IL90975A - Non-glycosylated, recombinant human il2 in reduced form, the process for obtaining it and its use as a medicament - Google Patents
Non-glycosylated, recombinant human il2 in reduced form, the process for obtaining it and its use as a medicamentInfo
- Publication number
- IL90975A IL90975A IL9097589A IL9097589A IL90975A IL 90975 A IL90975 A IL 90975A IL 9097589 A IL9097589 A IL 9097589A IL 9097589 A IL9097589 A IL 9097589A IL 90975 A IL90975 A IL 90975A
- Authority
- IL
- Israel
- Prior art keywords
- leu
- thr
- glu
- lys
- asn
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 32
- 230000008569 process Effects 0.000 title claims abstract description 24
- 239000003814 drug Substances 0.000 title claims abstract description 8
- 102000000588 Interleukin-2 Human genes 0.000 claims abstract description 54
- 108010002350 Interleukin-2 Proteins 0.000 claims abstract description 54
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims abstract description 14
- 230000004071 biological effect Effects 0.000 claims abstract description 14
- 102000055277 human IL2 Human genes 0.000 claims abstract description 14
- 235000018417 cysteine Nutrition 0.000 claims abstract description 9
- 150000001945 cysteines Chemical class 0.000 claims abstract 3
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- 108010025306 histidylleucine Proteins 0.000 claims description 7
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- BVLIJXXSXBUGEC-SRVKXCTJSA-N Asn-Asn-Tyr Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O BVLIJXXSXBUGEC-SRVKXCTJSA-N 0.000 claims description 4
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- VADLTGVIOIOKGM-BZSNNMDCSA-N Phe-His-Leu Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CN=CN1 VADLTGVIOIOKGM-BZSNNMDCSA-N 0.000 claims description 4
- ZTVSVSFBHUVYIN-UFYCRDLUSA-N Phe-Tyr-Met Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(O)=O)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=C(O)C=C1 ZTVSVSFBHUVYIN-UFYCRDLUSA-N 0.000 claims description 4
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- 230000002062 proliferating effect Effects 0.000 description 1
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- 239000004332 silver Substances 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8810184A FR2635527B1 (fr) | 1988-07-28 | 1988-07-28 | Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL90975A0 IL90975A0 (en) | 1990-02-09 |
| IL90975A true IL90975A (en) | 1994-11-28 |
Family
ID=9368873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9097589A IL90975A (en) | 1988-07-28 | 1989-07-14 | Non-glycosylated, recombinant human il2 in reduced form, the process for obtaining it and its use as a medicament |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5874076A (de) |
| EP (1) | EP0353150B1 (de) |
| JP (1) | JP3016793B2 (de) |
| KR (1) | KR0131070B1 (de) |
| CN (1) | CN1036532C (de) |
| AT (1) | ATE110783T1 (de) |
| AU (1) | AU624625B2 (de) |
| DE (1) | DE68917826T2 (de) |
| DK (1) | DK370489A (de) |
| ES (1) | ES2058573T3 (de) |
| FI (1) | FI96209C (de) |
| FR (1) | FR2635527B1 (de) |
| HU (1) | HU207099B (de) |
| IE (1) | IE64232B1 (de) |
| IL (1) | IL90975A (de) |
| MX (1) | MX16912A (de) |
| NZ (1) | NZ230111A (de) |
| PT (1) | PT91295B (de) |
| RU (1) | RU2105011C1 (de) |
| UA (1) | UA26846C2 (de) |
| ZA (1) | ZA895419B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2660863B1 (fr) * | 1990-04-17 | 1994-01-21 | Roussel Uclaf | Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour preparer une composition pharmaceutique destinee au traitement de cancers primitifs de la plevre. |
| FR2668368B1 (fr) * | 1990-10-30 | 1995-03-10 | Roussel Uclaf | Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour preparer une composition pharmaceutique destinee au traitement des tumeurs malignes epitheliales. |
