IL42016A - History of dopamine and their preparation - Google Patents
History of dopamine and their preparationInfo
- Publication number
- IL42016A IL42016A IL42016A IL4201673A IL42016A IL 42016 A IL42016 A IL 42016A IL 42016 A IL42016 A IL 42016A IL 4201673 A IL4201673 A IL 4201673A IL 42016 A IL42016 A IL 42016A
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- hydrogen
- phenethylamine
- methoxylated
- propyl7
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 9
- 150000001875 compounds Chemical class 0.000 claims abstract 7
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims abstract 6
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000002253 acid Substances 0.000 claims abstract 5
- ANOUKFYBOAKOIR-UHFFFAOYSA-N 3,4-dimethoxyphenylethylamine Chemical compound COC1=CC=C(CCN)C=C1OC ANOUKFYBOAKOIR-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 229910000085 borane Inorganic materials 0.000 claims abstract 3
- 150000007513 acids Chemical class 0.000 claims abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract 2
- 239000011707 mineral Substances 0.000 claims abstract 2
- 229940117803 phenethylamine Drugs 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- -1 dopamine derivative compound Chemical class 0.000 claims 5
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
- 239000012442 inert solvent Substances 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 229910000042 hydrogen bromide Inorganic materials 0.000 claims 2
- 229940048346 phenethylamine hydrochloride Drugs 0.000 claims 2
- LISAIUHOJQKVHK-UHFFFAOYSA-N 1-(3-bromopropyl)-3-methoxybenzene Chemical compound COC1=CC=CC(CCCBr)=C1 LISAIUHOJQKVHK-UHFFFAOYSA-N 0.000 claims 1
- 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims 1
- DUTRTHUPRZLRSD-UHFFFAOYSA-N 4-(2-methoxyphenyl)butan-2-one Chemical compound COC1=CC=CC=C1CCC(C)=O DUTRTHUPRZLRSD-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 229960003638 dopamine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- UMYZWICEDUEWIM-UHFFFAOYSA-N 1-(3,4-dimethoxyphenyl)propan-2-one Chemical compound COC1=CC=C(CC(C)=O)C=C1OC UMYZWICEDUEWIM-UHFFFAOYSA-N 0.000 abstract 4
- LYUQWQRTDLVQGA-UHFFFAOYSA-N 3-phenylpropylamine Chemical class NCCCC1=CC=CC=C1 LYUQWQRTDLVQGA-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- WUAXWQRULBZETB-UHFFFAOYSA-N homoveratric acid Chemical compound COC1=CC=C(CC(O)=O)C=C1OC WUAXWQRULBZETB-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000005932 reductive alkylation reaction Methods 0.000 abstract 2
- 230000002829 reductive effect Effects 0.000 abstract 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 2
- KWTSXDURSIMDCE-UHFFFAOYSA-N 1-phenylpropan-2-amine Chemical class CC(N)CC1=CC=CC=C1 KWTSXDURSIMDCE-UHFFFAOYSA-N 0.000 abstract 1
- XMZQWZJMTBCUFT-UHFFFAOYSA-N 3-bromopropylbenzene Chemical class BrCCCC1=CC=CC=C1 XMZQWZJMTBCUFT-UHFFFAOYSA-N 0.000 abstract 1
- WECUIGDEWBNQJJ-UHFFFAOYSA-N 4-phenylbutan-2-amine Chemical class CC(N)CCC1=CC=CC=C1 WECUIGDEWBNQJJ-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical class NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- AKGGYBADQZYZPD-UHFFFAOYSA-N benzylacetone Chemical class CC(=O)CCC1=CC=CC=C1 AKGGYBADQZYZPD-UHFFFAOYSA-N 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 150000005217 methyl ethers Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- QCCDLTOVEPVEJK-UHFFFAOYSA-N phenylacetone Chemical class CC(=O)CC1=CC=CC=C1 QCCDLTOVEPVEJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000007925 phenylethylamine derivatives Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24346672A | 1972-04-12 | 1972-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42016A0 IL42016A0 (en) | 1973-06-29 |
| IL42016A true IL42016A (en) | 1976-05-31 |
Family
ID=22918877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42016A IL42016A (en) | 1972-04-12 | 1973-04-12 | History of dopamine and their preparation |
Country Status (31)
| Country | Link |
|---|---|
| JP (2) | JPS5825656B2 (fr) |
| KR (1) | KR790000113B1 (fr) |
| AR (1) | AR203822A1 (fr) |
| AT (1) | AT323719B (fr) |
| AU (1) | AU472734B2 (fr) |
| BE (1) | BE798051A (fr) |
| BG (1) | BG23001A3 (fr) |
| CA (1) | CA1018188A (fr) |
| CH (2) | CH569691A5 (fr) |
| CS (2) | CS190406B2 (fr) |
| CY (1) | CY963A (fr) |
| DD (1) | DD107670B3 (fr) |
| DE (1) | DE2317710C2 (fr) |
| DK (1) | DK142750C (fr) |
| ES (1) | ES413639A1 (fr) |
| FR (1) | FR2182947B1 (fr) |
| GB (1) | GB1392674A (fr) |
| HK (1) | HK50178A (fr) |
| HU (2) | HU167597B (fr) |
| IE (1) | IE37511B1 (fr) |
| IL (1) | IL42016A (fr) |
| KE (1) | KE2870A (fr) |
| MY (1) | MY7800381A (fr) |
| NL (1) | NL174459C (fr) |
| PH (1) | PH11041A (fr) |
| PL (2) | PL90695B1 (fr) |
| RO (2) | RO65105A (fr) |
| SE (1) | SE399064B (fr) |
| SU (1) | SU496719A3 (fr) |
| YU (2) | YU36483B (fr) |
| ZA (1) | ZA732136B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH585693A5 (fr) * | 1974-02-08 | 1977-03-15 | Ciba Geigy Ag | |
| US4342692A (en) * | 1980-10-20 | 1982-08-03 | Usv Pharmaceutical Corporation | Pyrrolidines |
| ZA825227B (en) * | 1981-07-22 | 1984-03-28 | Syntex Inc | Substituted pyrrolidine cardiovascular system regulators antihypertensives |
| JPS6061523A (ja) * | 1983-09-16 | 1985-04-09 | Shionogi & Co Ltd | 経口用ドブタミン製剤 |
| ZA881076B (en) * | 1987-02-24 | 1989-10-25 | Lilly Co Eli | Dobutamine salts |
| JPH0383364U (fr) * | 1989-12-18 | 1991-08-23 | ||
| AU658188B2 (en) * | 1991-05-20 | 1995-04-06 | Tsumura & Co. | Phellodendrine analogs and allergy type IV suppressor containing the same as active ingredient |
| ATE155125T1 (de) * | 1993-04-13 | 1997-07-15 | Duphar Int Res | Herstellung von dobutamin verbindungen |
| EP0620208B1 (fr) * | 1993-04-13 | 1997-07-09 | Duphar International Research B.V | Production de composés de la dobutamine |
| WO2004031129A2 (fr) | 2002-10-03 | 2004-04-15 | New Era Biotech, Ltd. | Nouveaux composes destines au traitement des maladies auto-immunes, des maladies immuno-allergiques et des rejets en cas de greffes d'organes ou de tissus |
| CA2560922C (fr) | 2004-03-26 | 2014-01-07 | New Era Biotech, Ltd. | Ameliorations apportees a des composes destines a etre utilises dans le traitement du sida ou d'autres maladies virales et infections associees au vih et compositions contenant ces composes, methodes de traitement de ces maladies et de ces infections et methodes de fabrication de ces composes et de ces compositions |
| GB0804213D0 (en) | 2008-03-06 | 2008-04-16 | New Era Biotech Ltd | A method of printing or preventing pain |
| US9192585B2 (en) | 2009-07-31 | 2015-11-24 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| US8802734B2 (en) | 2009-09-09 | 2014-08-12 | Novaremed Limited | Method of treating or preventing pain |
| EP2747759A4 (fr) * | 2011-08-25 | 2015-05-13 | Cognition Therapeutics Inc | Compositions et méthodes pour le traitement de maladies neurodégénératives |
| AU2015210852B2 (en) | 2014-01-31 | 2019-01-24 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| DK3634394T3 (da) | 2017-05-15 | 2026-03-02 | Cognition Therapeutics Inc | Sammensætninger til behandling af neurogenerative sygdomme |
| CN114524734B (zh) * | 2021-12-27 | 2024-04-26 | 嘉实（湖南）医药科技有限公司 | 一种盐酸多巴酚丁胺的制备方法 |
| CN117326958B (zh) * | 2023-09-21 | 2025-07-11 | 锦州奥鸿药业有限责任公司 | 一种高纯度盐酸多巴酚丁胺的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2276619A (en) * | 1942-03-17 | N-phentlaliphatic-dihtoroxyphentnl |
-
1973
- 1973-03-28 ZA ZA732136A patent/ZA732136B/xx unknown
- 1973-04-09 GB GB1683573A patent/GB1392674A/en not_active Expired
- 1973-04-09 CY CY963A patent/CY963A/xx unknown
- 1973-04-09 DE DE2317710A patent/DE2317710C2/de not_active Expired
- 1973-04-10 FR FR7312845A patent/FR2182947B1/fr not_active Expired
- 1973-04-10 SE SE7305032A patent/SE399064B/xx unknown
- 1973-04-10 IE IE563/73A patent/IE37511B1/xx unknown
- 1973-04-11 SU SU1908277A patent/SU496719A3/ru active
- 1973-04-11 KR KR7300573A patent/KR790000113B1/ko not_active Expired
- 1973-04-11 AT AT318773A patent/AT323719B/de not_active IP Right Cessation
- 1973-04-11 DK DK196773A patent/DK142750C/da not_active IP Right Cessation
- 1973-04-11 CA CA168,428A patent/CA1018188A/en not_active Expired
- 1973-04-11 CH CH517473A patent/CH569691A5/xx not_active IP Right Cessation
- 1973-04-11 CH CH1112475A patent/CH580563A5/xx not_active IP Right Cessation
- 1973-04-11 BE BE1004956A patent/BE798051A/fr not_active IP Right Cessation
- 1973-04-11 AU AU54385/73A patent/AU472734B2/en not_active Expired
- 1973-04-11 YU YU00976/73A patent/YU36483B/xx unknown
- 1973-04-11 NL NLAANVRAGE7305097,A patent/NL174459C/xx not_active IP Right Cessation
- 1973-04-11 BG BG023268A patent/BG23001A3/xx unknown
- 1973-04-12 CS CS732601A patent/CS190406B2/cs unknown
- 1973-04-12 RO RO7374457A patent/RO65105A/fr unknown
- 1973-04-12 HU HUEI552A patent/HU167597B/hu unknown
- 1973-04-12 CS CS77171A patent/CS190448B2/cs unknown
- 1973-04-12 HU HUEI469A patent/HU166213B/hu unknown
- 1973-04-12 PL PL1973161874A patent/PL90695B1/pl unknown
- 1973-04-12 ES ES413639A patent/ES413639A1/es not_active Expired
- 1973-04-12 AR AR247523A patent/AR203822A1/es active
- 1973-04-12 IL IL42016A patent/IL42016A/en unknown
- 1973-04-12 DD DD73170118A patent/DD107670B3/de unknown
- 1973-04-12 RO RO7383749A patent/RO70892A/fr unknown
- 1973-04-12 PH PH14508A patent/PH11041A/en unknown
- 1973-04-12 PL PL1973183808A patent/PL94207B1/pl unknown
- 1973-04-12 JP JP48041750A patent/JPS5825656B2/ja not_active Expired
-
1978
- 1978-08-10 KE KE2870A patent/KE2870A/xx unknown
- 1978-09-07 HK HK501/78A patent/HK50178A/xx unknown
- 1978-12-30 MY MY381/78A patent/MY7800381A/xx unknown
-
1979
- 1979-12-28 YU YU3212/79A patent/YU37113B/xx unknown
-
1982
- 1982-08-27 JP JP57149025A patent/JPS58131945A/ja active Granted
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