-15 1989-09-15 New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)

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IL11032194A IL110321A0 (en) 1989-09-15 1994-07-14 Intermediates to n-aryl and n-heteroarylamide and urea derivatives
IL11032494A IL110324A0 (en) 1989-09-15 1994-07-14 Intermediates to n-aryl and n-heteroarylamide and urea derivatives

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ES2127878T3 (es) 1999-05-01
CA2025301A1 (en) 1991-03-16
EP0418071A3 (en) 1992-03-25
PL291471A1 (en) 1992-06-26
IL95610A0 (en) 1991-06-30
CA2025301C (en) 2001-10-16
PL165357B1 (pl) 1994-12-30
PT95310B (pt) 1997-06-30
DE69032981T2 (de) 1999-07-08
DE69018908T2 (de) 1995-08-24
HUT70027A (en) 1995-09-28
DE69032981D1 (de) 1999-04-08
GR3029826T3 (en) 1999-06-30
ATE177082T1 (de) 1999-03-15
FI904537A0 (fi) 1990-09-14
NZ235323A (en) 1993-02-25
AU652345B2 (en) 1994-08-25
WO1991004027A1 (en) 1991-04-04
CN1050183A (zh) 1991-03-27
IE66324B1 (en) 1995-12-27
JPH03120243A (ja) 1991-05-22
DK0418071T3 (da) 1995-09-04
IL110321A0 (en) 1994-10-21
DK0609960T3 (da) 1999-09-27
PT95310A (pt) 1991-05-22
AU6255390A (en) 1991-04-18
HU9302945D0 (en) 1993-12-28
EP0609960B1 (en) 1999-03-03
EP0418071B1 (en) 1995-04-26
KR930011303B1 (ko) 1993-11-29
NO904022L (no) 1991-03-18
JPH0825974B2 (ja) 1996-03-13
DE69018908D1 (de) 1995-06-01
EG19358A (en) 1994-12-30
PL291472A1 (en) 1992-07-13
ZA907346B (en) 1992-05-27
ES2071033T3 (es) 1995-06-16
PL165370B1 (pl) 1994-12-30
EP0418071A2 (en) 1991-03-20
FI111362B (fi) 2003-07-15
ATE121730T1 (de) 1995-05-15
IL110324A0 (en) 1994-10-21
MX22406A (es) 1994-01-31
NO904022D0 (no) 1990-09-14
EP0609960A1 (en) 1994-08-10
IE903336A1 (en) 1991-04-10
KR910006233A (ko) 1991-04-27
DD298092A5 (de) 1992-02-06
PL291470A1 (en) 1992-07-13

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