IL77338A - Oxetanones,their manufacture and pharmaceutical compositions containing them - Google Patents
Oxetanones,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL77338A IL77338A IL77338A IL7733885A IL77338A IL 77338 A IL77338 A IL 77338A IL 77338 A IL77338 A IL 77338A IL 7733885 A IL7733885 A IL 7733885A IL 77338 A IL77338 A IL 77338A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- opt
- ring
- oxetanones
- substd
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- -1 carbamoylethyl Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 101100134927 Gallus gallus COR8 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH610284 | 1984-12-21 | ||
| CH393485 | 1985-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL77338A true IL77338A (en) | 1991-04-15 |
Family
ID=25694219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL77338A IL77338A (en) | 1984-12-21 | 1985-12-16 | Oxetanones,their manufacture and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4931463A (da) |
| EP (1) | EP0185359B1 (da) |
| CN (1) | CN1012643B (da) |
| AT (1) | ATE70061T1 (da) |
| AU (1) | AU583569B2 (da) |
| CA (1) | CA1270837A (da) |
| CS (1) | CS262425B2 (da) |
| DE (1) | DE3584829D1 (da) |
| DK (1) | DK166724B1 (da) |
| DO (1) | DOP1985004386A (da) |
| FI (1) | FI91403C (da) |
| HU (1) | HU200172B (da) |
| IE (1) | IE58926B1 (da) |
| IL (1) | IL77338A (da) |
| MC (1) | MC1728A1 (da) |
| NO (1) | NO171160C (da) |
| NZ (1) | NZ214565A (da) |
| PH (1) | PH26291A (da) |
| PT (1) | PT81748B (da) |
| ZW (1) | ZW20385A1 (da) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246960A (en) * | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| US4895973A (en) * | 1986-08-14 | 1990-01-23 | G. D. Searle & Company | Substituted glutaric acid lactones in the treatment of hyperlipidemia |
| US4806564A (en) * | 1987-05-26 | 1989-02-21 | Merck & Co., Inc. | Antihypercholesterolemic beta-lactones |
| US4816477A (en) * | 1987-05-26 | 1989-03-28 | Merck & Co., Inc. | Antihypercholesterolemic β-lactones |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5260310A (en) * | 1990-02-26 | 1993-11-09 | Hoffmann-La Roche Inc. | Oxetanone compounds and pharmaceutical compositions containing them |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| PL191222B1 (pl) * | 1997-02-05 | 2006-03-31 | Hoffmann La Roche | Zastosowanie tetrahydrolipstatyny do wytwarzania doustnego farmaceutycznego preparatu do leczenia cukrzycy typu II |
| SK141899A3 (en) * | 1997-04-15 | 2000-09-12 | Csir Corporate Building | Pharmaceutical compositions having appetite suppressant activity |
| GB2396815B (en) * | 1999-10-27 | 2004-09-08 | Phytopharm Plc | A composition comprising a pregnenone derivative and an NSAID |
| WO2001032670A1 (en) * | 1999-10-29 | 2001-05-10 | John Jason Gentry Mullins | Oxetanone derivatives |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| ATE293477T1 (de) | 2000-07-28 | 2005-05-15 | Hoffmann La Roche | Neue verwendung von lipase-inhibitoren |
| CA2417607C (en) | 2000-08-09 | 2008-01-29 | Christine Feinle | Lipase inhibitors for the treatment of dyspepsia |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| US6392061B1 (en) * | 2000-10-16 | 2002-05-21 | Zpro Chemical, Inc. | Process for making (2S, 3S, 5S) oxetanone derivatives |
| WO2002044152A1 (en) | 2000-10-16 | 2002-06-06 | F. Hoffmann-La Roche Ag | Indoline derivatives and their use as 5-ht2 receptor ligands |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| BR0116605A (pt) | 2000-12-27 | 2003-09-30 | Hoffmann La Roche | Composto, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo, sua utilização e processo para o tratamento e profilaxia de distúrbios do sistema nervoso central, distúrbios cardiovasculares, distúrbios gastrintestinais e apnéia do sono |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| AU2002338896B2 (en) | 2001-05-21 | 2006-04-27 | F.Hoffman-La Roche Ag | Quinoline derivatives as ligands for the neuropeptide Y receptor |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| PL372295A1 (en) | 2002-02-04 | 2005-07-11 | F.Hoffmann-La Roche Ag | Quinoline derivatives as npy antagonists |
