IL77338A - Oxetanones,their manufacture and pharmaceutical compositions containing them - Google Patents

Oxetanones,their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL77338A
IL77338A IL77338A IL7733885A IL77338A IL 77338 A IL77338 A IL 77338A IL 77338 A IL77338 A IL 77338A IL 7733885 A IL7733885 A IL 7733885A IL 77338 A IL77338 A IL 77338A
Authority
IL
Israel
Prior art keywords
alkyl
opt
ring
oxetanones
substd
Prior art date
Application number
IL77338A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL77338A publication Critical patent/IL77338A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12Beta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
IL77338A 1984-12-21 1985-12-16 Oxetanones,their manufacture and pharmaceutical compositions containing them IL77338A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH610284 1984-12-21
CH393485 1985-09-12

Publications (1)

Publication Number Publication Date
IL77338A true IL77338A (en) 1991-04-15

Family

ID=25694219

Family Applications (1)

Application Number Title Priority Date Filing Date
IL77338A IL77338A (en) 1984-12-21 1985-12-16 Oxetanones,their manufacture and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (2) US4931463A (cs)
EP (1) EP0185359B1 (cs)
CN (1) CN1012643B (cs)
AT (1) ATE70061T1 (cs)
AU (1) AU583569B2 (cs)
CA (1) CA1270837A (cs)
CS (1) CS262425B2 (cs)
DE (1) DE3584829D1 (cs)
DK (1) DK166724B1 (cs)
DO (1) DOP1985004386A (cs)
FI (1) FI91403C (cs)
HU (1) HU200172B (cs)
IE (1) IE58926B1 (cs)
IL (1) IL77338A (cs)
MC (1) MC1728A1 (cs)
NO (1) NO171160C (cs)
NZ (1) NZ214565A (cs)
PH (1) PH26291A (cs)
PT (1) PT81748B (cs)
ZW (1) ZW20385A1 (cs)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1328881C (en) * 1984-12-21 1994-04-26 Pierre Barbier Process for the manufacture of oxetanones
US5246960A (en) * 1984-12-21 1993-09-21 Hoffmann-La Roche Inc. Oxetanones
US4895973A (en) * 1986-08-14 1990-01-23 G. D. Searle & Company Substituted glutaric acid lactones in the treatment of hyperlipidemia
US4816477A (en) * 1987-05-26 1989-03-28 Merck & Co., Inc. Antihypercholesterolemic β-lactones
US4806564A (en) * 1987-05-26 1989-02-21 Merck & Co., Inc. Antihypercholesterolemic beta-lactones
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
US5260310A (en) * 1990-02-26 1993-11-09 Hoffmann-La Roche Inc. Oxetanone compounds and pharmaceutical compositions containing them
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor
RU2201272C2 (ru) * 1997-02-05 2003-03-27 Ф.Хоффманн-Ля Рош Аг Применение ингибиторов желудочно-кишечной липазы
AP2003002729A0 (en) * 1997-04-15 2003-06-30 Csir Pharmaceutical compositions having appetite suppressant activity
GB2355657B (en) * 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
CA2358921A1 (en) * 1999-10-29 2001-05-10 John Jason Gentry Mullins Oxetanone derivatives
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
EP1307263B1 (en) 2000-07-28 2005-04-20 F. Hoffmann-La Roche Ag New use of lipase inhibitors
CN1323661C (zh) 2000-08-09 2007-07-04 霍夫曼-拉罗奇有限公司 脂酶抑制剂的用途
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
US6392061B1 (en) * 2000-10-16 2002-05-21 Zpro Chemical, Inc. Process for making (2S, 3S, 5S) oxetanone derivatives
WO2002044152A1 (en) 2000-10-16 2002-06-06 F. Hoffmann-La Roche Ag Indoline derivatives and their use as 5-ht2 receptor ligands
GB0030710D0 (en) 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
CN1250549C (zh) 2000-12-27 2006-04-12 霍夫曼-拉罗奇有限公司 吲哚衍生物及其作为5-ht2b和5-ht2c受体配体的应用
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
AU2002338896B2 (en) 2001-05-21 2006-04-27 F.Hoffman-La Roche Ag Quinoline derivatives as ligands for the neuropeptide Y receptor
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
GB0202015D0 (en) 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
KR100659428B1 (ko) 2002-02-04 2006-12-19 에프. 호프만-라 로슈 아게 Npy 길항제로서의 퀴놀린 유도체
KR100611854B1 (ko) 2002-02-28 2006-08-11 에프. 호프만-라 로슈 아게 신경 펩타이드 y(npy) 수용체 길항제로서의 티아졸유도체
WO2003088975A1 (en) * 2002-04-17 2003-10-30 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
US7728153B2 (en) 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
EP1560816A1 (en) 2002-07-05 2005-08-10 F. Hoffmann-La Roche Ag Quinazoline derivatives
EP1539722A1 (en) 2002-08-07 2005-06-15 F. Hoffmann-La Roche Ag Thiazole derivatives
EP1539746B1 (en) 2002-09-12 2006-11-15 F. Hoffmann-La Roche Ag N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
MXPA05005445A (es) 2002-11-25 2005-08-26 Hoffmann La Roche Derivados de indolilo.
GB0314967D0 (en) 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
EP1651627A2 (en) * 2003-07-15 2006-05-03 Ranbaxy Laboratories Limited Process for preparation of oxetan-2-ones
WO2005014592A1 (en) 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag 2-amino-5-benzoylthiazole npy antagonists
WO2005014593A1 (en) 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Thiazole derivatives as npy antagonists
US7074822B2 (en) * 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
DE102004009076A1 (de) * 2004-02-23 2005-10-27 Solvay Pharmaceuticals Gmbh Alkylcarbamat-substituierte β-Lactone, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US7121355B2 (en) * 2004-09-21 2006-10-17 Cnh America Llc Bulldozer autograding system
WO2006035296A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Process for the preparation of an orlistat derivative useful as reference standard in the determination of the purity of orlistat and process for the preparation of orlistat
KR100895758B1 (ko) 2005-05-03 2009-04-30 에프. 호프만-라 로슈 아게 5-ht2 리간드로서 테트라사이클릭 아자피라지노인돌린
JP2009504707A (ja) 2005-08-18 2009-02-05 エフ.ホフマン−ラ ロシュ アーゲー H3受容体調節剤として有用なチアゾリルピペリジン誘導体
US20090171104A1 (en) * 2005-10-05 2009-07-02 Killol Patel Process for the preparation of orlistat
EP1968967B1 (en) 2005-11-30 2011-04-27 F. Hoffmann-La Roche AG 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators
ATE466007T1 (de) 2005-11-30 2010-05-15 Hoffmann La Roche 5-substituierte indol-2-carbonsäureamidderivate
BRPI0619268A2 (pt) 2005-11-30 2011-09-20 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal
US7579351B2 (en) 2005-12-09 2009-08-25 Hoffmann-La Roche Inc. Tricyclic amide derivatives
ES2334580T3 (es) 2005-12-15 2010-03-12 F. Hoffmann-La Roche Ag Derivados de pirrolo(2,3-c)piridina.
AU2006326067A1 (en) 2005-12-16 2007-06-21 F. Hoffmann-La Roche Ag Pyrrolo [2 , 3-b] pyridine derivatives as H3 receptor modulators
BRPI0707916A2 (pt) * 2006-01-13 2011-05-17 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e uso destes compostos
ES2349160T3 (es) * 2006-01-23 2010-12-28 F. Hoffmann-La Roche Ag Derivados de la ciclohexil sulfonamida con actividad frente a los receptores h3.
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
AU2007267184A1 (en) * 2006-05-30 2007-12-06 F. Hoffmann-La Roche Ag Piperidinyl pyrimidine derivatives
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
EP2164839A2 (en) * 2007-06-06 2010-03-24 Ranbaxy Laboratories Limited Process for the preparation of orlistat
US7534788B2 (en) 2007-07-25 2009-05-19 Hoffmann-La Roche Inc. Benzofuran and benzothiophene-2-carboxylic acid amide derivatives
EP2212305A4 (en) * 2007-10-31 2011-10-26 Burnham Inst Medical Research BETA-lactone
WO2010112569A1 (en) 2009-03-31 2010-10-07 Robert Zimmermann Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
WO2010115825A2 (en) 2009-03-31 2010-10-14 Robert Zimmermann Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (en) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
JP7224331B2 (ja) 2017-07-12 2023-02-17 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 脂肪毒性損傷の低減のための化合物
CN112079821A (zh) * 2020-09-14 2020-12-15 中山万汉制药有限公司 奥利司他与苯氨基嘧啶类化合物形成的缀合物及其制备方法与用途

