IL42026A - Pyrazine 4-oxide derivatives and process for their preparation - Google Patents
Pyrazine 4-oxide derivatives and process for their preparationInfo
- Publication number
- IL42026A IL42026A IL42026A IL4202673A IL42026A IL 42026 A IL42026 A IL 42026A IL 42026 A IL42026 A IL 42026A IL 4202673 A IL4202673 A IL 4202673A IL 42026 A IL42026 A IL 42026A
- Authority
- IL
- Israel
- Prior art keywords
- general formula
- compound
- group
- pyrazine
- april
- Prior art date
Links
- RUIZBQQGWNBRFH-UHFFFAOYSA-N 1-oxidopyrazin-1-ium Chemical class [O-][N+]1=CC=NC=C1 RUIZBQQGWNBRFH-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000004965 peroxy acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- DZKRDHLYQRTDBU-UPHRSURJSA-N (z)-but-2-enediperoxoic acid Chemical compound OOC(=O)\C=C/C(=O)OO DZKRDHLYQRTDBU-UPHRSURJSA-N 0.000 abstract 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 abstract 1
- 101000837626 Homo sapiens Thyroid hormone receptor alpha Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract 1
- 102100028702 Thyroid hormone receptor alpha Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2366372 | 1972-04-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42026A0 IL42026A0 (en) | 1973-06-29 |
| IL42026A true IL42026A (en) | 1976-07-30 |
Family
ID=11208983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42026A IL42026A (en) | 1972-04-28 | 1973-04-13 | Pyrazine 4-oxide derivatives and process for their preparation |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5535384B2 (de) |
| AT (1) | AT326669B (de) |
| AU (1) | AU470007B2 (de) |
| BE (1) | BE798752A (de) |
| CA (1) | CA1000278A (de) |
| CH (1) | CH582161A5 (de) |
| CS (1) | CS172972B2 (de) |
| DE (1) | DE2319834C3 (de) |
| DK (1) | DK138796B (de) |
| FI (1) | FI55033C (de) |
| FR (1) | FR2183049B1 (de) |
| GB (1) | GB1361967A (de) |
| HK (1) | HK66876A (de) |
| HU (1) | HU165674B (de) |
| IL (1) | IL42026A (de) |
| MY (1) | MY7700077A (de) |
| NL (1) | NL178595C (de) |
| NO (1) | NO137728C (de) |
| SE (1) | SE387344B (de) |
| SU (1) | SU578876A3 (de) |
| ZA (1) | ZA732712B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1094287B (it) * | 1978-03-23 | 1985-07-26 | Erba Carlo Spa | Derivati della 2-idrossimetil-pirazina aventi attivita' ipolipemizzante |
| NL8202105A (nl) * | 1981-05-28 | 1982-12-16 | Erba Farmitalia | Werkwijze voor het bereiden van pyrazinederivaten. |
| CA1205075A (en) * | 1982-03-08 | 1986-05-27 | Claudio Santini | Preparation of pyrazine derivatives |
| GB2133004B (en) * | 1982-11-04 | 1986-06-11 | Ici Plc | Process for the extraction of metal values and novel metal extractants |
| IT1201417B (it) * | 1985-05-17 | 1989-02-02 | Montedison Spa | Procedimento per la preparazione di 2-carbossipirazine 4 ossido |
| US4962111A (en) * | 1989-06-08 | 1990-10-09 | The Research Foundation Of State University Of New York | Pyrazinoic acid esters as antituberculosis agents |
| US5643912A (en) * | 1993-12-17 | 1997-07-01 | The Research Foundation Of State University Of Ny | Pyrazinoic acid esters as anti-mycobacterium avium agents |
