IL73756A - 5-sulfamoylalkyl-3-aminoalkyl indole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

5-sulfamoylalkyl-3-aminoalkyl indole derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL73756A
IL73756A IL73756A IL7375684A IL73756A IL 73756 A IL73756 A IL 73756A IL 73756 A IL73756 A IL 73756A IL 7375684 A IL7375684 A IL 7375684A IL 73756 A IL73756 A IL 73756A
Authority
IL
Israel
Prior art keywords
sulfamoylalkyl
preparation
pharmaceutical compositions
compositions containing
indole derivatives
Prior art date
Application number
IL73756A
Other languages
English (en)
Other versions
IL73756A0 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IL73756A0 publication Critical patent/IL73756A0/xx
Publication of IL73756A publication Critical patent/IL73756A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL73756A 1983-12-06 1984-12-06 5-sulfamoylalkyl-3-aminoalkyl indole derivatives,their preparation and pharmaceutical compositions containing them IL73756A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332435A GB8332435D0 (en) 1983-12-06 1983-12-06 Chemical compounds

Publications (2)

Publication Number Publication Date
IL73756A0 IL73756A0 (en) 1985-03-31
IL73756A true IL73756A (en) 1988-02-29

Family

ID=10552845

Family Applications (1)

Application Number Title Priority Date Filing Date
IL73756A IL73756A (en) 1983-12-06 1984-12-06 5-sulfamoylalkyl-3-aminoalkyl indole derivatives,their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US4994483A (no)
JP (2) JPH062733B2 (no)
KR (1) KR850004459A (no)
CN (2) CN85104233A (no)
AT (1) AT381934B (no)
AU (1) AU575365B2 (no)
BE (1) BE901224A (no)
CA (1) CA1233183A (no)
CH (1) CH663411A5 (no)
CY (1) CY1562A (no)
DE (1) DE3444572C2 (no)
DK (2) DK583684A (no)
ES (2) ES8607234A1 (no)
FI (1) FI80260C (no)
FR (1) FR2555987B1 (no)
GB (2) GB8332435D0 (no)
HK (1) HK85690A (no)
HU (2) HU196752B (no)
IL (1) IL73756A (no)
IT (1) IT1178268B (no)
NL (1) NL8403719A (no)
NO (1) NO162764C (no)
NZ (1) NZ210469A (no)
PT (1) PT80572B (no)
SE (1) SE458446B (no)
SG (1) SG65790G (no)
ZA (1) ZA849498B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8430624D0 (en) * 1984-12-04 1985-01-09 Glaxo Group Ltd Chemical compounds
FR2574077A1 (fr) * 1984-12-04 1986-06-06 Glaxo Group Ltd Derives d'indoles, leur preparation et les compositions pharmaceutiques les contenant
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB2208646B (en) * 1987-08-13 1991-06-26 Glaxo Group Ltd Indole derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JPH01312506A (ja) * 1988-06-13 1989-12-18 Mitsui Petrochem Ind Ltd カラーフィルター
SI21560B (sl) * 1990-06-07 2005-04-30 Astrazeneca Ab 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IT1264813B1 (it) * 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
EP2666772B1 (en) * 2002-12-20 2017-03-01 Basf Se Synthesis of amines and intermediates for the synthesis thereof
EP1626956A1 (en) * 2003-05-12 2006-02-22 Potluri, Ramesh Babu A novel process for preparation of indole derivatives
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
KR20130136010A (ko) 2005-04-13 2013-12-11 네우렉슨 인코포레이티드 Ｎｏｓ 저해 활성을 갖는 치환된 인돌 화합물
EP2010527B1 (en) * 2006-04-13 2013-08-14 Neuraxon Inc. 1,5 and 3,6- substituted indole compounds having nos inhibitory activity
WO2008056378A2 (en) * 2006-11-09 2008-05-15 Natco Pharma Limited Novel process for the preparation of naratriptan hydrochloride
AU2008214205B2 (en) * 2007-02-11 2014-04-24 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
MX2010005343A (es) * 2007-11-16 2010-08-09 Neuraxon Inc Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina.
US20090163451A1 (en) * 2007-11-16 2009-06-25 Frank Porreca Methods for treating visceral pain
WO2009062319A1 (en) 2007-11-16 2009-05-22 Neuraxon, Inc. Indole compounds and methods for treating visceral pain
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
CA2775404C (en) 2009-09-25 2017-01-03 Dr. Reddy's Laboratories Limited Formulations comprising triptan compounds
WO2012165262A1 (ja) * 2011-05-27 2012-12-06 国立大学法人徳島大学 ベンジルアミン誘導体
AU2012287120B2 (en) 2011-07-22 2017-02-23 The University Of Chicago Treatments for migraine and related disorders
CN102827062A (zh) * 2012-09-17 2012-12-19 扬子江药业集团四川海蓉药业有限公司 苹果酸阿莫曲坦的制备方法
US9394314B2 (en) 2012-12-21 2016-07-19 Map Pharmaceuticals, Inc. 8′-hydroxy-dihydroergotamine compounds and compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322787A (en) * 1964-09-25 1967-05-30 Merck & Co Inc Alpha-hydrazino-beta-(3-indolyl) alkanoic acid derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
US3730723A (en) * 1971-06-17 1973-05-01 Eastman Kodak Co Direct positive processes utilizing silver halide surface image emulsions containing desensitizers
US4283410A (en) * 1978-06-15 1981-08-11 Miles Laboratories, Inc. 3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
GB2083463B (en) * 1980-08-12 1984-05-10 Glaxo Group Ltd Heterocyclic compounds
NZ197996A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 1-(3-(omega-aminoalkyl)-1h-indol-5-yl)alkanamides
GR79215B (no) * 1982-06-07 1984-10-22 Glaxo Group Ltd
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
FR2574077A1 (fr) * 1984-12-04 1986-06-06 Glaxo Group Ltd Derives d'indoles, leur preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ES538336A0 (es) 1986-06-01
CY1562A (en) 1991-05-17
SE8406200D0 (sv) 1984-12-06
GB2150932A (en) 1985-07-10
CN85104233A (zh) 1987-01-07
AT381934B (de) 1986-12-10
NO162764B (no) 1989-11-06
ES8607234A1 (es) 1986-06-01
SE458446B (sv) 1989-04-03
DK583684A (da) 1985-06-07
DE3444572A1 (de) 1985-06-20
DE3444572C2 (de) 1993-10-14
SG65790G (en) 1990-10-26
JPS60155156A (ja) 1985-08-15
SE8406200L (sv) 1985-06-07
NO844879L (no) 1985-06-07
BE901224A (fr) 1985-06-06
GB2150932B (en) 1987-10-28
DK214090A (da) 1990-09-06
HUT36455A (en) 1985-09-30
IL73756A0 (en) 1985-03-31
IT1178268B (it) 1987-09-09
CN1015055B (zh) 1991-12-11
FI844789A0 (fi) 1984-12-05
AU575365B2 (en) 1988-07-28
FI844789L (fi) 1985-06-07
FR2555987B1 (fr) 1987-07-17
HK85690A (en) 1990-10-25
HUT40624A (en) 1987-01-28
DK583684D0 (da) 1984-12-06
FI80260C (fi) 1990-05-10
CH663411A5 (fr) 1987-12-15
ES546631A0 (es) 1987-10-16
CA1233183A (en) 1988-02-23
PT80572B (en) 1986-12-22
GB8430810D0 (en) 1985-01-16
FI80260B (fi) 1990-01-31
NO162764C (no) 1990-02-14
HU196752B (en) 1989-01-30
PT80572A (en) 1985-06-01
DK214090D0 (da) 1990-09-06
US4994483A (en) 1991-02-19
ZA849498B (en) 1986-09-24
FR2555987A1 (fr) 1985-06-07
JPH03184958A (ja) 1991-08-12
JPH062733B2 (ja) 1994-01-12
NL8403719A (nl) 1985-07-01
IT8449265A0 (it) 1984-12-06
ATA387384A (de) 1986-05-15
AU3636784A (en) 1985-06-13
KR850004459A (ko) 1985-07-15
GB8332435D0 (en) 1984-01-11
ES8800150A1 (es) 1987-10-16
NZ210469A (en) 1989-01-27
CN85106225A (zh) 1987-02-18

