IL95046A - Substituted 2-imidazolines and pharmaceutical compositions containing them. - Google Patents
Substituted 2-imidazolines and pharmaceutical compositions containing them.Info
- Publication number
- IL95046A IL95046A IL9504690A IL9504690A IL95046A IL 95046 A IL95046 A IL 95046A IL 9504690 A IL9504690 A IL 9504690A IL 9504690 A IL9504690 A IL 9504690A IL 95046 A IL95046 A IL 95046A
- Authority
- IL
- Israel
- Prior art keywords
- chloro
- fluoro
- pyridyl
- bromo
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nonmetallic Welding Materials (AREA)
- External Artificial Organs (AREA)
- Lubricants (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK344489A DK344489D0 (da) | 1989-07-12 | 1989-07-12 | Substituerede 2-imidazoliner og fremstilling og anvendelse deraf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL95046A0 IL95046A0 (en) | 1991-06-10 |
| IL95046A true IL95046A (en) | 1995-03-15 |
Family
ID=8122944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9504690A IL95046A (en) | 1989-07-12 | 1990-07-11 | Substituted 2-imidazolines and pharmaceutical compositions containing them. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5262430A (de) |
| EP (1) | EP0482108B1 (de) |
| JP (1) | JPH04506968A (de) |
| KR (1) | KR927003578A (de) |
| CN (1) | CN1049343A (de) |
| AT (1) | ATE135703T1 (de) |
| AU (1) | AU637393B2 (de) |
| CA (1) | CA2064095A1 (de) |
| DD (1) | DD296489A5 (de) |
| DE (1) | DE69026087T2 (de) |
| DK (2) | DK344489D0 (de) |
| ES (1) | ES2086409T3 (de) |
| FI (1) | FI920118A0 (de) |
| GR (1) | GR1000716B (de) |
| IE (1) | IE74210B1 (de) |
| IL (1) | IL95046A (de) |
| NO (1) | NO920143L (de) |
| NZ (1) | NZ234451A (de) |
| PT (1) | PT94685B (de) |
| WO (1) | WO1991000862A1 (de) |
| YU (1) | YU136390A (de) |
| ZA (1) | ZA905422B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4201709A1 (de) * | 1992-01-23 | 1993-07-29 | Bayer Ag | (alpha)-aryl-(alpha)-hydroxy-ss-imidazolinyl-propionsaeureamide |
| US5750543A (en) * | 1996-02-01 | 1998-05-12 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US6410562B1 (en) | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| US20090162342A1 (en) * | 2001-06-07 | 2009-06-25 | Sanomune Inc. | Therapeutic uses of glandular kallikrein |
| BRPI0511722A (pt) * | 2004-06-01 | 2008-01-08 | Hoffmann La Roche | 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina |
| WO2013173923A1 (en) | 2012-05-25 | 2013-11-28 | Diamedica, Inc. | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
| PT2854841T (pt) | 2012-06-04 | 2017-05-15 | Diamedica Inc | Isoformas de glicosilação da calicreína 1 em tecido humano |
| US11857608B2 (en) | 2017-03-09 | 2024-01-02 | Diamedica Inc. | Dosage forms of tissue kallikrein 1 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5936885B2 (ja) * | 1976-06-24 | 1984-09-06 | 第一製薬株式会社 | 糖尿病治療剤 |
| ZW13782A1 (en) * | 1981-07-28 | 1982-10-06 | Reckitt & Colmann Prod Ltd | Imidazoline derivatives |
| GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
-
1989
- 1989-07-12 DK DK344489A patent/DK344489D0/da not_active Application Discontinuation
-
1990
- 1990-07-11 ZA ZA905422A patent/ZA905422B/xx unknown
- 1990-07-11 IL IL9504690A patent/IL95046A/en not_active IP Right Cessation
- 1990-07-11 CN CN90107080A patent/CN1049343A/zh active Pending
- 1990-07-11 NZ NZ234451A patent/NZ234451A/xx unknown
- 1990-07-12 ES ES90912283T patent/ES2086409T3/es not_active Expired - Lifetime
- 1990-07-12 US US07/781,269 patent/US5262430A/en not_active Expired - Fee Related
- 1990-07-12 DD DD90342726A patent/DD296489A5/de not_active IP Right Cessation
- 1990-07-12 DK DK90912283.0T patent/DK0482108T3/da active
