|
US4879236A
(en)
*
|
1984-05-16 |
1989-11-07 |
The Texas A&M University System |
Method for producing a recombinant baculovirus expression vector
|
|
JPS619288A
(ja)
*
|
1984-06-21 |
1986-01-16 |
Dai Ichi Seiyaku Co Ltd |
ペプチド類の製法
|
|
IL80529A0
(en)
*
|
1985-11-14 |
1987-02-27 |
Daiichi Seiyaku Co |
Method of producing peptides
|
|
AU599348B2
(en)
*
|
1985-12-18 |
1990-07-19 |
Microgenesys, Inc. |
Method for producing selected polypeptides in virally infected insect cells and polypeptides isolated therefrom
|
|
US6150328A
(en)
|
1986-07-01 |
2000-11-21 |
Genetics Institute, Inc. |
BMP products
|
|
IL83003A
(en)
|
1986-07-01 |
1995-07-31 |
Genetics Inst |
Osteoinductive factors
|
|
GR871029B
(en)
|
1986-07-14 |
1987-11-02 |
Genetics Inst |
Novel osteoinductive factors
|
|
EP0260090A3
(en)
*
|
1986-09-08 |
1988-07-27 |
David H.L. Bishop |
Expression of hepatitis b viral antigens from recombinant baculovirus vectors
|
|
US5071748A
(en)
*
|
1986-09-09 |
1991-12-10 |
Genetics Institute, Inc. |
Mixed baculovirus compositions and uses thereof
|
|
ZA876696B
(en)
*
|
1986-09-09 |
1988-05-25 |
Genetics Inst |
Method for producing a heterologous protein in insect cells
|
|
US5041379A
(en)
*
|
1987-03-16 |
1991-08-20 |
American Biogenetic Science, Inc. |
Heliothis expression systems
|
|
US5024947A
(en)
*
|
1987-07-24 |
1991-06-18 |
Cetus Corporation |
Serum free media for the growth on insect cells and expression of products thereby
|
|
US5443964A
(en)
*
|
1987-08-10 |
1995-08-22 |
Duke University |
Poxvirus insertion/expression vector
|
|
US5578468A
(en)
*
|
1987-08-10 |
1996-11-26 |
Duke University |
Site-specific RNA cleavage
|
|
GB8810808D0
(en)
*
|
1988-05-06 |
1988-06-08 |
Wellcome Found |
Vectors
|
|
JP2511494B2
(ja)
*
|
1988-05-12 |
1996-06-26 |
善治 松浦 |
日本脳炎ウイルス表面抗原蛋白質の製造法
|
|
JPH0221955A
(ja)
*
|
1988-07-07 |
1990-01-24 |
Nippon Steel Corp |
流体噴射ノズル
|
|
SE8802939D0
(sv)
*
|
1988-08-19 |
1988-08-19 |
Kabigen Ab |
A method for the production and isolation of a fusion protein in eukaryotic cells
|
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
|
AU4647889A
(en)
*
|
1988-11-18 |
1990-06-12 |
Cetus Corporation |
Insect signal peptide mediated secretion of recombinant proteins
|
|
US5244805A
(en)
*
|
1989-05-17 |
1993-09-14 |
University Of Georgia Research Foundation, Inc. |
Baculovirus expression vectors
|
|
AU674500B2
(en)
|
1991-11-04 |
1997-01-02 |
Genetics Institute, Llc |
Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
|
|
PT1378572E
(pt)
|
1993-05-12 |
2007-01-31 |
Genetics Inst |
Composições de bmp-11
|
|
US6291206B1
(en)
|
1993-09-17 |
2001-09-18 |
Genetics Institute, Inc. |
BMP receptor proteins
|
|
US6027919A
(en)
|
1993-12-07 |
2000-02-22 |
Genetics Institute, Inc. |
BMP-12 and BMP-13 proteins and DNA encoding them
|
|
DE69434651T2
(de)
|
1993-12-07 |
2007-03-08 |
Genetics Institute, Inc., Cambridge |
Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
|
|
WO1995017515A1
(en)
*
|
1993-12-23 |
1995-06-29 |
University Technologies International Inc. |
Methods of expressing proteins in insect cells and methods of killing insects
|
|
US5629167A
(en)
|
1994-04-19 |
1997-05-13 |
Biocine S.P.A. |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
|
|
US6544523B1
(en)
|
1996-11-13 |
2003-04-08 |
Chiron Corporation |
Mutant forms of Fas ligand and uses thereof
|
|
US6165748A
(en)
|
1997-07-11 |
2000-12-26 |
Genetics Institute, Inc. |
Frazzled nucleotide sequences and expression products
|
|
ATE505478T1
(de)
|
1997-08-27 |
2011-04-15 |
Novartis Vaccines & Diagnostic |
Molekular-mimetika von meningokokkalen b epitopen
|
|
WO1999024578A2
(en)
|
1997-11-06 |
1999-05-20 |
Chiron S.P.A. |
Neisserial antigens
|
|
CN1224708C
(zh)
|
1998-01-14 |
2005-10-26 |
启龙股份公司 |
脑膜炎奈瑟氏球菌抗原
|
|
GB9808932D0
(en)
|
1998-04-27 |
1998-06-24 |
Chiron Spa |
Polyepitope carrier protein
|
|
EP2261350A3
(en)
|
1998-05-01 |
2012-01-04 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
WO2000022130A2
(en)
|
1998-10-15 |
2000-04-20 |
Chiron Corporation |
Metastatic breast and colon cancer regulated genes
|
|
WO2000036118A2
(en)
|
1998-12-16 |
2000-06-22 |
Chiron Corporation |
HUMAN CYCLIN-DEPENDENT KINASE (hPNQALRE)
|
|
US6727224B1
(en)
|
1999-02-01 |
2004-04-27 |
Genetics Institute, Llc. |
Methods and compositions for healing and repair of articular cartilage
|
|
NZ530640A
(en)
|
1999-04-30 |
2006-06-30 |
Chiron S |
Conserved neisserial antigens
|
|
GB9911683D0
(en)
|
1999-05-19 |
1999-07-21 |
Chiron Spa |
Antigenic peptides
|
|
GB9916529D0
(en)
|
1999-07-14 |
1999-09-15 |
Chiron Spa |
Antigenic peptides
|
|
EP1305412A2
(en)
|
1999-10-14 |
2003-05-02 |
Clontech Laboratories Inc. |
Anthozoa derived chromo/fluoroproteins and methods for using the same
|
|
ES2225241T3
(es)
|
1999-10-15 |
2005-03-16 |
Genetics Institute, Llc |
Formulaciones de acido hialuronico para suministrar proteinas osteogenicas.
|
|
PT2275552E
(pt)
|
1999-10-29 |
2015-12-07 |
Glaxosmithkline Biolog Sa |
Péptidos antigénicos de neisseria
|
|
WO2001051515A2
(en)
|
2000-01-10 |
2001-07-19 |
Chiron Corporation |
Genes differentially expressed in breast cancer
|
|
BR0107679A
(pt)
|
2000-01-17 |
2004-07-06 |
Chiron Spa |
Vacina de vesìcula de membrana externa (omv) compreendendo proteìnas de membrana externa do grupo sérico b de neisseria meningitidis
|
|
US6689599B1
(en)
|
2000-10-20 |
2004-02-10 |
Genetics Institute, Llc |
Aggrecanase molecules
|
|
ATE439372T1
(de)
|
2000-10-27 |
2009-08-15 |
Novartis Vaccines & Diagnostic |
Nukleinsäuren und proteine von gruppen a und b- streptokokken
|
|
TW200526779A
(en)
|
2001-02-08 |
2005-08-16 |
Wyeth Corp |
Modified and stabilized GDF propeptides and uses thereof
|
|
GB0107658D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Streptococcus pneumoniae
|
|
GB0107661D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Staphylococcus aureus
|
|
AU2002258728A1
(en)
|
2001-04-06 |
2002-10-21 |
Georgetown University |
Gene brcc-3 and diagnostic and therapeutic uses thereof
|
|
WO2002081639A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene brcc2 and diagnostic and therapeutic uses thereof
|
|
AU2002305151A1
(en)
|
2001-04-06 |
2002-10-21 |
Georgetown University |
Gene scc-112 and diagnostic and therapeutic uses thereof
|
|
EP1399023B1
(en)
|
2001-06-01 |
2008-04-30 |
Wyeth |
COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9;
|
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
|
US7125701B2
(en)
|
2001-07-27 |
2006-10-24 |
Wyeth |
Aggrecanase molecules
|
|
AU2002366592B2
(en)
|
2001-12-12 |
2008-01-10 |
Novartis Vaccines And Diagnostics S.R.L. |
Immunisation against Chlamydia trachomatis
|
|
ES2329666T3
(es)
|
2001-12-19 |
2009-11-30 |
The University Of Chicago |
Proteinas fluorescentes de maduracion rapida y procedimientos de uso de las mismas.
|
|
JP2005515779A
(ja)
|
2002-01-31 |
2005-06-02 |
ワイス |
アグレカナーゼ分子
|
|
PL373396A1
(en)
|
2002-02-05 |
2005-08-22 |
Wyeth |
Truncated aggrecanase molecules
|
|
US7244565B2
(en)
|
2002-04-10 |
2007-07-17 |
Georgetown University |
Gene shinc-3 and diagnostic and therapeutic uses thereof
|
|
US7138512B2
(en)
|
2002-04-10 |
2006-11-21 |
Georgetown University |
Gene SHINC-2 and diagnostic and therapeutic uses thereof
|
|
WO2003099854A2
(en)
|
2002-05-24 |
2003-12-04 |
Nps Allelix Corp. |
Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
|
|
CA2485695A1
(en)
|
2002-05-24 |
2003-12-04 |
Fred W. Wagner |
Method for universal enzymatic production of bioactive peptides
|
|
EP2279746B1
(en)
|
2002-11-15 |
2013-10-02 |
Novartis Vaccines and Diagnostics S.r.l. |
Surface proteins in neisseria meningitidis
|
|
GB0308198D0
(en)
|
2003-04-09 |
2003-05-14 |
Chiron Srl |
ADP-ribosylating bacterial toxin
|
|
KR20060133961A
(ko)
|
2003-09-12 |
2006-12-27 |
와이어쓰 |
골형성 단백질 전달용의 주사 가능한 인산칼슘 고형 로드및 페이스트
|
|
CA2546319A1
(en)
|
2003-11-21 |
2005-07-28 |
Nps Allelix Corp. |
Production of glucagon like peptide 2 and analogs
|
|
NZ548255A
(en)
|
2004-02-02 |
2010-10-29 |
Ambrx Inc |
Modified human interferon polypeptides and their uses
|
|
KR101222281B1
(ko)
|
2004-03-29 |
2013-01-28 |
가르파마 컴퍼니 리미티드 |
신규 갈렉틴 9 개변체 단백질 및 그 용도
|
|
JP4755174B2
(ja)
|
2004-04-07 |
2011-08-24 |
ザ ユニヴァーシティー オヴ シカゴ |
単量体赤色蛍光タンパク質
|
|
CN102603895B
(zh)
|
2004-06-18 |
2016-09-28 |
Ambrx公司 |
新颖抗原结合多肽和其用途
|
|
BRPI0512396A
(pt)
|
2004-07-21 |
2008-03-11 |
Ambrx Inc |
polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente
|
|
KR20070090023A
(ko)
|
2004-12-22 |
2007-09-04 |
암브룩스, 인코포레이티드 |
변형 인간 성장 호르몬
|
|
NZ555308A
(en)
|
2004-12-22 |
2010-10-29 |
Ambrx Inc |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
BRPI0609695A2
(pt)
|
2005-03-21 |
2011-10-18 |
Applera Corp |
composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para tratar uma doença e uma paciente sofrendo uma terapia
|
|
EP3683230A1
(en)
|
2005-05-12 |
2020-07-22 |
ZymoGenetics, Inc. |
Compositions and methods for modulating immune responses
|
|
WO2007053732A2
(en)
|
2005-11-01 |
2007-05-10 |
Mayo Foundation For Medical Education And Research |
Promoter polymorphisms of the blys gene and use in diagnostic methods
|
|
ES2547554T3
(es)
|
2005-11-16 |
2015-10-07 |
Ambrx, Inc. |
Métodos y composiciones que comprenden aminoácidos no naturales
|
|
WO2009030978A2
(en)
|
2006-06-09 |
2009-03-12 |
Novartis Ag |
Conformers of bacterial adhesins
|
|
MX2009002523A
(es)
|
2006-09-08 |
2009-03-20 |
Ambrx Inc |
Polipeptido de plasma humano modificado o andamios fc y sus usos.
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
AU2008232937B2
(en)
|
2007-03-30 |
2012-09-27 |
Ambrx, Inc. |
Modified FGF-21 polypeptides and their uses
|
|
CA2971794C
(en)
|
2007-10-04 |
2020-03-24 |
Zymogenetics, Inc. |
B7 family member zb7h6 and related compositions and methods
|
|
WO2009059305A2
(en)
|
2007-11-01 |
2009-05-07 |
The University Of Chicago |
Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
|
|
EP2217265B1
(en)
|
2007-11-20 |
2017-05-10 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
WO2009073511A2
(en)
|
2007-11-30 |
2009-06-11 |
Mayo Foundation For Medical Education And Research |
Polymorphisms of the blys gene and use in diagnostic methods
|
|
NZ586947A
(en)
|
2008-02-08 |
2012-11-30 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
UA103774C2
(uk)
|
2008-07-23 |
2013-11-25 |
Амбркс, Інк. |
Модифіковані поліпептиди бичачого гранулоцитарного колонієстимулювального фактора (g-csf) та їх застосування
|
|
MX357314B
(es)
|
2008-09-26 |
2018-07-04 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
|
|
BR122012024318A2
(pt)
|
2008-09-26 |
2019-07-30 |
Ambrx, Inc. |
Polipeptídeos modificados de eritropoetina animal e seus usos
|
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
|
EP2333074A1
(en)
|
2009-12-14 |
2011-06-15 |
Robert Steinfeld |
Substances and methods for the treatment of lysosmal storage diseases
|
|
JP2013515080A
(ja)
|
2009-12-21 |
2013-05-02 |
アンブルックス,インコーポレイテッド |
修飾されているウシのソマトトロピンポリペプチドおよびそれらの使用
|
|
EP2805965A1
(en)
|
2009-12-21 |
2014-11-26 |
Ambrx, Inc. |
Modified porcine somatotropin polypeptides and their uses
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
SMT201900495T1
(it)
|
2010-08-17 |
2019-11-13 |
Ambrx Inc |
Polipeptidi di relaxina modificati e loro usi
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
JP6122430B2
(ja)
|
2011-07-27 |
2017-04-26 |
ジェネトン |
改善されたバキュロウイルス発現系
|
|
JP6735672B2
(ja)
|
2013-09-12 |
2020-08-05 |
バイオマリン ファーマシューティカル インコーポレイテッド |
アデノ随伴ウイルス第viii因子ベクター
|
|
CN114805531A
(zh)
|
2014-10-24 |
2022-07-29 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
|
EP3352787A1
(en)
|
2015-09-24 |
2018-08-01 |
BioMarin Pharmaceutical Inc. |
Adeno-associated virus factor viii vectors, associated viral particles and therapeutic formulations comprising the same
|
|
DK3373980T3
(da)
|
2015-11-12 |
2025-06-30 |
The Res Institute At Nationwide Childrens Hospital |
Fremgangsmåder til behandling af muskeldystrofi
|
|
JP7418957B2
(ja)
|
2015-11-16 |
2024-01-22 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
タイチン系ミオパチー及び他のタイチノパチーの治療のための材料及び方法
|
|
EP3491008A2
(en)
|
2016-07-26 |
2019-06-05 |
BioMarin Pharmaceutical Inc. |
Novel adeno-associated virus capsid proteins
|
|
TW201837051A
(zh)
|
2017-02-08 |
2018-10-16 |
美商必治妥美雅史谷比公司 |
包含藥物動力學增強劑之經修飾之鬆弛素(relaxin)多肽及其用途
|
|
US20200231986A1
(en)
|
2017-09-29 |
2020-07-23 |
Massachusetts Eye And Ear Infirmary |
Production of adeno-associated viruses in insect cells
|
|
IL275880B2
(en)
|
2018-01-31 |
2025-10-01 |
Res Inst Nationwide Childrens Hospital |
