ATA664173A - Verfahren zur herstellung des neuen tri-p-toluolsulfonats von s-ademosyl-l-methionin - Google Patents

Verfahren zur herstellung des neuen tri-p-toluolsulfonats von s-ademosyl-l-methionin

Info

Publication number
ATA664173A
ATA664173A AT664173A AT664173A ATA664173A AT A664173 A ATA664173 A AT A664173A AT 664173 A AT664173 A AT 664173A AT 664173 A AT664173 A AT 664173A AT A664173 A ATA664173 A AT A664173A
Authority
AT
Austria
Prior art keywords
ademosyl
methionine
preparing
toluene sulfonate
new tri
Prior art date
Application number
AT664173A
Other languages
English (en)
Other versions
AT341684B (de
Inventor
Alberto Fiecchi
Original Assignee
Bioresearch Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Sas filed Critical Bioresearch Sas
Publication of ATA664173A publication Critical patent/ATA664173A/de
Application granted granted Critical
Publication of AT341684B publication Critical patent/AT341684B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT664173A 1972-08-02 1973-07-27 Verfahren zur herstellung des neuen tri-p-toluolsulfonats von s-adenosyl -l-methionin AT341684B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2779372 1972-08-02

Publications (2)

Publication Number Publication Date
ATA664173A true ATA664173A (de) 1977-06-15
AT341684B AT341684B (de) 1978-02-27

Family

ID=11222342

Family Applications (1)

Application Number Title Priority Date Filing Date
AT664173A AT341684B (de) 1972-08-02 1973-07-27 Verfahren zur herstellung des neuen tri-p-toluolsulfonats von s-adenosyl -l-methionin

Country Status (29)

Country Link
US (1) US3893999A (de)
JP (1) JPS5235726B2 (de)
AR (1) AR195350A1 (de)
AT (1) AT341684B (de)
AU (1) AU474015B2 (de)
BE (1) BE802981A (de)
CA (1) CA1006872A (de)
CH (1) CH592112A5 (de)
CS (1) CS195254B2 (de)
DD (1) DD107461A5 (de)
DE (1) DE2336401C3 (de)
DK (1) DK131868C (de)
ES (1) ES417377A1 (de)
FI (1) FI52466C (de)
FR (1) FR2194425B1 (de)
GB (1) GB1425384A (de)
HK (1) HK31580A (de)
HU (1) HU167266B (de)
IE (1) IE37913B1 (de)
IL (1) IL42764A (de)
MX (1) MX4544E (de)
NL (1) NL152864B (de)
NO (1) NO137941C (de)
PL (1) PL87381B1 (de)
RO (1) RO63451A (de)
SE (1) SE400085B (de)
SU (1) SU646915A3 (de)
YU (1) YU36037B (de)
ZA (1) ZA734876B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
AR221676A1 (es) * 1974-07-12 1981-03-13 Bioresearch Sas Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
US4109079A (en) * 1975-10-16 1978-08-22 Yamasa Shoyu Kabushiki Kaisha Stabilized s-adenosyl-l-methionine preparations
GB2064523B (en) * 1979-12-04 1983-06-29 Kanegafuchi Chemical Ind Stable composition of s-adenosyl-l-methionine
IT1137640B (it) 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1169774B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
AU2538588A (en) * 1987-10-09 1989-05-02 Mario De Rosa Lipophilic salts of s-adenosyl-l-methionine (sam) with acylated taurine derivatives
DE19515275A1 (de) * 1995-04-26 1996-10-31 Knoll Ag Neue Verwendung von (S)-Adenosyl-L-methionin(SAMe)
US6759395B2 (en) 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
US8063024B2 (en) * 2005-01-26 2011-11-22 University Of Manitoba Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
CA2677053C (en) * 2007-01-31 2016-03-15 Methylation Sciences International Srl Extended release pharmaceutical formulations of s-adenosylmethionine
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20090197824A1 (en) * 2008-01-31 2009-08-06 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
US20110027342A1 (en) * 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
EP2696879A4 (de) 2011-04-15 2014-11-26 Scimar Ltd Verwendung von s-adenosylmethionin, vitamin e und vitamin c zur vorbeugung und behandlung kardiovaskulärer dysfunktion
CN106074589A (zh) 2012-10-17 2016-11-09 甲基化物科学国际有限公司 包含s‑腺苷甲硫氨酸及没食子酸酯的组合物
EP2945959B1 (de) 2013-01-16 2020-05-13 Hebert Sam-E LLC Stabile indole-3-propionat salze von s-adenosyl-l-methionine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946781A (en) * 1957-02-06 1960-07-26 Merck & Co Inc Process for the preparation of adenosyl homocysteine
US3642772A (en) * 1968-09-04 1972-02-15 Boehringer Mannheim Gmbh Process for preparing s-adenosyl homocysteine

Also Published As

Publication number Publication date
YU36037B (en) 1981-11-13
ES417377A1 (es) 1976-02-16
DK131868B (da) 1975-09-15
SU646915A3 (ru) 1979-02-05
AU474015B2 (en) 1976-07-08
CS195254B2 (en) 1980-01-31
HU167266B (de) 1975-09-27
AR195350A1 (es) 1973-09-28
CH592112A5 (de) 1977-10-14
DE2336401C3 (de) 1980-03-13
NL7310706A (de) 1974-02-05
FI52466B (de) 1977-05-31
NO137941C (no) 1978-05-31
IE37913L (en) 1974-02-02
DD107461A5 (de) 1974-08-05
IE37913B1 (en) 1977-11-09
IL42764A (en) 1976-04-30
FR2194425B1 (de) 1976-04-09
AU5868073A (en) 1975-01-30
CA1006872A (en) 1977-03-15
FI52466C (fi) 1977-09-12
SE400085B (sv) 1978-03-13
NO137941B (no) 1978-02-13
NL152864B (nl) 1977-04-15
ZA734876B (en) 1974-06-26
PL87381B1 (de) 1976-06-30
DK131868C (da) 1976-03-08
HK31580A (en) 1980-06-20
YU203073A (en) 1981-04-30
RO63451A (fr) 1978-07-15
AT341684B (de) 1978-02-27
DE2336401A1 (de) 1974-02-14
US3893999A (en) 1975-07-08
JPS5235726B2 (de) 1977-09-10
DE2336401B2 (de) 1979-07-12
MX4544E (es) 1982-06-08
IL42764A0 (en) 1974-01-14
GB1425384A (en) 1976-02-18
FR2194425A1 (de) 1974-03-01
BE802981A (fr) 1973-11-16
JPS4992215A (de) 1974-09-03

Similar Documents

Publication Publication Date Title
ATA664173A (de) Verfahren zur herstellung des neuen tri-p-toluolsulfonats von s-ademosyl-l-methionin
AT331258B (de) Verfahren zur herstellung von neuen 1,2,3-oxathiazin-4-onen
AT329076B (de) Verfahren zur herstellung von neuen 1-aminouracilen
ATA993573A (de) Verfahren zur herstellung von neuen cephalosporinathern
AT330791B (de) Verfahren zur herstellung von neuen phenylcarbamoylpyrazolinverbindungen
ATA779373A (de) Verfahren zur herstellung von neuen a-phenylindolderivaten
AT324312B (de) Verfahren zur herstellung von neuen trifluormethylsalicylaniliden
AT330955B (de) Verfahren zur herstellung von neuen beta-lactamen
AT328078B (de) Verfahren zur herstellung von neuen cyanomethylthioacetylcephalosporinen
AT324333B (de) Verfahren zur herstellung von neuen substituierten 5-chromanolen
AT324338B (de) Verfahren zur herstellung von neuen 2,6-diamino-dihydropyridinen
AT323750B (de) Verfahren zur herstellung von neuen nitroimidazolyl-triazolc-pyridazinen
AT328441B (de) Verfahren zur herstellung von neuen 2,10-dichlor-12-methyl-12h-dibenzo- (d,g) (1,3)-dioxocinderivaten
AT327213B (de) Verfahren zur herstellung von neuen lactamen
AT331805B (de) Verfahren zur herstellung von neuen triazinobenzimidazolen
AT326145B (de) Verfahren zur herstellung von neuen phosphonoureidoverbindungen
AT330142B (de) Verfahren zur herstellung von neuen n-alkenoyl -n'- formyl-methylendiaminen
AT315166B (de) Verfahren zur Herstellung von neuen 2-Acyl-5-nitrothiazolen
AT316747B (de) Verfahren zur Herstellung von neuen Alkyl-7-deoxy-7-mercaptoalkylthio-α-thiolincosaminiden
AT322104B (de) Verfahren zur herstellung von neuen pyrono-rifamycinen
AT333740B (de) Verfahren zur herstellung von neuen indanderivaten
AT323885B (de) Verfahren zur herstellung von neuen 3-formylrifamycinazinen
AT337684B (de) Verfahren zur herstellung von neuen hexahydro-cyclopenta (b) furanderivaten
AT323714B (de) Verfahren zur herstellung von neuen 6,9-dioxo-8-hydroxy-2-suestituierten-bicyclo-(3,3,1)-non-7-en-3-olen
AT324347B (de) Verfahren zur herstellung von neuen substituierten azetidin-2-onen

Legal Events

Date Code Title Description
EIH Change in the person of patent owner
EIH Change in the person of patent owner
ELA Expired due to lapse of time