- 1990-07-12 AU AU61644/90A patent/AU637393B2/en not_active Ceased
- 1990-07-12 FI FI920118A patent/FI920118A0/fi not_active Application Discontinuation
- 1990-07-12 EP EP90912283A patent/EP0482108B1/de not_active Expired - Lifetime
- 1990-07-12 GR GR900100535A patent/GR1000716B/el unknown
- 1990-07-12 WO PCT/DK1990/000184 patent/WO1991000862A1/en not_active Ceased
- 1990-07-12 KR KR1019920700067A patent/KR927003578A/ko not_active Ceased
- 1990-07-12 DE DE69026087T patent/DE69026087T2/de not_active Expired - Fee Related
- 1990-07-12 AT AT90912283T patent/ATE135703T1/de not_active IP Right Cessation
- 1990-07-12 JP JP2511434A patent/JPH04506968A/ja active Pending
- 1990-07-12 PT PT94685A patent/PT94685B/pt not_active IP Right Cessation
- 1990-07-12 CA CA002064095A patent/CA2064095A1/en not_active Abandoned
- 1990-07-12 YU YU136390A patent/YU136390A/sh unknown
- 1990-07-12 IE IE254690A patent/IE74210B1/en not_active IP Right Cessation
-
1992
- 1992-01-10 NO NO92920143A patent/NO920143L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6164490A (en) | 1991-02-06 |
| FI920118A7 (fi) | 1992-01-10 |
| EP0482108A1 (de) | 1992-04-29 |
| ES2086409T3 (es) | 1996-07-01 |
| CN1049343A (zh) | 1991-02-20 |
| CA2064095A1 (en) | 1991-01-13 |
| DD296489A5 (de) | 1991-12-05 |
| IE74210B1 (en) | 1997-07-16 |
| DE69026087T2 (de) | 1996-08-29 |
| NO920143D0 (no) | 1992-01-10 |
| IL95046A0 (en) | 1991-06-10 |
| YU136390A (sh) | 1993-10-20 |
| IE902546A1 (en) | 1991-02-27 |
| JPH04506968A (ja) | 1992-12-03 |
| AU637393B2 (en) | 1993-05-27 |
| GR900100535A (en) | 1991-12-10 |
| ATE135703T1 (de) | 1996-04-15 |
| US5262430A (en) | 1993-11-16 |
| PT94685A (pt) | 1991-03-20 |
| NZ234451A (en) | 1991-08-27 |
| PT94685B (pt) | 1997-04-30 |
| KR927003578A (ko) | 1992-12-18 |
| EP0482108B1 (de) | 1996-03-20 |
| FI920118A0 (fi) | 1992-01-10 |
| GR1000716B (el) | 1992-11-23 |
| WO1991000862A1 (en) | 1991-01-24 |
| DK0482108T3 (da) | 1996-07-22 |
| DK344489D0 (da) | 1989-07-12 |
| DE69026087D1 (de) | 1996-04-25 |
| NO920143L (no) | 1992-03-04 |
| ZA905422B (en) | 1991-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2572591B2 (ja) | 新規キノロン誘導体およびその塩 | |
| KR100196356B1 (ko) | 당뇨병 치료제 | |
| WO1999016766A1 (en) | Benzodioxole derivatives | |
| JPH04230381A (ja) | 置換されたピロロ−ピリジン類 | |
| JPH07116182B2 (ja) | トランス−６−〔２−（ｎ−ヘテロアリ−ル−３，５−ジ置換ピラゾ−ル−４−イル）エチル〕−またはエテニル〕テトラヒドロ−４−ヒドロキシピラン−２−オン | |
| JPH11514676A (ja) | 立体選択的脱酸素化反応 | |
| EP0482108B1 (de) | Substituierte 2-imidazoline und verfahren zur herstellung sowie deren verwendung | |
| JPWO1992002514A1 (ja) | 新規なベンゾピラン誘導体 | |
| JPS63280070A (ja) | ベンズアゼピン誘導体 | |
| AU749097B2 (en) | Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists | |
| JP6117948B2 (ja) | アルドステロン合成酵素阻害薬としての使用のためのジヒドロキノリン−２−オン誘導体 | |
| JPH06247935A (ja) | ６，７−ジアルコキシ−３，４−ジヒドロイソキノリン−８−オール類、その製造法及び該化合物を用いた６，７−ジアルコキシ−１，２，３，４−テトラヒドロイソキノリン−８−オール類の製造法 | |
| JPH04308570A (ja) | １−ピペラジニル−２−ブテンおよび２−ブチン、その製法およびその中間体 | |
| US5821245A (en) | Use of naphthalene derivatives in treating lung carcinoma | |
| CN105102445A (zh) | 作为醛固酮合酶(cyp11b2或cyp11b1)抑制剂的新二氢喹啉-2-酮衍生物 | |
| US6797714B2 (en) | Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists | |
| JP3985121B2 (ja) | ジヒドロキノリン誘導体 | |
| JPH0340025B2 (de) | ||
| CN105073732B (zh) | 用作醛固酮合酶抑制剂的二氢喹啉‑2‑酮衍生物 | |
| US4251663A (en) | Thiosubstituted pyridines | |
| US4645766A (en) | 1,2-dihydro-2-oxo-3-hydroxymethyl pyridines, compositions and use | |
| JPH0233714B2 (de) | ||
| JPH0319232B2 (de) | ||
| CZ20002257A3 (cs) | Karboxysubstituované chromanové deriváty, které lze použít jako beta-3-adrenoreceptorové agonisty | |
| JP2006514666A (ja) | ベンゾピラン系化合物、その製造方法及び用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |