DK193887A - PEPTID WITH BRONCHODIL ARTS AND HYPOTENSIVE ACTIVITY - Google Patents

PEPTID WITH BRONCHODIL ARTS AND HYPOTENSIVE ACTIVITY

Info

Publication number
DK193887A
DK193887A DK193887A DK193887A DK193887A DK 193887 A DK193887 A DK 193887A DK 193887 A DK193887 A DK 193887A DK 193887 A DK193887 A DK 193887A DK 193887 A DK193887 A DK 193887A
Authority
DK
Denmark
Prior art keywords
lys
leu
arg
bronchodil
peptid
Prior art date
Application number
DK193887A
Other languages
Danish (da)
Other versions
DK193887D0 (en
Inventor
Osamu Ito
Shinro Tachibana
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DK193887D0 publication Critical patent/DK193887D0/en
Publication of DK193887A publication Critical patent/DK193887A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/17—Vasoactive intestinal peptides; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A peptide having the following structure: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala- Val-Lys-Lys-Tyr-Leu-Asn-Se r-Ile-Leu-Asn-Gly-Y (wherein X is Met or Leu; and Y is OH, Lys-OH, Arg-OH, Lys-Arg-OH, or Lys-NH2 when X is Met, or Y is Lys-NH2, Lys-OH, or Lys-Arg-OH when X is Leu), a process for synthesizing it, a pharmaceutical composition containing it, and its use in the preparation of a medicament having bronchodilative and hypotensive activity are disclosed.
DK193887A 1986-04-17 1987-04-14 PEPTID WITH BRONCHODIL ARTS AND HYPOTENSIVE ACTIVITY DK193887A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61086987A JPS62246595A (en) 1986-04-17 1986-04-17 Peptide having bronchodilative action and depressive action

Publications (2)

Publication Number Publication Date
DK193887D0 DK193887D0 (en) 1987-04-14
DK193887A true DK193887A (en) 1987-10-18

Family

ID=13902213

Family Applications (1)

Application Number Title Priority Date Filing Date
DK193887A DK193887A (en) 1986-04-17 1987-04-14 PEPTID WITH BRONCHODIL ARTS AND HYPOTENSIVE ACTIVITY

Country Status (10)

Country Link
US (2) US4757133A (en)
EP (1) EP0241926B1 (en)
JP (1) JPS62246595A (en)
AT (1) ATE84048T1 (en)
CA (1) CA1288894C (en)
DE (1) DE3783257T2 (en)
DK (1) DK193887A (en)
ES (1) ES2052507T3 (en)
GR (1) GR3006718T3 (en)
NO (1) NO871574L (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939224A (en) * 1987-02-26 1990-07-03 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
SE8702520D0 (en) * 1987-06-16 1987-06-16 Kabigen Ab MAMMAL INTESTINE HORMONE PRECURSOR
IL87055A (en) * 1988-07-08 1994-06-24 Illana Gozes Conjugates of vasoactive intestinal peptide (vip) and of fragments thereof and pharmaceutical compositions comprising them
US5128242A (en) * 1989-06-19 1992-07-07 The Administrators Of The Tulane Educational Fund Hypothalamic polypeptides with adenylate cyclase stimulating activity
US5234907A (en) * 1989-06-30 1993-08-10 Hoffmann-La Roche Inc. Synthetic vasoactive intestinal peptide analogs
US5141924A (en) * 1989-06-30 1992-08-25 Hoffmann-La Roche, Inc. Synthetic vasoactive intestinal peptide analogs
US5236904A (en) * 1989-09-18 1993-08-17 Senetek, Plc Erection-inducing methods and compositions
US5447912A (en) * 1989-09-18 1995-09-05 Senetek, Plc Erection-inducing methods and compositions
JPH04193896A (en) * 1989-10-26 1992-07-13 Meiji Seika Kaisha Ltd Active peptide
JPH03181499A (en) * 1989-12-11 1991-08-07 Akira Kaji Novel peptide
ES2063406T3 (en) * 1990-06-26 1995-01-01 Sanwa Kagaku Kenkyusho Co PROCEDURE FOR THE PREPARATION OF VASOACTIVE INTESTINAL POLYPEPTIDE ANALOGS.
JPH05238950A (en) * 1991-04-22 1993-09-17 Sanwa Kagaku Kenkyusho Co Ltd Readily absorbable vip pharmaceutical
US5958881A (en) * 1991-04-25 1999-09-28 Korman; Louis Y. Composition containing VIP for injection and a method of enhancing visualization of tissues during medical procedures
US5623050A (en) * 1991-08-22 1997-04-22 Takeda Chemical Industries, Ltd. Stable polypeptides having c-AMP production enhancing activity and the use thereof
US5998368A (en) * 1991-10-31 1999-12-07 Yeda Research And Development Co. Ltd. Derivatives of structurally modified VIP and pharmaceutical compositions containing them
US5681816A (en) * 1992-04-24 1997-10-28 Korman; Louis Y. Method of inducing temporary paralysis of the gastrointestinal tract during medical procedure
US5252747A (en) * 1992-09-11 1993-10-12 Abbott Laboratories Chiral quinolone intermediates
EP0796867B1 (en) * 1995-06-09 2003-11-05 Itoham Foods Inc. Peptide, bronchodilator and blood flow ameliorant
US7332473B2 (en) 2002-11-27 2008-02-19 Itoham Foods Inc. Peptides and medicinal compositions containing the same
AU2005294125A1 (en) * 2004-10-08 2006-04-20 Transition Therapeutics Inc. Vasoactive intestinal polypeptide pharmaceuticals
US20080214440A1 (en) * 2004-10-08 2008-09-04 Forbes Medi-Tech (Research), Inc. Vasoactive intestinal polypeptide compositions
US20090170775A1 (en) * 2004-10-08 2009-07-02 Transition Therapeutics, Inc. Vasoactive intestinal polypeptide compositions
US7595294B2 (en) * 2004-10-08 2009-09-29 Transition Therapeutics, Inc. Vasoactive intestinal polypeptide pharmaceuticals
US20070293429A1 (en) * 2004-10-08 2007-12-20 Therapei Pharmaceuticals, Inc. Vasoactive Intestinal Polypeptide Compositions
RU2009103811A (en) * 2006-07-06 2010-08-20 Ф.Хоффманн-Ля Рош Аг (Ch) ANALOGUES OF VASOACTIVE INTESTINAL PEPTIDE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880826A (en) * 1971-09-17 1975-04-29 Sami I Said Vasoactive intestinal peptide
US3862927A (en) * 1973-02-26 1975-01-28 Sami I Said Process for preparation of vasoactive intestinal peptide
US4016258A (en) * 1975-08-05 1977-04-05 Said Sami I Vasoactive intestinal peptide from fowl
US4605641A (en) * 1984-10-09 1986-08-12 Hoffmann-La Roche Inc. Synthetic vasoactive intestinal peptide analogs

Also Published As

Publication number Publication date
US4757133A (en) 1988-07-12
DE3783257D1 (en) 1993-02-11
DK193887D0 (en) 1987-04-14
DE3783257T2 (en) 1993-05-13
EP0241926A2 (en) 1987-10-21
ES2052507T3 (en) 1994-07-16
NO871574L (en) 1987-10-19
ATE84048T1 (en) 1993-01-15
EP0241926A3 (en) 1989-03-08
CA1288894C (en) 1991-09-10
US4822774A (en) 1989-04-18
JPS62246595A (en) 1987-10-27
EP0241926B1 (en) 1992-12-30
NO871574D0 (en) 1987-04-14
GR3006718T3 (en) 1993-06-30

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment