IL42764A - S-adenosyl-2-methionine tri-p-toluene sulfonate,its preparation and therapeutic compositions containing it - Google Patents
S-adenosyl-2-methionine tri-p-toluene sulfonate,its preparation and therapeutic compositions containing itInfo
- Publication number
- IL42764A IL42764A IL42764A IL4276473A IL42764A IL 42764 A IL42764 A IL 42764A IL 42764 A IL42764 A IL 42764A IL 4276473 A IL4276473 A IL 4276473A IL 42764 A IL42764 A IL 42764A
- Authority
- IL
- Israel
- Prior art keywords
- sam
- acid
- tri
- aqueous solution
- toluensulphonate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 8
- 230000001225 therapeutic effect Effects 0.000 title claims abstract 7
- 238000000034 method Methods 0.000 claims abstract 11
- 239000007864 aqueous solution Substances 0.000 claims abstract 9
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000004060 metabolic process Effects 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 229960004452 methionine Drugs 0.000 claims abstract 3
- 150000001412 amines Chemical class 0.000 claims abstract 2
- 150000003943 catecholamines Chemical class 0.000 claims abstract 2
- 150000002632 lipids Chemical class 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 230000002969 morbid Effects 0.000 claims 3
- 239000011347 resin Substances 0.000 claims 3
- 229920005989 resin Polymers 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 125000000129 anionic group Chemical group 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910021653 sulphate ion Inorganic materials 0.000 claims 1
- 239000001117 sulphuric acid Substances 0.000 claims 1
- 235000011149 sulphuric acid Nutrition 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2779372 | 1972-08-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42764A0 IL42764A0 (en) | 1974-01-14 |
| IL42764A true IL42764A (en) | 1976-04-30 |
Family
ID=11222342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42764A IL42764A (en) | 1972-08-02 | 1973-07-17 | S-adenosyl-2-methionine tri-p-toluene sulfonate,its preparation and therapeutic compositions containing it |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US3893999A (ro) |
| JP (1) | JPS5235726B2 (ro) |
| AR (1) | AR195350A1 (ro) |
| AT (1) | AT341684B (ro) |
| AU (1) | AU474015B2 (ro) |
| BE (1) | BE802981A (ro) |
| CA (1) | CA1006872A (ro) |
| CH (1) | CH592112A5 (ro) |
| CS (1) | CS195254B2 (ro) |
| DD (1) | DD107461A5 (ro) |
| DE (1) | DE2336401C3 (ro) |
| DK (1) | DK131868C (ro) |
| ES (1) | ES417377A1 (ro) |
| FI (1) | FI52466C (ro) |
| FR (1) | FR2194425B1 (ro) |
| GB (1) | GB1425384A (ro) |
| HK (1) | HK31580A (ro) |
| HU (1) | HU167266B (ro) |
| IE (1) | IE37913B1 (ro) |
| IL (1) | IL42764A (ro) |
| MX (1) | MX4544E (ro) |
| NL (1) | NL152864B (ro) |
| NO (1) | NO137941C (ro) |
| PL (1) | PL87381B1 (ro) |
| RO (1) | RO63451A (ro) |
| SE (1) | SE400085B (ro) |
| SU (1) | SU646915A3 (ro) |
| YU (1) | YU36037B (ro) |
| ZA (1) | ZA734876B (ro) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE39517B1 (en) * | 1973-06-27 | 1978-10-25 | Bioresearch Sas | Double salts of s-adenosyl-l-methhionine |
| AR221676A1 (es) * | 1974-07-12 | 1981-03-13 | Bioresearch Sas | Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico |
| US4109079A (en) * | 1975-10-16 | 1978-08-22 | Yamasa Shoyu Kabushiki Kaisha | Stabilized s-adenosyl-l-methionine preparations |
| GB2064523B (en) * | 1979-12-04 | 1983-06-29 | Kanegafuchi Chemical Ind | Stable composition of s-adenosyl-l-methionine |
| IT1137640B (it) * | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1137892B (it) * | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1139974B (it) * | 1981-09-11 | 1986-09-24 | Bioresearch Srl | Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo |
| IT1169773B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Processo per la produzione di sali stabili della solfo-adenosil-l-metionina |
| IT1169774B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina |
| IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
