IL42026A - Pyrazine 4-oxide derivatives and process for their preparation - Google Patents
Pyrazine 4-oxide derivatives and process for their preparationInfo
- Publication number
- IL42026A IL42026A IL42026A IL4202673A IL42026A IL 42026 A IL42026 A IL 42026A IL 42026 A IL42026 A IL 42026A IL 4202673 A IL4202673 A IL 4202673A IL 42026 A IL42026 A IL 42026A
- Authority
- IL
- Israel
- Prior art keywords
- general formula
- compound
- group
- pyrazine
- april
- Prior art date
Links
- RUIZBQQGWNBRFH-UHFFFAOYSA-N 1-oxidopyrazin-1-ium Chemical class [O-][N+]1=CC=NC=C1 RUIZBQQGWNBRFH-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000004965 peroxy acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- DZKRDHLYQRTDBU-UPHRSURJSA-N (z)-but-2-enediperoxoic acid Chemical compound OOC(=O)\C=C/C(=O)OO DZKRDHLYQRTDBU-UPHRSURJSA-N 0.000 abstract 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 abstract 1
- 101000837626 Homo sapiens Thyroid hormone receptor alpha Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract 1
- 102100028702 Thyroid hormone receptor alpha Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1361967 Pyrazine 4 oxide and derivatives thereof CARLO ERBA SpA 12 April 1972 [28 April 1972] 17645/73 Heading C2C The invention comprises compounds of the general formula wherein each of R<SP>1</SP>, R<SP>2</SP> and R<SP>3</SP>, which may be the same or different, is a hydrogen or halogen atom or a C 1 to C 6 alkyl or alkoxy group, at least one of R<SP>1</SP>, R<SP>2</SP> and R<SP>3</SP> being other than a hydrogen atom; R<SP>4</SP> is a hydroxyl or C 1 to C 6 alkoxy group or a group of formula -NR<SP>5</SP>R<SP>6</SP> wherein each of R<SP>5</SP> and R<SP>6</SP>, which may be the same or different, is a hydrogen atom or a C 1 to C 6 alkyl group; or, when R<SP>4</SP> is a hydroxyl group, a pharmaceutically acceptable salt of said compound. The compounds can be prepared by oxidizing a compound of general formula wherein R<SP>1</SP> to R<SP>4</SP> are as defined above, and then if desired converting by methods know per se. The compound with the general formula of this invention so produced into another compound of the general formula of this invention and if desired, when R<SP>4</SP> is a hydroxyl group, reacting the compound of the general formula of the invention with a base to give a pharmaceutically acceptable salt. The oxidation is preferably performed with peracids, which may be prepared in situ. The preferred peracids are peracetic, m-chloro perbenzoic and permaleic acid.
[GB1361967A]
Claims (1)
1. accordin to claim or insufficientOCRQuality
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2366372 | 1972-04-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42026A0 IL42026A0 (en) | 1973-06-29 |
| IL42026A true IL42026A (en) | 1976-07-30 |
Family
ID=11208983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42026A IL42026A (en) | 1972-04-28 | 1973-04-13 | Pyrazine 4-oxide derivatives and process for their preparation |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5535384B2 (en) |
| AT (1) | AT326669B (en) |
| AU (1) | AU470007B2 (en) |
| BE (1) | BE798752A (en) |
| CA (1) | CA1000278A (en) |
| CH (1) | CH582161A5 (en) |
| CS (1) | CS172972B2 (en) |
| DE (1) | DE2319834C3 (en) |
| DK (1) | DK138796B (en) |
| FI (1) | FI55033C (en) |
| FR (1) | FR2183049B1 (en) |
| GB (1) | GB1361967A (en) |
| HK (1) | HK66876A (en) |
| HU (1) | HU165674B (en) |
| IL (1) | IL42026A (en) |
| MY (1) | MY7700077A (en) |
| NL (1) | NL178595C (en) |
| NO (1) | NO137728C (en) |
| SE (1) | SE387344B (en) |
| SU (1) | SU578876A3 (en) |
| ZA (1) | ZA732712B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1094287B (en) * | 1978-03-23 | 1985-07-26 | Erba Carlo Spa | DERIVATIVES OF 2-HYDROXYMETHY-PYRAZINE HAVING LIPOLIPEMIZING ACTIVITY |