| BR0308108A (pt) | 2002-02-28 | 2004-12-07 | Hoffmann La Roche | Compostos; processo para a preparação de composto; composição farmacêutica que compreende o mesmo, utilização dos compostos e método de tratamento e profilaxia de enfermidades e de obesidade |
| US7728153B2 (en) | 2002-04-17 | 2010-06-01 | The Burnham Institute For Medical Research | Method for the asymmetric synthesis of beta-lactone compounds |
| WO2003088975A1 (en) * | 2002-04-17 | 2003-10-30 | The Burnham Institute | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation |
| CA2489251A1 (en) | 2002-07-05 | 2004-01-15 | F. Hoffmann-La Roche Ag | Quinazoline derivatives |
| AU2003253364B2 (en) | 2002-08-07 | 2007-06-07 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| WO2004024726A1 (en) | 2002-09-12 | 2004-03-25 | F. Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
| DE60323130D1 (de) | 2002-11-25 | 2008-10-02 | Hoffmann La Roche | Indolderivaten |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| WO2005005403A2 (en) * | 2003-07-15 | 2005-01-20 | Ranbaxy Laboratories Limited | Process for preparation of oxetan-2-ones |
| CN100393718C (zh) | 2003-08-12 | 2008-06-11 | 霍夫曼-拉罗奇有限公司 | 作为npy拮抗剂的噻唑衍生物 |
| CA2533463A1 (en) | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | 2-amino-5-benzoylthiazole npy antagonists |
| DE102004009076A1 (de) * | 2004-02-23 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Alkylcarbamat-substituierte β-Lactone, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US7074822B2 (en) * | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| US7121355B2 (en) * | 2004-09-21 | 2006-10-17 | Cnh America Llc | Bulldozer autograding system |
| WO2006035296A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Process for the preparation of an orlistat derivative useful as reference standard in the determination of the purity of orlistat and process for the preparation of orlistat |
| CA2609634C (en) | 2005-05-03 | 2011-02-01 | F. Hoffmann-La Roche Ag | Tetracyclic azapyrazinoindolines as 5-ht2 ligands |
| DE602006006712D1 (de) | 2005-08-18 | 2009-06-18 | Hoffmann La Roche | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren |
| US20090171104A1 (en) * | 2005-10-05 | 2009-07-02 | Killol Patel | Process for the preparation of orlistat |
| ATE507222T1 (de) | 2005-11-30 | 2011-05-15 | Hoffmann La Roche | 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren |
| CA2630270A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 5-substituted indole-2-carboxamide derivatives |
| DE602006020482D1 (de) | 2005-11-30 | 2011-04-14 | Hoffmann La Roche | 1,5-substituierte indol-2-yl amidderivative |
| ES2333672T3 (es) | 2005-12-09 | 2010-02-25 | F. Hoffmann-La Roche Ag | Derivados de amida triciclica para tratamiento de obesidad. |
| CN101326187A (zh) | 2005-12-15 | 2008-12-17 | 霍夫曼-拉罗奇有限公司 | 吡咯并[2,3-c]吡啶衍生物 |
| BRPI0619985A2 (pt) | 2005-12-16 | 2011-10-25 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos |
| BRPI0707916A2 (pt) * | 2006-01-13 | 2011-05-17 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e uso destes compostos |
| KR101047274B1 (ko) * | 2006-01-23 | 2011-07-06 | 에프. 호프만-라 로슈 아게 | Ｈ3 수용체 활성을 갖는 사이클로헥실 설폰아마이드 유도체 |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| EP2032554A1 (en) * | 2006-05-30 | 2009-03-11 | F. Hoffmann-Roche AG | Piperidinyl pyrimidine derivatives |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| SG182171A1 (en) * | 2007-06-06 | 2012-07-30 | Ranbaxy Lab Ltd | Process for the preparation of orlistat |
| WO2009013195A1 (en) | 2007-07-25 | 2009-01-29 | F. Hoffmann-La Roche Ag | Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators |
| US8258321B2 (en) * | 2007-10-31 | 2012-09-04 | Burnham Institute For Medical Research | Beta-lactone compounds |
| US8993509B2 (en) | 2009-03-31 | 2015-03-31 | Robert Zimmerman | Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity |
| WO2010112569A1 (en) | 2009-03-31 | 2010-10-07 | Robert Zimmermann | Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor |
| CA2798330A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP3651784B1 (en) * | 2017-07-12 | 2022-09-28 | Mayo Foundation for Medical Education and Research | Compounds for the reducing lipotoxic damage |
| CN112079821A (zh) * | 2020-09-14 | 2020-12-15 | 中山万汉制药有限公司 | 奥利司他与苯氨基嘧啶类化合物形成的缀合物及其制备方法与用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2478388A (en) * | 1945-09-28 | 1949-08-09 | Eastman Kodak Co | beta-lactones from unsaturated aldehydes and unsaturated ketones |
| JPS608117B2 (ja) * | 1977-02-08 | 1985-02-28 | 財団法人微生物化学研究会 | 新生理活性物質エステラスチンおよびその製造法 |
| GB2023604B (en) * | 1978-05-25 | 1982-07-28 | Microbial Chem Res Found | Physiologically active derivatives of esterastin and production thereof |
| JPS56128774A (en) * | 1980-03-14 | 1981-10-08 | Microbial Chem Res Found | New physiologically active substance ebelactone and its preparation |
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
-
1985
- 1985-11-12 CA CA000495058A patent/CA1270837A/en not_active Expired - Lifetime
- 1985-11-15 ZW ZW203/85A patent/ZW20385A1/xx unknown
- 1985-12-04 FI FI854797A patent/FI91403C/fi not_active IP Right Cessation
- 1985-12-09 CS CS859016A patent/CS262425B2/cs not_active IP Right Cessation
- 1985-12-16 NZ NZ214565A patent/NZ214565A/xx unknown
- 1985-12-16 IL IL77338A patent/IL77338A/xx not_active IP Right Cessation
- 1985-12-16 AU AU51259/85A patent/AU583569B2/en not_active Expired
- 1985-12-17 EP EP85116096A patent/EP0185359B1/de not_active Expired - Lifetime
- 1985-12-17 AT AT85116096T patent/ATE70061T1/de not_active IP Right Cessation
- 1985-12-17 DE DE8585116096T patent/DE3584829D1/de not_active Expired - Lifetime
- 1985-12-18 PH PH33205A patent/PH26291A/en unknown
- 1985-12-18 HU HU854832A patent/HU200172B/hu unknown
- 1985-12-18 MC MC851814A patent/MC1728A1/fr unknown
- 1985-12-19 CN CN85108888A patent/CN1012643B/zh not_active Expired
- 1985-12-20 PT PT81748A patent/PT81748B/pt unknown
- 1985-12-20 NO NO855213A patent/NO171160C/no not_active IP Right Cessation
- 1985-12-20 IE IE327785A patent/IE58926B1/en not_active IP Right Cessation
- 1985-12-20 DK DK600385A patent/DK166724B1/da not_active IP Right Cessation
- 1985-12-30 DO DO1985004386A patent/DOP1985004386A/es unknown
-
1987
- 1987-12-17 US US07/134,322 patent/US4931463A/en not_active Expired - Lifetime
-
1990
- 1990-03-19 US US07/495,809 patent/US5175186A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5175186A (en) | 1992-12-29 |
| ZW20385A1 (en) | 1986-03-05 |
| DK600385D0 (da) | 1985-12-20 |
| CN1012643B (zh) | 1991-05-22 |
| AU583569B2 (en) | 1989-05-04 |
| HUT39440A (en) | 1986-09-29 |
| IE58926B1 (en) | 1993-12-01 |
| EP0185359A3 (en) | 1987-08-26 |
| DK166724B1 (da) | 1993-07-05 |
| US4931463A (en) | 1990-06-05 |
| DK600385A (da) | 1986-06-22 |
| HU200172B (en) | 1990-04-28 |
| CN85108888A (zh) | 1986-07-09 |
| NO171160C (no) | 1993-02-03 |
| PH26291A (en) | 1992-04-10 |
| MC1728A1 (fr) | 1986-12-15 |
| FI854797A7 (fi) | 1986-06-22 |
| EP0185359A2 (de) | 1986-06-25 |
| IE853277L (en) | 1986-06-21 |
| NZ214565A (en) | 1989-06-28 |
| NO855213L (no) | 1986-06-23 |
| NO171160B (no) | 1992-10-26 |
| AU5125985A (en) | 1986-06-26 |
| PT81748A (en) | 1986-01-02 |
| FI854797A0 (fi) | 1985-12-04 |
| CA1270837A (en) | 1990-06-26 |
| CS262425B2 (en) | 1989-03-14 |
| ATE70061T1 (de) | 1991-12-15 |
| FI91403B (fi) | 1994-03-15 |
| DOP1985004386A (es) | 1991-04-20 |
| DE3584829D1 (de) | 1992-01-16 |
| FI91403C (fi) | 1994-06-27 |
| PT81748B (pt) | 1988-07-29 |
| EP0185359B1 (de) | 1991-12-04 |
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