| IT1200589B (it) * | 1985-02-14 | 1989-01-27 | Gibipharma Spa | Derivati naturali attivita farmagologica |
| AU2538588A (en) * | 1987-10-09 | 1989-05-02 | Mario De Rosa | Lipophilic salts of s-adenosyl-l-methionine (sam) with acylated taurine derivatives |
| DE19515275A1 (de) * | 1995-04-26 | 1996-10-31 | Knoll Ag | Neue Verwendung von (S)-Adenosyl-L-methionin(SAMe) |
| US6759395B2 (en) | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
| US8063024B2 (en) * | 2005-01-26 | 2011-11-22 | University Of Manitoba | Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance |
| US20090012036A1 (en) * | 2005-05-24 | 2009-01-08 | Hebert Rolland F | Stable S-adenosyl-L-methionine |
| ITMI20060629A1 (it) * | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
| US20080206333A1 (en) * | 2007-01-31 | 2008-08-28 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| US20090088404A1 (en) * | 2007-01-31 | 2009-04-02 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| US20090197824A1 (en) * | 2008-01-31 | 2009-08-06 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| ITMI20071374A1 (it) * | 2007-07-10 | 2009-01-11 | Gnosis Spa | Sali stabili di s-adenosilmetionina e processo per il loro ottenimento. |
| US20100004191A1 (en) * | 2008-07-01 | 2010-01-07 | Rolland F Hebert | Compositions of S-adenosyl-L-methionine. |
| US20110027342A1 (en) | 2009-07-28 | 2011-02-03 | Msi Methylation Sciences, Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
| US8329208B2 (en) * | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
| US20140187509A1 (en) * | 2011-04-15 | 2014-07-03 | Scimar Ltd. | Use of s-adenosylmethionine, vitamin e, and vitamin c for the prevention and treatment of cardiovascular dysfunction |
| IN2015DN04151A (ro) | 2012-10-17 | 2015-10-16 | Methylation Sciences Internat Srl | |
| ES2824807T3 (es) | 2013-01-16 | 2021-05-13 | Hebert Sam E Llc | Sales de indol-3-propionato estables de S-adenosil-L-metionina |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2946781A (en) * | 1957-02-06 | 1960-07-26 | Merck & Co Inc | Process for the preparation of adenosyl homocysteine |
| US3642772A (en) * | 1968-09-04 | 1972-02-15 | Boehringer Mannheim Gmbh | Process for preparing s-adenosyl homocysteine |
-
1973
- 1973-07-16 IE IE1192/73A patent/IE37913B1/xx unknown
- 1973-07-17 IL IL42764A patent/IL42764A/en unknown
- 1973-07-17 ZA ZA734876A patent/ZA734876B/xx unknown
- 1973-07-17 US US380097A patent/US3893999A/en not_active Expired - Lifetime
- 1973-07-17 DE DE2336401A patent/DE2336401C3/de not_active Expired
- 1973-07-19 FR FR7326500A patent/FR2194425B1/fr not_active Expired
- 1973-07-19 GB GB3449973A patent/GB1425384A/en not_active Expired
- 1973-07-25 RO RO7300075582A patent/RO63451A/ro unknown
- 1973-07-26 CS CS735374A patent/CS195254B2/cs unknown
- 1973-07-26 YU YU2030/73A patent/YU36037B/xx unknown
- 1973-07-27 AR AR249310A patent/AR195350A1/es active
- 1973-07-27 AT AT664173A patent/AT341684B/de not_active IP Right Cessation
- 1973-07-27 CA CA177,689A patent/CA1006872A/en not_active Expired
- 1973-07-30 BE BE134028A patent/BE802981A/xx not_active IP Right Cessation
- 1973-07-30 AU AU58680/73A patent/AU474015B2/en not_active Expired
- 1973-07-30 ES ES417377A patent/ES417377A1/es not_active Expired
- 1973-08-01 DK DK422773A patent/DK131868C/da not_active IP Right Cessation
- 1973-08-01 NO NO3084/73A patent/NO137941C/no unknown
- 1973-08-01 PL PL1973164439A patent/PL87381B1/pl unknown
- 1973-08-01 SU SU731945967A patent/SU646915A3/ru active
- 1973-08-01 DD DD172669A patent/DD107461A5/xx unknown
- 1973-08-01 MX MX737933U patent/MX4544E/es unknown
- 1973-08-01 SE SE7310587A patent/SE400085B/xx unknown
- 1973-08-01 HU HUEE2163A patent/HU167266B/hu unknown
- 1973-08-02 FI FI732438A patent/FI52466C/fi active
- 1973-08-02 CH CH1125173A patent/CH592112A5/xx not_active IP Right Cessation
- 1973-08-02 NL NL737310706A patent/NL152864B/xx not_active IP Right Cessation
- 1973-08-02 JP JP48086440A patent/JPS5235726B2/ja not_active Expired
-
1980
- 1980-06-12 HK HK315/80A patent/HK31580A/xx unknown
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