Similar Documents

Publication Publication Date Title
IL73756A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL68913A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL81201A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL86877A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL69157A0 (en) Fluoromorphinan derivatives,their preparation and pharmaceutical compositions containing them
ZA849499B (en) Indole derivatives,processes for their preparation and pharmaceutical compositions containing them
IL70756A (en) 3-amino-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
IL72151A0 (en) Tetrahydropyridazinone derivatives,their preparation and pharmaceutical compositions containing them
IL73332A0 (en) Triazine derivatives,their preparation and pharmaceutical compositions containing them
IL72298A0 (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL68360A (en) Imidazopyrazolopyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL68817A0 (en) Oxoazetidine derivatives,their preparation and pharmaceutical compositions containing them
IL71633A (en) Ergoline derivatives,their preparation and pharmaceutical compositions containing them
IL70755A (en) 3-amino-4-cyano-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
IL66223A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL73222A0 (en) Benzenesulfonyl-lactam derivatives,their preparation and pharmaceutical compositions containing them
DE3572977D1 (en) Indole derivatives, their preparation, their use as medicines and compositions containing them
IL73259A0 (en) Imidazoline derivatives,their preparation and pharmaceutical compositions containing them
IL73897A0 (en) Benzimidazole derivatives,their preparation and pharmaceutical compositions containing them
IL73902A (en) Gonadoliberin derivatives,their preparation and pharmaceutical compositions containing them
IL70611A (en) Tetrahydrocarbazole derivatives,their preparation and pharmaceutical compositions comprising them
IL72173A0 (en) Guanine derivatives,their preparation and pharmaceutical compositions containing them
IL68496A (en) 8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them
DE3380093D1 (en) 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
IL73776A (en) N-phenyl-1h-tetrazole-5-carboxamide derivatives,their preparation and pharmaceutical compositions containing them