BE751290A - Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties - Google Patents

Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties

Info

Publication number
BE751290A
BE751290A BE751290DA BE751290A BE 751290 A BE751290 A BE 751290A BE 751290D A BE751290D A BE 751290DA BE 751290 A BE751290 A BE 751290A
Authority
BE
Belgium
Prior art keywords
glu
thr
leu
ser
asn
Prior art date
Application number
Other languages
French (fr)
Inventor
H Bossert
S Guttmann
R Huguenin
J Pless
E Sandrin
H Willems
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE751290A publication Critical patent/BE751290A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Polypeptide having pharmacodynamic properties. They have the formula (I) S-CH2-CHX-CO-Ser-Asn-Leu-Ser-Thy-Cys-Val-Leu-Gly-Lys-Leu-Ser-Glu-- Glu-Leu-His-Lys-Leu-Glu-Thr-Tyr Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Y. (where X is H, NH2, RCONH- or R'OCONH- where R is alkyl, aryl or aralkyl opt. substd. R' is alkyl or alkenyl or an opt. substd. aryl or aralkyl group and which cannot be eliminated by trifluoroacetic acid, Y is the group L-prolinamide or L-proline-L-valinamide) and in which the following replacements may be made. Ser by Thr or Aln; Asn by Asp, Glu, Gln; Thr by Ser or Aln; Lys by BOC - Lys, Orn or Arg; Gln by Glu, Asn or Asp; Glu by OTB-glu, Gln, Asp or Asn; Leu by Tyr; Tyr by Phenyl-Aln and Arg by Orn, Lys. Compounds (I) may be used in medicaments to lower the level of blood-calcium and to enhance bone mineralisation, together with pharmaceutically acceptable carriers.
BE751290D 1970-06-01 1970-06-01 Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties BE751290A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE751290 1970-06-01

Publications (1)

Publication Number Publication Date
BE751290A true BE751290A (en) 1970-12-01

Family

ID=3856573

Family Applications (1)

Application Number Title Priority Date Filing Date
BE751290D BE751290A (en) 1970-06-01 1970-06-01 Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties

Country Status (1)

Country Link
BE (1) BE751290A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112494637A (en) * 2020-12-08 2021-03-16 中山大学附属第七医院(深圳) Application of salmon calcitonin in preparation of medicines for treating depression

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112494637A (en) * 2020-12-08 2021-03-16 中山大学附属第七医院(深圳) Application of salmon calcitonin in preparation of medicines for treating depression
CN112494637B (en) * 2020-12-08 2023-05-23 中山大学附属第七医院(深圳) Application of salmon calcitonin in preparation of medicament for treating depression

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: SANDOZ S.A.

Effective date: 19900601