IL83509A - 5-Substituted 5'.amido-2',5'-dideoxyuridine derivatives and medicaments containing them - Google Patents

5-Substituted 5'.amido-2',5'-dideoxyuridine derivatives and medicaments containing them

Info

Publication number
IL83509A
IL83509A IL8350987A IL8350987A IL83509A IL 83509 A IL83509 A IL 83509A IL 8350987 A IL8350987 A IL 8350987A IL 8350987 A IL8350987 A IL 8350987A IL 83509 A IL83509 A IL 83509A
Authority
IL
Israel
Prior art keywords
dideoxy
ethyl
ethyluridine
uridine
acetamido
Prior art date
Application number
IL8350987A
Other languages
English (en)
Other versions
IL83509A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868620070A external-priority patent/GB8620070D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL83509A0 publication Critical patent/IL83509A0/xx
Publication of IL83509A publication Critical patent/IL83509A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL8350987A 1986-08-18 1987-08-12 5-Substituted 5'.amido-2',5'-dideoxyuridine derivatives and medicaments containing them IL83509A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868620070A GB8620070D0 (en) 1986-08-18 1986-08-18 Pyrimidine derivatives
GB878711336A GB8711336D0 (en) 1986-08-18 1987-05-14 Pyrimidine derivatives

Publications (2)

Publication Number Publication Date
IL83509A0 IL83509A0 (en) 1988-01-31
IL83509A true IL83509A (en) 1994-05-30

Family

ID=26291195

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8350987A IL83509A (en) 1986-08-18 1987-08-12 5-Substituted 5'.amido-2',5'-dideoxyuridine derivatives and medicaments containing them

Country Status (22)