| DE69031596T2 (de) * | 1990-11-23 | 1998-02-26 | Roussel Uclaf | Verfahren zur herstellung eines proteins gehörend zu der klasse der cytokine, das mindestens eine intramolekulare disulfidbrücke enthält, durch oxidation bei einem ph-wert kleiner als 5.0 des entsprechenden rekombinanten reduzierten proteins |
| FR2671728B1 (fr) * | 1991-01-17 | 1995-01-20 | Roussel Uclaf | Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour la preparation de compositions pharmaceutiques destinees au traitement des pneumathorax. |
| FR2684878B1 (fr) * | 1991-12-12 | 1994-02-11 | Roussel Uclaf | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
| US6470207B1 (en) * | 1999-03-23 | 2002-10-22 | Surgical Navigation Technologies, Inc. | Navigational guidance via computer-assisted fluoroscopic imaging |
| US20050203578A1 (en) * | 2001-08-15 | 2005-09-15 | Weiner Michael L. | Process and apparatus for treating biological organisms |
| RU2372356C2 (ru) * | 2003-08-07 | 2009-11-10 | Займоджинетикс, Инк. | Полипептид с антивирусной активностью, его получение и применение |
| KR102777151B1 (ko) | 2017-11-21 | 2025-03-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인터루킨-2의 부분 효능제 |
| CN111944036B (zh) | 2019-05-14 | 2024-09-06 | 上海盖浦生物科技有限公司 | 一种增殖免疫细胞的突变体蛋白 |
| WO2021146436A2 (en) | 2020-01-14 | 2021-07-22 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341562C (en) * | 1982-03-31 | 2007-11-27 | Tadatsugu Taniguchi | Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell |
| US5643566A (en) * | 1982-09-23 | 1997-07-01 | Cetus Corporation | Formulation processes for lipophilic proteins |
| US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| JPS60115528A (ja) * | 1983-11-28 | 1985-06-22 | Takeda Chem Ind Ltd | ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物 |
| US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US4604377A (en) * | 1984-03-28 | 1986-08-05 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
| EP0158487B1 (de) * | 1984-04-09 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Stabile Interleukin-2-Zusammensetzung |
| US4654830A (en) * | 1984-11-27 | 1987-03-31 | Monolithic Memories, Inc. | Method and structure for disabling and replacing defective memory in a PROM |
| US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| JPH0829113B2 (ja) * | 1986-11-11 | 1996-03-27 | 武田薬品工業株式会社 | ヒトインタ−ロイキン−２の製造法 |
-
1988
- 1988-07-28 FR FR8810184A patent/FR2635527B1/fr not_active Expired - Fee Related
-
1989
- 1989-07-14 IL IL9097589A patent/IL90975A/en unknown
- 1989-07-17 ZA ZA895419A patent/ZA895419B/xx unknown
- 1989-07-25 MX MX1691289A patent/MX16912A/es unknown
- 1989-07-26 DE DE68917826T patent/DE68917826T2/de not_active Expired - Lifetime
- 1989-07-26 AT AT89402124T patent/ATE110783T1/de not_active IP Right Cessation
- 1989-07-26 EP EP89402124A patent/EP0353150B1/de not_active Expired - Lifetime
- 1989-07-26 ES ES89402124T patent/ES2058573T3/es not_active Expired - Lifetime
- 1989-07-27 JP JP1192769A patent/JP3016793B2/ja not_active Expired - Lifetime
- 1989-07-27 HU HU893827A patent/HU207099B/hu not_active IP Right Cessation
- 1989-07-27 NZ NZ230111A patent/NZ230111A/en unknown
- 1989-07-27 DK DK370489A patent/DK370489A/da not_active Application Discontinuation
- 1989-07-27 PT PT91295A patent/PT91295B/pt not_active IP Right Cessation
- 1989-07-27 FI FI893587A patent/FI96209C/fi not_active IP Right Cessation
- 1989-07-27 IE IE244389A patent/IE64232B1/en not_active IP Right Cessation
- 1989-07-27 UA UA5010517A patent/UA26846C2/uk unknown
- 1989-07-28 CN CN89106242A patent/CN1036532C/zh not_active Expired - Fee Related
- 1989-07-28 AU AU39024/89A patent/AU624625B2/en not_active Ceased
- 1989-07-28 KR KR1019890010832A patent/KR0131070B1/ko not_active Expired - Fee Related
-
1992
- 1992-01-08 RU SU5010517A patent/RU2105011C1/ru active
-
1995
- 1995-10-17 US US08/544,092 patent/US5874076A/en not_active Expired - Fee Related
-
1996
- 1996-02-12 US US08/601,434 patent/US5814314A/en not_active Expired - Fee Related
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