| NL8202105A (en) * | 1981-05-28 | 1982-12-16 | Erba Farmitalia | PROCESS FOR PREPARING PYRAZINE DERIVATIVES. |
| IL68036A (en) * | 1982-03-08 | 1986-08-31 | Erba Farmitalia | Preparation of 5-methyl-pyrazine-4-oxide-2-carboxylic acid and ester and amide derivatives |
| EP0112617B1 (en) * | 1982-11-04 | 1986-12-30 | Imperial Chemical Industries Plc | Process for the extraction of metal values and novel metal extractants |
| IT1201417B (en) * | 1985-05-17 | 1989-02-02 | Montedison Spa | PROCEDURE FOR THE PREPARATION OF 2-CARBOXYPYRAZINE 4 OXIDE |
| US4962111A (en) * | 1989-06-08 | 1990-10-09 | The Research Foundation Of State University Of New York | Pyrazinoic acid esters as antituberculosis agents |
| US5643912A (en) * | 1993-12-17 | 1997-07-01 | The Research Foundation Of State University Of Ny | Pyrazinoic acid esters as anti-mycobacterium avium agents |
| CN113493421A (en) * | 2020-04-08 | 2021-10-12 | 鲁南制药集团股份有限公司 | 1, 2-di (4-pyridyl) ethane-acipimox eutectic crystal |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3452014A (en) * | 1964-08-14 | 1969-06-24 | Upjohn Co | 2,5-dimethylpyrazine p-toluenesulfonate |
| AT291264B (en) * | 1969-05-05 | 1971-07-12 | Daiichi Seiyaku Company Ltd | Process for the preparation of new pyrazine carboxylic acid derivatives |
| NL6907199A (en) * | 1969-05-09 | 1970-11-11 | Hypoglycaemic pyrazine derivs |
-
1973
- 1973-04-12 AU AU54413/73A patent/AU470007B2/en not_active Expired
- 1973-04-12 GB GB1764573A patent/GB1361967A/en not_active Expired
- 1973-04-13 IL IL42026A patent/IL42026A/en unknown
- 1973-04-18 AT AT345073A patent/AT326669B/en active Protection Beyond IP Right Term
- 1973-04-18 DE DE2319834A patent/DE2319834C3/en not_active Expired
- 1973-04-19 ZA ZA732712A patent/ZA732712B/en unknown
- 1973-04-24 CS CS2929A patent/CS172972B2/cs unknown
- 1973-04-25 NO NO1705/73A patent/NO137728C/en unknown
- 1973-04-26 FI FI1336/73A patent/FI55033C/en active
- 1973-04-26 BE BE130442A patent/BE798752A/en not_active IP Right Cessation
- 1973-04-26 JP JP4832373A patent/JPS5535384B2/ja not_active Expired
- 1973-04-26 NL NLAANVRAGE7305867,A patent/NL178595C/en not_active IP Right Cessation
- 1973-04-27 DK DK232573AA patent/DK138796B/en not_active IP Right Cessation
- 1973-04-27 CH CH605873A patent/CH582161A5/xx active Protection Beyond IP Right Term
- 1973-04-27 CA CA169,694A patent/CA1000278A/en not_active Expired
- 1973-04-27 HU HUEA129A patent/HU165674B/hu unknown
- 1973-04-27 SE SE7305965A patent/SE387344B/en unknown
- 1973-04-27 FR FR7315308A patent/FR2183049B1/fr not_active Expired
- 1973-04-27 SU SU7301908970A patent/SU578876A3/en active
-
1976
- 1976-10-28 HK HK668/76*UA patent/HK66876A/en unknown
-
1977
- 1977-12-30 MY MY77/77A patent/MY7700077A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE798752A (en) | 1973-08-16 |
| AU470007B2 (en) | 1976-02-26 |
| NO137728C (en) | 1978-04-12 |
| AT326669B (en) | 1975-12-29 |
| FI55033C (en) | 1979-05-10 |
| DK138796B (en) | 1978-10-30 |
| FR2183049A1 (en) | 1973-12-14 |
| DK138796C (en) | 1979-04-30 |
| SE387344B (en) | 1976-09-06 |
| DE2319834A1 (en) | 1973-11-15 |
| CA1000278A (en) | 1976-11-23 |
| CS172972B2 (en) | 1977-01-28 |
| AU5441373A (en) | 1974-10-17 |
| FI55033B (en) | 1979-01-31 |
| ATA345073A (en) | 1975-03-15 |
| JPS4954386A (en) | 1974-05-27 |
| FR2183049B1 (en) | 1975-10-31 |
| ZA732712B (en) | 1974-11-27 |
| DE2319834C3 (en) | 1983-02-03 |
| IL42026A0 (en) | 1973-06-29 |
| NL7305867A (en) | 1973-10-30 |
| HK66876A (en) | 1976-11-05 |
| DE2319834B2 (en) | 1982-06-24 |
| HU165674B (en) | 1974-10-28 |
| NL178595C (en) | 1986-04-16 |
| JPS5535384B2 (en) | 1980-09-12 |
| CH582161A5 (en) | 1976-11-30 |
| NO137728B (en) | 1978-01-02 |
| NL178595B (en) | 1985-11-18 |
| GB1361967A (en) | 1974-07-30 |
| SU578876A3 (en) | 1977-10-30 |
| MY7700077A (en) | 1977-12-31 |
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