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US2478388A (en) * 1945-09-28 1949-08-09 Eastman Kodak Co beta-lactones from unsaturated aldehydes and unsaturated ketones
JPS608117B2 (ja) * 1977-02-08 1985-02-28 財団法人微生物化学研究会 新生理活性物質エステラスチンおよびその製造法
GB2023604B (en) * 1978-05-25 1982-07-28 Microbial Chem Res Found Physiologically active derivatives of esterastin and production thereof
JPS56128774A (en) * 1980-03-14 1981-10-08 Microbial Chem Res Found New physiologically active substance ebelactone and its preparation
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives

Also Published As

Publication number Publication date
NO171160B (no) 1992-10-26
EP0185359B1 (de) 1991-12-04
FI854797A7 (fi) 1986-06-22
FI854797A0 (fi) 1985-12-04
ATE70061T1 (de) 1991-12-15
DE3584829D1 (de) 1992-01-16
NO855213L (no) 1986-06-23
CN85108888A (zh) 1986-07-09
PH26291A (en) 1992-04-10
IE58926B1 (en) 1993-12-01
IE853277L (en) 1986-06-21
US4931463A (en) 1990-06-05
AU583569B2 (en) 1989-05-04
HU200172B (en) 1990-04-28
CA1270837A (en) 1990-06-26
ZW20385A1 (en) 1986-03-05
DK166724B1 (da) 1993-07-05
FI91403B (fi) 1994-03-15
CN1012643B (zh) 1991-05-22
US5175186A (en) 1992-12-29
NZ214565A (en) 1989-06-28
PT81748A (en) 1986-01-02
DK600385D0 (da) 1985-12-20
FI91403C (fi) 1994-06-27
NO171160C (no) 1993-02-03
AU5125985A (en) 1986-06-26
DOP1985004386A (es) 1991-04-20
MC1728A1 (fr) 1986-12-15
CS262425B2 (en) 1989-03-14
EP0185359A2 (de) 1986-06-25
PT81748B (pt) 1988-07-29
HUT39440A (en) 1986-09-29
EP0185359A3 (en) 1987-08-26
DK600385A (da) 1986-06-22

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