Gene therapy for brachioradial muscular dystrophy type 2C
|
|
AU2019265560A1
(en)
|
2018-05-09 |
2020-11-26 |
Biomarin Pharmaceutical Inc. |
Methods of treating phenylketonuria
|
|
EP3794112A1
(en)
|
2018-05-14 |
2021-03-24 |
BioMarin Pharmaceutical Inc. |
Stable expression of aav vectors in juvenile subjects
|
|
TW202005978A
(zh)
|
2018-05-14 |
2020-02-01 |
美商拜奧馬林製藥公司 |
新穎肝靶向腺相關病毒載體
|
|
BR112020026853A2
(pt)
|
2018-06-29 |
2021-04-20 |
Research Institute At Nationwide Children's Hospital |
produtos de vírus adeno-associados recombinantes e métodos para tratar a distrofia muscular de cinturas tipo 2a
|
|
JP2022521776A
(ja)
|
2019-02-26 |
2022-04-12 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
Β-サルコグリカンのアデノ随伴ウイルスベクター送達および筋ジストロフィーの治療
|
|
TW202104592A
(zh)
|
2019-05-14 |
2021-02-01 |
美商拜奧馬林製藥公司 |
重複投予基因療法載體之方法
|
|
AU2020331987B2
(en)
|
2019-08-21 |
2025-10-16 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of alpha-sarcoglycan and the treatment of muscular dystrophy
|
|
BR112022005392A2
(pt)
|
2019-09-27 |
2022-09-06 |
Biomarin Pharm Inc |
Caracterização de partículas virais de terapia genética que usa cromatografia por exclusão de tamanho e tecnologias de dispersão de luz multiangular
|
|
CN114829391A
(zh)
|
2019-11-14 |
2022-07-29 |
生物马林药物股份有限公司 |
用肝特异性基因疗法载体治疗遗传性血管性水肿
|
|
US20230075854A1
(en)
|
2020-02-10 |
2023-03-09 |
Biomarin Pharmaceutical Inc. |
Virus-free cell cultures
|
|
WO2021183895A1
(en)
|
2020-03-13 |
2021-09-16 |
Biomarin Pharmaceutical Inc. |
Treatment of fabry disease with aav gene therapy vectors
|
|
AR122409A1
(es)
|
2020-04-03 |
2022-09-07 |
Biomarin Pharm Inc |
Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas
|
|
WO2021236908A2
(en)
|
2020-05-20 |
2021-11-25 |
Biomarin Pharmaceutical Inc. |
Use of regulatory proteins for the production of adeno-associated virus
|
|
IL302128A
(en)
|
2020-11-02 |
2023-06-01 |
Biomarin Pharm Inc |
A process for the enrichment of adeno-associated virus
|
|
AR127217A1
(es)
|
2021-10-01 |
2023-12-27 |
Biomarin Pharm Inc |
Tratamiento de angioedema hereditario con vectores de genoterapia de aav y formulaciones terapéuticas
|
|
US12285497B2
(en)
|
2021-10-15 |
2025-04-29 |
Research Institute At Nationwide Children's Hospital |
Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy
|
|
EP4590839A1
(en)
|
2022-09-22 |
2025-07-30 |
Dinaqor AG |
Treatment of cardiomyopathy with aav gene therapy vectors
|
|
WO2024064863A2
(en)
|
2022-09-22 |
2024-03-28 |
Biomarin Pharmaceutical Inc. |
Treatment of arrhythmogenic cardiomyopathy with aav gene therapy vectors
|
|
WO2024151568A1
(en)
|
2023-01-09 |
2024-07-18 |
Biomarin Pharmaceutical Inc. |
Epigenetic modifiers improve aav gene therapy durability
|
|
WO2024238591A2
(en)
|
2023-05-15 |
2024-11-21 |
Biomarin Pharmaceutical Inc. |
Methods of treating anti-aav seropositive hemophilia patients
|
|
WO2025214477A1
(en)
|
2024-04-12 |
2025-10-16 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Treatment of genetic cardiomyopathies with aav gene therapy vectors
|