SE400085B - Forfarande for framstellning av tri-p-toluensulfonat av s-adenosyl-l-metionin (sam) - Google Patents

Forfarande for framstellning av tri-p-toluensulfonat av s-adenosyl-l-metionin (sam)

Info

Publication number
SE400085B
SE400085B SE7310587A SE7310587A SE400085B SE 400085 B SE400085 B SE 400085B SE 7310587 A SE7310587 A SE 7310587A SE 7310587 A SE7310587 A SE 7310587A SE 400085 B SE400085 B SE 400085B
Authority
SE
Sweden
Prior art keywords
metionin
adenosyl
sam
procedure
toluene sulphonate
Prior art date
Application number
SE7310587A
Other languages
English (en)
Swedish (sv)
Inventor
Alberto Fiecchi
Original Assignee
Bioresearch Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Sas filed Critical Bioresearch Sas
Publication of SE400085B publication Critical patent/SE400085B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
SE7310587A 1972-08-02 1973-08-01 Forfarande for framstellning av tri-p-toluensulfonat av s-adenosyl-l-metionin (sam) SE400085B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2779372 1972-08-02

Publications (1)

Publication Number Publication Date
SE400085B true SE400085B (sv) 1978-03-13

Family

ID=11222342

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7310587A SE400085B (sv) 1972-08-02 1973-08-01 Forfarande for framstellning av tri-p-toluensulfonat av s-adenosyl-l-metionin (sam)

Country Status (29)

Country Link
US (1) US3893999A (xx)
JP (1) JPS5235726B2 (xx)
AR (1) AR195350A1 (xx)
AT (1) AT341684B (xx)
AU (1) AU474015B2 (xx)
BE (1) BE802981A (xx)
CA (1) CA1006872A (xx)
CH (1) CH592112A5 (xx)
CS (1) CS195254B2 (xx)
DD (1) DD107461A5 (xx)
DE (1) DE2336401C3 (xx)
DK (1) DK131868C (xx)
ES (1) ES417377A1 (xx)
FI (1) FI52466C (xx)
FR (1) FR2194425B1 (xx)
GB (1) GB1425384A (xx)
HK (1) HK31580A (xx)
HU (1) HU167266B (xx)
IE (1) IE37913B1 (xx)
IL (1) IL42764A (xx)
MX (1) MX4544E (xx)
NL (1) NL152864B (xx)
NO (1) NO137941C (xx)
PL (1) PL87381B1 (xx)
RO (1) RO63451A (xx)
SE (1) SE400085B (xx)
SU (1) SU646915A3 (xx)
YU (1) YU36037B (xx)
ZA (1) ZA734876B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
AR221676A1 (es) * 1974-07-12 1981-03-13 Bioresearch Sas Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
US4109079A (en) * 1975-10-16 1978-08-22 Yamasa Shoyu Kabushiki Kaisha Stabilized s-adenosyl-l-methionine preparations
GB2064523B (en) * 1979-12-04 1983-06-29 Kanegafuchi Chemical Ind Stable composition of s-adenosyl-l-methionine
IT1137640B (it) 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1169774B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
AU2538588A (en) * 1987-10-09 1989-05-02 Mario De Rosa Lipophilic salts of s-adenosyl-l-methionine (sam) with acylated taurine derivatives
DE19515275A1 (de) * 1995-04-26 1996-10-31 Knoll Ag Neue Verwendung von (S)-Adenosyl-L-methionin(SAMe)
US6759395B2 (en) 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
US8063024B2 (en) * 2005-01-26 2011-11-22 University Of Manitoba Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
CA2677053C (en) * 2007-01-31 2016-03-15 Methylation Sciences International Srl Extended release pharmaceutical formulations of s-adenosylmethionine
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20090197824A1 (en) * 2008-01-31 2009-08-06 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
US20110027342A1 (en) * 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
EP2696879A4 (en) 2011-04-15 2014-11-26 Scimar Ltd USE OF S-ADENOSYLMETHIONINE, VITAMIN E AND VITAMIN C IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DYSFUNCTION
CN106074589A (zh) 2012-10-17 2016-11-09 甲基化物科学国际有限公司 包含s‑腺苷甲硫氨酸及没食子酸酯的组合物
EP2945959B1 (en) 2013-01-16 2020-05-13 Hebert Sam-E LLC Stable indole-3-propionate salts of s-adenosyl-l-methionine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946781A (en) * 1957-02-06 1960-07-26 Merck & Co Inc Process for the preparation of adenosyl homocysteine
US3642772A (en) * 1968-09-04 1972-02-15 Boehringer Mannheim Gmbh Process for preparing s-adenosyl homocysteine

Also Published As

Publication number Publication date
YU36037B (en) 1981-11-13
ES417377A1 (es) 1976-02-16
DK131868B (da) 1975-09-15
SU646915A3 (ru) 1979-02-05
AU474015B2 (en) 1976-07-08
CS195254B2 (en) 1980-01-31
HU167266B (xx) 1975-09-27
AR195350A1 (es) 1973-09-28
ATA664173A (de) 1977-06-15
CH592112A5 (xx) 1977-10-14
DE2336401C3 (de) 1980-03-13
NL7310706A (xx) 1974-02-05
FI52466B (xx) 1977-05-31
NO137941C (no) 1978-05-31
IE37913L (en) 1974-02-02
DD107461A5 (xx) 1974-08-05
IE37913B1 (en) 1977-11-09
IL42764A (en) 1976-04-30
FR2194425B1 (xx) 1976-04-09
AU5868073A (en) 1975-01-30
CA1006872A (en) 1977-03-15
FI52466C (fi) 1977-09-12
NO137941B (no) 1978-02-13
NL152864B (nl) 1977-04-15
ZA734876B (en) 1974-06-26
PL87381B1 (xx) 1976-06-30
DK131868C (da) 1976-03-08
HK31580A (en) 1980-06-20
YU203073A (en) 1981-04-30
RO63451A (fr) 1978-07-15
AT341684B (de) 1978-02-27
DE2336401A1 (de) 1974-02-14
US3893999A (en) 1975-07-08
JPS5235726B2 (xx) 1977-09-10
DE2336401B2 (de) 1979-07-12
MX4544E (es) 1982-06-08
IL42764A0 (en) 1974-01-14
GB1425384A (en) 1976-02-18
FR2194425A1 (xx) 1974-03-01
BE802981A (fr) 1973-11-16
JPS4992215A (xx) 1974-09-03

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