NL7007420A - Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties - Google Patents

Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties

Info

Publication number
NL7007420A
NL7007420A NL7007420A NL7007420A NL7007420A NL 7007420 A NL7007420 A NL 7007420A NL 7007420 A NL7007420 A NL 7007420A NL 7007420 A NL7007420 A NL 7007420A NL 7007420 A NL7007420 A NL 7007420A
Authority
NL
Netherlands
Prior art keywords
glu
thr
leu
ser
asn
Prior art date
Application number
NL7007420A
Other versions
NL163773C (en
NL163773B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NL7007420A publication Critical patent/NL7007420A/en
Publication of NL163773B publication Critical patent/NL163773B/en
Application granted granted Critical
Publication of NL163773C publication Critical patent/NL163773C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Polypeptide having pharmacodynamic properties. They have the formula (I) S-CH2-CHX-CO-Ser-Asn-Leu-Ser-Thy-Cys-Val-Leu-Gly-Lys-Leu-Ser-Glu-- Glu-Leu-His-Lys-Leu-Glu-Thr-Tyr Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Y. (where X is H, NH2, RCONH- or R'OCONH- where R is alkyl, aryl or aralkyl opt. substd. R' is alkyl or alkenyl or an opt. substd. aryl or aralkyl group and which cannot be eliminated by trifluoroacetic acid, Y is the group L-prolinamide or L-proline-L-valinamide) and in which the following replacements may be made. Ser by Thr or Aln; Asn by Asp, Glu, Gln; Thr by Ser or Aln; Lys by BOC - Lys, Orn or Arg; Gln by Glu, Asn or Asp; Glu by OTB-glu, Gln, Asp or Asn; Leu by Tyr; Tyr by Phenyl-Aln and Arg by Orn, Lys. Compounds (I) may be used in medicaments to lower the level of blood-calcium and to enhance bone mineralisation, together with pharmaceutically acceptable carriers.
NL7007420.A 1969-06-03 1970-05-22 PROCESS FOR PREPARING A POLYPEPTIDE WITH THERAPEUTIC PROPERTIES AND A MEDICINAL PRODUCT CONTAINING THIS POLYPEPTIDE AND EVEN FORMING PRODUCTS OBTAINED USING THIS LAST METHODS. NL163773C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH840569 1969-06-03

Publications (3)

Publication Number Publication Date
NL7007420A true NL7007420A (en) 1970-12-07
NL163773B NL163773B (en) 1980-05-16
NL163773C NL163773C (en) 1980-10-15

Family

ID=4339814

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7007420.A NL163773C (en) 1969-06-03 1970-05-22 PROCESS FOR PREPARING A POLYPEPTIDE WITH THERAPEUTIC PROPERTIES AND A MEDICINAL PRODUCT CONTAINING THIS POLYPEPTIDE AND EVEN FORMING PRODUCTS OBTAINED USING THIS LAST METHODS.

Country Status (3)

Country Link
MY (1) MY7600262A (en)
NL (1) NL163773C (en)
ZA (1) ZA703752B (en)

Also Published As

Publication number Publication date
ZA703752B (en) 1972-01-26
NL163773C (en) 1980-10-15
MY7600262A (en) 1976-12-31
NL163773B (en) 1980-05-16

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Legal Events

Date Code Title Description
V4 Lapsed because of reaching the maximum lifetime of a patent