Country Link
US (2) US4851519A (cs)
EP (1) EP0257378B1 (cs)
JP (1) JPH0794453B2 (cs)
CN (1) CN1020106C (cs)
AU (1) AU602909B2 (cs)
CA (1) CA1303031C (cs)
CS (1) CS272225B2 (cs)
DE (1) DE3771146D1 (cs)
DK (1) DK375787A (cs)
ES (1) ES2040715T3 (cs)
FI (1) FI86639C (cs)
GR (1) GR3002636T3 (cs)
HU (1) HU199500B (cs)
IE (1) IE61061B1 (cs)
IL (1) IL83509A (cs)
MC (1) MC1846A1 (cs)
MX (1) MX174238B (cs)
NO (1) NO170884C (cs)
NZ (1) NZ221412A (cs)
PH (1) PH24653A (cs)
PT (1) PT85551B (cs)
ZW (1) ZW14187A1 (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK163128C (da) * 1986-08-12 1992-06-15 Hoffmann La Roche Pyrimidinnucleosider, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende pyrimidinnucleosiderne og anvendelse af pyrimidinnucleosiderne
NO170884C (no) * 1986-08-18 1992-12-23 Hoffmann La Roche Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater
US5312961A (en) * 1989-02-14 1994-05-17 Elf Sanofi 2-amino-7-hydroxytetralin carboxylalkyl ethers
EP0516851B1 (en) * 1990-02-28 1996-06-19 Teikoku Seiyaku Kabushiki Kaisha Physiologically active substance well capable of permeating biomembrane
US5652335A (en) * 1990-02-28 1997-07-29 Teikoku Seiyaku Kabushiki Kaisha Physiologically active substance well capable of permeating biomembrane
US5306722A (en) * 1992-09-02 1994-04-26 Bristol-Myers Squibb Company Thymidine derivatives and therapeutic method of use
US6040298A (en) * 1992-12-23 2000-03-21 Oclassen Pharmaceuticals, Inc. Methods for treatment with compositions effective against acyclovir-resistant strains of herpes viruses
GB9514268D0 (en) * 1995-07-13 1995-09-13 Hoffmann La Roche Pyrimidine nucleoside
GB9606264D0 (en) * 1995-07-13 1996-05-29 Hoffmann La Roche Pyrimidine nucleoside derivatives
GB9608199D0 (en) * 1995-08-04 1996-06-26 Hoffmann La Roche Pyrimide nucleoside derivatives
US5783689A (en) * 1996-11-12 1998-07-21 University Of Notre Dame Antibacterial and antifungal nucleosides
EP1771435A4 (en) * 2004-06-19 2008-02-13 Human Biomolecular Res Inst MODULATORS OF NEUROTRANSMITTERS OF THE CENTRAL NERVOUS SYSTEM
US7629447B2 (en) * 2006-09-12 2009-12-08 Wako Pure Chemical Industries, Ltd. Dideoxynucleoside derivatives
JP5205873B2 (ja) * 2006-09-12 2013-06-05 和光純薬工業株式会社 新規なジデオキシヌクレオシド誘導体
JP5785168B2 (ja) * 2009-07-31 2015-09-24 エスリス ゲーエムベーハーｅｔｈｒｉｓ ＧｍｂＨ タンパク質発現用未修飾および修飾ヌクレオチドの組み合わせを有するｒｎａ
DE102013225402A1 (de) 2013-12-10 2015-06-11 BSH Hausgeräte GmbH Haushaltsgerät mit einer in einem Stauraum versenkbaren Tür und verschiebbarer Drehachse einer Lagereinheit sowie Verfahren zum öffnen und Schließen einer derartigen Tür
DE102013225401A1 (de) 2013-12-10 2015-06-11 BSH Hausgeräte GmbH Haushaltsgerät mit einer in einen Verstauraum einfahrbaren Tür und Verfahren zum öffnen und Schließen einer Tür eines Haushaltsgeräts
DE102013225403A1 (de) 2013-12-10 2015-06-11 BSH Hausgeräte GmbH Haushaltsgerät mit einer in einem Verstauraum versenkbaren Tür mit vertikaler Lageveränderungsmöglichkeit einer Drehachse einer Lagereinheit sowie Verfahren zum öffnen und Schließen einer Tür
DE102015206576A1 (de) 2015-04-13 2016-10-13 BSH Hausgeräte GmbH Haushaltsgerät mit einer in einem Verstauraum versenkbaren Tür mit spezifischer Lagereinheit
DE102015206577B4 (de) 2015-04-13 2025-01-16 BSH Hausgeräte GmbH Haushaltsgerät mit einer in einem Verstauraum versenkbaren Tür mit elliptischer Kulisse zur Bewegung eines Lagerbügels einer Tür-Lagereinheit
DK3307262T3 (da) 2015-06-15 2021-08-09 Nmd Pharma As Forbindelser til anvendelse ved behandling af neuromuskulære lidelser
US11730714B2 (en) 2017-12-14 2023-08-22 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US10385028B2 (en) 2017-12-14 2019-08-20 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US11147788B2 (en) 2017-12-14 2021-10-19 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
DE102018201950A1 (de) 2018-02-08 2019-08-08 BSH Hausgeräte GmbH Gargerät mit einem Technikteil für eine versenkbare Tür, welches eine Führungsbahn in einer oberen Höhenhälfte des Technikteils aufweist
DE102018201949A1 (de) 2018-02-08 2019-08-08 BSH Hausgeräte GmbH Gargerät mit einer in einen Verstauraum versenkbaren Tür mit einem spezifischen Koppelmodul, sowie Verfahren zum Bewegen einer Tür
WO2025149479A1 (en) * 2024-01-12 2025-07-17 Roche Diagnostics Gmbh Synthesis of modified nucleoside triphosphates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4128639A (en) * 1977-12-14 1978-12-05 Research Corporation Nitrosourea analogs of thymidine
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3045342A1 (de) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen Neue substituierte pyrimidin-nukleoside mit antiviraler und cytostatischer wirkung, verfahren zu deren herstellung und daraus bereitete arzneiformen
DE3045375A1 (de) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen
US4762823A (en) * 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
DK363987A (da) * 1986-08-08 1988-02-09 Hoffmann La Roche Pyrimidinderivater
DK163128C (da) * 1986-08-12 1992-06-15 Hoffmann La Roche Pyrimidinnucleosider, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende pyrimidinnucleosiderne og anvendelse af pyrimidinnucleosiderne
NO170884C (no) * 1986-08-18 1992-12-23 Hoffmann La Roche Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater

Also Published As

Publication number Publication date
DK375787A (da) 1988-02-19
DK375787D0 (da) 1987-07-17
MX174238B (es) 1994-05-02
US4851519A (en) 1989-07-25
NZ221412A (en) 1990-11-27
FI873555A7 (fi) 1988-02-19
NO170884C (no) 1992-12-23
FI86639B (fi) 1992-06-15
ES2040715T3 (es) 1993-11-01
PT85551A (en) 1987-09-01
NO872961D0 (no) 1987-07-15
IE61061B1 (en) 1994-09-21
FI86639C (fi) 1992-09-25
DE3771146D1 (de) 1991-08-08
CS272225B2 (en) 1991-01-15
AU602909B2 (en) 1990-11-01
PT85551B (pt) 1990-05-31
NO872961L (no) 1988-02-19
US5010060A (en) 1991-04-23
JPH0794453B2 (ja) 1995-10-11
MX7769A (es) 1993-11-01
HU199500B (en) 1990-02-28
ZW14187A1 (en) 1988-02-24
AU7684187A (en) 1988-02-25
CN87105758A (zh) 1988-03-02
CS583487A2 (en) 1990-03-14
EP0257378A1 (de) 1988-03-02
NO170884B (no) 1992-09-14
GR3002636T3 (en) 1993-01-25
IE872191L (en) 1988-02-18
HUT45544A (en) 1988-07-28
PH24653A (en) 1990-09-07
CN1020106C (zh) 1993-03-17
MC1846A1 (fr) 1988-09-30
JPS6351384A (ja) 1988-03-04
EP0257378B1 (de) 1991-07-03
CA1303031C (en) 1992-06-09
FI873555A0 (fi) 1987-08-17
IL83509A0 (en) 1988-01-31

Similar Documents

Publication Publication Date Title
IL83509A (en) 5-Substituted 5'.amido-2',5'-dideoxyuridine derivatives and medicaments containing them
JP3530218B2 (ja) ▲ｎ４▼−アシル−５’−デオキシ−５−フルオロシチジン誘導体の新規製造法
US6211158B1 (en) Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents
DK168323B1 (da) Anvendelse af visse pyrimidinnucleosider til fremstilling af et lægemiddel mod VZV-infektioner; hidtil ukendte pyrimidinnucleosider, sådanne forbindelser til anvendelse i human terapi samt fremgangsmåde til fremstilling af forbindelserne
Urata et al. Synthesis and properties of mirror-image DNA
RU2211223C2 (ru) Новые нуклеозиды, имеющие бициклическую сахарную группировку, и содержащие их олигонуклеотиды
CA1330990C (en) Antiviral compounds
US5110926A (en) Process for the preparation of a carbocyclic nucleoside analogue
IE36478B1 (en) 1,2,4-triazole nucleosides
US5128458A (en) 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
HU193893B (en) Process for preparing antiviral 2-deoxy-2,2-difluoropentozyl nucleoside derivatives
DE3924424A1 (de) Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
JPH01153698A (ja) ２’，３’−ジデオキシ−２’−フルオローヌクレオシド
US3463850A (en) Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
NO171507B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive nukleotidderivater
NO178497B (no) Fremgangsmåte for fremstilling av 9-substituerte guaninderivater og mellomprodukter for anvendelse i fremgangsmåten
US4863927A (en) 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
US5583225A (en) Syntheses of acyclic guanine nucleosides
US5290927A (en) Process for preparing 2',3'-dideoxyadenosine
US3872084A (en) Purine nucleoside 3,5-cyclicphosphate compounds
Hancox et al. Some reactions of 4′-thionucleosides and their sulfones
Lehbauer et al. Nucleotides, Part LXIX, Synthesis of Phosphoramidite Building Blocks of Isoxanthopterin N8‐(2′‐Deoxy‐β‐d‐ribonucleosides): New Fluorescence Markers for Oligonucleotide Synthesis
US5696255A (en) Process for the production of 2-fluoropurine derivatives
JPH0336519B2 (cs)
KR960005719B1 (ko) 피리미딘 유도체, 이의 제조방법 및 이를 포함하는 항바이러스성 약제

Legal Events

Date Code Title Description
RH Patent void