IL87908A - Azaspirane derivatives and immunomodulating pharmaceutical compositions containing same - Google Patents

Azaspirane derivatives and immunomodulating pharmaceutical compositions containing same

Info

Publication number
IL87908A
IL87908A IL87908A IL8790888A IL87908A IL 87908 A IL87908 A IL 87908A IL 87908 A IL87908 A IL 87908A IL 8790888 A IL8790888 A IL 8790888A IL 87908 A IL87908 A IL 87908A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
containing same
azaspirane
derivatives
Prior art date
Application number
IL87908A
Other languages
English (en)
Other versions
IL87908A0 (en
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of IL87908A0 publication Critical patent/IL87908A0/xx
Publication of IL87908A publication Critical patent/IL87908A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL87908A 1987-09-28 1988-09-25 Azaspirane derivatives and immunomodulating pharmaceutical compositions containing same IL87908A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes

Publications (2)

Publication Number Publication Date
IL87908A0 IL87908A0 (en) 1989-03-31
IL87908A true IL87908A (en) 1993-02-21

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
IL87908A IL87908A (en) 1987-09-28 1988-09-25 Azaspirane derivatives and immunomodulating pharmaceutical compositions containing same

Country Status (24)

Country Link
US (1) US4963557A (de)
EP (1) EP0310321B1 (de)
JP (1) JP2582888B2 (de)
KR (1) KR0166336B1 (de)
CN (1) CN1031618C (de)
AT (1) ATE114463T1 (de)
AU (1) AU619780B2 (de)
CA (1) CA1313189C (de)
CY (1) CY1955A (de)
DE (1) DE3852266T2 (de)
DK (1) DK170042B1 (de)
ES (1) ES2064356T3 (de)
FI (1) FI93006C (de)
GR (1) GR3014931T3 (de)
HK (1) HK1006274A1 (de)
HU (1) HU208809B (de)
IE (1) IE67891B1 (de)
IL (1) IL87908A (de)
MX (1) MX9203765A (de)
NO (1) NO173824C (de)
NZ (1) NZ226354A (de)
PT (1) PT88603B (de)
WO (1) WO1989002889A1 (de)
ZW (1) ZW12388A1 (de)

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EP0542860B1 (de) * 1990-08-10 1998-05-20 AnorMED Inc Immunosuppressive zusammensetzungen
US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
JPH06501468A (ja) * 1990-09-24 1994-02-17 スミスクライン・ビーチャム・コーポレイション 方法
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
EP0617610B1 (de) * 1991-12-18 1997-03-19 Minnesota Mining And Manufacturing Company Aerosolzusammensetzungen für arzneimittelsuspensionen
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
DE4222459C2 (de) * 1992-07-08 1995-09-14 Sigma Tau Ind Farmaceuti 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
EP0690715B1 (de) * 1993-03-26 2003-05-28 Beth Israel Hospital Association Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315271D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315341D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
SG43383A1 (en) * 1995-07-13 1997-10-17 Smithkline Beecham Corp N n-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2- propanamine dimaleate
AU6637096A (en) * 1995-07-13 1997-02-10 Smithkline Beecham Corporation N,n-dimethyl-8,8-dipropyl-2-azaspiro{4,5}decane-2-propanamin e dimaleate
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
AU6636996A (en) * 1995-07-13 1997-02-10 Anormed Inc. 2-{2-(dimethylamino)ethyl}-8,8-dipropyl-2-azaspiro{4.5}decan edimaleate
CN1219129A (zh) * 1996-05-17 1999-06-09 安诺梅德公司 取代的氮杂螺烷在治疗哮喘中的用途
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
MXPA05009708A (es) * 2003-03-10 2006-05-25 Callisto Pharmaceuticals Inc Metodo para el tratamiento de cancer con composiciones de azaspirina.
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
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GB823338A (en) * 1956-11-07 1959-11-11 Thomae Gmbh Dr K Diquaternary salts of aminoalkyl piperidines
US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3418324A (en) * 1961-03-13 1968-12-24 Geschickter Fund Med Res Heterocyclic secondary amines
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DE1770697C3 (de) * 1967-07-06 1981-04-23 Dupher International Research B.V., Weesp 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
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Also Published As

Publication number Publication date
EP0310321A2 (de) 1989-04-05
CN1032437A (zh) 1989-04-19
DE3852266T2 (de) 1995-05-18
PT88603B (pt) 1992-12-31
IE67891B1 (en) 1996-05-01
EP0310321B1 (de) 1994-11-30
NO173824B (no) 1993-11-01
WO1989002889A1 (en) 1989-04-06
JP2582888B2 (ja) 1997-02-19
IE882929L (en) 1989-03-28
KR0166336B1 (ko) 1999-01-15
NO901392D0 (no) 1990-03-27
NO173824C (no) 1994-02-09
HU208809B (en) 1995-06-28
JPH03500290A (ja) 1991-01-24
CN1031618C (zh) 1996-04-24
EP0310321A3 (de) 1991-02-06
HK1006274A1 (en) 1999-02-19
ZW12388A1 (en) 1989-01-04
DE3852266D1 (de) 1995-01-12
DK77090D0 (da) 1990-03-23
US4963557A (en) 1990-10-16
FI93006C (fi) 1995-02-10
HU885889D0 (en) 1991-11-28
HUT57722A (en) 1991-12-30
DK170042B1 (da) 1995-05-08
ES2064356T3 (es) 1995-02-01
KR890701562A (ko) 1989-12-20
AU619780B2 (en) 1992-02-06
IL87908A0 (en) 1989-03-31
DK77090A (da) 1990-03-23
NO901392L (no) 1990-03-27
ATE114463T1 (de) 1994-12-15
CY1955A (en) 1997-05-16
PT88603A (pt) 1988-10-01
NZ226354A (en) 1991-02-26
CA1313189C (en) 1993-01-26
FI901530A0 (fi) 1990-03-27
GR3014931T3 (en) 1995-05-31
FI93006B (fi) 1994-10-31
AU2533388A (en) 1989-04-18
MX9203765A (es) 1992-07-01

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Legal Events

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KB Patent renewed
RH1 Patent not in force