| CN113493421A (zh) * | 2020-04-08 | 2021-10-12 | 鲁南制药集团股份有限公司 | 一种1,2-二(4-吡啶基)乙烷-阿昔莫司共晶 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3452014A (en) * | 1964-08-14 | 1969-06-24 | Upjohn Co | 2,5-dimethylpyrazine p-toluenesulfonate |
| AT291264B (de) * | 1969-05-05 | 1971-07-12 | Daiichi Seiyaku Company Ltd | Verfahren zur Herstellung von neuen Pyrazincarbonsäurederivaten |
| NL6907199A (en) * | 1969-05-09 | 1970-11-11 | Hypoglycaemic pyrazine derivs |
-
1973
- 1973-04-12 GB GB1764573A patent/GB1361967A/en not_active Expired
- 1973-04-12 AU AU54413/73A patent/AU470007B2/en not_active Expired
- 1973-04-13 IL IL42026A patent/IL42026A/en unknown
- 1973-04-18 DE DE2319834A patent/DE2319834C3/de not_active Expired
- 1973-04-18 AT AT345073A patent/AT326669B/de active Protection Beyond IP Right Term
- 1973-04-19 ZA ZA732712A patent/ZA732712B/xx unknown
- 1973-04-24 CS CS2929A patent/CS172972B2/cs unknown
- 1973-04-25 NO NO1705/73A patent/NO137728C/no unknown
- 1973-04-26 BE BE130442A patent/BE798752A/xx not_active IP Right Cessation
- 1973-04-26 JP JP4832373A patent/JPS5535384B2/ja not_active Expired
- 1973-04-26 NL NLAANVRAGE7305867,A patent/NL178595C/xx not_active IP Right Cessation
- 1973-04-26 FI FI1336/73A patent/FI55033C/fi active
- 1973-04-27 CA CA169,694A patent/CA1000278A/en not_active Expired
- 1973-04-27 SE SE7305965A patent/SE387344B/xx unknown
- 1973-04-27 CH CH605873A patent/CH582161A5/xx active Protection Beyond IP Right Term
- 1973-04-27 FR FR7315308A patent/FR2183049B1/fr not_active Expired
- 1973-04-27 DK DK232573AA patent/DK138796B/da not_active IP Right Cessation
- 1973-04-27 SU SU7301908970A patent/SU578876A3/ru active
- 1973-04-27 HU HUEA129A patent/HU165674B/hu unknown
-
1976
- 1976-10-28 HK HK668/76*UA patent/HK66876A/xx unknown
-
1977
- 1977-12-30 MY MY77/77A patent/MY7700077A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2183049A1 (de) | 1973-12-14 |
| CS172972B2 (de) | 1977-01-28 |
| MY7700077A (en) | 1977-12-31 |
| ATA345073A (de) | 1975-03-15 |
| IL42026A0 (en) | 1973-06-29 |
| DE2319834C3 (de) | 1983-02-03 |
| HK66876A (en) | 1976-11-05 |
| NO137728B (no) | 1978-01-02 |
| CH582161A5 (de) | 1976-11-30 |
| NL178595B (nl) | 1985-11-18 |
| CA1000278A (en) | 1976-11-23 |
| AU5441373A (en) | 1974-10-17 |
| HU165674B (de) | 1974-10-28 |
| GB1361967A (en) | 1974-07-30 |
| AT326669B (de) | 1975-12-29 |
| FI55033C (fi) | 1979-05-10 |
| NL178595C (nl) | 1986-04-16 |
| DK138796B (da) | 1978-10-30 |
| SU578876A3 (ru) | 1977-10-30 |
| ZA732712B (en) | 1974-11-27 |
| JPS5535384B2 (de) | 1980-09-12 |
| AU470007B2 (en) | 1976-02-26 |
| NO137728C (no) | 1978-04-12 |
| NL7305867A (de) | 1973-10-30 |
| JPS4954386A (de) | 1974-05-27 |
| BE798752A (fr) | 1973-08-16 |
| DK138796C (de) | 1979-04-30 |
| DE2319834B2 (de) | 1982-06-24 |
| DE2319834A1 (de) | 1973-11-15 |
| SE387344B (sv) | 1976-09-06 |
| FI55033B (fi) | 1979-01-31 |
| FR2183049B1 (de) | 1975-10-31 |
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